Epimerization and hydrolysis of 3,6-dimethyl-2,3,5,6-tetrahydro[1,2,4]thiadiazino[6,5,4-hi]indole 1,1-dioxide

Journal of Chromatography A

Volumn 1217, Issue 52, 2010, Pages 8136-8145

  Carrozzo, Marina M ^a   Cannazza, Giuseppe ^a   Battisti, Umberto ^a   Braghiroli, Daniela ^a   Troisi, Luigino ^b   Parenti, Carlo ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF SALENTO   (Italy)

Author keywords

Chiral benzothiadiazines; Dynamic chromatography; Epimerization; Stopped flow chromatography

Indexed keywords

ABSOLUTE CONFIGURATION; ACIDIC CONDITIONS; AQUEOUS SOLVENTS; ARTIFICIAL MEMBRANES; CHIRAL BENZOTHIADIAZINES; CHIRAL CHROMATOGRAPHY; DIELECTRIC CONSTANTS; DYNAMIC CHROMATOGRAPHY; EPIMERIZATION; EPIMERS; HPLC METHOD; IN-VIVO; MOLECULAR MODELLING; PHYSIOLOGICAL BUFFERS; STOPPED FLOW;

CHEMICAL STABILITY; HYDROLYSIS;

CHROMATOGRAPHY;

2,3 DIHYDRO 3 METHYL 1H INDOL 7 SULFONAMIDE; 2,3 DIHYDRO 3 METHYL 1H INDOLE; 2,3 DIHYDRO 3 METHYL 1H INDOLE 1 CARBOXYLIC ACID 1,1 DIMETHYLETHYL ESTER; 3,6 DIMETHYL 2,3,5,6 TETRAHYDRO[1,2,4]THIADIAZINO[6,5,4-HI]INDOLE 1,1 DIOXIDE; BENZOTHIADIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL COMPOSITION; CHEMICAL INTERACTION; CHEMICAL REACTION KINETICS; CHEMICAL STRUCTURE; CHIRALITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIELECTRIC CONSTANT; EPIMERIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOLECULAR STABILITY; PH; PRIORITY JOURNAL; SEPARATION TECHNIQUE; SOLVENT EFFECT; STEREOISOMERISM; SYNTHESIS; TEMPERATURE SENSITIVITY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROLYSIS; INDOLES; MODELS, CHEMICAL; STEREOISOMERISM;

EID: 78649889573     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2010.10.044     Document Type: Article

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