메뉴 건너뛰기




Volumn 8, Issue 1, 2014, Pages

Analysis of the quantitative balance between insulin-like growth factor (IGF)-1 ligand, receptor, and binding protein levels to predict cell sensitivity and therapeutic efficacy

Author keywords

Insulin like growth factor (IGF); Mathematical modeling; Ovarian cancer

Indexed keywords

LIGAND; NEUTRALIZING ANTIBODY; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

EID: 84908093056     PISSN: None     EISSN: 17520509     Source Type: Journal    
DOI: 10.1186/s12918-014-0098-y     Document Type: Article
Times cited : (19)

References (94)
  • 1
    • 0031587697 scopus 로고    scopus 로고
    • Seminars in medicine of the Beth Israel Deaconess Medical Center. Insulin-like growth factors
    • 9032050
    • Le Roith D. Seminars in medicine of the Beth Israel Deaconess Medical Center. Insulin-like growth factors. N Engl J Med 1997, 336:633-640. 9032050.
    • (1997) N Engl J Med , vol.336 , pp. 633-640
    • Le Roith, D.1
  • 2
    • 84861991929 scopus 로고    scopus 로고
    • The insulin-like growth factor system in cancer
    • vi, 22682634
    • Weroha SJ, Haluska P. The insulin-like growth factor system in cancer. Endocrinol Metab Clin North Am 2012, 41:335-350. vi, 22682634.
    • (2012) Endocrinol Metab Clin North Am , vol.41 , pp. 335-350
    • Weroha, S.J.1    Haluska, P.2
  • 3
    • 0242594016 scopus 로고    scopus 로고
    • The IGF-1 receptor in cancer biology
    • 14601044
    • Baserga R, Peruzzi F, Reiss K. The IGF-1 receptor in cancer biology. Int J Cancer 2003, 107:873-877. 14601044.
    • (2003) Int J Cancer , vol.107 , pp. 873-877
    • Baserga, R.1    Peruzzi, F.2    Reiss, K.3
  • 4
    • 0028332092 scopus 로고
    • Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts
    • 8196606
    • Sell C, Dumenil G, Deveaud C, Miura M, Coppola D, DeAngelis T, Rubin R, Efstratiadis A, Baserga R. Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts. Mol Cell Biol 1994, 14:3604-3612. 8196606.
    • (1994) Mol Cell Biol , vol.14 , pp. 3604-3612
    • Sell, C.1    Dumenil, G.2    Deveaud, C.3    Miura, M.4    Coppola, D.5    DeAngelis, T.6    Rubin, R.7    Efstratiadis, A.8    Baserga, R.9
  • 8
    • 0027423419 scopus 로고
    • Role of insulin-like growth factors in embryonic and postnatal growth
    • 8402902
    • Baker J, Liu JP, Robertson EJ, Efstratiadis A. Role of insulin-like growth factors in embryonic and postnatal growth. Cell 1993, 75:73-82. 8402902.
    • (1993) Cell , vol.75 , pp. 73-82
    • Baker, J.1    Liu, J.P.2    Robertson, E.J.3    Efstratiadis, A.4
  • 9
    • 0033303817 scopus 로고    scopus 로고
    • Insulin-like growth factor I is essential for terminal end bud formation and ductal morphogenesis during mammary development
    • 10537134
    • Ruan W, Kleinberg DL. Insulin-like growth factor I is essential for terminal end bud formation and ductal morphogenesis during mammary development. Endocrinology 1999, 140:5075-5081. 10537134.
    • (1999) Endocrinology , vol.140 , pp. 5075-5081
    • Ruan, W.1    Kleinberg, D.L.2
  • 10
    • 0033306843 scopus 로고    scopus 로고
    • Evidence that insulin-like growth factor I and growth hormone are required for prostate gland development
    • 10218945
    • Ruan W, Powell-Braxton L, Kopchick JJ, Kleinberg DL. Evidence that insulin-like growth factor I and growth hormone are required for prostate gland development. Endocrinology 1999, 140:1984-1989. 10218945.
    • (1999) Endocrinology , vol.140 , pp. 1984-1989
    • Ruan, W.1    Powell-Braxton, L.2    Kopchick, J.J.3    Kleinberg, D.L.4
  • 11
    • 0032947596 scopus 로고    scopus 로고
    • Insulin-like growth factor I regulates renal development in rodents
    • 10322637
    • Rogers SA, Powell-Braxton L, Hammerman MR. Insulin-like growth factor I regulates renal development in rodents. Dev Genet 1999, 24:293-298. 10322637.
    • (1999) Dev Genet , vol.24 , pp. 293-298
    • Rogers, S.A.1    Powell-Braxton, L.2    Hammerman, M.R.3
  • 12
    • 0027496895 scopus 로고
    • Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)
    • 8402901
    • Liu JP, Baker J, Perkins AS, Robertson EJ, Efstratiadis A. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 1993, 75:59-72. 8402901.
    • (1993) Cell , vol.75 , pp. 59-72
    • Liu, J.P.1    Baker, J.2    Perkins, A.S.3    Robertson, E.J.4    Efstratiadis, A.5
  • 14
    • 3042775027 scopus 로고    scopus 로고
    • The insulin like growth factor-1 receptor (IGF-1R) as a drug target: novel approaches to cancer therapy
    • 15231297
    • Bahr C, Groner B. The insulin like growth factor-1 receptor (IGF-1R) as a drug target: novel approaches to cancer therapy. Growth Horm IGF Res 2004, 14:287-295. 15231297.
