메뉴 건너뛰기




Volumn 31, Issue SUPPL. 1, 2011, Pages 45-52

Hepatitis C virus genotype 4 therapy: Progress and challenges

Author keywords

Genotype 4; Hepatitis C; Pegylated interferon; Ribavirin

Indexed keywords

ALPHA INTERFERON; INTERFERON; NITAZOXANIDE; PEGINTERFERON; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2A PLUS RIBAVIRIN; PROTEINASE INHIBITOR; RIBAVIRIN;

EID: 78650852334     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2010.02385.x     Document Type: Article
Times cited : (51)

References (67)
  • 1
    • 1642288430 scopus 로고    scopus 로고
    • Hepatitis C. WHO Fact Sheet 164
    • World Health Organization., Geneva, Switzerland: World Health Organization, Available at, accessed 12 October 2008).
    • World Health Organization. Hepatitis C. WHO Fact Sheet 164. Geneva, Switzerland: World Health Organization, 2000 Available at (accessed 12 October 2008).
    • (2000)
  • 2
    • 26444432835 scopus 로고    scopus 로고
    • Prevalence and treatment of hepatitis C virus genotypes 4, 5, and 6
    • Nguyen MH, Keeffe EB. Prevalence and treatment of hepatitis C virus genotypes 4, 5, and 6. Clin Gastroenterol Hepatol 2005; 3 (Suppl. 2): S97-101.
    • (2005) Clin Gastroenterol Hepatol , vol.3 , Issue.SUPPL. 2
    • Nguyen, M.H.1    Keeffe, E.B.2
  • 3
    • 7444256169 scopus 로고    scopus 로고
    • Genetic diversity and evolution of hepatitis C virus - 15 years on
    • Simmonds P. Genetic diversity and evolution of hepatitis C virus - 15 years on. J Gen Virol 2004; 85 (Part 11): 3173-88.
    • (2004) J Gen Virol , vol.85 , Issue.PART 11 , pp. 3173-88
    • Simmonds, P.1
  • 4
    • 78650846615 scopus 로고    scopus 로고
    • Egyptian Ministry of Health Annual report, 2007. Available at, accessed 12 October 2008).
    • Egyptian Ministry of Health Annual report, 2007. Available at (accessed 12 October 2008).
  • 7
    • 0031047036 scopus 로고    scopus 로고
    • Chronic liver disease in the Alexandria governorate, Egypt: contribution of schistosomiasis and hepatitis virus infections
    • Angelico M, Renganathan E, Gandin C, et al. Chronic liver disease in the Alexandria governorate, Egypt: contribution of schistosomiasis and hepatitis virus infections. J Hepatol 1997; 26: 236-43.
    • (1997) J Hepatol , vol.26 , pp. 236-43
    • Angelico, M.1    Renganathan, E.2    Gandin, C.3
  • 10
    • 0036788158 scopus 로고    scopus 로고
    • Distribution of hepatitis C genotype andco-infection rate with hepatitis G in Saudi Arabia
    • Al-Knawy B, Okamoto H, El-Mekki A, et al. Distribution of hepatitis C genotype andco-infection rate with hepatitis G in Saudi Arabia. Hepatol Res 2002; 24: 95-8.
    • (2002) Hepatol Res , vol.24 , pp. 95-8
    • Al-Knawy, B.1    Okamoto, H.2    El-Mekki, A.3
  • 12
    • 0031670838 scopus 로고    scopus 로고
    • Hepatitis C virus infection and genotypes in Southern Israel and the Gaza Strip
    • Shemer-Avni Y, el Astal Z, Kemper O, et al. Hepatitis C virus infection and genotypes in Southern Israel and the Gaza Strip. J Med Virol 1998; 56: 230-3.
    • (1998) J Med Virol , vol.56 , pp. 230-3
    • Shemer-Avni, Y.1    el Astal, Z.2    Kemper, O.3
  • 13
    • 0036074102 scopus 로고    scopus 로고
    • Hepatitis C virus infection in Jordanian haemodialysis units
    • J Med Microbiol
    • Bdour S. Hepatitis C virus infection in Jordanian haemodialysis units: serological diagnosis and genotyping. J Med Microbiol 2002; 51: 700-4.
