-
1
-
-
0026437190
-
FDA's policy statement for the development of new stereoisomeric drugs
-
Announcement
-
Announcement. FDA's policy statement for the development of new stereoisomeric drugs. Chirality 1992;4:338-340.
-
(1992)
Chirality
, vol.4
, pp. 338-340
-
-
-
2
-
-
3042573233
-
S18986, Positive allosteric modulator of AMPA receptors as a novel cognition enhancer in rodents
-
Lestage P, Danober L, Lockart B, Roger A, Lebrun C, Robin JL, Desos P, Cordi A. S18986, Positive allosteric modulator of AMPA receptors as a novel cognition enhancer in rodents. Res Pract Alzheimer's Dis 2002;6:253-259.
-
(2002)
Res Pract Alzheimer's Dis
, vol.6
, pp. 253-259
-
-
Lestage, P.1
Danober, L.2
Lockart, B.3
Roger, A.4
Lebrun, C.5
Robin, J.L.6
Desos, P.7
Cordi, A.8
-
3
-
-
18344371827
-
50-Alkyl-benzothiadiazides: A new subgroup of AMPA receptor modulators with improved affinity
-
DOI 10.1016/S0968-0896(01)00405-9, PII S0968089601004059
-
Philips D, Sonnenberg J, Arai AC, Vaswani R, Krutzik PO, Kleisli T, Kessler M, Granger R, Lynch G, Chamberline AR. 50-Alkyl-benzothiadiazides: a new subgroup of AMPA receptor modulators with improved affinity. Bioorg Med Chem 2002;10:1229-1248. (Pubitemid 34214688)
-
(2002)
Bioorganic and Medicinal Chemistry
, vol.10
, Issue.5
, pp. 1229-1248
-
-
Phillips, D.1
Sonnenberg, J.2
Arai, A.C.3
Vaswani, R.4
Krutzik, P.O.5
Kleisli, T.6
Kessler, M.7
Granger, R.8
Lynch, G.9
Richard Chamberlin, A.10
-
4
-
-
0037030706
-
Synthesis of 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide derivatives as potential allosteric modulators of AMPA/Kainate receptors
-
Braghiroli D, Puia G, Cannazza G, Tait A, Parenti C, Losi G, Baraldi M. Synthesis of 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide derivatives as potential allosteric modulators of AMPA/Kainate receptors. J Med Chem 2002;45:2355-2357.
-
(2002)
J Med Chem
, vol.45
, pp. 2355-2357
-
-
Braghiroli, D.1
Puia, G.2
Cannazza, G.3
Tait, A.4
Parenti, C.5
Losi, G.6
Baraldi, M.7
-
5
-
-
15644381026
-
4H-1,2,4-pyridothiadiazine 1,1-dioxides and 2,3-dihydro-4H-1,2,4- pyridothiadiazine 1,1-dioxides chemically related to diazixide and cyclothiazide as powerful positive allosteric modulators of (R/S)-2-amino-3-(3-hydroxy-5- methylisoxazol-4-yl)propionic acid receptors: Design, synthesis, pharmacology, and structure-activity relationships
-
Pirotte B, Podona T, Diouf O, de Tullio P, Lebrun P, Dupont L, Somers F, Delarge J, Morain P, Lestage P, Lepagnol J, Spedding M. 4H-1,2,4- pyridothiadiazine 1,1-dioxides and 2,3-dihydro-4H-1,2,4-pyridothiadiazine 1,1-dioxides chemically related to diazixide and cyclothiazide as powerful positive allosteric modulators of (R/S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4- yl)propionic acid receptors: design, synthesis, pharmacology, and structure-activity relationships. J Med Chem 1998;41:2946-2959.
-
(1998)
J Med Chem
, vol.41
, pp. 2946-2959
-
-
Pirotte, B.1
Podona, T.2
Diouf, O.3
De Tullio, P.4
Lebrun, P.5
Dupont, L.6
Somers, F.7
Delarge, J.8
Morain, P.9
Lestage, P.10
Lepagnol, J.11
Spedding, M.12
-
6
-
-
2442671651
-
New trends in the development of positive allosteric modulators
-
Graindorge E, Francotte P, Boverie S, de Tullio P, Pirotte B. New trends in the development of positive allosteric modulators. Curr Med Chem 2004;4:95-103.