    • (2004) Growth Horm IGF Res , vol.14 , pp. 287-295
    • Bahr, C.1    Groner, B.2
  • 15
    • 10344222098 scopus 로고    scopus 로고
    • The therapeutic potential of agents targeting the type I insulin-like growth factor receptor
    • 15566314
    • Zhang H, Yee D. The therapeutic potential of agents targeting the type I insulin-like growth factor receptor. Expert Opin Investig Drugs 2004, 13:1569-1577. 15566314.
    • (2004) Expert Opin Investig Drugs , vol.13 , pp. 1569-1577
    • Zhang, H.1    Yee, D.2
  • 16
    • 0028958031 scopus 로고
    • Insulin-like growth factors and their binding proteins: biological actions
    • 7758431
    • Jones JI, Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev 1995, 16:3-34. 7758431.
    • (1995) Endocr Rev , vol.16 , pp. 3-34
    • Jones, J.I.1    Clemmons, D.R.2
  • 17
    • 0034692430 scopus 로고    scopus 로고
    • Role of the insulin-like growth factor family in cancer development and progression
    • 10995803
    • Yu H, Rohan T. Role of the insulin-like growth factor family in cancer development and progression. J Natl Cancer Inst 2000, 92:1472-1489. 10995803.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1472-1489
    • Yu, H.1    Rohan, T.2
  • 18
    • 0031743951 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology
    • 9972281
    • Butler AA, Yakar S, Gewolb IH, Karas M, Okubo Y, LeRoith D. Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology. Comp Biochem Physiol B Biochem Mol Biol 1998, 121:19-26. 9972281.
    • (1998) Comp Biochem Physiol B Biochem Mol Biol , vol.121 , pp. 19-26
    • Butler, A.A.1    Yakar, S.2    Gewolb, I.H.3    Karas, M.4    Okubo, Y.5    LeRoith, D.6
  • 20
    • 16544392180 scopus 로고    scopus 로고
    • Insulin and IGF-1 receptor trafficking and signalling
    • discussion 141-127, 265-128, 15562826
    • Foti M, Moukil MA, Dudognon P, Carpentier JL. Insulin and IGF-1 receptor trafficking and signalling. Novartis Found Symp 2004, 262:125-141. discussion 141-127, 265-128, 15562826.
    • (2004) Novartis Found Symp , vol.262 , pp. 125-141
    • Foti, M.1    Moukil, M.A.2    Dudognon, P.3    Carpentier, J.L.4
  • 21
    • 34547960588 scopus 로고    scopus 로고
    • Insulin-like growth factor type-I receptor internalization and recycling mediate the sustained phosphorylation of Akt
    • 17545147
    • Romanelli RJ, LeBeau AP, Fulmer CG, Lazzarino DA, Hochberg A, Wood TL. Insulin-like growth factor type-I receptor internalization and recycling mediate the sustained phosphorylation of Akt. J Biol Chem 2007, 282:22513-22524. 17545147.
    • (2007) J Biol Chem , vol.282 , pp. 22513-22524
    • Romanelli, R.J.1    LeBeau, A.P.2    Fulmer, C.G.3    Lazzarino, D.A.4    Hochberg, A.5    Wood, T.L.6
  • 22
    • 0033610892 scopus 로고    scopus 로고
    • Beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor
    • 9822622
    • Lin FT, Daaka Y, Lefkowitz RJ. beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor. J Biol Chem 1998, 273:31640-31643. 9822622.
    • (1998) J Biol Chem , vol.273 , pp. 31640-31643
    • Lin, F.T.1    Daaka, Y.2    Lefkowitz, R.J.3
  • 23
    • 0033199917 scopus 로고    scopus 로고
    • Altered ligand binding by insulin-like growth factor II/mannose 6-phosphate receptors bearing missense mutations in human cancers
    • 10485478
    • Devi GR, De Souza AT, Byrd JC, Jirtle RL, MacDonald RG. Altered ligand binding by insulin-like growth factor II/mannose 6-phosphate receptors bearing missense mutations in human cancers. Cancer Res 1999, 59:4314-4319. 10485478.
    • (1999) Cancer Res , vol.59 , pp. 4314-4319
    • Devi, G.R.1    De Souza, A.T.2    Byrd, J.C.3    Jirtle, R.L.4    MacDonald, R.G.5
  • 24
    • 0033304507 scopus 로고    scopus 로고
    • The insulin-like growth factor-binding protein (IGFBP) superfamily
    • 10605625
    • Hwa V, Oh Y, Rosenfeld RG. The insulin-like growth factor-binding protein (IGFBP) superfamily. Endocr Rev 1999, 20:761-787. 10605625.
    • (1999) Endocr Rev , vol.20 , pp. 761-787
    • Hwa, V.1    Oh, Y.2    Rosenfeld, R.G.3
  • 25
    • 0038398622 scopus 로고    scopus 로고
    • The insulin-like growth factor system and cancer
    • 12767520
    • LeRoith D, Roberts CT. The insulin-like growth factor system and cancer. Cancer Lett 2003, 195:127-137. 12767520.