    • (2002) serological diagnosis and genotyping , vol.51 , pp. 700-4
    • Bdour, S.1
  • 14
    • 0028132879 scopus 로고
    • Hepatitis C virus genotype 4 is highly prevalent in central Africa (Gabon)
    • Xu L-Z, Larzul D, Delaporte E, Bréchot C, Kremsdorf D. Hepatitis C virus genotype 4 is highly prevalent in central Africa (Gabon). J Gen Virol 1994; 75: 2393-8.
    • (1994) J Gen Virol , vol.75 , pp. 2393-8
    • Xu, L.1    Larzul, D.2    Delaporte, E.3    Bréchot, C.4    Kremsdorf, D.5
  • 15
    • 0041852686 scopus 로고    scopus 로고
    • Phylogenetic analysis of hepatitis C virus isolates indicates a unique pattern of endemic infection in Cameroon
    • Ndjomou J, Pybus OG, Matz B. Phylogenetic analysis of hepatitis C virus isolates indicates a unique pattern of endemic infection in Cameroon. J Gen Virol 2003; 84: 2333-41.
    • (2003) J Gen Virol , vol.84 , pp. 2333-41
    • Ndjomou, J.1    Pybus, O.G.2    Matz, B.3
  • 16
    • 70350512885 scopus 로고    scopus 로고
    • Pépin predominance of hepatitis C virus genotype 4 infection and rapid transmission between 1935 and 1965 in the Central African Republic
    • Njouom R, Frost E, Deslandes S, et al. Pépin predominance of hepatitis C virus genotype 4 infection and rapid transmission between 1935 and 1965 in the Central African Republic. J Gen Virol 2009; 90 (Part 10): 2452-6.
    • (2009) J Gen Virol , vol.90 , Issue.PART 10 , pp. 2452-6
    • Njouom, R.1    Frost, E.2    Deslandes, S.3
  • 17
    • 0031765060 scopus 로고    scopus 로고
    • Prevalence and genotype of hepatitis C virus infection in pregnant women and blood donors in Ghana
    • Wansbrough-Jones MH, Frimpong E, Cant B, et al. Prevalence and genotype of hepatitis C virus infection in pregnant women and blood donors in Ghana. Trans R Soc Trop Med Hyg 1998; 92: 496-9.
    • (1998) Trans R Soc Trop Med Hyg , vol.92 , pp. 496-9
    • Wansbrough-Jones, M.H.1    Frimpong, E.2    Cant, B.3
  • 18
    • 7444256169 scopus 로고    scopus 로고
    • Genetic diversity and evolution of hepatitis C virus - 15 years on
    • Simmonds P. Genetic diversity and evolution of hepatitis C virus - 15 years on. J Gen Virol 2004; 85: 3173-88.
    • (2004) J Gen Virol , vol.85 , pp. 3173-88
    • Simmonds, P.1
  • 19
    • 42249110672 scopus 로고    scopus 로고
    • Hepatitis C genotype 4: what we know and what we don't yet know
    • Kamal S, Nasser I. Hepatitis C genotype 4: what we know and what we don't yet know. Hepatology 2008; 47: 1371-83.
    • (2008) Hepatology , vol.47 , pp. 1371-83
    • Kamal, S.1    Nasser, I.2
  • 20
    • 21844457406 scopus 로고    scopus 로고
    • Changing of hepatitis C virus genotype patterns in France at the beginning of the third millennium
    • J Viral Hepat
    • Payan C, Roudot-Thoraval F, Marcellin P, et al. Changing of hepatitis C virus genotype patterns in France at the beginning of the third millennium: the GEMHEP GenoCII Study. J Viral Hepat 2005; 12: 405-13.
    • (2005) the GEMHEP GenoCII Study , vol.12 , pp. 405-13
    • Payan, C.1    Roudot-Thoraval, F.2    Marcellin, P.3
  • 21
    • 11444267247 scopus 로고    scopus 로고
    • Heterogeneity of hepatitis C virus genotype 4 strains circulating in south-western France
    • Nicot F, Legrand-Abravanel F, Sandres-Saune K, et al. Heterogeneity of hepatitis C virus genotype 4 strains circulating in south-western France. J Gen Virol 2005; 86: 107-14.
