Potent reversal of multidrug resistance by ningalins and its use in drug combinations against human colon carcinoma xenograft in nude mice

Cancer Chemotherapy and Pharmacology

Volumn 56, Issue 4, 2005, Pages 379-390

  Chou, Ting Chao ^a   Guan, Yongbiao ^a   Soenen, Danielle R ^b   Danishefsky, Samuel J ^a   Boger, Dale L ^b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Combination index; MDR reversal; Ningalin; Therapeutic potentiation

Indexed keywords

2,3 BIS(2 METHOXY 4 NITRO 4 SULFOPHENYL) 5 CARBOXANILIDE 2H TETRASODIUM HYDROXIDE; ANTINEOPLASTIC AGENT; AZIDOPINE; DOXORUBICIN; GLYCOPROTEIN P; HYDROXIDE; NINGALIN; PACLITAXEL; TENIPOSIDE; TRITIUM; UNCLASSIFIED DRUG; VINBLASTINE; VINBLASTINE SULFATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CARCINOMA; CANCER INHIBITION; CARCINOMA CELL; COLON CARCINOMA; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG CYTOTOXICITY; DRUG DETERMINATION; DRUG DOSE REDUCTION; DRUG EFFECT; DRUG EFFICACY; DRUG LABELING; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SENSITIVITY; DRUG TRANSPORT; DRUG USE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IC 50; LEUKEMIA; LEUKEMIA P 388 CELL; MALE; MARINE ENVIRONMENT; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; NUDE MOUSE; OBSERVATION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN BINDING; REMISSION; XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL FACTORS; COLONIC NEOPLASMS; DRUG RESISTANCE, MULTIPLE; DRUG SYNERGISM; HUMANS; MICE; MICE, NUDE; STRUCTURE-ACTIVITY RELATIONSHIP; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 23244448041     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-005-1019-y     Document Type: Article

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