Effect of flavonoids on rat splenocytes, a structure-activity relationship study

Biochemical Pharmacology

Volumn 76, Issue 4, 2008, Pages 495-506

  López Posadas, Rocío ^a   Ballester, Isabel ^b   Abadía Molina, Ana Clara ^a   Suárez, María Dolores ^a   Zarzuelo, Antonio ^a   Martínez Augustin, Olga ^a   Sánchez de Medina, Fermín ^a  

^a UNIVERSITY OF GRANADA   (Spain)

^b HARVARD UNIVERSITY   (United States)

Author keywords

Flavonoid; Lymphocyte; Proliferation; Toxicity; Viability

Indexed keywords

APIGENIN; CASPASE 3; CHRYSIN; CONCANAVALIN A; CYCLOOXYGENASE 2; DAIDZEIN; DIOSMETIN; FISETIN; FLAVANOID; GAMMA INTERFERON; GENISTEIN; HESPERETIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 2; ISORHAMNETIN; KAEMPFEROL; LUTEOLIN; MORIN; MYRICETIN; NARINGENIN; POLYPHENOL; QUERCETIN; RESVERATROL; RUTOSIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; DOWN REGULATION; DRUG EFFECT; DRUG INHIBITION; ENZYME ACTIVATION; FEMALE; LEUKOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPLEEN CELL; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING;

ANIMALS; CELL PROLIFERATION; CELL SURVIVAL; CYCLOOXYGENASE 2; CYTOKINES; FLAVONOIDS; GENE EXPRESSION REGULATION; LYMPHOCYTES; NITRIC OXIDE SYNTHASE TYPE II; RATS; SPLEEN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 48149083967     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2008.06.001     Document Type: Article

References (57)