    • (2005) J Gen Virol , vol.86 , pp. 107-14
    • Nicot, F.1    Legrand-Abravanel, F.2    Sandres-Saune, K.3
  • 22
    • 20044366379 scopus 로고    scopus 로고
    • Different seroprelavence and molecular epidemiology pattern of hepatitis C virus infection in Italy
    • Ansaldi F, Bruzzone B, Salamaso S, et al. Different seroprelavence and molecular epidemiology pattern of hepatitis C virus infection in Italy. J Med Virol 2005; 76: 327-32.
    • (2005) J Med Virol , vol.76 , pp. 327-32
    • Ansaldi, F.1    Bruzzone, B.2    Salamaso, S.3
  • 25
    • 33846002756 scopus 로고    scopus 로고
    • Complete nucleotide sequence of genotype 4 hepatitis C viruses isolated from patients co-infected with human immunodeficiency virus type 1
    • Franco S, Tural C, Clotet B, Martínez MA. Complete nucleotide sequence of genotype 4 hepatitis C viruses isolated from patients co-infected with human immunodeficiency virus type 1. Virus Res 2007; 123: 161-9.
    • (2007) Virus Res , vol.123 , pp. 161-9
    • Franco, S.1    Tural, C.2    Clotet, B.3    Martínez, M.A.4
  • 26
    • 71549168619 scopus 로고    scopus 로고
    • Emergence of hepatitis C virus genotype 4 phylogenetic analysis reveals three distinct epidemiological profiles
    • de Bruijne J, Schinkel J, Prins M Emergence of hepatitis C virus genotype 4 phylogenetic analysis reveals three distinct epidemiological profiles. J Clin Microbiol 2009; 47: 3832-8.
    • (2009) J Clin Microbiol , vol.47 , pp. 3832-8
    • de Bruijne, J.1    Schinkel, J.2    Prins, M.3
  • 27
    • 65249116434 scopus 로고    scopus 로고
    • Evidence of a large, international network of HCV transmission in HIV-positive men who have sex with men
    • van de Laar T, Pybus O, Bruisten S, et al. Evidence of a large, international network of HCV transmission in HIV-positive men who have sex with men. Gastroenterology 2009; 136: 1609-17.
    • (2009) Gastroenterology , vol.136 , pp. 1609-17
    • van de Laar, T.1    Pybus, O.2    Bruisten, S.3
  • 28
    • 0037179698 scopus 로고    scopus 로고
    • Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection
    • Fried MW, Shiffman ML, Reddy KR, et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002; 347: 975-82.
    • (2002) N Engl J Med , vol.347 , pp. 975-82
    • Fried, M.W.1    Shiffman, M.L.2    Reddy, K.R.3
  • 29
    • 0035934568 scopus 로고    scopus 로고
    • Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C
    • Lancet
    • Manns MP, McHutchison JG, Gordon SC, et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001; 358: 958-65.
    • (2001) a randomised trial , vol.358 , pp. 958-65
    • Manns, M.P.1    McHutchison, J.G.2    Gordon, S.C.3
  • 30
    • 0034674034 scopus 로고    scopus 로고
    • Infection with hepatitis C virus genotype 4 is associated with a poor response to interferon-alpha
    • Zylberberg H, Chaix ML, Brechot C. Infection with hepatitis C virus genotype 4 is associated with a poor response to interferon-alpha. Ann Intern Med 2000; 132: 845-6.
    • (2000) Ann Intern Med , vol.132 , pp. 845-6
    • Zylberberg, H.1    Chaix, M.L.2    Brechot, C.3
  • 31
    • 0033962163 scopus 로고    scopus 로고
    • Interferon therapy in patients with chronic hepatitis C and schistosomiasis
    • Kamal SM, Madwar MA, Peters T, Fawzy R, Rasenack J. Interferon therapy in patients with chronic hepatitis C and schistosomiasis. J Hepatol 2000; 32: 172-4.
    • (2000) J Hepatol , vol.32 , pp. 172-4
    • Kamal, S.M.1    Madwar, M.A.2    Peters, T.3    Fawzy, R.4    Rasenack, J.5
  • 33
    • 0033930712 scopus 로고    scopus 로고
    • Improved response to ribavirin interferon combination compared with interferon alone in patients with type 4 chronic hepatitis C without cirrhosis
    • Koshy A, Marcellin P, Martinot M, Madda JP. Improved response to ribavirin interferon combination compared with interferon alone in patients with type 4 chronic hepatitis C without cirrhosis. Liver 2000; 20: 335-9.
