Clostridium difficile infection: A review of the literature

Asian Pacific Journal of Tropical Medicine

Volumn 7, Issue S1, 2014, Pages S6-S13

  Khan, Fahmi Yousef ^a   Elzouki, Abdul Naser ^a  

^a HAMAD GENERAL HOSPITAL   (Qatar)

Author keywords

Clostridium difficile infection; Metronidazole; Nosocomial diarrhoea; Pseudomembranous colitis; Vancomycin

Indexed keywords

EID: 84908154147     PISSN: 19957645     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1995-7645(14)60197-8     Document Type: Article

References (74)

1. Kutty PK, Woods CW, Sena AC, Benoit SR, Naggie S, Frederick J, et al. Risk factors for and estimated incidence of community-associated Clostridium difficile infection, North Carolina, USA. Emerg Infect Dis 2010, 16:198-204.
2. Hall IC, O'Toole E Intestinal flora in newborn infants with a description of a new pathogenic anaerobe, Bacillus difficilis. Am J Dis Child 1935, 49:390-402.
3. Bartlett JG Clinical practice. Antibiotic-associated diarrhea. N Engl J Med 2002, 346:334-339.
4. Ricciardi R, Rothenberger DA, Madoff RD, Baxter NN Increasing prevalence and severity of Clostridium difficile colitis in hospitalized patients in the United States. Arch Surg 2007, 142:624-631.
5. O'Brien JA, Lahue BJ, Caro JJ, Davidson DM The emerging infectious challenge of Clostridium difficile-associated disease in Massachusetts hospitals: clinical and economic consequences. Infect Control Hosp Epidemiol 2007, 28:1219-1227.
6. Rupnik M, Dupuy B, Fairweather NF, Gerding DN, Johnson S, Just I, et al. Revised nomenclature of Clostridium difficile toxins and associated genes. J Med Microbiol 2005, 54:113-117.
7. Bobak D, Arfons LM, Creger RJ, Lazarus HM Clostridium difficile-associated disease in human stem cell transplant recipients: coming epidemic or false alarm?. Bone Marrow Transplant 2008, 42:705-713.
8. Genth H, Dreger SC, Huelsenbeck J, Just I Clostridium difficile toxins: more than mere inhibitors of Rho proteins. Int J Biochem Cell Biol 2008, 40:592-597.
9. Akerlund T, Svenungsson B, Lagergren A, Burman LG Correlation of disease severity with fecal toxin levels in patients with Clostridium difficile-associated diarrhea and distribution of PCR ribotypes and toxin yields in vitro of corresponding isolates. J Clin Microbiol 2006, 44:353-358.
10. Tillotson GS, Tillotson J Clostridium difficile-a moving target. F1000 Med Rep 2011, 3:6.
11. McDonald LC, Killgore GE, Thompson A, Owens RC, Kazakova SV, Sambol SP, et al. An epidemic, toxin gene-variant strain of Clostridium difficile. N Engl J Med 2005, 353:2433-2441.
12. Vaishnavi C Clostridium difficile infection: clinical spectrum and approach to management. Indian J Gastroenterol 2011, 30:245-254.
13. Freeman J, Bauer MP, Baines SD, Corver J, Fawley WN, Goorhuis B, et al. The changing epidemiology of Clostridium difficile Infections. Clin Microbiol Rev 2010, 23:529-549.
14. Riley TV Epidemic Clostridium difficile. Med J Aust 2006, 185:133-134.
15. Clements AC, Magalhães RJ, Tatem AJ, Paterson DL, Riley TV Clostridium difficile PCR ribotype 027: assessing the risks of further worldwide spread. Lancet Infect Dis 2010, 10:395-404.
16. Bauer MP, Notermans DW, van Benthem BH, Brazier JS, Wilcox MH, Rupnik M, et al. Clostridium difficile infection in Europe: a hospital-based survey. Lancet 2011, 377:63-73.
17. Gastmeier P, Weitzel-Kage D, Behnke M, Eckmanns T Surveillance of Clostridium difficile-associated diarrhoea with the German nosocomial infection surveillance system KISS (CDAD-KISS). Int J Antimicrob Agents 2009, 33(Suppl 1):S19-S23.
