Analysis of IFN-γ-induced cell cycle arrest and cell death in hepatocytes

Journal of Biochemistry

Volumn 121, Issue 4, 1997, Pages 677-683

  Kano, Arihiro ^a   Watanabe, Yoshifumi ^a,b   Takeda, Naoki ^b   Aizawa, Shin Ichi ^b   Akaike, Toshihiro ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Apoptosis; Cell cycle; Hepatocytes; IFN ; p53

Indexed keywords

CYCLOHEXIMIDE; DNA FRAGMENT; GAMMA INTERFERON; MESSENGER RNA; PROTEIN P21; PROTEIN P53; PROTEIN SYNTHESIS INHIBITOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE; CELL DEATH; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; LIVER CELL CULTURE; MOUSE; NONHUMAN; NORTHERN BLOTTING;

ANIMALIA;

EID: 0030998520     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a021639     Document Type: Article

References (44)

1. McClain, C.J. and Cohen, D.A. (1989) Increased tumor necrosis factor product ion by monocytes in alcoholic hepatitis. Hepatology 9, 349-351
2. Yoshioka, K,. Kukumu, S., Arao, M., Tsutsumi, Y., and Inouu, M. (1981) Tumor nerosis factor α production by peripheral blood mononuclear cells of patients with chronic liver disease, Hepatology 10, 769-773
3. Ehlers, S., Mielko, M.E.A., Blankenstein, T., and Hahn, H. (1992) Kinetic analysis of cytokinc gene expression in the livers of naive and immune mice infected with Listeria monocytogenes. J. Immunol. 149, 3016-3022
4. Peters, M., Vierling, J., Gershwin, M.E., Milich, D., Chisari F.V., and Hoofnagle, J.H, (1991) Immunology and the liver., Hepatology 13, 977-094
5. Watanabe, Y., Morita, M., and Akuike, T, (1996) Concanavalin A induces perforin-medinted but not Fas-mediated hepatic injury. Hepatalogy 24, 702-710
6. Mizuhnra, H., Uno, M., Seki, N., Yamashita, M., Yamaoka, M., Ogawa, T., Kaneda, K., Fujii, T., Stmoh, H., and Fujiwarn, H. 119961 Critical involvement of Interferon gamma in the pathogencsis of T-cell activulion associated hepatitis and regulatory mechanisms of interleukin-6 for the manifestations of hepatitis. Hepatology 23, 1608-1615
7. Gilles, P.N., Guerrette, D.L., Ulevitch, R.J., Schreiber, R.D., and Chisari, F.V. (1992) HBsAg retention sensitizes the hepatocyte to injury by physiological concentrations of Interferon-γ. Hepatology 16, 655-663
8. Franco, A., Burnubn, V., Nutali, P., Balsanu, C. Musca, A., and Balsuno, F. (1988) Expression of class 1 and II major histoeompatihilily antigens on human hepatocytes. Hepatology 8, 449-454
9. Volpes, R., Oord, J.J.v.d., Vos, R.D., Depla, E., Ley, M.D., and Desrnet, V.J, (1991) Expression of the Interferon-γ receptor in normal and pathological human liver tissue. J. Hepatol. 12, 195-202
10. Ellis, R.E., Yuan, J., and Horvilz, H.R. (1991) Mechunisms and functions of cell death. Annu. Rev. Cell Biol. 7, 663-698
11. Lin, Y. and Benchimol, S. (1995) Cytokines inhibit p53-mediated apoptosis but not p53-mediated G1 arrest. Mol. Cell. Biol. 15, 6045-6054
12. Lowe. S.W., Schmitt, E.M., Smith, S.W., Osborne, H.A., and lacks, T. (1993) p53 is required for radiation-induced apoptosig in mouse thymocytes. Nature 362, 847-852
13. Lane, D.P. (1993) A death in the life of p53. Nature 362, 786-787
14. Caelles, C., Helmberg, A., and Karin. M. (1994) p53-dependent apoptiwis in the absence of transcriptional activation of p53tin-Hot nones. Nature 370. 220-223
15. Ashkenas. J. and Werh, Z. (1996) Proteolysis and the biochemistry of life- or death decisions, J. Exp. Med. 183, 1947-1951
16. Wu, X. and Levine. A.J. (1994) p53 and E2F-1 cooperate to mediate apoptosis. Proc Natl Acad. Acadl. Sci. USA 91. 3602-3606
17. Leisi. M., Ganntner. F., Bohlinger. I., Gerernuinn, P.O., Tiegs, G., and Wendel. A. (1994) Murine hcpatwyte apoptosis induced in vitm and in vivo by TNFα reiiuires transcriptional arrest. J. Immunol. 153, 1778-1788
18. Morita, M., Watanabe, Y., and Akaiike. T. (1995) Protective effect of hepatovyte growth factor on internm-fntnma-induced cyioiuxidiy in mouse hepntocytes. Htpntofagy 21, 1585-1593
19. Tsukada. T., Tumooku, Y., Tiikai, S., I'cda. Y., Nishikawa, S., Yap. T., Tokumigii, T,.Takeda. N., Suda. Y., Alw. S., Mat.suo. I., Ikawa, Y., and Aiwiwa, S (1993) Enhanced proliferative potenliai in the culture of cells from p53-deticic'tit mice. Oncogene 8, 3313-3322
20. Morita, M., Watmiabe, Y., and Akaike. T. (19940 Inflammatory cytokinvs up-reulute inli'ivellular adhesion molecule-1 expression on primiiry cultun'd niouxc hcpalficyles and T-lymphocyte adhesion, llupatnlngy 19. 426-431
21. Muir, D., Varon. S., and Munihorpv. M. (1990) An enzymelinked immunnnorhent iwwiy for bromodeoxyuridine incorporation usinig fixed microcultures. Anal. Kiorhtnn. 183. 377-382