    • (2000) Liver , vol.20 , pp. 335-9
    • Koshy, A.1    Marcellin, P.2    Martinot, M.3    Madda, J.P.4
  • 34
    • 3042673841 scopus 로고    scopus 로고
    • Results of a randomized clinical trial of genotype-4 infected subjects when treated with standard or pegylated interferon alfa-2b in combination with ribavirin
    • abstract
    • Esmat GH, Abouzied A, Abdel-Hamid M, et al. Results of a randomized clinical trial of genotype-4 infected subjects when treated with standard or pegylated interferon alfa-2b in combination with ribavirin. Hepatology 2003; 38 (Suppl.): 314A-5A (abstract).
    • (2003) Hepatology , vol.38 , Issue.SUPPL.
    • Esmat, G.H.1    Abouzied, A.2    Abdel-Hamid, M.3
  • 35
    • 4344635133 scopus 로고    scopus 로고
    • ®) significantly enhance sustained virological and biochemical response rate in chronic hepatitis C genotype 4 patients in Saudi Arabia
    • abstract
    • ®) significantly enhance sustained virological and biochemical response rate in chronic hepatitis C genotype 4 patients in Saudi Arabia. Hepatology 2003; 38 (Suppl.): 636A (abstract).
    • (2003) Hepatology , vol.38 , Issue.SUPPL.
    • Shobokshi, A.1    Serebour, P.E.2    Skakni, L.3
  • 36
    • 19944409281 scopus 로고    scopus 로고
    • Peginterferon a-2b plus ribavirin compared with interferon a-2b plus ribavirin for initial treatment of chronic hepatitis C in Saudi patients commonly infected with genotype 4
    • Alfaleh FZ, Hadad Q, Khuroo MS, et al. Peginterferon a-2b plus ribavirin compared with interferon a-2b plus ribavirin for initial treatment of chronic hepatitis C in Saudi patients commonly infected with genotype 4. Liver Int 2004; 24: 568-74.
    • (2004) Liver Int , vol.24 , pp. 568-74
    • Alfaleh, F.Z.1    Hadad, Q.2    Khuroo, M.S.3
  • 37
    • 4544344295 scopus 로고    scopus 로고
    • Peginterferon alfa-2b plus ribavirin for the treatment of chronic hepatitis C genotype 4
    • Hasan F, Asker H, Al-Khaldi J, et al. Peginterferon alfa-2b plus ribavirin for the treatment of chronic hepatitis C genotype 4. Am J Gastroenterol 2004; 99: 1733-7.
    • (2004) Am J Gastroenterol , vol.99 , pp. 1733-7
    • Hasan, F.1    Asker, H.2    Al-Khaldi, J.3
  • 38
    • 0346727453 scopus 로고    scopus 로고
    • Optimized virologic response in hepatitis C virus genotype 4 with peginterferon-alpha2a and ribavirin
    • Diago M, Hassanein T, Rodes J, Ackrill AM, Sedarati F. Optimized virologic response in hepatitis C virus genotype 4 with peginterferon-alpha2a and ribavirin. Ann Intern Med 2004; 140: 72-3.
    • (2004) Ann Intern Med , vol.140 , pp. 72-3
    • Diago, M.1    Hassanein, T.2    Rodes, J.3    Ackrill, A.M.4    Sedarati, F.5
  • 40
    • 21144449073 scopus 로고    scopus 로고
    • Peginterferon alpha-2b and ribavirin therapy in chronic hepatitis C genotype 4 impact of treatment duration and viral kinetics on sustained virological response
    • Kamal SM, El Tawil AA, Nakano T, et al. Peginterferon alpha-2b and ribavirin therapy in chronic hepatitis C genotype 4 impact of treatment duration and viral kinetics on sustained virological response. Gut 2005; 54: 858-66.