18. Cherifi S, Delmee M, Van Broeck J, Beyer I, Byl B, Mascart G Management of an outbreak of Clostridium difficile-associated disease among geriatric patients. Infect Control Hosp Epidemiol 2006, 27:1200-1205.
19. Paltansing S, van den Berg RJ, Guseinova RA, Visser CE, van der Vorm ER, Kuijper EJ Characteristics and incidence of Clostridium difficile-associated disease in The Netherlands, 2005. Clin Microbiol Infect 2007, 13:1058-1064.
20. Loo VG, Poirier L, Miller MA, Oughton M, Libman MD, Michaud S, et al. A predomantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med 2005, 353:2442-2449.
21. Wilson V, Cheek L, Satta G, Walker-Bone K, Cubbon M, Citron D, et al. Predictors of death after Clostridium difficile infection: a report on 128 strain-typed cases from a teaching hospital in the United Kingdom. Clin Infect Dis 2010, 50:e77-e81.
22. Gerding DN, Johnson S, Peterson LR, Mulligan ME, Silva J Clostridium difficile-associated diarrhea and colitis. Infect Control Hosp Epidemiol 1995, 16:459-477.
23. Bartlett JG Clinical practice. Antibiotic-associated diarrhea. N Engl J Med 2002, 346:334-339.
24. Surowiec D, Kuyumjian AG, Wynd MA, Cicogna CE Past, present, and future therapies for Clostridium difficile-associated disease. Ann Pharmacother 2006, 40:2155-2163.
25. Schroeder MS Clostridium difficile-associated diarrhea. Am Fam Physician 2005, 71:921-928.
26. Thompson I Clostridium difficile-associated disease: update and focus on non-antibiotic strategies. Age Ageing 2008, 37:14-18.
27. McFarland LV, Surawicz CM, Stamm WE Risk factors for Clostridium difficile carriage and C. difficile-associated diarrhea in a cohort of hospitalized patients. J Infect Dis 1990, 162:678-684.
28. Kelly CP, Pothoulakis C, LaMont JT Clostridium difficile colitis. N Engl J Med 1994, 330:257-262.
29. Anand A, Bashey B, Mir T, Glatt AE Epidemiology, clinical manifestations, and outcome of Clostridium difficile-associated diarrhea. Am J Gastroenterol 1994, 89:519-523.
30. Wanahita A, Goldsmith EA, Musher DM Conditions associated with leukocytosis in a tertiary care hospital, with particular attention to the role of infection caused by Clostridium difficile. Clin Infect Dis 2002, 34:1585-1592.
31. Jaber MR, Olafsson S, Fung WL, Reeves ME Clinical review of the management of fulminant Clostridium difficile infection. Am J Gastroenterol 2008, 103:3195-3203.
32. Adams SD, Mercer DW Fulminant Clostridium difficile colitis. Curr Opin Crit Care 2007, 13:450-455.
33. Staneck JL, Weckbach LS, Allen SD, Siders JA, Gilligan PH, Coppitt G, et al. Multicenter evaluation of four methods for Clostridium difficile detection: immunoCard C. difficile, cytotoxin assay, culture, and latex agglutination. J Clin Microbiol 1996, 34:2718-2721.
34. Fenner L, Widmer AF, Goy G, Rudin S, Frei R Rapid and reliable diagnostic algorithm for detection of Clostridium difficile. J Clin Microbiol 2008, 46:328-330.
35. Surawicz CM, Brandt LJ, Binion DG, Ananthakrishnan AN, Curry SR, Gilligan PH, et al. Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections. Am J Gastroenterol 2013, 108:478-498.
36. Heinlen L, Ballard JD Clostridium difficile infection. Am J Med Sci 2010, 340:247-252.
37. Cohen SH, Gerding DN, Johnson S, Kelly CP, Loo VG, McDonald LC, et al. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA). Infect Control Hosp Epidemiol 2010, 31:431-455.