    • (2003) Cancer Lett , vol.195 , pp. 127-137
    • LeRoith, D.1    Roberts, C.T.2
  • 26
    • 33645560435 scopus 로고    scopus 로고
    • Insulin-like growth factor-binding protein-5 (IGFBP-5): a critical member of the IGF axis
    • 16526944
    • Beattie J, Allan GJ, Lochrie JD, Flint DJ. Insulin-like growth factor-binding protein-5 (IGFBP-5): a critical member of the IGF axis. Biochem J 2006, 395:1-19. 16526944.
    • (2006) Biochem J , vol.395 , pp. 1-19
    • Beattie, J.1    Allan, G.J.2    Lochrie, J.D.3    Flint, D.J.4
  • 27
    • 0036905115 scopus 로고    scopus 로고
    • Cellular actions of the insulin-like growth factor binding proteins
    • 12466191
    • Firth SM, Baxter RC. Cellular actions of the insulin-like growth factor binding proteins. Endocr Rev 2002, 23:824-854. 12466191.
    • (2002) Endocr Rev , vol.23 , pp. 824-854
    • Firth, S.M.1    Baxter, R.C.2
  • 28
    • 0042031012 scopus 로고    scopus 로고
    • Insulin-like growth factor-binding protein-5 inhibits the growth of human breast cancer cells in vitro and in vivo
    • 12777377
    • Butt AJ, Dickson KA, McDougall F, Baxter RC. Insulin-like growth factor-binding protein-5 inhibits the growth of human breast cancer cells in vitro and in vivo. J Biol Chem 2003, 278:29676-29685. 12777377.
    • (2003) J Biol Chem , vol.278 , pp. 29676-29685
    • Butt, A.J.1    Dickson, K.A.2    McDougall, F.3    Baxter, R.C.4
  • 29
    • 0034455310 scopus 로고    scopus 로고
    • Overexpression of insulin-like growth factor binding protein-5 helps accelerate progression to androgen-independence in the human prostate LNCaP tumor model through activation of phosphatidylinositol 3′-kinase pathway
    • 10830316
    • Miyake H, Nelson C, Rennie PS, Gleave ME. Overexpression of insulin-like growth factor binding protein-5 helps accelerate progression to androgen-independence in the human prostate LNCaP tumor model through activation of phosphatidylinositol 3′-kinase pathway. Endocrinology 2000, 141:2257-2265. 10830316.
    • (2000) Endocrinology , vol.141 , pp. 2257-2265
    • Miyake, H.1    Nelson, C.2    Rennie, P.S.3    Gleave, M.E.4
  • 30
    • 77954583916 scopus 로고    scopus 로고
    • Tumor-associated retinal astrocytes promote retinoblastoma cell proliferation through production of IGFBP-5
    • 20508032
    • Xu XL, Lee TC, Offor N, Cheng C, Liu A, Fang Y, Jhanwar SC, Abramson DH, Cobrinik D. Tumor-associated retinal astrocytes promote retinoblastoma cell proliferation through production of IGFBP-5. Am J Pathol 2010, 177:424-435. 20508032.
    • (2010) Am J Pathol , vol.177 , pp. 424-435
    • Xu, X.L.1    Lee, T.C.2    Offor, N.3    Cheng, C.4    Liu, A.5    Fang, Y.6    Jhanwar, S.C.7    Abramson, D.H.8    Cobrinik, D.9
  • 31
    • 0025819877 scopus 로고
    • Phosphorylation of insulin-like growth factor (IGF)-binding protein 1 in cell culture and in vivo: effects on affinity for IGF-I
    • 1715565
    • Jones JI, D'Ercole AJ, Camacho-Hubner C, Clemmons DR. Phosphorylation of insulin-like growth factor (IGF)-binding protein 1 in cell culture and in vivo: effects on affinity for IGF-I. Proc Natl Acad Sci U S A 1991, 88:7481-7485. 1715565.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 7481-7485
    • Jones, J.I.1    D'Ercole, A.J.2    Camacho-Hubner, C.3    Clemmons, D.R.4
  • 32
    • 0025131648 scopus 로고
    • Receptors for insulin and insulin-like growth factor-I can form hybrid dimers. Characterisation of hybrid receptors in transfected cells
    • 1698059
    • Soos MA, Whittaker J, Lammers R, Ullrich A, Siddle K. Receptors for insulin and insulin-like growth factor-I can form hybrid dimers. Characterisation of hybrid receptors in transfected cells. Biochem J 1990, 270:383-390. 1698059.
    • (1990) Biochem J , vol.270 , pp. 383-390
    • Soos, M.A.1    Whittaker, J.2    Lammers, R.3    Ullrich, A.4    Siddle, K.5
  • 33
    • 0024358352 scopus 로고
    • Insulin-like growth factor I receptor beta-subunit heterogeneity. Evidence for hybrid tetramers composed of insulin-like growth factor I and insulin receptor heterodimers
    • 2546949
    • Moxham CP, Duronio V, Jacobs S. Insulin-like growth factor I receptor beta-subunit heterogeneity. Evidence for hybrid tetramers composed of insulin-like growth factor I and insulin receptor heterodimers. J Biol Chem 1989, 264:13238-13244. 2546949.
    • (1989) J Biol Chem , vol.264 , pp. 13238-13244
    • Moxham, C.P.1    Duronio, V.2    Jacobs, S.3
  • 34
    • 0032800850 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanism of IGF-I signaling
    • 10430101
    • Pandini G, Vigneri R, Costantino A, Frasca F, Ippolito A, Fujita-Yamaguchi Y, Siddle K, Goldfine ID, Belfiore A. Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanism of IGF-I signaling. Clin Cancer Res 1999, 5:1935-1944. 10430101.