    • (2005) Gut , vol.54 , pp. 858-66
    • Kamal, S.M.1    El Tawil, A.A.2    Nakano, T.3
  • 41
    • 32444449114 scopus 로고    scopus 로고
    • Response of hepatitis C genotype-4 naive patients to 24 weeks of peg-interferon-a2b/ribavirin or induction-dose interferon-a2b/ribavirin/amantadine
    • Am J Gastroenterol
    • Zayadi A-R, Attia M, Barakat EMF, et al. Response of hepatitis C genotype-4 naive patients to 24 weeks of peg-interferon-a2b/ribavirin or induction-dose interferon-a2b/ribavirin/amantadine: a non-randomized controlled study. Am J Gastroenterol 2005; 100: 2447-52.
    • (2005) a non-randomized controlled study , vol.100 , pp. 2447-52
    • Zayadi, A.1    Attia, M.2    Barakat, E.M.F.3
  • 42
    • 33750100192 scopus 로고    scopus 로고
    • Treatment of hepatitis C virus genotype 4 with peginterferon alfa-2a
    • World J Gastroenterol
    • Derbala MF, Al Kaabi SR, El Dweik NZ, et al. Treatment of hepatitis C virus genotype 4 with peginterferon alfa-2a: impact of bilharziasis and fibrosis stage. World J Gastroenterol 2006; 12: 5692-8.
    • (2006) impact of bilharziasis and fibrosis stage , vol.12 , pp. 5692-8
    • Derbala, M.F.1    Al Kaabi, S.R.2    El Dweik, N.Z.3
  • 44
    • 68549115307 scopus 로고    scopus 로고
    • Virological Response at 4 weeks predict outcome of Hepatitis C treatment with pegylated interferon and ribavirin
    • Martinot-Peignoux M, Maylin S, Moucari R, et al. Virological Response at 4 weeks predict outcome of Hepatitis C treatment with pegylated interferon and ribavirin. Antivir Ther 2009; 14: 501-11.
    • (2009) Antivir Ther , vol.14 , pp. 501-11
    • Martinot-Peignoux, M.1    Maylin, S.2    Moucari, R.3
  • 45
    • 37749046123 scopus 로고    scopus 로고
    • Pegylated interferon alpha-2b plus ribavirin in patients with genotype 4 chronic hepatitis C
    • Hepatology
    • Kamal S, Kamary S, Shardell M, et al. Pegylated interferon alpha-2b plus ribavirin in patients with genotype 4 chronic hepatitis C: the role of rapid and early virologic response. Hepatology 2000; 46: 1732-40.
    • (2000) the role of rapid and early virologic response , vol.46 , pp. 1732-40
    • Kamal, S.1    Kamary, S.2    Shardell, M.3
  • 46
    • 48749099989 scopus 로고    scopus 로고
    • Peginterferon alfa-2a and ribavirin for 24 weeks in hepatitis C type 1 and 4 patients with rapid virological response
    • Austrian Hepatitis Study Group
    • Ferenci P, Laferl H, Austrian Hepatitis Study Group et al. Peginterferon alfa-2a and ribavirin for 24 weeks in hepatitis C type 1 and 4 patients with rapid virological response. Gastroenterology 2008; 135: 45-8.
    • (2008) Gastroenterology , vol.135 , pp. 45-8
    • Ferenci, P.1    Laferl, H.2
  • 47
    • 60449108708 scopus 로고    scopus 로고
    • Improved virologic response in chronic hepatitis C genotype 4 treated with nitazoxanide, peginterferon, and ribavirin
    • Rossignol JF, Elfert A, El-Gohary Y, Keeffe EB. Improved virologic response in chronic hepatitis C genotype 4 treated with nitazoxanide, peginterferon, and ribavirin. Gastroenterology 2009; 136: 856-62.
    • (2009) Gastroenterology , vol.136 , pp. 856-62
    • Rossignol, J.F.1    Elfert, A.2    El-Gohary, Y.3    Keeffe, E.B.4
  • 48
    • 70349292099 scopus 로고    scopus 로고
    • Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    • Ge D, et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 2009; 461: 399-401.
    • (2009) Nature , vol.461 , pp. 399-401
    • Ge, D.1
  • 49
    • 70349533037 scopus 로고    scopus 로고
    • Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C
    • Tanaka Y., et al. Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C. Nat Genet 2009; 41: 1105-10.
    • (2009) Nat Genet , vol.41 , pp. 1105-10
    • Tanaka, Y.1
  • 50
    • 70349548852 scopus 로고    scopus 로고
    • IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy
    • Suppiah V, et al. IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy. Nat Genet 2009; 41: 1100-4.
