A high serum iron level causes mouse retinal iron accumulation despite an intact blood-retinal barrier

American Journal of Pathology

Volumn 184, Issue 11, 2014, Pages 2862-2867

  Zhao, Liangliang ^a,b   Li, Yafeng ^b   Song, Delu ^b   Song, Ying ^b   Theurl, Milan ^b   Wang, Chenguang ^a,b   Cwanger, Alyssa ^b   Su, Guanfang ^a   Dunaief, Joshua L ^b  

^a THE SECOND HOSPITAL OF JILIN UNIVERSITY   (China)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 6; FERRITIN; HEPCIDIN; IRON; IRON SACCHARATE; MESSENGER RNA; RETINAL;

ANIMAL EXPERIMENT; ARTICLE; BLOOD RETINA BARRIER; CONTROLLED STUDY; GENE CONTROL; IMMUNOFLUORESCENCE; IRON BLOOD LEVEL; IRON METABOLISM; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PHOTORECEPTOR; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; RETINA; UPREGULATION; ANIMAL; BLOOD; GENETICS; IRON OVERLOAD; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY;

ANIMALS; BLOOD-RETINAL BARRIER; BONE MORPHOGENETIC PROTEIN 6; HEPCIDINS; IRON; IRON OVERLOAD; MICE; MICE, KNOCKOUT; OXIDATIVE STRESS; RETINA;

EID: 84908181354     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2014.07.008     Document Type: Article

References (23)

1. J.P. Gnana-Prakasam, P.M. Martin, S.B. Smith, and V. Ganapathy Expression and function of iron-regulatory proteins in retina IUBMB Life 62 2010 363 370
2. D. Song, and J.L. Dunaief Retinal iron homeostasis in health and disease Front Aging Neurosci 5 2013 24
3. M. Hadziahmetovic, T. Dentchev, Y. Song, N. Haddad, X. He, P. Hahn, D. Pratico, R. Wen, Z.L. Harris, J.D. Lambris, J. Beard, and J.L. Dunaief Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD Invest Ophthalmol Vis Sci 49 2008 2728 2736
4. P. Hahn, Y. Qian, T. Dentchev, L. Chen, J. Beard, Z.L. Harris, and J.L. Dunaief Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration Proc Natl Acad Sci U S A 101 2004 13850 13855
5. M. Hadziahmetovic, Y. Song, P. Ponnuru, J. Iacovelli, A. Hunter, N. Haddad, J. Beard, J.R. Connor, S. Vaulont, and J.L. Dunaief Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice Invest Ophthalmol Vis Sci 52 2011 109 118
6. D. Meynard, L. Kautz, V. Darnaud, F. Canonne-Hergaux, H. Coppin, and M.-P. Roth Lack of the bone morphogenetic protein BMP6 induces massive iron overload Nat Genet 41 2009 478 481
7. M. Hadziahmetovic, Y. Song, N. Wolkow, J. Iacovelli, L. Kautz, M.-P. Roth, and J.L. Dunaief Bmp6 regulates retinal iron homeostasis and has altered expression in age-related macular degeneration Am J Pathol 179 2011 335 348
8. S. Soe-Lin, S.S. Apte, B. Andriopoulos, M.C. Andrews, M. Schranzhofer, T. Kahawita, D. Garcia-Santos, and P. Ponka Nramp1 promotes efficient macrophage recycling of iron following erythrophagocytosis in vivo Proc Natl Acad Sci U S A 106 2009 5960 5965
9. H. Gunshin, B. Mackenzie, U.V. Berger, Y. Gunshin, M.F. Romero, W.F. Boron, S. Nussberger, J.L. Gollan, and M.A. Hediger Cloning and characterization of a mammalian proton-coupled metal-ion transporter Nature 388 1997 482 488
10. A. Donovan, A. Brownlie, Y. Zhou, J. Shepard, S.J. Pratt, J. Moynihan, B.H. Paw, A. Drejer, B. Barut, A. Zapata, T.C. Law, C. Brugnara, S.E. Lux, G.S. Pinkus, J.L. Pinkus, P.D. Kingsley, J. Palis, M.D. Fleming, N.C. Andrews, and L.I. Zon Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter Nature 403 2000 776 781
11. E. Nemeth, M.S. Tuttle, J. Powelson, M.B. Vaughn, A. Donovan, D.M. Ward, T. Ganz, and J. Kaplan Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization Science 306 2004 2090 2093
12. E. Ramos, L. Kautz, R. Rodriguez, M. Hansen, V. Gabayan, Y. Ginzburg, M.-P. Roth, E. Nemeth, and T. Ganz Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice Hepatology 53 2011 1333 1341
13. M. Pak, M.A. Lopez, V. Gabayan, T. Ganz, and S. Rivera Suppression of hepcidin during anemia requires erythropoietic activity Blood 108 2006 3730 3735
14. X.-B. Liu, N.-B.H. Nguyen, K.D. Marquess, F. Yang, and D.J. Haile Regulation of hepcidin and ferroportin expression by lipopolysaccharide in splenic macrophages Blood Cells Mol Dis 35 2005 47 56
15. J.P. Gnana-Prakasam, P.M. Martin, B.A. Mysona, P. Roon, S.B. Smith, and V. Ganapathy Hepcidin expression in mouse retina and its regulation via lipopolysaccharide/Toll-like receptor-4 pathway independent of Hfe Biochem J 411 2008 79 88
16. P. Hahn, T. Dentchev, Y. Qian, T. Rouault, Z.L. Harris, and J.L. Dunaief Immunolocalization and regulation of iron handling proteins ferritin and ferroportin in the retina Mol Vis 10 2004 598 607
17. M.J. Solloway, A.T. Dudley, E.K. Bikoff, K.M. Lyons, B.L.M. Hogan, and E.J. Robertson Mice lacking Bmp6 function Dev Genet 22 1998 321 339
18. J.L. Dunaief, T. Dentchev, G.-S. Ying, and A.H. Milam The role of apoptosis in age-related macular degeneration Arch Ophthalmol 120 2002 1435 1442
19. C. Xin-Zhao Wang, K. Zhang, B. Aredo, and H. Lu Ufret-Vincenty RL: novel method for the rapid isolation of RPE cells specifically for RNA extraction and analysis Exp Eye Res 102 2012 1 9
20. D. Song, Y. Song, M. Hadziahmetovic, Y. Zhong, and J.L. Dunaief Systemic administration of the iron chelator deferiprone protects against light-induced photoreceptor degeneration in the mouse retina Free Radic Biol Med 53 2012 64 71
21. T.A. Rouault The role of iron regulatory proteins in mammalian iron homeostasis and disease Nat Chem Biol 2 2006 406 414
22. M.U. Muckenthaler, B. Galy, and M.W. Hentze Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network Annu Rev Nutr 28 2008 197 213
23. E.W.-T. Chong, J.A. Simpson, L.D. Robman, A.M. Hodge, K.Z. Aung, D.R. English, G.G. Giles, and R.H. Guymer Red meat and chicken consumption and its association with age-related macular degeneration Am J Epidemiol 169 2009 867 876