-
(2004)
Curr Med Chem
, vol.4
, pp. 95-103
-
-
Graindorge, E.1
Francotte, P.2
Boverie, S.3
De Tullio, P.4
Pirotte, B.5
-
7
-
-
2442614201
-
Glutamate hypothesis of schizophrenia and approach for possible therapeutic drugs
-
DOI 10.2174/1568015043357011
-
Hashimoto K, Okamura N, Shimizu E, Iyo M. Glutamate hypothesis of schizophrenia and approach for possible therapeutic drugs. Curr Med Chem 2004;4:147-154. (Pubitemid 38639374)
-
(2004)
Current Medicinal Chemistry - Central Nervous System Agents
, vol.4
, Issue.2
, pp. 147-154
-
-
Hashimoto, K.1
Okamura, N.2
Shimizu, E.3
Iyo, M.4
-
8
-
-
17844407467
-
Therapeutic potential of positive AMPA modulators and their relationship to AMPA receptor subunits. A review of preclinical data
-
Black MD. Therapeutic potential of positive AMPA modulators and their relationship to AMPA receptor subunits. A review of preclinical data. Psychopharmacology 2005;179:154-163.
-
(2005)
Psychopharmacology
, vol.179
, pp. 154-163
-
-
Black, M.D.1
-
9
-
-
34347213071
-
Design, synthesis and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide as positive allosteric modulators of AMPA receptors
-
Francotte P, de Tullio P, Goffin E, Dintilhac G, Graindgorge E, Fraikin P, Lestage P, Danober L, Thomas JY, Caignard DH, Pirotte B. Design, synthesis and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide as positive allosteric modulators of AMPA receptors. J Med Chem 2007;50:3153-3157.
-
(2007)
J Med Chem
, vol.50
, pp. 3153-3157
-
-
Francotte, P.1
De Tullio, P.2
Goffin, E.3
Dintilhac, G.4
Graindgorge, E.5
Fraikin, P.6
Lestage, P.7
Danober, L.8
Thomas, J.Y.9
Caignard, D.H.10
Pirotte, B.11
-
10
-
-
0003037941
-
Dynamic phenomena during enantiomer resolution by complexation gas chromatography. A kinetic study of enantiomerization
-
Bürkle W, Karfunkel H, Schurig V. Dynamic phenomena during enantiomer resolution by complexation gas chromatography. A kinetic study of enantiomerization. J Chromatogr 1984;288:1-14.
-
(1984)
J Chromatogr
, vol.288
, pp. 1-14
-
-
Bürkle, W.1
Karfunkel, H.2
Schurig, V.3
-
12
-
-
0028883544
-
Racemization, enantiomerization, diastereomerization, and epimerization: Their meaning and pharmacological significance
-
Reist M, Testa B, Carrupt P-A, Jung M, Schurig V. Racemization, enantiomerization, diastereomerization, and epimerization: their meaning and pharmacological significance. Chirality 1995;7:396-400.
-
(1995)
Chirality
, vol.7
, pp. 396-400
-
-
Reist, M.1
Testa, B.2
Carrupt, P.-A.3
Jung, M.4
Schurig, V.5
-
13
-
-
0000844121
-
Determination of enantiomerization barriers by computer simulation of interconversion profiles: Enantiomerization of diaziridines during chiral inclusion gas chromatography
-
Jung M, Schurig V. Determination of enantiomerization barriers by computer simulation of interconversion profiles: enantiomerization of diaziridines during chiral inclusion gas chromatography. J Am Chem Soc 1992;114:529-534.