    • (2009) Nat Genet , vol.41 , pp. 1100-4
    • Suppiah, V.1
  • 51
    • 77954733618 scopus 로고    scopus 로고
    • A chromosome 19 SNP (RS12979860) predicts outcome (EVR/SVR) in HCV patients treated with interferon, independent of pegylation or ribavirin
    • Asselah T, Essioux L, Marcellin P, et al. A chromosome 19 SNP (RS12979860) predicts outcome (EVR/SVR) in HCV patients treated with interferon, independent of pegylation or ribavirin. J Hepatol 2010; 62: A1180.
    • (2010) J Hepatol , vol.62
    • Asselah, T.1    Essioux, L.2    Marcellin, P.3
  • 52
    • 34250625319 scopus 로고    scopus 로고
    • Observational VHC4 study group Epidemiological characteristics and response to peginterferon plus ribavirin treatment of hepatitis C virus genotype 4 infection
    • Roulot D, Bourcier V, Grando V., et al. Observational VHC4 study group Epidemiological characteristics and response to peginterferon plus ribavirin treatment of hepatitis C virus genotype 4 infection. J Viral Hepat 2007; 14: 460-7.
    • (2007) J Viral Hepat , vol.14 , pp. 460-7
    • Roulot, D.1    Bourcier, V.2    Grando, V.3
  • 53
    • 67650132966 scopus 로고    scopus 로고
    • Predictive value of complete and partial early virological response on sustained virological response rates of genotype-4 chronic hepatitis C patients treated with PEG-interferon plus ribavirin
    • Elefsiniotis IS, Vezali E, Mihas C, Saroglou G. Predictive value of complete and partial early virological response on sustained virological response rates of genotype-4 chronic hepatitis C patients treated with PEG-interferon plus ribavirin. Intervirology 2009; 52: 247-51.
    • (2009) Intervirology , vol.52 , pp. 247-51
    • Elefsiniotis, I.S.1    Vezali, E.2    Mihas, C.3    Saroglou, G.4
  • 54
    • 34547738021 scopus 로고    scopus 로고
    • Clinical and pathological characteristics and response to combination therapy of genotype 4 chronic hepatitis C patients
    • J Chemother
    • Trapero-Marugan M, Moreno-Monteagudo JA, Garcia-Buey L, et al. Clinical and pathological characteristics and response to combination therapy of genotype 4 chronic hepatitis C patients: experience from a Spanish center. J Chemother 2007; 19: 423-7.
    • (2007) experience from a Spanish center , vol.19 , pp. 423-7
    • Trapero-Marugan, M.1    Moreno-Monteagudo, J.A.2    Garcia-Buey, L.3
  • 55
    • 4344714257 scopus 로고    scopus 로고
    • Peginterferon alpha-2b plus ribavirin with or without amantadine [] for the treatment of non-responders to standard interferon and ribavirin
    • Hasan F, Al-Khaldi J, Asker H, et al. Peginterferon alpha-2b plus ribavirin with or without amantadine [] for the treatment of non-responders to standard interferon and ribavirin. Antivir Ther 2004; 9: 499-503.
    • (2004) Antivir Ther , vol.9 , pp. 499-503
    • Hasan, F.1    Al-Khaldi, J.2    Asker, H.3
  • 56
    • 18344364551 scopus 로고    scopus 로고
    • Response to interferon-based therapies in HIV-infected patients with chronic hepatitis C due to genotype 4
    • Soriano V, Nunez M, Sanchez-Conde M, et al. Response to interferon-based therapies in HIV-infected patients with chronic hepatitis C due to genotype 4. Antiviral Ther 2005; 10: 167-70.
    • (2005) Antiviral Ther , vol.10 , pp. 167-70
    • Soriano, V.1    Nunez, M.2    Sanchez-Conde, M.3
  • 57
    • 23044510877 scopus 로고    scopus 로고
    • Pegylated interferon and ribavirin therapy for chronic hepatitis C virus genotype 4 infection
    • Legrand-Abravanel F, Nicot F, Boulestin A, et al. Pegylated interferon and ribavirin therapy for chronic hepatitis C virus genotype 4 infection. J Med Virol 2005; 77: 66-9.
