MDA-7/IL-24 inhibits Nrf2-mediated antioxidant response through activation of p38 pathway and inhibition of ERK pathway involved in cancer cell apoptosis

Cancer Gene Therapy

Volumn 21, Issue 10, 2014, Pages 416-426

  Tian, H ^a   Zhang, D ^a   Gao, Z ^a   Li, H ^a   Zhang, B ^a   Zhang, Q ^a   Li, L ^a   Cheng, Q ^a   Pei, D ^a   Zheng, J ^a  

^a XUZHOU MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CONDITIONALLY REPLICATING ADENOVIRUS; E1A PROTEIN; INTERLEUKIN 24; JANUS KINASE 1; JANUS KINASE 2; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; ZD 55; ANTIOXIDANT; INTERLEUKIN DERIVATIVE; INTERLEUKIN-24; KEAP1 PROTEIN, HUMAN; PROTEIN BINDING; SIGNAL PEPTIDE;

ANTIOXIDANT RESPONSIVE ELEMENT; APOPTOSIS; ARTICLE; CANCER GENE THERAPY; CARCINOMA CELL; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOLIC FRACTION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; ONCOLYTIC VIROTHERAPY; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REPRESSOR GENE; SIGNAL TRANSDUCTION; UPREGULATION; ADENOVIRIDAE; BIOLOGICAL MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENE VECTOR; GENETICS; METABOLISM; NEOPLASM; PROTEIN TRANSPORT; TUMOR CELL LINE;

ADENOVIRIDAE; ANTIOXIDANT RESPONSE ELEMENTS; ANTIOXIDANTS; APOPTOSIS; CELL LINE, TUMOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC VECTORS; HUMANS; INTERLEUKINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAP KINASE SIGNALING SYSTEM; MODELS, BIOLOGICAL; NEOPLASMS; NF-E2-RELATED FACTOR 2; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN BINDING; PROTEIN TRANSPORT; REACTIVE OXYGEN SPECIES;

EID: 84908153251     PISSN: 09291903     EISSN: 14765500     Source Type: Journal    
DOI: 10.1038/cgt.2014.45     Document Type: Article

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