    • (1999) Clin Cancer Res , vol.5 , pp. 1935-1944
    • Pandini, G.1    Vigneri, R.2    Costantino, A.3    Frasca, F.4    Ippolito, A.5    Fujita-Yamaguchi, Y.6    Siddle, K.7    Goldfine, I.D.8    Belfiore, A.9
  • 35
    • 79961004321 scopus 로고    scopus 로고
    • Signalling by insulin and IGF receptors: supporting acts and new players
    • 21498522
    • Siddle K. Signalling by insulin and IGF receptors: supporting acts and new players. J Mol Endocrinol 2011, 47:R1-R10. 21498522.
    • (2011) J Mol Endocrinol , vol.47 , pp. R1-R10
    • Siddle, K.1
  • 39
    • 84873403918 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor signaling increases proliferation and hyperplasia of the ovarian surface epithelium and decreases follicular integrity through upregulation of the PI3-kinase pathway
    • 23388061
    • King SM, Modi DA, Eddie SL, Burdette JE. Insulin and insulin-like growth factor signaling increases proliferation and hyperplasia of the ovarian surface epithelium and decreases follicular integrity through upregulation of the PI3-kinase pathway. J Ovarian Res 2013, 6:12. 23388061.
    • (2013) J Ovarian Res , vol.6 , pp. 12
    • King, S.M.1    Modi, D.A.2    Eddie, S.L.3    Burdette, J.E.4
  • 40
    • 12344328267 scopus 로고    scopus 로고
    • High insulin-like growth factor-2 (IGF-2) gene expression is an independent predictor of poor survival for patients with advanced stage serous epithelial ovarian cancer
    • 15661221
    • Sayer RA, Lancaster JM, Pittman J, Gray J, Whitaker R, Marks JR, Berchuck A. High insulin-like growth factor-2 (IGF-2) gene expression is an independent predictor of poor survival for patients with advanced stage serous epithelial ovarian cancer. Gynecol Oncol 2005, 96:355-361. 15661221.
    • (2005) Gynecol Oncol , vol.96 , pp. 355-361
    • Sayer, R.A.1    Lancaster, J.M.2    Pittman, J.3    Gray, J.4    Whitaker, R.5    Marks, J.R.6    Berchuck, A.7
  • 41
    • 0345392848 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF)-I, IGF-II and IGF type I receptor (IGFR-I) expression in prostatic cancer
    • 14666684
    • Cardillo MR, Monti S, Di Silverio F, Gentile V, Sciarra F, Toscano V. Insulin-like growth factor (IGF)-I, IGF-II and IGF type I receptor (IGFR-I) expression in prostatic cancer. Anticancer Res 2003, 23:3825-3835. 14666684.
    • (2003) Anticancer Res , vol.23 , pp. 3825-3835
    • Cardillo, M.R.1    Monti, S.2    Di Silverio, F.3    Gentile, V.4    Sciarra, F.5    Toscano, V.6
  • 42
    • 17544374485 scopus 로고    scopus 로고
    • The role of the insulin-like growth factor system in colorectal cancer: review of current knowledge
    • 15650828
    • Durai R, Yang W, Gupta S, Seifalian AM, Winslet MC. The role of the insulin-like growth factor system in colorectal cancer: review of current knowledge. Int J Colorectal Dis 2005, 20:203-220. 15650828.
    • (2005) Int J Colorectal Dis , vol.20 , pp. 203-220
    • Durai, R.1    Yang, W.2    Gupta, S.3    Seifalian, A.M.4    Winslet, M.C.5
  • 43
    • 0038491208 scopus 로고    scopus 로고
    • Expression of insulin-like growth factor I receptor and survival in patients with clear cell renal cell carcinoma
    • 12853790
    • Parker A, Cheville JC, Lohse C, Cerhan JR, Blute ML. Expression of insulin-like growth factor I receptor and survival in patients with clear cell renal cell carcinoma. J Urol 2003, 170:420-424. 12853790.
    • (2003) J Urol , vol.170 , pp. 420-424
    • Parker, A.1    Cheville, J.C.2    Lohse, C.3    Cerhan, J.R.4    Blute, M.L.5
  • 44
    • 33644976163 scopus 로고    scopus 로고
    • IGF-1R is overexpressed in poor-prognostic subtypes of multiple myeloma
    • 16239907
    • Chng WJ, Gualberto A, Fonseca R. IGF-1R is overexpressed in poor-prognostic subtypes of multiple myeloma. Leukemia 2006, 20:174-176. 16239907.
    • (2006) Leukemia , vol.20 , pp. 174-176
    • Chng, W.J.1    Gualberto, A.2    Fonseca, R.3
  • 46
    • 70449450646 scopus 로고    scopus 로고
    • Local expression of insulin-like growth factor-I, insulin-like growth factor-I receptor, and estrogen receptor alpha in ovarian cancer
    • 19887867
    • An Y, Cai L, Wang Y, Zhu D, Guan Y, Zheng J. Local expression of insulin-like growth factor-I, insulin-like growth factor-I receptor, and estrogen receptor alpha in ovarian cancer. Onkologie 2009, 32:638-644. 19887867.