    • (2005) J Med Virol , vol.77 , pp. 66-9
    • Legrand-Abravanel, F.1    Nicot, F.2    Boulestin, A.3
  • 58
    • 52149084563 scopus 로고    scopus 로고
    • Response to pegylated interferon plus ribavirin in HIV-infected patients with chronic hepatitis C due to genotype 4
    • Martín-Carbonero L, Puoti M, García-Samaniego J, et al. Response to pegylated interferon plus ribavirin in HIV-infected patients with chronic hepatitis C due to genotype 4. J Viral Hepat 2008; 15: 710-5.
    • (2008) J Viral Hepat , vol.15 , pp. 710-5
    • Martín-Carbonero, L.1    Puoti, M.2    García-Samaniego, J.3
  • 60
    • 33646562220 scopus 로고    scopus 로고
    • Duration of peginterferon therapy in acute hepatitis C
    • Hepatology
    • Kamal SM, Moustafa KN, Chen J, et al. Duration of peginterferon therapy in acute hepatitis C: a randomized trial. Hepatology 2006; 43: 923-31.
    • (2006) a randomized trial , vol.43 , pp. 923-31
    • Kamal, S.M.1    Moustafa, K.N.2    Chen, J.3
  • 62
    • 24944502327 scopus 로고    scopus 로고
    • Efficacy and tolerability of peginterferon alpha-2a with or without ribavirin in thalassaemia major patients with chronic hepatitis C virus infection
    • Inati A, Taher A, Ghorra S, et al. Efficacy and tolerability of peginterferon alpha-2a with or without ribavirin in thalassaemia major patients with chronic hepatitis C virus infection. Br J Haematol 2005; 130: 644-6.
    • (2005) Br J Haematol , vol.130 , pp. 644-6
    • Inati, A.1    Taher, A.2    Ghorra, S.3
  • 63
    • 78650849285 scopus 로고    scopus 로고
    • Peginterferon alfa-2b therapy with and without ribavirin in patients with thalassemia: a randomized study. Abstract 585 presented at the 41st Annual Meeting of the European Association for the Study of the Liver, 26-30 April 2006, Austria Center, Vienna, Austria.
    • Kamal S, Fouly A, Mohamed S, et al. Peginterferon alfa-2b therapy with and without ribavirin in patients with thalassemia: a randomized study. Abstract 585 presented at the 41st Annual Meeting of the European Association for the Study of the Liver, 26-30 April 2006, Austria Center, Vienna, Austria.
    • Kamal, S.1    Fouly, A.2    Mohamed, S.3
  • 64
    • 78650803267 scopus 로고    scopus 로고
    • Pegylated Interferon alfa-2a Plus Ribavirin over Pegylated Interferon alfa-2b plus Ribavirin in Chronic Hepatitis C Genotype 4
    • Liver Int, in press).
    • Kamal S, Ahmed A, Mahmoud S, et al. Pegylated Interferon alfa-2a Plus Ribavirin over Pegylated Interferon alfa-2b plus Ribavirin in Chronic Hepatitis C Genotype 4: a randomized trial and quality of life analysis. Liver Int 2010 (in press).
    • (2010) a randomized trial and quality of life analysis
    • Kamal, S.1    Ahmed, A.2    Mahmoud, S.3
  • 65
    • 47649102538 scopus 로고    scopus 로고
    • Very early viral kinetics on interferon treatment in chronic hepatitis C virus genotype 4 infection
    • Jessner W, Gschwantler M, Formann E, et al. Very early viral kinetics on interferon treatment in chronic hepatitis C virus genotype 4 infection. Antivir Ther 2008; 13: 581-9.
    • (2008) Antivir Ther , vol.13 , pp. 581-9
    • Jessner, W.1    Gschwantler, M.2    Formann, E.3
  • 66
    • 41149156316 scopus 로고    scopus 로고
    • Liver gene expression signature to predict response to pegylated interferon plus ribavirin combination therapy in patients with chronic hepatitis C
    • Asselah T, Bieche I, Narguet S, et al. Liver gene expression signature to predict response to pegylated interferon plus ribavirin combination therapy in patients with chronic hepatitis C. Gut 2008; 57: 516-24.
    • (2008) Gut , vol.57 , pp. 516-24
    • Asselah, T.1    Bieche, I.2    Narguet, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.