-
1
-
-
84872166765
-
Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis
-
Odegaard JI, Chawla A (2013) Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis. Science 339: 172-177.
-
(2013)
Science
, vol.339
, pp. 172-177
-
-
Odegaard, J.I.1
Chawla, A.2
-
2
-
-
84857985148
-
The cellular and signaling networks linking the immune system and metabolism in disease
-
Osborn O, Olefsky JM (2012) The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med 18: 363-374.
-
(2012)
Nat Med
, vol.18
, pp. 363-374
-
-
Osborn, O.1
Olefsky, J.M.2
-
4
-
-
0027459878
-
Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
-
Hotamisligil GS, Shargill NS, Spiegelman BM (1993) Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259: 87-91.
-
(1993)
Science
, vol.259
, pp. 87-91
-
-
Hotamisligil, G.S.1
Shargill, N.S.2
Spiegelman, B.M.3
-
5
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
Hirosumi J, Tuncman G, Chang L, Gorgun CZ, Uysal KT, et al. (2002) A central role for JNK in obesity and insulin resistance. Nature 420: 333-336.
-
(2002)
Nature
, vol.420
, pp. 333-336
-
-
Hirosumi, J.1
Tuncman, G.2
Chang, L.3
Gorgun, C.Z.4
Uysal, K.T.5
-
6
-
-
14644427890
-
Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
-
Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, et al. (2005) Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med 11: 183-190.
-
(2005)
Nat Med
, vol.11
, pp. 183-190
-
-
Cai, D.1
Yuan, M.2
Frantz, D.F.3
Melendez, P.A.4
Hansen, L.5
-
7
-
-
0035979775
-
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta
-
Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, et al. (2001) Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 293: 1673-1677.
-
(2001)
Science
, vol.293
, pp. 1673-1677
-
-
Yuan, M.1
Konstantopoulos, N.2
Lee, J.3
Hansen, L.4
Li, Z.W.5
-
8
-
-
20044387026
-
IKK-beta links inflammation to obesity-induced insulin resistance
-
Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, et al. (2005) IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med 11: 191-198.
-
(2005)
Nat Med
, vol.11
, pp. 191-198
-
-
Arkan, M.C.1
Hevener, A.L.2
Greten, F.R.3
Maeda, S.4
Li, Z.W.5
-
9
-
-
0030615201
-
Nuclear factor-kappaB: A pivotal transcription factor in chronic inflammatory diseases
-
Barnes PJ, Karin M (1997) Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336: 1066-1071.
-
(1997)
N Engl J Med
, vol.336
, pp. 1066-1071
-
-
Barnes, P.J.1
Karin, M.2
-
12
-
-
34047119110
-
Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation
-
Hosogai N, Fukuhara A, Oshima K, Miyata Y, Tanaka S, et al. (2007) Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes 56: 901-911.
-
(2007)
Diabetes
, vol.56
, pp. 901-911
-
-
Hosogai, N.1
Fukuhara, A.2
Oshima, K.3
Miyata, Y.4
Tanaka, S.5
-
13
-
-
35148854599
-
Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice
-
Ye J, Gao Z, Yin J, He Q (2007) Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab 293: E1118-1128.
-
(2007)
Am J Physiol Endocrinol Metab
, vol.293
, pp. E1118-1128
-
-
Ye, J.1
Gao, Z.2
Yin, J.3
He, Q.4
-
14
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
-
Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, et al. (2004) Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306: 457-461.
-
(2004)
Science
, vol.306
, pp. 457-461
-
-
Ozcan, U.1
Cao, Q.2
Yilmaz, E.3
Lee, A.H.4
Iwakoshi, N.N.5
-
15
-
-
33748069813
-
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
-
Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, et al. (2006) Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 313: 1137-1140.
-
(2006)
Science
, vol.313
, pp. 1137-1140
-
-
Ozcan, U.1
Yilmaz, E.2
Ozcan, L.3
Furuhashi, M.4
Vaillancourt, E.5
-
16
-
-
37449014525
-
Direct monitoring of in vivo ER stress during the development of insulin resistance with ER stress-activated indicator transgenic mice
-
Yoshiuchi K, Kaneto H, Matsuoka TA, Kohno K, Iwawaki T, et al. (2008) Direct monitoring of in vivo ER stress during the development of insulin resistance with ER stress-activated indicator transgenic mice. Biochem Biophys Res Commun 366: 545-550.
-
(2008)
Biochem Biophys Res Commun
, vol.366
, pp. 545-550
-
-
Yoshiuchi, K.1
Kaneto, H.2
Matsuoka, T.A.3
Kohno, K.4
Iwawaki, T.5
-
17
-
-
84878785347
-
Immunological goings-on in visceral adipose tissue
-
Mathis D (2013) Immunological Goings-on in Visceral Adipose Tissue. Cell Metab 17: 851-859.