    • (2009) Onkologie , vol.32 , pp. 638-644
    • An, Y.1    Cai, L.2    Wang, Y.3    Zhu, D.4    Guan, Y.5    Zheng, J.6
  • 48
    • 41649110046 scopus 로고    scopus 로고
    • Insulin-like growth factor binding protein-3 (IGFBP-3) acts as an invasion-metastasis suppressor in ovarian endometrioid carcinoma
    • 17952116
    • Torng PL, Lee YC, Huang CY, Ye JH, Lin YS, Chu YW, Huang SC, Cohen P, Wu CW, Lin CT. Insulin-like growth factor binding protein-3 (IGFBP-3) acts as an invasion-metastasis suppressor in ovarian endometrioid carcinoma. Oncogene 2008, 27:2137-2147. 17952116.
    • (2008) Oncogene , vol.27 , pp. 2137-2147
    • Torng, P.L.1    Lee, Y.C.2    Huang, C.Y.3    Ye, J.H.4    Lin, Y.S.5    Chu, Y.W.6    Huang, S.C.7    Cohen, P.8    Wu, C.W.9    Lin, C.T.10
  • 49
    • 0026281597 scopus 로고
    • Identification and molecular characterization of insulin-like growth factor binding proteins (IGFBP-1, -2, -3, -4, -5 and -6)
    • 1725860
    • Shimasaki S, Ling N. Identification and molecular characterization of insulin-like growth factor binding proteins (IGFBP-1, -2, -3, -4, -5 and -6). Prog Growth Factor Res 1991, 3:243-266. 1725860.
    • (1991) Prog Growth Factor Res , vol.3 , pp. 243-266
    • Shimasaki, S.1    Ling, N.2
  • 50
    • 84863900275 scopus 로고    scopus 로고
    • Insulin-like growth factor receptor inhibitors: baby or the bathwater?
    • 22761272
    • Yee D. Insulin-like growth factor receptor inhibitors: baby or the bathwater?. J Natl Cancer Inst 2012, 104:975-981. 22761272.
    • (2012) J Natl Cancer Inst , vol.104 , pp. 975-981
    • Yee, D.1
  • 52
    • 84908109000 scopus 로고    scopus 로고
    • Evans CRL T, Chan E, Tait B, Michael SA, Day S, Stephens AW, Franke A, Poondru S, Puzanov I: Phase I dose-escalation study of continuous oral dosing of OSI-906, a dual tyrosine kinase inhibitor of insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR), in patients with advanced solid tumors.J Clin Oncol 2010, 28:15s. (suppl; abstr 2531).
    • Evans CRL T, Chan E, Tait B, Michael SA, Day S, Stephens AW, Franke A, Poondru S, Puzanov I: Phase I dose-escalation study of continuous oral dosing of OSI-906, a dual tyrosine kinase inhibitor of insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR), in patients with advanced solid tumors.J Clin Oncol 2010, 28:15s. (suppl; abstr 2531).
  • 54
    • 84861506168 scopus 로고    scopus 로고
    • Targeting the insulin-like growth factor receptor: developing biomarkers from gene expression profiling
    • 22471706
    • Boone DN, Lee AV. Targeting the insulin-like growth factor receptor: developing biomarkers from gene expression profiling. Crit Rev Oncog 2012, 17:161-173. 22471706.
    • (2012) Crit Rev Oncog , vol.17 , pp. 161-173
    • Boone, D.N.1    Lee, A.V.2
  • 57
    • 77952760202 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor-1 receptors act as ligand-specific amplitude modulators of a common pathway regulating gene transcription
    • 20360006
    • Boucher J, Tseng YH, Kahn CR. Insulin and insulin-like growth factor-1 receptors act as ligand-specific amplitude modulators of a common pathway regulating gene transcription. J Biol Chem 2010, 285:17235-17245. 20360006.
    • (2010) J Biol Chem , vol.285 , pp. 17235-17245
    • Boucher, J.1    Tseng, Y.H.2    Kahn, C.R.3
  • 58
    • 0026070118 scopus 로고
    • Growth-promoting effects of insulin-like growth factor-1 (IGF-1) on hematopoietic cells: overexpression of introduced IGF-1 receptor abrogates interleukin-3 dependency of murine factor-dependent cells by a ligand-dependent mechanism
    • 1651135
    • McCubrey JA, Steelman LS, Mayo MW, Algate PA, Dellow RA, Kaleko M. Growth-promoting effects of insulin-like growth factor-1 (IGF-1) on hematopoietic cells: overexpression of introduced IGF-1 receptor abrogates interleukin-3 dependency of murine factor-dependent cells by a ligand-dependent mechanism. Blood 1991, 78:921-929. 1651135.
    • (1991) Blood , vol.78 , pp. 921-929
    • McCubrey, J.A.1    Steelman, L.S.2    Mayo, M.W.3    Algate, P.A.4    Dellow, R.A.5    Kaleko, M.6
  • 59
    • 70449677662 scopus 로고    scopus 로고
    • Human aortic smooth muscle cells are insulin resistant at the receptor level but sensitive to IGF1 and IGF2
    • 19589910
    • Chisalita SI, Johansson GS, Liefvendahl E, Back K, Arnqvist HJ. Human aortic smooth muscle cells are insulin resistant at the receptor level but sensitive to IGF1 and IGF2. J Mol Endocrinol 2009, 43:231-239. 19589910.
    • (2009) J Mol Endocrinol , vol.43 , pp. 231-239
    • Chisalita, S.I.1    Johansson, G.S.2    Liefvendahl, E.3    Back, K.4    Arnqvist, H.J.5
  • 60
    • 0001287861 scopus 로고
    • Observations on the social behaviour of cells in tissue culture. II. Monolayering of fibroblasts
    • 13173482
    • Abercrombie M, Heaysman JE. Observations on the social behaviour of cells in tissue culture. II. Monolayering of fibroblasts. Exp Cell Res 1954, 6:293-306. 13173482.
