메뉴 건너뛰기




Volumn 6, Issue 1, 2013, Pages

Insulin and insulin-like growth factor signaling increases proliferation and hyperplasia of the ovarian surface epithelium and decreases follicular integrity through upregulation of the PI3-kinase pathway

Author keywords

Insulin; Insulin like growth factor; Ovarian follicle; Ovarian surface epithelium

Indexed keywords

BROXURIDINE; COLLAGEN TYPE 4; CYTOKERATIN 8; INSULIN; INSULIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MUELLERIAN INHIBITING FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; SOMATOMEDIN; SOMATOMEDIN C; SOMATOMEDIN RECEPTOR;

EID: 84873403918     PISSN: None     EISSN: 17572215     Source Type: Journal    
DOI: 10.1186/1757-2215-6-12     Document Type: Article
Times cited : (27)

References (47)
  • 1
    • 0035008525 scopus 로고    scopus 로고
    • Ovarian surface epithelium: Biology, endocrinology, and pathology
    • DOI 10.1210/er.22.2.255
    • Ovarian surface epithelium: biology, endocrinology, and pathology. Auersperg N, Wong AS, Choi KC, Kang SK, Leung PC, Endocr Rev 2001 22 255 288 10.1210/er.22.2.255 11294827 (Pubitemid 32458162)
    • (2001) Endocrine Reviews , vol.22 , Issue.2 , pp. 255-288
    • Auersperg, N.1    Wong, A.S.T.2    Choi, K.-C.3    Kang, S.K.4    Leung, P.C.K.5
  • 2
    • 0015230305 scopus 로고
    • Incessant ovulation-a factor in ovarian neoplasia?
    • 4104488
    • Incessant ovulation-a factor in ovarian neoplasia? Fathalla MF, Lancet 1971 2 163 4104488
    • (1971) Lancet , vol.2 , pp. 163
    • Fathalla, M.F.1
  • 3
    • 67649990600 scopus 로고    scopus 로고
    • Regulation of the proliferative activity of ovarian surface epithelial cells by follicular fluid
    • 10.1016/j.anireprosci.2008.10.012 19042098
    • Regulation of the proliferative activity of ovarian surface epithelial cells by follicular fluid. Doyle LK, Donadeu FX, Anim Reprod Sci 2009 114 443 448 10.1016/j.anireprosci.2008.10.012 19042098
    • (2009) Anim Reprod Sci , vol.114 , pp. 443-448
    • Doyle, L.K.1    Donadeu, F.X.2
  • 4
    • 0035254982 scopus 로고    scopus 로고
    • Human ovarian surface epithelial (OSE) cells express LH/HCG receptors, and HCG inhibits apoptosis of ose cells via up-regulation of insulin-like growth factor-1
    • DOI 10.1002/1097-0215(200002)9999:9999<::AID-IJC1060>3.0.CO;2-0
    • Human ovarian surface epithelial (OSE) cells express LH/hCG receptors, and hCG inhibits apoptosis of OSE cells via up-regulation of insulin-like growth factor-1. Kuroda H, Mandai M, Konishi I, Tsuruta Y, Kusakari T, Kariya M, Fujii S, Int J Cancer 2001 91 309 315 10.1002/1097-0215(200002)9999:9999<::AID- IJC1060>3.0.CO;2-0 11169952 (Pubitemid 32049623)
    • (2001) International Journal of Cancer , vol.91 , Issue.3 , pp. 309-315
    • Kuroda, H.1    Mandai, M.2    Konishi, I.3    Tsuruta, Y.4    Kusakari, T.5    Kariya, M.6    Fujii, S.7
  • 5
    • 0027502045 scopus 로고
    • Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity
    • Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity. Soos MA, Field CE, Siddle K, Biochem J 1993 290 Pt 2 419 426 8452530 (Pubitemid 23094937)
    • (1993) Biochemical Journal , vol.290 , Issue.2 , pp. 419-426
    • Soos, M.A.1    Field, C.E.2    Siddle, K.3
  • 6
    • 68149134500 scopus 로고    scopus 로고
    • Growth effects of insulin and insulin analogues
    • 10.1080/13813450902835690 19485703
    • Growth effects of insulin and insulin analogues. Sandow J, Arch Physiol Biochem 2009 115 72 85 10.1080/13813450902835690 19485703
    • (2009) Arch Physiol Biochem , vol.115 , pp. 72-85
    • Sandow, J.1
  • 7
    • 0027946429 scopus 로고
    • Characterization of cultured human ovarian surface epithelial cells: Phenotypic plasticity and premalignant changes