-
(1992)
J Am Chem Soc
, vol.114
, pp. 529-534
-
-
Jung, M.1
Schurig, V.2
-
14
-
-
0038180240
-
Dynamic HPLC: A method for determination rate constants, energy barriers, and equilibration constants of molecular dynamic processes
-
Veciana J, Crespo MI. Dynamic HPLC: a method for determination rate constants, energy barriers, and equilibration constants of molecular dynamic processes. Angew Chem Int Ed Engl 1991;30:74-77.
-
(1991)
Angew Chem Int Ed Engl
, vol.30
, pp. 74-77
-
-
Veciana, J.1
Crespo, M.I.2
-
15
-
-
0034899754
-
Determination of enantiomerization barriers by dynamic and stopped-flow chromatographic methods
-
DOI 10.1002/chir.1052
-
Trapp O, Schoetz G, Schurig V. Determination of enantiomerization barriers by dynamic and stopped-flow chromatographic methods. Chirality 2001;13:403-414. (Pubitemid 32729794)
-
(2001)
Chirality
, vol.13
, Issue.8
, pp. 403-414
-
-
Trapp, O.1
Schoetz, G.2
Schurig, V.3
-
16
-
-
0037762887
-
Determination of the interconversion energy barrier of enantiomers by separation methods
-
DOI 10.1016/S0021-9673(03)00238-3
-
Krupcik J, Oswald P, Majek P, Sandra P, Armstrong DW. Determination of the interconversion energy barrier of enantiomers by separation methods. J Chromatogr A 2003;1000:779-800. (Pubitemid 36638485)
-
(2003)
Journal of Chromatography a
, vol.1000
, Issue.1-2
, pp. 779-800
-
-
Krupcik, J.1
Oswald, P.2
Majek, P.3
Sandra, P.4
Armstrong, D.W.5
-
17
-
-
22244434936
-
Stereolabile chiral compounds: Analysis by dynamic chromatography and stopped-flow methods
-
DOI 10.1039/b502508g
-
Wolf C. Stereolabile chiral compounds: analysis by dynamic chromatography and stopped-flow methods. Chem Soc Rev 2005;34:595-608. (Pubitemid 40992747)
-
(2005)
Chemical Society Reviews
, vol.34
, Issue.7
, pp. 595-608
-
-
Wolf, C.1
-
18
-
-
33746408979
-
Dynamic HPLC on chiral stationary phases: A powerful tool for the investigation of stereosimulation processes
-
D'Acquarica I, Gasparrini F, Pierini M, Villani C, Zappia G. Dynamic HPLC on chiral stationary phases: a powerful tool for the investigation of stereosimulation processes. J Sep Sci 2006;29:1508-1516.
-
(2006)
J Sep Sci
, vol.29
, pp. 1508-1516
-
-
D'Acquarica, I.1
Gasparrini, F.2
Pierini, M.3
Villani, C.4
Zappia, G.5
-
19
-
-
30044437787
-
A unified equation for fast and precise access to rate constants of first order reactions in dynamic and on-column reaction chromatography
-
Trapp O. A unified equation for fast and precise access to rate constants of first order reactions in dynamic and on-column reaction chromatography. Anal Chem 2006;78:189-198.
-
(2006)
Anal Chem
, vol.78
, pp. 189-198
-
-
Trapp, O.1
-
21
-
-
33745426581
-
Fast and precise access to enantiomerization rate constants in dynamic chromatography
-
DOI 10.1002/chir.20276
-
Trapp O. Fast and precise access to enantiomerization rate constants in dynamic chromatography. Chirality 2006;18:489-497. (Pubitemid 43946217)
-
(2006)
Chirality
, vol.18
, Issue.7
, pp. 489-497
-
-
Trapp, O.1
-
22
-
-
32844457214
-
The unified equation for the evaluation of first order reactions in dynamic electrophoresis
-
DOI 10.1002/elps.200500708
-
Trapp O. The unified equation for the evaluation of first order reactions in dynamic electrophoresis. Electrophoresis 2006;27:534-541. (Pubitemid 43250766)
-
(2006)
Electrophoresis
, vol.27
, Issue.3
, pp. 534-541
-
-
Trapp, O.1
-
23
-
-
33947158154
-
A dynamic molecular probe to investigate catalytic effects and Joule heating in enantioselective micellar electrokinetic chromatography
-
Trapp O. A dynamic molecular probe to investigate catalytic effects and Joule heating in enantioselective micellar electrokinetic chromatography. Electrophoresis 2007;28:691-696.