    • (1954) Exp Cell Res , vol.6 , pp. 293-306
    • Abercrombie, M.1    Heaysman, J.E.2
  • 61
    • 84867874350 scopus 로고    scopus 로고
    • Contact inhibition (of proliferation) redux
    • 22835462
    • McClatchey AI, Yap AS. Contact inhibition (of proliferation) redux. Curr Opin Cell Biol 2012, 24:685-694. 22835462.
    • (2012) Curr Opin Cell Biol , vol.24 , pp. 685-694
    • McClatchey, A.I.1    Yap, A.S.2
  • 62
    • 65449144474 scopus 로고    scopus 로고
    • Transforming growth factor beta depletion is the primary determinant of Smad signaling kinetics
    • 19223462
    • Clarke DC, Brown ML, Erickson RA, Shi Y, Liu X. Transforming growth factor beta depletion is the primary determinant of Smad signaling kinetics. Mol Cell Biol 2009, 29:2443-2455. 19223462.
    • (2009) Mol Cell Biol , vol.29 , pp. 2443-2455
    • Clarke, D.C.1    Brown, M.L.2    Erickson, R.A.3    Shi, Y.4    Liu, X.5
  • 63
    • 79955391837 scopus 로고    scopus 로고
    • IGF-1 increases invasive potential of MCF 7 breast cancer cells and induces activation of latent TGF-beta1 resulting in epithelial to mesenchymal transition
    • 21535875
    • Walsh LA, Damjanovski S. IGF-1 increases invasive potential of MCF 7 breast cancer cells and induces activation of latent TGF-beta1 resulting in epithelial to mesenchymal transition. Cell Commun Signal 2011, 9:10. 21535875.
    • (2011) Cell Commun Signal , vol.9 , pp. 10
    • Walsh, L.A.1    Damjanovski, S.2
  • 64
    • 84862907716 scopus 로고    scopus 로고
    • IGF1/insulin receptor kinase inhibition by BMS-536924 is better tolerated than alloxan-induced hypoinsulinemia and more effective than metformin in the treatment of experimental insulin-responsive breast cancer
    • 21946410
    • Dool CJ, Mashhedi H, Zakikhani M, David S, Zhao Y, Birman E, Carboni JM, Gottardis M, Blouin MJ, Pollak M. IGF1/insulin receptor kinase inhibition by BMS-536924 is better tolerated than alloxan-induced hypoinsulinemia and more effective than metformin in the treatment of experimental insulin-responsive breast cancer. Endocr Relat Cancer 2011, 18:699-709. 21946410.
    • (2011) Endocr Relat Cancer , vol.18 , pp. 699-709
    • Dool, C.J.1    Mashhedi, H.2    Zakikhani, M.3    David, S.4    Zhao, Y.5    Birman, E.6    Carboni, J.M.7    Gottardis, M.8    Blouin, M.J.9    Pollak, M.10
  • 65
    • 84859169880 scopus 로고    scopus 로고
    • Drug development: Raise standards for preclinical cancer research
    • 22460880
    • Begley CG, Ellis LM. Drug development: Raise standards for preclinical cancer research. Nature 2012, 483:531-533. 22460880.
    • (2012) Nature , vol.483 , pp. 531-533
    • Begley, C.G.1    Ellis, L.M.2
  • 66
    • 0023886620 scopus 로고
    • Receptor-mediated endocytosis and lysosomal processing of insulin-like growth factor I by mitogenically responsive cells
    • 2966062
    • Furlanetto RW. Receptor-mediated endocytosis and lysosomal processing of insulin-like growth factor I by mitogenically responsive cells. Endocrinology 1988, 122:2044-2053. 2966062.
    • (1988) Endocrinology , vol.122 , pp. 2044-2053
    • Furlanetto, R.W.1
  • 67
    • 84877103013 scopus 로고    scopus 로고
    • Endocytosis of receptor tyrosine kinases
    • 23637288
    • Goh LK, Sorkin A. Endocytosis of receptor tyrosine kinases. Cold Spring Harb Perspect Biol 2013, 5:a017459. 23637288.
    • (2013) Cold Spring Harb Perspect Biol , vol.5 , pp. a017459
    • Goh, L.K.1    Sorkin, A.2
  • 68
    • 48649110734 scopus 로고    scopus 로고
    • Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis
    • 18632619
    • Sehat B, Andersson S, Girnita L, Larsson O. Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis. Cancer Res 2008, 68:5669-5677. 18632619.
    • (2008) Cancer Res , vol.68 , pp. 5669-5677
    • Sehat, B.1    Andersson, S.2    Girnita, L.3    Larsson, O.4
  • 69
    • 0030461226 scopus 로고    scopus 로고
    • Control of EGF receptor signaling by clathrin-mediated endocytosis
    • 8953040
    • Vieira AV, Lamaze C, Schmid SL. Control of EGF receptor signaling by clathrin-mediated endocytosis. Science 1996, 274:2086-2089. 8953040.