-
(2013)
Cell Metab
, vol.17
, pp. 851-859
-
-
Mathis, D.1
-
18
-
-
77951918926
-
Macrophages, inflammation, and insulin resistance
-
Olefsky JM, Glass CK (2010) Macrophages, inflammation, and insulin resistance. Annu Rev Physiol 72: 219-246.
-
(2010)
Annu Rev Physiol
, vol.72
, pp. 219-246
-
-
Olefsky, J.M.1
Glass, C.K.2
-
19
-
-
80355133234
-
Macrophage-mediated inflammation in metabolic disease
-
Chawla A, Nguyen KD, Goh YP (2011) Macrophage-mediated inflammation in metabolic disease. Nat Rev Immunol 11: 738-749.
-
(2011)
Nat Rev Immunol
, vol.11
, pp. 738-749
-
-
Chawla, A.1
Nguyen, K.D.2
Goh, Y.P.3
-
20
-
-
0348230958
-
Obesity is associated with macrophage accumulation in adipose tissue
-
Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, et al. (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112: 1796-1808.
-
(2003)
J Clin Invest
, vol.112
, pp. 1796-1808
-
-
Weisberg, S.P.1
McCann, D.2
Desai, M.3
Rosenbaum, M.4
Leibel, R.L.5
-
21
-
-
9144223683
-
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
-
Xu H, Barnes GT, Yang Q, Tan G, Yang D, et al. (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112: 1821-1830.
-
(2003)
J Clin Invest
, vol.112
, pp. 1821-1830
-
-
Xu, H.1
Barnes, G.T.2
Yang, Q.3
Tan, G.4
Yang, D.5
-
22
-
-
33846026712
-
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
-
Lumeng CN, Bodzin JL, Saltiel AR (2007) Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 117: 175-184.
-
(2007)
J Clin Invest
, vol.117
, pp. 175-184
-
-
Lumeng, C.N.1
Bodzin, J.L.2
Saltiel, A.R.3
-
24
-
-
33847280286
-
T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity
-
Wu H, Ghosh S, Perrard XD, Feng L, Garcia GE, et al. (2007) T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity. Circulation 115: 1029-1038.
-
(2007)
Circulation
, vol.115
, pp. 1029-1038
-
-
Wu, H.1
Ghosh, S.2
Perrard, X.D.3
Feng, L.4
Garcia, G.E.5
-
25
-
-
38149142633
-
Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration
-
Rausch ME, Weisberg S, Vardhana P, Tortoriello DV (2008) Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration. Int J Obes (Lond) 32: 451-463.
-
(2008)
Int J Obes (Lond)
, vol.32
, pp. 451-463
-
-
Rausch, M.E.1
Weisberg, S.2
Vardhana, P.3
Tortoriello, D.V.4
-
26
-
-
46249117032
-
Tlymphocyte infiltration in visceral adipose tissue: A primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance
-
Kintscher U, Hartge M, Hess K, Foryst-Ludwig A, Clemenz M, et al. (2008) Tlymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance. Arterioscler Thromb Vasc Biol 28: 1304-1310.
-
(2008)
Arterioscler Thromb Vasc Biol
, vol.28
, pp. 1304-1310
-
-
Kintscher, U.1
Hartge, M.2
Hess, K.3
Foryst-Ludwig, A.4
Clemenz, M.5
-
27
-
-
54049086276
-
Interferon-gamma, a Th1 cytokine, regulates fat inflammation: A role for adaptive immunity in obesity
-
Rocha VZ, Folco EJ, Sukhova G, Shimizu K, Gotsman I, et al. (2008) Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity. Circ Res 103: 467-476.
-
(2008)
Circ Res
, vol.103
, pp. 467-476
-
-
Rocha, V.Z.1
Folco, E.J.2
Sukhova, G.3
Shimizu, K.4
Gotsman, I.5
-
28
-
-
65649117802
-
Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity
-
Duffaut C, Galitzky J, Lafontan M, Bouloumie A (2009) Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity. Biochem Biophys Res Commun 384: 482-485.
-
(2009)
Biochem Biophys Res Commun
, vol.384
, pp. 482-485
-
-
Duffaut, C.1
Galitzky, J.2
Lafontan, M.3
Bouloumie, A.4
-
29
-
-
21244474452
-
Adipose tissues as an ancestral immune organ: Site-specific change in obesity
-
Caspar-Bauguil S, Cousin B, Galinier A, Segafredo C, Nibbelink M, et al. (2005) Adipose tissues as an ancestral immune organ: site-specific change in obesity. FEBS Lett 579: 3487-3492.
