Mutagenesis of non-conserved active site residues improves the activity and narrows the specificity of human thymidine kinase 2

Biochemical and Biophysical Research Communications

Volumn 354, Issue 3, 2007, Pages 802-807

  Gerth, Monica L ^a   Lutz, Stefan ^a  

^a EMORY UNIVERSITY   (United States)

Author keywords

Deoxyribonucleoside kinase; Human thymidine kinase 2; Nucleoside analog; Site directed mutagenesis

Indexed keywords

AMINO ACID; DEOXYCYTIDINE; DEOXYRIBONUCLEOSIDE; PURINE NUCLEOSIDE DERIVATIVE; THYMIDINE; THYMIDINE KINASE; THYMIDINE KINASE 2; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; ENZYME ACTIVITY; ENZYME PURIFICATION; ENZYME SPECIFICITY; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CATALYSIS; DEOXYCYTIDINE; DROSOPHILA MELANOGASTER; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; NUCLEOSIDES; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PHYLOGENY; PURINES; SUBSTRATE SPECIFICITY; THYMIDINE; THYMIDINE KINASE;

DROSOPHILA MELANOGASTER;

EID: 33846648000     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.01.070     Document Type: Article

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