1. Beecher G.R. Overview of dietary flavonoids: nomenclature, occurrence and intake. J Nutr 133 (2003) 3248S-3254S
2. Cermak R., and Wolffram S. The potential of flavonoids to influence drug metabolism and pharmacokinetics by local gastrointestinal mechanisms. Curr Drug Metab 7 (2006) 729-744
3. Giovannini C., Filesi C., D'Archivio M., Scazzocchio B., Santangelo C., and Masella R. Polyphenols and endogenous antioxidant defences: effects on glutathione and glutathione related enzymes. Ann Ist Super Sanita 42 (2006) 336-347
4. Sang S., Hou Z., Lambert J.D., and Yang C.S. Redox properties of tea polyphenols and related biological activities. Antioxid Redox Signal 7 (2005) 1704-1714
5. Friedman M. Overview of antibacterial, antitoxin, antiviral, and antifungal activities of tea flavonoids and teas. Mol Nutr Food Res 51 (2007) 116-134
6. Li Y., Fang H., and Xu W. Recent advance in the research of flavonoids as anticancer agents. Mini Rev Med Chem 7 (2007) 663-678
7. Fresco P., Borges F., Diniz C., and Marques M.P. New insights on the anticancer properties of dietary polyphenols. Med Res Rev 26 (2006) 747-766
8. Oak M.H., El Bedoui J., and Schini-Kerth V.B. Antiangiogenic properties of natural polyphenols from red wine and green tea. J Nutr Biochem 16 (2005) 1-8
9. Dryden G.W., Song M., and McClain C. Polyphenols and gastrointestinal diseases. Curr Opin Gastroenterol 22 (2006) 165-170
10. Middleton Jr. E. Effect of plant flavonoids on immune and inflammatory cell function. Adv Exp Med Biol 439 (1998) 175-182
11. Jo E.H., Lee S.J., Ahn N.S., Park J.S., Hwang J.W., Kim S.H., et al. Induction of apoptosis in MCF-7 and MDA-MB-231 breast cancer cells by Oligonol is mediated by Bcl-2 family regulation and MEK/ERK signaling. Eur J Cancer Prev 16 (2007) 342-347
12. Shim H.Y., Park J.H., Paik H.D., Nah S.Y., Kim D.S., and Han Y.S. Genistein-induced apoptosis of human breast cancer MCF-7 cells involves calpain-caspase and apoptosis signaling kinase 1-p38 mitogen-activated protein kinase activation cascades. Anticancer Drugs 18 (2007) 649-657
13. Yamamoto Y., and Gaynor R.B. Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer. J Clin Invest 107 (2001) 135-142
14. Kalra N., Seth K., Prasad S., Singh M., Pant A.B., and Shukla Y. The aflavins induced apoptosis of LNCaP cells is mediated through induction of p53, down-regulation of NF-kappa B and mitogen-activated protein kinases pathways. Life Sci 80 (2007) 2137-2146
15. Sanchez de Medina F., Galvez J., Romero J.A., and Zarzuelo A. Effect of quercitrin on acute and chronic experimental colitis in the rat. J Pharmacol Exp Ther 278 (1996) 771-779
16. Galvez J., Cruz T., Crespo E., Ocete M.A., Lorente M.D., Sanchez de Medina F., et al. Rutoside as mucosal protective in acetic acid-induced rat colitis. Planta Med 63 (1997) 409-414
17. Sanchez de Medina F., Vera B., Galvez J., and Zarzuelo A. Effect of quercitrin on the early stages of hapten induced colonic inflammation in the rat. Life Sci 70 (2002) 3097-3108
18. Ocete M.A., Galvez J., Crespo M.E., Cruz T., Gonzalez M., Torres M.I., et al. Effects of morin on an experimental model of acute colitis in rats. Pharmacology 57 (1998) 261-270
19. Crespo M.E., Galvez J., Cruz T., Ocete M.A., and Zarzuelo A. Anti-inflammatory activity of diosmin and hesperidin in rat colitis induced by TNBS. Planta Med 65 (1999) 651-653
20. Ukil A., Maity S., and Das P.K. Protection from experimental colitis by the aflavin-3,3′-digallate correlates with inhibition of IKK and NF-kappaB activation. Br J Pharmacol 149 (2006) 121-131
21. Mazzon E., Muia C., Paola R.D., Genovese T., Menegazzi M., De Sarro A., et al. Green tea polyphenol extract attenuates colon injury induced by experimental colitis. Free Radic Res 39 (2005) 1017-1025
22. Mochizuki M., and Hasegawa N. Therapeutic efficacy of pycnogenol in experimental inflammatory bowel diseases. Phytother Res 18 (2004) 1027-1028
23. Kwon K.H., Murakami A., Tanaka T., and Ohigashi H. Dietary rutin, but not its aglycone quercetin, ameliorates dextran sulfate sodium-induced experimental colitis in mice: attenuation of pro-inflammatory gene expression. Biochem Pharmacol 69 (2005) 395-406
24. Comalada M., Ballester I., Bailon E., Sierra S., Xaus J., Galvez J., et al. Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: analysis of the structure-activity relationship. Biochem Pharmacol 72 (2006) 1010-1021
25. Lopez-Posadas R., Ballester I., Gonzalez R., Romero I., Suarez M.D., Zarzuelo A., et al. Immunomodulatory effect of flavonoids on IEC18 cells-a structure-activity relationship study. Gastroenterology 132 (2007) A236
26. Ruiz P.A., Braune A., Holzlwimmer G., Quintanilla-Fend L., and Haller D. Quercetin inhibits TNF-induced NF-kappaB transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells. J Nutr 137 (2007) 1208-1215
27. Ruiz P.A., and Haller D. Functional diversity of flavonoids in the inhibition of the proinflammatory NF-kappaB, IRF, and Akt signaling pathways in murine intestinal epithelial cells. J Nutr 136 (2006) 664-671
28. Theoharides T.C., Kempuraj D., and Iliopoulou B.P. Mast cells, T cells, and inhibition by luteolin: implications for the pathogenesis and treatment of multiple sclerosis. Adv Exp Med Biol 601 (2007) 423-430
29. Min Y.D., Choi C.H., Bark H., Son H.Y., Park H.H., Lee S., et al. Quercetin inhibits expression of inflammatory cytokines through attenuation of NF-kappaB and p38 MAPK in HMC-1 human mast cell line. Inflamm Res 56 (2007) 210-215
30. Middleton Jr. E., Kandaswami C., and Theoharides T.C. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 52 (2000) 673-751