38. Yassin SF, Young-Fadok TM, Zein NN, Pardi DS Clostridium difficile-associated diarrhea and colitis. Mayo Clin Proc 2001, 76:725-730.
39. Persson S, Torpdahl M, Olsen KE New multiplex PCR method for the detection of Clostridium difficile toxin A (tcdA) and toxin B (tcdB) and the binary toxin (cdtA/cdtB) genes applied to a Danish strain collection. Clin Microbiol Infect 2008, 14:1057-1064.
40. Deshpande A, Pasupuleti V, Rolston DD, Jain A, Deshpande N, Pant C, et al. Diagnostic accuracy of real-time polymerase chain reaction in detection of Clostridium difficile in the stool samples of patients with suspected Clostridium difficile infection: a meta-analysis. Clin Infect Dis 2011, 53(7):e81-e90.
41. Kim H, Jeong SH, Kim M, Lee Y, Lee K Detection of Clostridium difficile toxin A/B genes by multiplex real-time PCR for the diagnosis of C. difficile infection. J Med Microbiol 2012, 61:274-277.
42. Babady NE, Stiles J, Ruggiero P, Khosa P, Huang D, Shuptar S, et al. Evaluation of the Cepheid Xpert Clostridium difficile Epi assay for diagnosis of Clostridium difficile infection and typing of the NAP1 strain at a cancer hospital. J Clin Microbiol 2010, 48:4519-4524.
43. Mylonakis E, Ryan ET, Calderwood SB Clostridium difficile-associated diarrhea: a review. Arch Intern Med 2001, 161:525-533.
44. Calfee DP Clostridium difficile: a reemerging pathogen. Geriatrics 2008, 63:10-21.
45. Poutanen SM, Simor AE Clostridium difficile-associated diarrhea in adults. CMAJ 2004, 171:51-58.
46. Gebhard RL, Gerding DN, Olson MM, Peterson LR, McClain CJ, Ansel HJ, et al. Clinical and endoscopic findings in patients early in the course of Clostridium difficile-associated pseudomembranous colitis. Am J Med 1985, 78:45-48.
47. Gerding DN, Brazier JS Optimal methods for identifying Clostridium difficile infections. Clin Infect Dis 1993, 16(Suppl 4):S439-S442.
48. Johal SS, Hammond J, Solomon K, James PD, Mahida YR Clostridium difficile associated diarrhoea in hospitalized patients: onset in the community and hospital and role of flexible sigmoidoscopy. Gut 2004, 53(5):673-677.
49. Dallal RM, Harbrecht BG, Boujoukas AJ, Sirio CA, Farkas LM, Lee KK, et al. Fulminant Clostridium difficile: an underappreciated and increasing cause of death and complications. Ann Surg 2002, 235:363-372.
50. Cloud J, Kelly CP Update on Clostridium difficile associated disease. Curr Opin Gastroenterol 2007, 23:4-9.
51. Drekonja DM, Butler M, MacDonald R, Bliss D, Filice GA, Rector TS, et al. Comparative effectiveness of Clostridium difficile treatments: a systematic review. Ann Intern Med 2011, 155:839-847.
52. Al-Nassir WN, Sethi AK, Li Y, et al. Both oral metronidazole and oral vancomycin promote persistent overgrowth of vancomycin-resistant enterococci during treatment of Clostridium difficile-associated disease. Antimicrob Agents Chemother 2008, 52:2403-2406.
53. Pépin J, Valiquette L, Alary ME, Villemure P, Pelletier A, Forget K, et al. Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity. CMAJ 2004, 171:466-472.
54. Nelson RL, Kelsey P, Leeman H, Meardon N, Patel H, Paul K, et al. Antibiotic treatment for Clostridium difficile-associated diarrhea in adults. Cochrane Database Syst Rev 2011, 10.1002/14651858.CD004610.pub4.
55. Cheng AC, Ferguson JK, Richards MJ, Robson JM, Gilbert GL, McGregor A, et al. Australasian society for infectious diseases guidelines for the diagnosis and treatment of Clostridium difficile infection. Med J Aust 2011, 194(7):353-358.