    • (1996) Science , vol.274 , pp. 2086-2089
    • Vieira, A.V.1    Lamaze, C.2    Schmid, S.L.3
  • 70
    • 0029976245 scopus 로고    scopus 로고
    • Receptor-mediated effects on ligand availability influence relative mitogenic potencies of epidermal growth factor and transforming growth factor alpha
    • 8600155
    • Reddy CC, Wells A, Lauffenburger DA. Receptor-mediated effects on ligand availability influence relative mitogenic potencies of epidermal growth factor and transforming growth factor alpha. J Cell Physiol 1996, 166:512-522. 8600155.
    • (1996) J Cell Physiol , vol.166 , pp. 512-522
    • Reddy, C.C.1    Wells, A.2    Lauffenburger, D.A.3
  • 71
    • 0026833077 scopus 로고
    • Mathematical model for the effects of epidermal growth factor receptor trafficking dynamics on fibroblast proliferation responses
    • 1368006
    • Starbuck C, Lauffenburger DA. Mathematical model for the effects of epidermal growth factor receptor trafficking dynamics on fibroblast proliferation responses. Biotechnol Prog 1992, 8:132-143. 1368006.
    • (1992) Biotechnol Prog , vol.8 , pp. 132-143
    • Starbuck, C.1    Lauffenburger, D.A.2
  • 72
    • 0021333875 scopus 로고
    • Relationship between epidermal growth factor receptor occupancy and mitogenic response. Quantitative analysis using a steady state model system
    • 6325444
    • Knauer DJ, Wiley HS, Cunningham DD. Relationship between epidermal growth factor receptor occupancy and mitogenic response. Quantitative analysis using a steady state model system. J Biol Chem 1984, 259:5623-5631. 6325444.
    • (1984) J Biol Chem , vol.259 , pp. 5623-5631
    • Knauer, D.J.1    Wiley, H.S.2    Cunningham, D.D.3
  • 73
    • 0027979788 scopus 로고
    • Evidence that human bone cells in culture produce insulin-like growth factor-binding protein-4 and -5 proteases
    • 7506211
    • Kanzaki S, Hilliker S, Baylink DJ, Mohan S. Evidence that human bone cells in culture produce insulin-like growth factor-binding protein-4 and -5 proteases. Endocrinology 1994, 134:383-392. 7506211.
    • (1994) Endocrinology , vol.134 , pp. 383-392
    • Kanzaki, S.1    Hilliker, S.2    Baylink, D.J.3    Mohan, S.4
  • 74
    • 77952554793 scopus 로고    scopus 로고
    • Mechanisms of antibody-mediated insulin-like growth factor I receptor (IGF-IR) down-regulation in MCF-7 breast cancer cells
    • 20103837
    • Ohtani M, Numazaki M, Yajima Y, Fujita-Yamaguchi Y. Mechanisms of antibody-mediated insulin-like growth factor I receptor (IGF-IR) down-regulation in MCF-7 breast cancer cells. Biosci Trends 2009, 3:131-138. 20103837.
    • (2009) Biosci Trends , vol.3 , pp. 131-138
    • Ohtani, M.1    Numazaki, M.2    Yajima, Y.3    Fujita-Yamaguchi, Y.4
  • 76
    • 70849120946 scopus 로고    scopus 로고
    • Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease
    • 19752219
    • Belfiore A, Frasca F, Pandini G, Sciacca L, Vigneri R. Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease. Endocr Rev 2009, 30:586-623. 19752219.
    • (2009) Endocr Rev , vol.30 , pp. 586-623
    • Belfiore, A.1    Frasca, F.2    Pandini, G.3    Sciacca, L.4    Vigneri, R.5
  • 79
    • 0033570090 scopus 로고    scopus 로고
    • Quantification of short term signaling by the epidermal growth factor receptor
    • 10514507
    • Kholodenko BN, Demin OV, Moehren G, Hoek JB. Quantification of short term signaling by the epidermal growth factor receptor. J Biol Chem 1999, 274:30169-30181. 10514507.
    • (1999) J Biol Chem , vol.274 , pp. 30169-30181
    • Kholodenko, B.N.1    Demin, O.V.2    Moehren, G.3    Hoek, J.B.4
  • 80
    • 0036212767 scopus 로고    scopus 로고
    • Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors
    • 11923843
    • Schoeberl B, Eichler-Jonsson C, Gilles ED, Muller G. Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors. Nat Biotechnol 2002, 20:370-375. 11923843.
    • (2002) Nat Biotechnol , vol.20 , pp. 370-375
    • Schoeberl, B.1    Eichler-Jonsson, C.2    Gilles, E.D.3    Muller, G.4
  • 83
    • 77956274693 scopus 로고    scopus 로고
    • Identification of optimal drug combinations targeting cellular networks: integrating phospho-proteomics and computational network analysis
    • 20643779
    • Iadevaia S, Lu Y, Morales FC, Mills GB, Ram PT. Identification of optimal drug combinations targeting cellular networks: integrating phospho-proteomics and computational network analysis. Cancer Res 2010, 70:6704-6714. 20643779.
    • (2010) Cancer Res , vol.70 , pp. 6704-6714
    • Iadevaia, S.1    Lu, Y.2    Morales, F.C.3    Mills, G.B.4    Ram, P.T.5
  • 84
    • 84879478714 scopus 로고    scopus 로고
    • Modeling the insulin-like growth factor system in articular cartilage
    • 23840540
    • Zhang L, Smith DW, Gardiner BS, Grodzinsky AJ. Modeling the insulin-like growth factor system in articular cartilage. PLoS One 2013, 8:e66870. 23840540.