31. Watson J.L., Vicario M., Wang A., Moreto M., and McKay D.M. Immune cell activation and subsequent epithelial dysfunction by Staphylococcus enterotoxin B is attenuated by the green tea polyphenol (-)-epigallocatechin gallate. Cell Immunol 237 (2005) 7-16
32. Suzuki J., Ogawa M., Sagesaka Y.M., and Isobe M. Tea catechins attenuate ventricular remodeling and graft arterial diseases in murine cardiac allografts. Cardiovasc Res 69 (2006) 272-279
33. Muthian G., and Bright J.J. Quercetin, a flavonoid phytoestrogen, ameliorates experimental allergic encephalomyelitis by blocking IL-12 signaling through JAK-STAT pathway in T lymphocyte. J Clin Immunol 24 (2004) 542-552
34. Ji L.L., Wang Z., Dong F., Zhang W.B., and Wang Z.T. Andrograpanin, a compound isolated from anti-inflammatory traditional Chinese medicine Andrographis paniculata, enhances chemokine SDF-1alpha-induced leukocytes chemotaxis. J Cell Biochem 95 (2005) 970-978
35. Enomoto R., Suzuki C., Koshiba C., Nishino T., Nakayama M., Hirano H., et al. Wogonin prevents immunosuppressive action but not anti-inflammatory effect induced by glucocorticoid. Ann N Y Acad Sci 1095 (2007) 412-417
36. Smith P.K., Krohn R.I., Hermanson G.T., Mallia A.K., Gartner F.H., Provenzano M.D., et al. Measurement of protein using bicinchoninic acid. Anal Biochem 150 (1985) 76-85
37. Weinberg J.B. Nitric oxide synthase 2 and cyclooxygenase 2 interactions in inflammation. Immunol Res 22 (2000) 319-341
38. Camuesco D., Comalada M., Rodriguez-Cabezas M.E., Nieto A., Lorente M.D., Concha A., et al. The intestinal anti-inflammatory effect of quercitrin is associated with an inhibition in iNOS expression. Br J Pharmacol 143 (2004) 908-918
39. Walle T. Absorption and metabolism of flavonoids. Free Radic Biol Med 36 (2004) 829-837
40. Spencer J.P., Chowrimootoo G., Choudhury R., Debnam E.S., Srai S.K., and Rice-Evans C. The small intestine can both absorb and glucuronidate luminal flavonoids. FEBS Lett 458 (1999) 224-230
41. Hirano T., Oka K., Kawashima E., and Akiba M. Effects of synthetic and naturally occurring flavonoids on mitogen-induced proliferation of human peripheral-blood lymphocytes. Life Sci 45 (1989) 1407-1411
42. You K.M., Son K.H., Chang H.W., Kang S.S., and Kim H.P. Vitexicarpin, a flavonoid from the fruits of Vitex rotundifolia, inhibits mouse lymphocyte proliferation and growth of cell lines in vitro. Planta Med 64 (1998) 546-550
43. Namgoong S.Y., Son K.H., Chang H.W., Kang S.S., and Kim H.P. Effects of naturally occurring flavonoids on mitogen-induced lymphocyte proliferation and mixed lymphocyte culture. Life Sci 54 (1994) 313-320
44. Smith D.M., and Dou Q.P. Green tea polyphenol epigallocatechin inhibits DNA replication and consequently induces leukemia cell apoptosis. Int J Mol Med 7 (2001) 645-652
45. Armstrong J.S., Hornung B., Lecane P., Jones D.P., and Knox S.J. Rotenone-induced G2/M cell cycle arrest and apoptosis in a human B lymphoma cell line PW. Biochem Biophys Res Commun 289 (2001) 973-978
46. Hirano T., Abe K., Gotoh M., Oka K., Nakazato T., Ito K., et al. Citrus flavone tangeretin inhibits leukaemic HL-60 cell growth partially through induction of apoptosis with less cytotoxicity on normal lymphocytes: green tea component, catechin, induces apoptosis of human malignant B cells via production of reactive oxygen species. Br J Cancer: Clin Cancer Res 72 (1995) 11:1380-8, 6040-9
47. Nakazato T., Ito K., Ikeda Y., and Kizaki M. Green tea component, catechin, induces apoptosis of human malignant B cells via production of reactive oxygen species. Clin Cancer Res 11 (2005) 6040-6049
48. Vargo M.A., Voss O.H., Poustka F., Cardounel A.J., Grotewold E., and Doseff A.I. Apigenin-induced-apoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells. Biochem Pharmacol 72 (2006) 681-692
49. Galvez J., Sanchez de Medina F., Jiménez J., and Zarzuelo A. Effects of flavonoids on gasrointestinal disorders. In: Atta-ur-Rahman (Ed). Studies in Natural Product Chemistry. Bioactive Natural Products (Part F) (2001), Elsevier Science Publishers, Amsterdam p. 565-604
50. Strauss G., Westhoff M.A., Fischer-Posovszky P., Fulda S., Schanbacher M., Eckhoff S.M., et al. 4-Hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG. Cell Death Differ 15 (2008) 332-343
51. Dunstl G., Weiland T., Schlaeger C., Nussler A., Kunstle G., and Wendel A. Activation of an alternative death receptor-induced signaling pathway in human hepatocytes under caspase arrest. Arch Biochem Biophys 462 (2007) 140-149
52. Straszewski-Chavez S.L., Visintin I.P., Karassina N., Los G., Liston P., Halaban R., et al. XAF1 mediates tumor necrosis factor-alpha-induced apoptosis and X-linked inhibitor of apoptosis cleavage by acting through the mitochondrial pathway. J Biol Chem 282 (2007) 13059-13072
53. Manach C., Williamson G., Morand C., Scalbert A., and Remesy C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 81 (2005) 230S-242S
54. Clifford M.N. Diet-derived phenols in plasma and tissues and their implications for health. Planta Med 70 (2004) 1103-1114
55. Hollman P.C.H. Absorption, bioavailability, and metabolism of flavonoids. Pharm Biol 42 Suppl. 1 (2004) 74-83
56. Morand C., Crespy V., Manach C., Besson C., Demigne C., and Remesy C. Plasma metabolites of quercetin and their antioxidant properties. Am J Physiol 275 (1998) R212-R219
57. de Boer V.C., Dihal A.A., van der Woude H., Arts I.C., Wolffram S., Alink G.M., et al. Tissue distribution of quercetin in rats and pigs. J Nutr 135 (2005) 1718-1725