56. Khan FY, Abu-Khattab M, Anand D, Baager K, Alaini A, Siddique MA, et al. Epidemiological features of Clostridium difficile infection among inpatients at Hamad General Hospital in the state of Qatar, 2006-2009. Travel Med Infect Dis 2012, 10:179-185.
57. Johnson S Recurrent Clostridium difficile infection: a review of risk factors, treatments, and outcomes. J Infect 2009, 58:403-410.
58. Pépin J, Routhier S, Gagnon S, Brazeau I Management and outcomes of a first recurrence of Clostridium difficile-associated disease in Quebec, Canada. Clin Infect Dis 2006, 42(6):758-764.
59. McFarland LV, Elmer GW, Surawicz CM Breaking the cycle: treatment strategies for 163 cases of recurrent Clostridium difficile disease. Am J Gastroenterol 2002, 97:1769-1775.
60. Gerding DN, Muto CA, Owens RC Treatment of Clostridium difficile infection. Clin Infect Dis 2008, 46(Suppl 1):S32-S42.
61. Tedesco FJ, Gordon D, Fortson WC Approach to patients with multiple relapses of antibiotic-associated pseudomembranous colitis. Am J Gastroenterol 1985, 80:867-868.
62. Aas J, Gessert CE, Bakken JS Recurrent Clostridium difficile colitis: case series involving 18 patients treated with donor stool administered via a nasogastric tube. Clin Infect Dis 2003, 36:580-585.
63. Bakken JS, Borody T, Brandt LJ, Brill JV, Demarco DC, Franzos MA, et al. Treating Clostridium difficile infection with fecal microbiota transplantation. Clin Gastroenterol Hepatol 2011, 9:1044-1049.
64. Persky S, Brandt LJ Treatment of recurrent Clostridium diffi cile-associated diarrhea by administration of donated stool directly though a colonoscope. Am J Gastroenterol 2000, 95:3283-3285.
65. Silverman MS, Davis I, Pillai DR Success of self-administered home fecal transplantation for chronic Clostridium difficile infection. Clin Gastroenterol Hepatol 2010, 8:471-473.
66. Gough E, Shaikh H, Manges AR Systematic review of intestinal microbiota transplantation (fecal bacteriotherapy) for recurrent Clostridium difficile infection. Clin Infect Dis 2011, 53:994-1002.
67. Buggy BP, Fekety R, Silva J Therapy of relapsing Clostridium difficile-associated diarrhea and colitis with the combination of vancomycin and rifampin. J Clin Gastroenterol 1987, 9:155-159.
68. Mogg GA, George RH, Youngs D, Johnson M, Thompson H, Burdon DW, et al. Randomized controlled trial of colestipol in antibiotic-associated colitis. Br J Surg 1982, 69:137-139.
69. Johnson S, Schriever C, Patel U, Patel T, Hecht DW, Gerding DN Rifaximin Redux: treatment of recurrent Clostridium difficile infections with rifaximin immediaely post-vancomycin treatment. Anaerobe 2009, 15:290-291.
70. Surawicz CM, McFarland LV, Greenberg RN, Rubin M, Fekety R, Mulligan ME, et al. The search for a better treatment for recurrent Clostridium difficile disease: use of high-dose vancomycin combined with Saccharomyces boulardii. Clin Infect Dis 2000, 31:1012-1017.
71. Surawicz CM, McFarland LV, Elmer G, Chinn J Treatment of recurrent Clostridium difficile colitis with vancomycin and Saccharomyces boulardii. Am J Gastroenterol 1989, 84:1285-1287.
72. McFarland LV, Surawicz CM, Greenberg RN, Fekety R, Elmer GW, Moyer KA, et al. A randomized placebo-controlled trial of Saccharomyces boulardii in combination with standard antibiotics for Clostridium difficile disease. JAMA 1994, 271:1913-1918.
73. Khanna S, Pardi DS Clostridium difficile infection: new insights into management. Mayo Clin Proc 2012, 87:1106-1117.
74. McFarland LV Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. Am J Gastroenterol 2006, 101(4):812-822.