Xenobiotic pregnane X receptor (PXR) regulates innate immunity via activation of NLRP3 inflammasome in vascular endothelial cells

Journal of Biological Chemistry

Volumn 289, Issue 43, 2014, Pages 30075-30081

  Wang, Shaolan ^a   Lei, Ting ^a   Zhang, Kang ^a   Zhao, Wenxiang ^a   Fang, Li ^b   Lai, Baochang ^a   Han, Jie ^a   Xiao, Lei ^a   Wang, Nanping ^a,b  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b PEKING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CHEMICAL ACTIVATION; DETOXIFICATION; IMMUNE SYSTEM; PATTERN RECOGNITION; TRANSCRIPTION;

CONSTITUTIVELY ACTIVES; DETOXIFICATION GENE; POTENTIAL FUNCTION; PREGNANE X RECEPTORS; REGULATORY MECHANISM; TOLL-LIKE RECEPTORS; TRANSCRIPTIONAL TARGETS; VASCULAR ENDOTHELIAL CELLS;

ENDOTHELIAL CELLS;

CASPASE RECRUITMENT DOMAIN PROTEIN 15; CASPASE RECRUITMENT DOMAIN PROTEIN 4; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; PATTERN RECOGNITION RECEPTOR; PREGNANE X RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; TRANSCRIPTION FACTOR; XENOBIOTIC AGENT; CARRIER PROTEIN; NLRP3 PROTEIN, HUMAN; STEROID RECEPTOR;

ARTICLE; CHROMATIN IMMUNOPRECIPITATION; DETOXIFICATION; ENDOTHELIUM CELL; ENZYME ACTIVATION; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOREGULATION; INNATE IMMUNITY; PROMOTER REGION; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; REPORTER GENE; VASCULAR ENDOTHELIUM; AGONISTS; AMINO ACID SEQUENCE; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING SITE; BOVINAE; DNA RESPONSIVE ELEMENT; GENE EXPRESSION REGULATION; GENETICS; HEPG2 CELL LINE; METABOLISM; MOLECULAR GENETICS; UMBILICAL VEIN ENDOTHELIAL CELL;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CARRIER PROTEINS; CATTLE; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HEP G2 CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; IMMUNITY, INNATE; INFLAMMASOMES; MOLECULAR SEQUENCE DATA; RECEPTORS, PATTERN RECOGNITION; RECEPTORS, STEROID; RESPONSE ELEMENTS; XENOBIOTICS;

EID: 84908178835     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.578781     Document Type: Article

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