Redesigning human 2′-deoxycytidine kinase enantioselectivity for L-nucleoside analogues as reporters in positron emission tomography

ACS Chemical Biology

Volumn 9, Issue 10, 2014, Pages 2326-2333

  Muthu, Pravin ^a   Chen, Hannah X ^a   Lutz, Stefan ^a  

^a EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2' FLUORO 5 METHYL BETA LEVO ARABINOFURANOSYL) URACIL; 2' DEOXYCYTIDINE KINASE; DEOXYCYTIDINE KINASE; NUCLEOSIDE ANALOG; RADIOISOTOPE; THYMIDINE; THYMIDINE KINASE; THYMIDINE KINASE 2; UNCLASSIFIED DRUG; NUCLEOSIDE;

AMINO ACID SUBSTITUTION; ARTICLE; CHEMICAL STRUCTURE; ENANTIOMER; ENANTIOSELECTIVITY; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME PHOSPHORYLATION; GENE PROBE; HERPES SIMPLEX VIRUS; HUMAN; MOLECULAR DYNAMICS; MOLECULAR IMAGING; MUTATION; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PROTEIN ENGINEERING; PROTEIN EXPRESSION; REPORTER GENE; SITE DIRECTED MUTAGENESIS; TARGET CELL; TRANSGENE; CHEMISTRY; COMPARATIVE STUDY; COMPUTER SIMULATION; ENZYME SPECIFICITY; GENETICS; KINETICS; METABOLISM; NONPARAMETRIC TEST; PHOSPHORYLATION; STEREOISOMERISM;

COMPUTER SIMULATION; DEOXYCYTIDINE KINASE; GENES, REPORTER; HUMANS; KINETICS; MUTAGENESIS, SITE-DIRECTED; MUTATION; NUCLEOSIDES; PHOSPHORYLATION; POSITRON-EMISSION TOMOGRAPHY; STATISTICS, NONPARAMETRIC; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 84908131527     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb500463f     Document Type: Article

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