-
(2005)
FEBS Lett
, vol.579
, pp. 3487-3492
-
-
Caspar-Bauguil, S.1
Cousin, B.2
Galinier, A.3
Segafredo, C.4
Nibbelink, M.5
-
30
-
-
68349150756
-
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
-
Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, et al. (2009) CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med 15: 914-920.
-
(2009)
Nat Med
, vol.15
, pp. 914-920
-
-
Nishimura, S.1
Manabe, I.2
Nagasaki, M.3
Eto, K.4
Yamashita, H.5
-
31
-
-
68349137821
-
Normalization of obesity-associated insulin resistance through immunotherapy
-
Winer S, Chan Y, Paltser G, Truong D, Tsui H, et al. (2009) Normalization of obesity-associated insulin resistance through immunotherapy. Nat Med 15: 921-929.
-
(2009)
Nat Med
, vol.15
, pp. 921-929
-
-
Winer, S.1
Chan, Y.2
Paltser, G.3
Truong, D.4
Tsui, H.5
-
32
-
-
77956396699
-
Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: Implications for systemic inflammation and insulin resistance
-
Yang H, Youm YH, Vandanmagsar B, Ravussin A, Gimble JM, et al. (2010) Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance. J Immunol 185: 1836-1845.
-
(2010)
J Immunol
, vol.185
, pp. 1836-1845
-
-
Yang, H.1
Youm, Y.H.2
Vandanmagsar, B.3
Ravussin, A.4
Gimble, J.M.5
-
33
-
-
68349148211
-
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
-
Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, et al. (2009) Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med 15: 930-939.
-
(2009)
Nat Med
, vol.15
, pp. 930-939
-
-
Feuerer, M.1
Herrero, L.2
Cipolletta, D.3
Naaz, A.4
Wong, J.5
-
34
-
-
27444437321
-
Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
-
Cinti S, Mitchell G, Barbatelli G, Murano I, Ceresi E, et al. (2005) Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res 46: 2347-2355.
-
(2005)
J Lipid Res
, vol.46
, pp. 2347-2355
-
-
Cinti, S.1
Mitchell, G.2
Barbatelli, G.3
Murano, I.4
Ceresi, E.5
-
35
-
-
84856244046
-
RAE1epsilon ligand expressed on pancreatic islets recruits NKG2D receptorexpressing cytotoxic T cells independent of T cell receptor recognition
-
Markiewicz MA, Wise EL, Buchwald ZS, Pinto AK, Zafirova B, et al. (2012) RAE1epsilon ligand expressed on pancreatic islets recruits NKG2D receptorexpressing cytotoxic T cells independent of T cell receptor recognition. Immunity 36: 132-141.
-
(2012)
Immunity
, vol.36
, pp. 132-141
-
-
Markiewicz, M.A.1
Wise, E.L.2
Buchwald, Z.S.3
Pinto, A.K.4
Zafirova, B.5
-
36
-
-
0142197631
-
Roles of the NKG2D immunoreceptor and its ligands
-
Raulet DH (2003) Roles of the NKG2D immunoreceptor and its ligands. Nat Rev Immunol 3: 781-790.
-
(2003)
Nat Rev Immunol
, vol.3
, pp. 781-790
-
-
Raulet, D.H.1
-
37
-
-
33845866857
-
Inflammation and metabolic disorders
-
Hotamisligil GS (2006) Inflammation and metabolic disorders. Nature 444: 860-867.
-
(2006)
Nature
, vol.444
, pp. 860-867
-
-
Hotamisligil, G.S.1
-
38
-
-
58149500277
-
Emerging role of adipose tissue hypoxia in obesity and insulin resistance
-
Ye J (2009) Emerging role of adipose tissue hypoxia in obesity and insulin resistance. Int J Obes (Lond) 33: 54-66.
-
(2009)
Int J Obes (Lond)
, vol.33
, pp. 54-66
-
-
Ye, J.1
-
39
-
-
45549084383
-
Identification of amino acid residues within the C terminus of the Glut4 glucose transporter that are essential for insulin-stimulated redistribution to the plasma membrane
-
Song XM, Hresko RC, Mueckler M (2008) Identification of amino acid residues within the C terminus of the Glut4 glucose transporter that are essential for insulin-stimulated redistribution to the plasma membrane. J Biol Chem 283: 12571-12585.