-
(2007)
Electrophoresis
, vol.28
, pp. 691-696
-
-
Trapp, O.1
-
24
-
-
0034000649
-
Stereointegrity of Troger's base: Gas chromatographic determination of the enantiomerization barrier
-
Trapp O, Schurig V. Stereointegrity of Troger's base: gas chromatographic determination of the enantiomerization barrier. J Am Chem Soc 2000;122:1424-1430.
-
(2000)
J Am Chem Soc
, vol.122
, pp. 1424-1430
-
-
Trapp, O.1
Schurig, V.2
-
25
-
-
34948854924
-
High-throughput screening of catalysts by combining reactions and analysis
-
Trapp O, Weber SK, Bauch S, Hofstadt W. High-throughput screening of catalysts by combining reactions and analysis. Angew Chem Int Ed Engl 2007;46:7307-7310.
-
(2007)
Angew Chem Int Ed Engl
, vol.46
, pp. 7307-7310
-
-
Trapp, O.1
Weber, S.K.2
Bauch, S.3
Hofstadt, W.4
-
26
-
-
39749203611
-
Gas chromatographic high-throughput screening techniques in catalysis
-
DOI 10.1016/j.chroma.2007.10.086, PII S0021967307018675
-
Trapp O. Gas-chromatographic high-throughput screening techniques in catalysis (review article). J Chromatogr A 2008;1184:160-190. (Pubitemid 351296223)
-
(2008)
Journal of Chromatography a
, vol.1184
, Issue.1-2
, pp. 160-190
-
-
Trapp, O.1
-
27
-
-
0034746004
-
ChromWin-a computer program for the determination of enantiomerization barriers in dynamic chromatography
-
Trapp O, Schurig V. ChromWin-a computer program for the determination of enantiomerization barriers in dynamic chromatography. Comput Chem 2001;25:187-195.
-
(2001)
Comput Chem
, vol.25
, pp. 187-195
-
-
Trapp, O.1
Schurig, V.2
-
28
-
-
54049092753
-
A novel software tool for high-throughput measurements of interconversion barriers: DCXplorer
-
Trapp O. A novel software tool for high-throughput measurements of interconversion barriers: DCXplorer. J Chromatogr B 2008;875:42-47.
-
(2008)
J Chromatogr B
, vol.875
, pp. 42-47
-
-
Trapp, O.1
-
29
-
-
54049129637
-
Enantiomerization of chiral 2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4] benzothiadiazine 5,5-dioxide by stopped-flow multidimensional HPLC
-
Cannazza G, Carrozzo MM, Braghiroli D, Parenti C. Enantiomerization of chiral 2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine 5,5-dioxide by stopped-flow multidimensional HPLC. J Chromatogr B 2008;875:192-199.
-
(2008)
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
, vol.875
, Issue.1
, pp. 192-199
-
-
Cannazza, G.1
Carrozzo, M.M.2
Braghiroli, D.3
Parenti, C.4
-
30
-
-
55049103946
-
Enantiomerization and hydrolysis of (6)-7-chloro-3-methyl-3,4-dihydro-2H- 1,2,4-benzothiadiazine 1,1-dioxide by stopped-flow multidimensional high-performance liquid chromatography
-
Cannazza G, Carrozzo MM, Braghiroli D, Parenti C. Enantiomerization and hydrolysis of (6)-7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide by stopped-flow multidimensional high-performance liquid chromatography. J Chromatogr A 2008;1212:41-47.