    • (2013) PLoS One , vol.8 , pp. e66870
    • Zhang, L.1    Smith, D.W.2    Gardiner, B.S.3    Grodzinsky, A.J.4
  • 85
    • 81455158899 scopus 로고    scopus 로고
    • A multivariate model of ErbB network composition predicts ovarian cancer cell response to canertinib
    • 21830205
    • Prasasya RD, Vang KZ, Kreeger PK. A multivariate model of ErbB network composition predicts ovarian cancer cell response to canertinib. Biotechnol Bioeng 2012, 109:213-224. 21830205.
    • (2012) Biotechnol Bioeng , vol.109 , pp. 213-224
    • Prasasya, R.D.1    Vang, K.Z.2    Kreeger, P.K.3
  • 86
    • 0037336348 scopus 로고    scopus 로고
    • Mannose 6-phosphate receptors: new twists in the tale
    • 12612639
    • Ghosh P, Dahms NM, Kornfeld S. Mannose 6-phosphate receptors: new twists in the tale. Nat Rev Mol Cell Biol 2003, 4:202-212. 12612639.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 202-212
    • Ghosh, P.1    Dahms, N.M.2    Kornfeld, S.3
  • 87
    • 0027992324 scopus 로고
    • Functional properties of antibody insulin-like growth factor fusion proteins
    • 8106473
    • Shin SU, Friden P, Moran M, Morrison SL. Functional properties of antibody insulin-like growth factor fusion proteins. J Biol Chem 1994, 269:4979-4985. 8106473.
    • (1994) J Biol Chem , vol.269 , pp. 4979-4985
    • Shin, S.U.1    Friden, P.2    Moran, M.3    Morrison, S.L.4
  • 88
    • 0029434646 scopus 로고
    • Differential secretory polarity of IGFBP-6 vs. IGFBP-2 and IGFBP-4 in human intestinal epithelial cells: is it a way of modulating IGF-II bioavailability towards the IGF-responsive basolateral surface?
    • 8817662
    • Pommier GJ, Remacle-Bonnet MM, Tripier SG, Garrouste FL. Differential secretory polarity of IGFBP-6 vs. IGFBP-2 and IGFBP-4 in human intestinal epithelial cells: is it a way of modulating IGF-II bioavailability towards the IGF-responsive basolateral surface?. Prog Growth Factor Res 1995, 6:197-206. 8817662.
    • (1995) Prog Growth Factor Res , vol.6 , pp. 197-206
    • Pommier, G.J.1    Remacle-Bonnet, M.M.2    Tripier, S.G.3    Garrouste, F.L.4
  • 89
    • 0032768019 scopus 로고    scopus 로고
    • Targeted gene mutations define the roles of insulin and IGF-I receptors in mouse embryonic development
    • 10417963
    • Accili D, Nakae J, Kim JJ, Park BC, Rother KI. Targeted gene mutations define the roles of insulin and IGF-I receptors in mouse embryonic development. J Pediatr Endocrinol Metab 1999, 12:475-485. 10417963.
    • (1999) J Pediatr Endocrinol Metab , vol.12 , pp. 475-485
    • Accili, D.1    Nakae, J.2    Kim, J.J.3    Park, B.C.4    Rother, K.I.5
  • 91
    • 4444337046 scopus 로고    scopus 로고
    • Synthesis and characterization of biotinylated forms of insulin-like growth factor-1: topographical evaluation of the IGF-1/IGFBP-2 AND IGFBP-3 interface
    • 15350139
    • Robinson SA, Rosenzweig SA. Synthesis and characterization of biotinylated forms of insulin-like growth factor-1: topographical evaluation of the IGF-1/IGFBP-2 AND IGFBP-3 interface. Biochemistry 2004, 43:11533-11545. 15350139.
    • (2004) Biochemistry , vol.43 , pp. 11533-11545
    • Robinson, S.A.1    Rosenzweig, S.A.2
  • 92
    • 0025352515 scopus 로고
    • Chromaffin cells express two types of insulin-like growth factor receptors
    • 2167752
    • Danielsen A, Larsen E, Gammeltoft S. Chromaffin cells express two types of insulin-like growth factor receptors. Brain Res 1990, 518:95-100. 2167752.
    • (1990) Brain Res , vol.518 , pp. 95-100
    • Danielsen, A.1    Larsen, E.2    Gammeltoft, S.3
  • 93
    • 0026541365 scopus 로고
    • Expression of a type I insulin-like growth factor receptor with low affinity for insulin-like growth factor II
    • 1310594
    • Germain-Lee EL, Janicot M, Lammers R, Ullrich A, Casella SJ. Expression of a type I insulin-like growth factor receptor with low affinity for insulin-like growth factor II. Biochem J 1992, 281(Pt 2):413-417. 1310594.
    • (1992) Biochem J , vol.281 , pp. 413-417
    • Germain-Lee, E.L.1    Janicot, M.2    Lammers, R.3    Ullrich, A.4    Casella, S.J.5
  • 94
    • 0024358801 scopus 로고
    • Differential signalling potential of insulin- and IGF-1-receptor cytoplasmic domains
    • 2548842
    • Lammers R, Gray A, Schlessinger J, Ullrich A. Differential signalling potential of insulin- and IGF-1-receptor cytoplasmic domains. EMBO J 1989, 8:1369-1375. 2548842.
    • (1989) EMBO J , vol.8 , pp. 1369-1375
    • Lammers, R.1    Gray, A.2    Schlessinger, J.3    Ullrich, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.