Study of toll-like receptor 7 expression and interferon α in Egyptian patients with chronic hepatitis C Infection and Hepatocellular Carcinoma

Egyptian Journal of Medical Human Genetics

Volumn 15, Issue 4, 2014, Pages 387-392

  Abdel Raouf, Tahany A ^a   Ahmed, Alaa ^a   Zaki, Wafaa K ^a   Abdella, Heba M ^a   Zid, Mona Abo ^a  

^a AIN SHAMS UNIVERSITY   (Egypt)

Author keywords

HCC; HCV; IFN ; Innate immunity; TLR7; TLRs; Viral hepatitis; Viral load

Indexed keywords

ALPHA INTERFERON; RNA; TOLL LIKE RECEPTOR 7;

ADULT; ARTICLE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; EGYPTIAN; FEMALE; HEPATITIS C; HUMAN; LIVER CELL CARCINOMA; MALE; PROTEIN BLOOD LEVEL; RECEPTOR DOWN REGULATION; VIRUS LOAD;

EID: 84908136873     PISSN: 11108630     EISSN: 20902441     Source Type: Journal    
DOI: 10.1016/j.ejmhg.2014.07.003     Document Type: Article

References (34)

1. Klevens R.M., Hu D.J., Jiles R., Holmberg S.D. Evolving epidemiology of hepatitis C virus in the United States. Clin Infect Dis 2012, 55(Suppl 1):S3-S9. PMID: 20003764 [PubMed - in process].
2. WHO 2014. http://www.who.int/mediacentre/factsheets/fs164/en/.
3. Zhang Y.L., Guo Y.J., Li Bin, Sun S.H. Hepatitis C virus single-stranded RNA induces innate immunity via Toll-like receptor 7. J Hepatol 2009, 51:29-38.
4. Trinchieri G., Sher A. Cooperation of Toll-like receptor signals in innate immune defence. Nat Rev Immunol 2007, 7:179-190.
5. Arpaia N., Barton G.M. Toll-like receptors: key players in antiviral immunity. Curr Opin Virol 2011, 1:447-454.
6. Askar E., Ramadori G., Mihm S. Toll-like receptor 7 rs179008/Gln11Leu gene variants in chronic hepatitis C virus infection. J Med Virol 2010, 82:1859-1868.
7. Heil F., Hemmi H., Hochrein H., Ampenberger F., Kirschning C., Akira S., et al. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 2004, 303:1526-1529.
8. Sun L., Deng L., Ea C.K., Xia Z.P., Chen Z.J. The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol Cell 2004, 14(3):289-301.
9. Atencia R., Bustamante F.J., Valdivieso A., Arrieta A., Rinon M., et al. Differential expression of viral PAMP receptors mRNA in peripheral blood of patients with chronic hepatitis C infection. BMC Infect Dis 2007, 7(9):136-143.
10. Decalf J., Fernandes S., Longman R., Ahloulay M., Audat F., Lefrerre F., et al. 2007, 204:2423-2437.
11. Iwasaki A., Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat Immunol 2004, 5:987-995.
12. Grebely Jason, Prins Maria, Hellard Margaret, Cox Andrea L., Osburn William O., Lauer Georg, et al. Hepatitis C virus clearance, reinfection, and persistence, with insights from studies of injecting drug users: towards a vaccine. Lancet Infect Dis 2012, 12:408-414.
13. Chang S., Kodys K., Szabo G. Impaired expression and function of toll-like receptor 7 in hepatitis C virus infection in human hepatoma cells. Hepatology 2010, 51:35-42.
14. Kamal S.M. Hepatitis C virus genotype 4 therapy progress and challenges. Liver Int. 2011, 31(Suppl 1):45-52. [Review]. 10.1111/j.1478-3231.2010.02385.x.
15. Guidotti L.G., Chisari F.V. Immunobiology and pathogenesis of viral hepatitis. Annu Rev Pathol 2006, 1:23-61.
16. Billiau A., Matthys P. Interferon-gamma: a historical perspective. Cytokine Growth Factor Rev 2009, 20:97-113.
17. Kano A., Watanabe Y., Takeda N., Aizawa S., Akaike T. Analysis of IFN-gamma-induced cell cycle arrest and cell death in hepatocytes. J Biochem 1997, 121:677-683.
18. Frese M., Schwarzle V., Barth K., et al. Interferon-gamma inhibits replication of subgenomic and genomic hepatitis C virus RNAs. Hepatology 2002, 35:694-703.
19. Guidotti L.G., Ishikawa T., Hobbs M.V., Matzke B., Schreiber R., Chisari F.V. Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. Immunity 1996, 4:25-36.
20. Coussens L.M., Werb Z. Inflammation and cancer. Nature 2002, 420:860-867.
21. Hornung V., Rothenfusser S., Britsch S., Krug A., Jahrsdorfer B., Giese T., et al. Quantitative expression of toll-like receptors 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol 2002, 168:4531-4537. s.
22. Daw M.A., Dau A.A. Hepatitis C virus in Arab world: a state of concern. Sci World J 2012, 719494.
23. Lin K.J., Lin T.M., Wang C.H., Liu H.C., Lin Y.L., et al. AFFILIATIONS Down-regulation of Toll-like receptor 7 expression in hepatitis-virus-related human hepatocellular carcinoma. Human Pathol 2013, 44(4):534-541.
24. Mencin A., Kluwe J., Schwabe R. Toll-like receptors as targets in chronic liver diseases. Gut 2013, 58(5):704-720.
25. Taylor M.W., Tsukahara T., Brodsky L., Schaley J., Sanda C., Stephens M.J., et al. Changes in gene expression during peg interferon and ribavirin therapy of chronic hepatitis C distinguish responders from non responders to antiviral therapy. J Virol 2007, 81:3391-3401.
26. Kang J., Nan X., Jin M.S. Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodime. Immunity 2009, 31(6):873-884.
27. Mohammed K.I., Adel L.A., Ali-Eldin F.A., Eladawy S. Expression of Toll like receptors 3 & 7 in peripheral blood from patients with chronic hepatitis C virus infection and their correlation with interferon-alpha. Egypt J Immunol 2013, 20(1):13-22.
28. Chang. Toll-like receptors: target of hepatitis c virus: A Dissertation. University of Massachusetts Medical School eScholarship@UMMS GSBS. Dissertations and Theses Graduate School of Biomedical Sciences; 2008.
29. Ishii S., Koziel M.J. Immune responses during acute and chronic infection with hepatitis C virus. Clin Immunol 2008, 128:133-147.
30. Gilliet M., Cao W., Liu Y.J. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases. Nat Rev Immunol 2008, 8(8):594-606.
31. Abe T., Kaname Y., Hamamoto I., Tsuda Y., Wen X., Taguwa S., et al. Hepatitis C virus nonstructural protein 5A modulates the Toll-like receptor - MYD88-dependent signaling pathway in macrophage cell lines. J Virol 2007, 81(17):8953-8966.
32. Shiina M., Rehermann B. Cell culture-produced hepatitis C virus impairs plasmacytoid dendritic cell function. Hepatology 2008, 47:385-395.
33. Szabo G., Mandrekar p. Focus on: alcohol and the liver. Alcohol Res Health 2010, 33(1-2):87-96.
34. Aravalli R.N. Role of innate immunity in the development of hepatocellular carcinoma. World J Gastroenterol 2013, 19(43):7500-7514.