Fulminant Clostridium difficile colitis

Current Opinion in Critical Care

Volumn 13, Issue 4, 2007, Pages 450-455

  Adams, Sasha D ^a   Mercer, David W ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Antibiotics; Clostridium difficile; Fulminant colitis; Pseudomembranous colitis; Surgery

Indexed keywords

BACITRACIN; FUSIDIC ACID; HYPERTENSIVE AGENT; IMMUNOGLOBULIN; METRONIDAZOLE; NITAZOXANIDE; PROBIOTIC AGENT; TEICOPLANIN; VANCOMYCIN;

CLINICAL TRIAL; CLOSTRIDIUM DIFFICILE; COLITIS; COLON RESECTION; COMPUTER ASSISTED TOMOGRAPHY; DIARRHEA; ENZYME LINKED IMMUNOSORBENT ASSAY; HEMICOLECTOMY; HUMAN; HYPOALBUMINEMIA; HYPOTENSION; ILEOSTOMY; IMMUNOSUPPRESSIVE TREATMENT; INCIDENCE; LEUKOCYTOSIS; MYCOSIS; PARASITOSIS; PATHOGENESIS; PROGNOSIS; REVIEW; VIRULENCE;

ANTI-BACTERIAL AGENTS; COLITIS; ENTEROCOLITIS, PSEUDOMEMBRANOUS; HUMANS; UNITED STATES;

EID: 34347331380     PISSN: 10705295     EISSN: 15317072     Source Type: Journal    
DOI: 10.1097/MCC.0b013e3282638879     Document Type: Review

References (34)