22. Decker, T. and Lohmann-Matthes, M. (1988) A quick and simple method for the quunlitation of laclale drhydrogenase release in measurements of cellular cytotoxicity und tumor necrosis factor (TNF) activity. J. Immunol. Methods 15, 61-69
23. Korzeniewski, C. and Callewaert, D.M. (1983) An enzymerelease assay for natural cytotoxicity. J. Immunol. Methods 64, 313-320
24. Cohen, J.J., Duke, H.C., Fadok, V.A., and Selling. K.S. (1992) Apoptosis and programmed cell death in immunity. Annu. Rev Immunol. 10, 267-293
25. Gannon, J.V. and Lane, D.P. (1991) Protein synthesis required toanchor a mutant p53 protein which is temperature-sensitive for nuclear transport. Nature 349, 802-806
26. El-Deiry. W.S., Tokino, T., Velculescu. V,K., Levy, D.B. Parsons. R., Trent, J.M., Lin. D., Mercor, W.E., Kinzlsr, K.W., and Vollstem, B. (1993) WAFl, a potential mediator of p53 tumor suppression. Cell 75, 817-820
27. Harper, J.W., Adami, G.R., Wei. N., Keyomarsi. K., and Kllediro. S.J, (1993) The p21 cdk-interaetinu protein, Cipl. is a potent inhibitor of G1 cydin-dependent kinases. Cell 75, 805-816
28. Xionng. Y., Hannon, G.J., Xhtmii. H., Casso, D., Kobayashi, R. and Beach. D. (1993) p21 is universal inhibitor of cyelin kmases.Nature 366 701-704
29. Deists, LP. Keinstein, K., Berissi. H., Cohen. O. and Kinichi, A. (1995) Identification of n novel serine threnino kinase and a novel 15-kI protein as potential mediators of the γ miprfuroninduced cell death. Gene Dec. 9, 15-30
30. Cirawunder, U., Mclcliers, F., and Kolink, A. (1993) Interferon-γ arrests proliferation and causes apoptosis in stromal cell interleukin-7-dependent normal tmirine pre-B cell lines and elones in vitro, but does not induce differentiation to surface immunolobulin-positive B cells. Kur. J. Immunul. 23, 544-551
31. Friesel, R., Komoriya, A., and Maciag, T, (1987) Inhibition of endoihelial cell proliferation by gamma-interferon. J. Cell Biol. 104, 689-696
32. Uuschle, M., Campana, D., C'ardinn, S.R., Richard, C. Hottlirand, A.V., and Brenner. M.K. (1993) Interferon γ inhibits apoptotie cell death in B cell chronic lymphovytic leukemia. J. exp. Med. 177, 213-218
33. Miyashita, T. and Reed, J.C. (1995) Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80, 293-299
34. Strasser, A., Harris, A.W., Jacks, T., and C'ory. S. (1994) UNA damage can induce apoptosis in proliferating lymphoid cells via pulj-independent mechanisms inhibitable by Hcl-2. Cell 79, 329-339
35. Polviik, K,. Waldrnan. T., He. T., Kinkier, K.W., and N'ogelstein. B. (1996) Clenetic determinants of p53-induced apoptosis and growth arrest, Gmenes Den. 10, 1945-1952
36. Poluha, W., Poluha, O.K., Chang, B., Crosbie, N.K., Sehonhoff, C.M., Kilpatrick, D.L., and Ross, A.M. (1996) The cyclin-dependcnt kinase inhibitor, p'21 , is required for t.hi- survival of differentiating neurohlastoma colls. Mol. Cell. Hint. 16. 1335- 1341
37. Wang, J. and Walsh, K. (1996) Resistance1 to apoptnsis conferred by (inhibitor) during myocyte differentiation. Science 273, 359-361
38. Mimner, J., Mummenbrauer. T., Hauer, C., Sczukicl. G., Grosso. F., and Deppert. W. (1995) Negative fendbavk rugulatinn of wild-type piW biosynthesis. EMBO J. 14, 4442-4449
39. Chin. Y.E. Kitagawii, M., Su, W.S., You, Z., Iwamoto, Y., and Fu, X. (1996) Cell growth arrest and induction of cyclin-dopondent kinasc inhibitor p21 mediated by STAT1. Science 272, 719-722
40. Korrester. K., Ambs, S., Kapold, S.u., Kapust, H.H., Spillaiv, K.A., Weingberg, W.C., Felloy-Bowo, K., Wang, X.W., Goller, O.A., Tzeng, K., Billinr, T.R., und Harris, C.C. (1996) Nitric oxide-induced pull accumulation and regulation of indudMc nitric oxide svnthase expression by wild-type p53. Proc, Natl. Acad. Sci, USA 93. 2442-2447
41. Mi'ssmer. U.K., Ankarcrona, M., Nivotorn, P'., and Brne. B. (1994) p53 expression in nitric oxide-induced apoptosis. FEBS Lett. 355. 23-26
42. Adiimson. G.M, and Billings. R.K. (1993) Cytukinc toxicity and induction of NO synthase activity in cultured mouse hepatucytes. Toxical. Appl. Pharmacol. 119, 100-107
43. Deiss. L.P., Glalinka. H., Berisssi. H., Cohen. O., and Kimchi. A. (1996) Cathepsin D protuase mediates programmed cell death induced by Interferon-γ, Fas APO-1 and TNF-α. EMBO J. 15, 3861-3870
44. Kissil, J.L., Deiss. L.P., Hnyewitch. M., Raveh. T., Khuspekov, G. and Kimchi, A. (1995) Isolation of DAP, a novel mediator of Interferon-γ-induced cell death. J. Biol. Chem. 270. 27932-27936