    • Characterization of cultured human ovarian surface epithelial cells: phenotypic plasticity and premalignant changes. Auersperg N, Maines-Bandiera SL, Dyck HG, Kruk PA, Lab Invest 1994 71 510 518 7967506 (Pubitemid 24338158)
    • (1994) Laboratory Investigation , vol.71 , Issue.4 , pp. 510-518
    • Auersperg, N.1    Maines-Bandiera, S.L.2    Dyck, H.G.3    Kruk, P.A.4
  • 8
    • 0021398917 scopus 로고
    • Growth-stimulatory actions of insulin in vitro and in vivo
    • 10.1210/edrv-5-2-356 6376081
    • Growth-stimulatory actions of insulin in vitro and in vivo. Straus DS, Endocr Rev 1984 5 356 369 10.1210/edrv-5-2-356 6376081
    • (1984) Endocr Rev , vol.5 , pp. 356-369
    • Straus, D.S.1
  • 9
    • 56749184290 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor signalling in neoplasia
    • 10.1038/nrc2536 19029956
    • Insulin and insulin-like growth factor signalling in neoplasia. Pollak M, Nat Rev Cancer 2008 8 915 928 10.1038/nrc2536 19029956
    • (2008) Nat Rev Cancer , vol.8 , pp. 915-928
    • Pollak, M.1
  • 10
    • 0027050848 scopus 로고
    • Insulin-like growth factors and ovarian follicular development
    • DOI 10.1210/er.13.4.641
    • Insulin-like growth factors and ovarian follicular development. Giudice LC, Endocr Rev 1992 13 641 669 1281087 (Pubitemid 23037209)
    • (1992) Endocrine Reviews , vol.13 , Issue.4 , pp. 641-669
    • Giudice, L.C.1
  • 11
    • 67651177683 scopus 로고    scopus 로고
    • Three-dimensional ovarian organ culture as a tool to study normal ovarian surface epithelial wound repair
    • 10.1210/en.2008-1674 19423762
    • Three-dimensional ovarian organ culture as a tool to study normal ovarian surface epithelial wound repair. Jackson KS, Inoue K, Davis DA, Hilliard TS, Burdette JE, Endocrinology 2009 150 3921 3926 10.1210/en.2008-1674 19423762
    • (2009) Endocrinology , vol.150 , pp. 3921-3926
    • Jackson, K.S.1    Inoue, K.2    Davis, D.A.3    Hilliard, T.S.4    Burdette, J.E.5
  • 12
    • 80055112089 scopus 로고    scopus 로고
    • Alginate Hydrogels for Three-Dimensional Organ Culture of Ovaries and Oviducts
    • 10.3791/2804
    • Alginate Hydrogels for Three-Dimensional Organ Culture of Ovaries and Oviducts. King SM, Quartuccio S, Hilliard TS, Inoue K, Burdette JE, J Vis Exp 2011 52 10.3791/2804
    • (2011) J Vis Exp , vol.52
    • King, S.M.1    Quartuccio, S.2    Hilliard, T.S.3    Inoue, K.4    Burdette, J.E.5
  • 13
    • 33748321119 scopus 로고    scopus 로고
    • Alginate hydrogels as biomaterials
    • DOI 10.1002/mabi.200600069
    • Alginate hydrogels as biomaterials. Augst AD, Kong HJ, Mooney DJ, Macromol Biosci 2006 6 623 633 10.1002/mabi.200600069 16881042 (Pubitemid 44329266)
    • (2006) Macromolecular Bioscience , vol.6 , Issue.8 , pp. 623-633
    • Augst, A.D.1    Kong, H.J.2    Mooney, D.J.3
  • 14
    • 84869236449 scopus 로고    scopus 로고
    • Abdominal Obesity, Body Mass Index, and Hypertension in US Adults: NHANES 2007-2010
    • 22895451
    • Abdominal Obesity, Body Mass Index, and Hypertension in US Adults: NHANES 2007-2010. Ostchega Y, Hughes JP, Terry A, Fakhouri TH, Miller I, Am J Hypertens 2012 25 1271 8 22895451
    • (2012) Am J Hypertens , vol.25 , pp. 1271-1278
    • Ostchega, Y.1    Hughes, J.P.2    Terry, A.3    Fakhouri, T.H.4    Miller, I.5
  • 18
    • 0035123520 scopus 로고    scopus 로고
    • Energy balance and cancer: The role of insulin and insulin-like growth factor-I
    • Energy balance and cancer: the role of insulin and insulin-like growth factor-I. Kaaks R, Lukanova A, Proc Nutr Soc 2001 60 91 106 10.1079/PNS200070 11310428 (Pubitemid 32183103)
    • (2001) Proceedings of the Nutrition Society , vol.60 , Issue.1 , pp. 91-106