1. LaHatte LJ, Tedesco FJ, Schuman BM. Antibiotic-associated injury to the gut. In: Haubrich WS, Schaffner F, Berk JE, editors. Bockus Gastroenterology, Fifth edition. Philadelphia: WB Saunders; 1995. pp. 1657-1671.
2. Hall IC, O'Toole E. Intestinal flora in new-born infants with a description of a new pathogenic anaerobe: Bacillus difficilis. Am J Dis Child 1935; 48:390-402.
3. Larson HE, Parry JV, Price AB, et al. Undescribed toxin in pseudomembranous colitis. Br J Med 1977; 1:1246-1248.
4. Bartlett JG, Chang TW, Gurwith M, et al. Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia. N Engl J Med 1978; 298:531-534.
5. Settle CD, Wilcox MH, Fawley WN, et al. Prospective study of the risk of Clostridium difficile diarrhea in elderly patients following treatment with cefotaxime or piperacillin-tazobactam. Aliment Pharmacol Ther 1998; 12:1217-1223.
6. Wiesen P, Van Gossum A, Preiser JC. Diarrhoea in the critically ill. Curr Opin Crit Care 2006; 12:149-154.
7. Anand A, Bashey B, Mir T, Glatt AE. Epidemiology, clinical manifestations, and outcome of Clostridium difficile-associated diarrhea. Am J Gastroenterol 1994; 89:519-523.
8. Aslam S, Musher DM. An update on diagnosis, treatment, and prevention of Clostridium difficile-associated disease. Gastroenterol Clin North Am 2006; 35:315-335. This is a comprehensive review of pathogenesis of C. difficile, diagnostic methods, treatment options with a review of their efficacies, and the need for effective preventive measures.
9. Kelly CP, LaMont JT. Clostridium difficile infection. Annu Rev Med 1998; 49:375-390.
10. McCusker ME, Harris AD, Perencevich E, Roghmann MC. Fluoroquinolone use and Clostridium difficile-associated diarrhea. Emerg Infect Dis 2003; 9:730-733.
11. Jobe BA, Grasley A, Deveney KE, et al. Clostridium difficile colitis: an increasing hospital-acquired illness. Am J Surg 1995; 169:480-483.
12. Crabtree TD, Pelletier SJ, Gleason TG, et al. Clinical characteristics and antibiotic utilization in surgical patients with Clostridium difficile-associated diarrhea. Am Surg 1999; 65:507-511.
13. Kyne L, Farrell RJ, Kelly CP. Clostridium difficile. Gastroenterol Clin North Am 2001; 30:753-777.
14. Clabots CR, Johnson S, Olson MM, et al. Acquisition of Clostridium difficile by hospitalized patients: evidenced for colonized new admissions as a source of infection. J Infect Dis 1992; 166:561-567.
15. Fordtran JS. Colitis due to Clostridium difficile toxins: underdiagnosed, highly virulent, and nosocomial. Proc Bayl Univ Med Cent 2006; 19:3-12. This is an overview of the pathogenesis of C. difficile infection and disease, focusing on patient risk factors for severe disease, as well as diagnosis, treatment, and prevention measures.
16. Bartlett JG. Clinical practice. Antibiotic-associated diarrhea. N Engl J Med 2002; 346:334-339.
17. McFarland LV, Mulligan ME, Kwok RY, Stamm WE. Nosocomial acquisition of Clostridium difficile infection. N Engl J Med 1989; 320:204-210.
18. Dial S, Alrasadi K, Manoukian C, et al. Risk of Clostridium difficile diarrhea among hospital inpatients prescribed proton pump inhibitors: cohort and case-control studies. CMAJ 2004; 171:33-38.
19. Hurley BW, Nguyen CC. The spectrum of pseudomembranous enterocolitis and antibiotic-associated diarrhea. Arch Intern Med 2002; 162:2177-2184.
20. Kyne L, Merry C, O'Connell B, et al. Factors associated with prolonged symptoms and severe disease due to Clostridium difficile. Age Ageing 1999; 28:107-113.
21. Bartlett JG. Narrative review: The new epidemic of Clostridium difficile-associated enteric disease. Ann Intern Med 2006; 145:758-764.
22. Centers for Disease Control and Prevention (CDC). Severe Clostridium difficile-associated diseases in populations previously at low risk: four states, 2005. MMWR 2005; 54:1201-1205.
23. Mohan SS, McDermott BP, Parchuri S, Cunha BA. Lack of value of repeat stool testing for Clostridium difficile toxin. Am J Med 2006; 119:356-358.
24. Malnick SD, Zimhony O. Treatment of Clostridium difficile-associated diarrhea. Ann Pharmacother 2002; 36:1767-1775.
25. Klingler PJ, Metzger PP, Seelig MH, et al. Clostridium difficile infection: risk factors, medical and surgical management. Dig Dis 2000; 18:147-160.
26. Ash L, Baker ME, O'Malley CM Jr, et al. Colonic abnormalities on CT in adult hospitalized patients with Clostridium difficile colitis: prevalence and significance of findings. Am J Roentgenol 2006; 186:1393-1400.
27. Nair S, Yadav D, Corpuz M, Pitchumoni CS. Clostridium difficile colitis: factors influencing treatment failure and relapse: a prospective evaluation. Am J Gastroenterol 1998; 93:1873-1876.
28. McFarland LV. Meta-analysis of probiotics for the prevention of antibiotic-associated diarrhea and the treatment of Clostridium difficile disease. Am J Gastroenterol 2006; 101:812-822.
29. McPherson S, Rees CJ, Ellis R, et al. Intravenous immunoglobulin for the treatment of severe refractory and recurrent Clostridium difficile diarrhea. Dis Colon Rectum 2006; 49:640-645.
30. Musher DM, Logan N, Hamill RJ, et al. Nitazoxanide for the treatment of Clostridium difficile colitis. Clin Infect Dis 2006; 43:421-427.
31. Dallal RM, Harbrecht BG, Boujoukas AJ, et al. Fulminant Clostridium difficile: an underappreciated and increasing cause of death and complications. Ann Surg 2002; 235:363-372.
32. Lamontagne F, Labbe AC, Haeck O, et al. Impact of emergency colectomy on survival of patients with fulminant Clostridium difficile colitis during an epidemic caused by a hypervirulent strain. Ann Surg 2007; 245:267-272.
33. Longo WE, Mazuski JE, Virgo KS, et al. Outcome after colectomy for Clostridium difficile colitis. Dis Colon Rectum 2004; 47:1620-1626.
34. Koss K, Clark MA, Sanders DS, et al. The outcome of surgery in fulminant Clostridium difficile colitis. Colorectal Dis 2006; 8:149-154. This is a retrospective study of patients undergoing surgery for fulminant C. difficile colitis that advocates total colectomy to reduce mortality in select patients.