Ras-guanine-nucleotide-releasing factors 1 and 2 interact with PLCγ at focal adhesions to enable IL-1-induced Ca2+ signalling, ERK activation and MMP-3 expression

Biochemical Journal

Volumn 449, Issue 3, 2013, Pages 771-782

  Wang, Qin ^a   Siminovitch, Katherine A ^b   Downey, Gregory P ^c,d   Mcculloch, Christopher A ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

^c DEPARTMENT OF MEDICINE   (United States)

^d UNIVERSITY OF COLORADO   (United States)

Author keywords

Fibroblast; Inositol 1,4,5 trisphosphate (IP3); Phospholipase C ; Protease

Indexed keywords

CALCIUM ION; GUANINE; INTERLEUKIN 1; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE C GAMMA1; RAS GUANINE NUCLEOTIDE RELEASING FACTOR 1; RAS GUANINE NUCLEOTIDE RELEASING FACTOR 2; RAS PROTEIN; SMALL INTERFERING RNA; STROMELYSIN; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM SIGNALING; CONTROLLED STUDY; CYTOSOL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; CALCIUM SIGNALING; FOCAL ADHESIONS; INTERLEUKIN-1; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 3; MICE; NIH 3T3 CELLS; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; RAS GUANINE NUCLEOTIDE EXCHANGE FACTORS; RAS-GRF1; RNA, SMALL INTERFERING;

EID: 84872455053     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20121170     Document Type: Article

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