-
(2008)
J Chromatogr A
, vol.1212
, pp. 41-47
-
-
Cannazza, G.1
Carrozzo, M.M.2
Braghiroli, D.3
Parenti, C.4
-
31
-
-
84962221908
-
Hydrogenolysis of 3,4-dihydro-1,2,4-benothiadiazine-1,1-dioxide
-
Ghelardoni M, Pestellini V. Hydrogenolysis of 3,4-dihydro-1,2,4- benothiadiazine-1,1-dioxide. Ann Chim 1972;62:373-384.
-
(1972)
Ann Chim
, vol.62
, pp. 373-384
-
-
Ghelardoni, M.1
Pestellini, V.2
-
32
-
-
0034257093
-
Chiral resolution of the enantiomers of 7-chloro-3-methyl-3,4-dihydro-2H- 1,2,4-benzothiadiazine 1,1-dioxide using high performance liquid chromatography on cellulose-based chiral stationary phases
-
Cannazza G, Braghiroli D, Baraldi M, Parenti C. Chiral resolution of the enantiomers of 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide using high performance liquid chromatography on cellulose-based chiral stationary phases. J Pharm Biomed Anal 2000; 23:117-125.
-
(2000)
J Pharm Biomed Anal
, vol.23
, pp. 117-125
-
-
Cannazza, G.1
Braghiroli, D.2
Baraldi, M.3
Parenti, C.4
-
33
-
-
0035146258
-
Studies of enantiomerization of chiral 3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide type compounds
-
Cannazza G, Braghiroli D, Tait A, Baraldi M, Parenti C, Lindner W. Studies of enantiomerization of chiral 3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide type compounds. Chirality 2001;13:94-101.
-
(2001)
Chirality
, vol.13
, pp. 94-101
-
-
Cannazza, G.1
Braghiroli, D.2
Tait, A.3
Baraldi, M.4
Parenti, C.5
Lindner, W.6
-
34
-
-
33845689509
-
Energy barrier determinationof enantiomerization of chiral 3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide type compounds by enantioselective stopped-flow HPLC
-
Cannazza G, Braghiroli D, Iuliani P, Parenti C. Energy barrier determinationof enantiomerization of chiral 3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide type compounds by enantioselective stopped-flow HPLC. Tetrahedron: Asymmetry 2006;17:3158-3162.
-
(2006)
Tetrahedron: Asymmetry
, vol.17
, pp. 3158-3162
-
-
Cannazza, G.1
Braghiroli, D.2
Iuliani, P.3
Parenti, C.4
-
35
-
-
77950424282
-
Simultaneous determination of enantiomerization and hydrolysis kinetic parameters of chiral N-alkylbenzothiadiazine derivatives
-
Carrozzo MM, Cannazza G, Battisti U, Braghiroli D, Parenti C. Simultaneously determination of enantiomerization and hydrolysis kinetic parameters of chiral N-alkylbenzothiadiazine derivatives. Chirality 2009;DOI: 10.1002/chir. 20751.
-
(2001)
Chirality
, vol.22
, Issue.4
, pp. 389-397
-
-
Carrozzo, M.M.1
Cannazza, G.2
Battisti, U.3
Braghiroli, D.4
Parenti, C.5
-
36
-
-
0015124314
-
Hydrolysis of benzothaidiazines
-
Mollica A, Rehm CR, Smith JB, Govan HK. Hydrolysis of benzothaidiazines, J Pharm Sci 1971;60:1380-1384.
-
(1971)
J Pharm Sci
, vol.60
, pp. 1380-1384
-
-
Mollica, A.1
Rehm, C.R.2
Smith, J.B.3
Govan, H.K.4
-
37
-
-
77956702848
-
Idrogenolisi di 3,4-diidro-1,2,4-benzotiadiazine-1,1-diossido
-
Ghelardoni M, Pestellini V, Russo F. Idrogenolisi di 3,4-diidro-1,2,4- benzotiadiazine-1,1-diossido, Annali di chimica 1969;59:590-693.
-
(1969)
Annali di Chimica
, vol.59
, pp. 590-693
-
-
Ghelardoni, M.1
Pestellini, V.2
Russo, F.3
|