-
(2008)
J Biol Chem
, vol.283
, pp. 12571-12585
-
-
Song, X.M.1
Hresko, R.C.2
Mueckler, M.3
-
40
-
-
68649112523
-
Altered NK cell development and enhanced NK cell-mediated resistance to mouse cytomegalovirus in NKG2D-deficient mice
-
Zafirova B, Mandaric S, Antulov R, Krmpotic A, Jonsson H, et al. (2009) Altered NK cell development and enhanced NK cell-mediated resistance to mouse cytomegalovirus in NKG2D-deficient mice. Immunity 31: 270-282.
-
(2009)
Immunity
, vol.31
, pp. 270-282
-
-
Zafirova, B.1
Mandaric, S.2
Antulov, R.3
Krmpotic, A.4
Jonsson, H.5
-
41
-
-
77954506508
-
Identification and characterization of a promoter cassette conferring adipocyte-specific gene expression
-
Wang ZV, Deng Y, Wang QA, Sun K, Scherer PE (2010) Identification and characterization of a promoter cassette conferring adipocyte-specific gene expression. Endocrinology 151: 2933-2939.
-
(2010)
Endocrinology
, vol.151
, pp. 2933-2939
-
-
Wang, Z.V.1
Deng, Y.2
Wang, Q.A.3
Sun, K.4
Scherer, P.E.5
-
42
-
-
61449189831
-
Murine NKG2D ligands: ''double, double toil and trouble''
-
Samarakoon A, Chu H, Malarkannan S (2009) Murine NKG2D ligands: ''double, double toil and trouble''. Mol Immunol 46: 1011-1019.
-
(2009)
Mol Immunol
, vol.46
, pp. 1011-1019
-
-
Samarakoon, A.1
Chu, H.2
Malarkannan, S.3
-
43
-
-
24944500112
-
Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance
-
Oppenheim DE, Roberts SJ, Clarke SL, Filler R, Lewis JM, et al. (2005) Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance. Nature immunology 6: 928-937.
-
(2005)
Nature Immunology
, vol.6
, pp. 928-937
-
-
Oppenheim, D.E.1
Roberts, S.J.2
Clarke, S.L.3
Filler, R.4
Lewis, J.M.5
-
44
-
-
23244463012
-
Systemic NKG2D down-regulation impairs NK and CD8 T cell responses in vivo
-
Wiemann K, Mittrucker HW, Feger U, Welte SA, Yokoyama WM, et al. (2005) Systemic NKG2D down-regulation impairs NK and CD8 T cell responses in vivo. J Immunol 175: 720-729.
-
(2005)
J Immunol
, vol.175
, pp. 720-729
-
-
Wiemann, K.1
Mittrucker, H.W.2
Feger, U.3
Welte, S.A.4
Yokoyama, W.M.5
-
45
-
-
50549096379
-
Genetic influence on immune phenotype revealed strain-specific variations in peripheral blood lineages
-
Petkova SB, Yuan R, Tsaih SW, Schott W, Roopenian DC, et al. (2008) Genetic influence on immune phenotype revealed strain-specific variations in peripheral blood lineages. Physiol Genomics 34: 304-314.
-
(2008)
Physiol Genomics
, vol.34
, pp. 304-314
-
-
Petkova, S.B.1
Yuan, R.2
Tsaih, S.W.3
Schott, W.4
Roopenian, D.C.5
-
46
-
-
34249697436
-
Role of leptin in immunity
-
Lam QL, Lu L (2007) Role of leptin in immunity. Cell Mol Immunol 4: 1-13.
-
(2007)
Cell Mol Immunol
, vol.4
, pp. 1-13
-
-
Lam, Q.L.1
Lu, L.2
-
47
-
-
0037241472
-
Impairment of NK cell function by NKG2D modulation in NOD mice
-
Ogasawara K, Hamerman JA, Hsin H, Chikuma S, Bour-Jordan H, et al. (2003) Impairment of NK cell function by NKG2D modulation in NOD mice. Immunity 18: 41-51.
-
(2003)
Immunity
, vol.18
, pp. 41-51
-
-
Ogasawara, K.1
Hamerman, J.A.2
Hsin, H.3
Chikuma, S.4
Bour-Jordan, H.5
-
48
-
-
73449099959
-
Major histocompatibility complex class I-related chains A and B (MIC A/B): A novel role in nonalcoholic steatohepatitis
-
Kahraman A, Schlattjan M, Kocabayoglu P, Yildiz-Meziletoglu S, Schlensak M, et al. (2010) Major histocompatibility complex class I-related chains A and B (MIC A/B): a novel role in nonalcoholic steatohepatitis. Hepatology 51: 92-102.
-
(2010)
Hepatology
, vol.51
, pp. 92-102
-
-
Kahraman, A.1
Schlattjan, M.2
Kocabayoglu, P.3
Yildiz-Meziletoglu, S.4
Schlensak, M.5
|