    • Kaaks, R.1    Lukanova, A.2
  • 19
    • 0028307136 scopus 로고
    • Identification of insulin and insulin-like growth factor I (IGF I) receptors in ovarian cancer tissue
    • DOI 10.1006/gyno.1994.1115
    • Identification of insulin and insulin-like growth factor I (IGF I) receptors in ovarian cancer tissue. Beck EP, Russo P, Gliozzo B, Jaeger W, Papa V, Wildt L, Pezzino V, Lang N, Gynecol Oncol 1994 53 196 201 10.1006/gyno.1994.1115 8188079 (Pubitemid 24177044)
    • (1994) Gynecologic Oncology , vol.53 , Issue.2 , pp. 196-201
    • Beck, E.P.1
  • 20
    • 0032004513 scopus 로고    scopus 로고
    • Biological characterization of human epithelial ovarian carcinoma cells in primary culture: The insulin-like growth factor system
    • DOI 10.1006/excr.1997.3861
    • Biological characterization of human epithelial ovarian carcinoma cells in primary culture: the insulin-like growth factor system. Conover CA, Hartmann LC, Bradley S, Stalboerger P, Klee GG, Kalli KR, Jenkins RB, Exp Cell Res 1998 238 439 449 10.1006/excr.1997.3861 9473353 (Pubitemid 28372832)
    • (1998) Experimental Cell Research , vol.238 , Issue.2 , pp. 439-449
    • Conover, C.A.1    Hartmann, L.C.2    Bradley, S.3    Stalboerger, P.4    Klee, G.G.5    Kalli, K.R.6    Jenkins, R.B.7
  • 21
    • 12344328267 scopus 로고    scopus 로고
    • High insulin-like growth factor-2 (IGF-2) gene expression is an independent predictor of poor survival for patients with advanced stage serous epithelial ovarian cancer
    • DOI 10.1016/j.ygyno.2004.10.012, PII S0090825804008170
    • High insulin-like growth factor-2 (IGF-2) gene expression is an independent predictor of poor survival for patients with advanced stage serous epithelial ovarian cancer. Sayer RA, Lancaster JM, Pittman J, Gray J, Whitaker R, Marks JR, Berchuck A, Gynecol Oncol 2005 96 355 361 10.1016/j.ygyno.2004.10. 012 15661221 (Pubitemid 40127134)
    • (2005) Gynecologic Oncology , vol.96 , Issue.2 , pp. 355-361
    • Sayer, R.A.1    Lancaster, J.M.2    Pittman, J.3    Gray, J.4    Whitaker, R.5    Marks, J.R.6    Berchuck, A.7
  • 22
    • 66149092327 scopus 로고    scopus 로고
    • Hyperactivation of the insulin-like growth factor receptor i signaling pathway is an essential event for cisplatin resistance of ovarian cancer cells
    • 10.1158/0008-5472.CAN-08-3153 19318572
    • Hyperactivation of the insulin-like growth factor receptor I signaling pathway is an essential event for cisplatin resistance of ovarian cancer cells. Eckstein N, Servan K, Hildebrandt B, Politz A, von Jonquieres G, Wolf-Kummeth S, Napierski I, Hamacher A, Kassack MU, Budczies J, Cancer Res 2009 69 2996 3003 10.1158/0008-5472.CAN-08-3153 19318572
    • (2009) Cancer Res , vol.69 , pp. 2996-3003
    • Eckstein, N.1    Servan, K.2    Hildebrandt, B.3    Politz, A.4    Von Jonquieres, G.5    Wolf-Kummeth, S.6    Napierski, I.7    Hamacher, A.8    Kassack, M.U.9    Budczies, J.10
  • 24
    • 0344237221 scopus 로고    scopus 로고
    • Roles of luteinizing hormone/chorionic gonadotropin receptor in anchorage-dependent and -independent growth in human ovarian surface epithelial cell lines
    • DOI 10.1111/j.1349-7006.2003.tb01384.x
    • Roles of luteinizing hormone/chorionic gonadotropin receptor in anchorage-dependent and -independent growth in human ovarian surface epithelial cell lines. Tashiro H, Katabuchi H, Begum M, Li X, Nitta M, Ohtake H, Okamura H, Cancer Sci 2003 94 953 959 10.1111/j.1349-7006.2003.tb01384.x 14611671 (Pubitemid 37508977)
    • (2003) Cancer Science , vol.94 , Issue.11 , pp. 953-959
    • Tashiro, H.1    Katabuchi, H.2    Begum, M.3    Li, X.4    Nitta, M.5    Ohtake, H.6    Okamura, H.7
  • 25
    • 33845956069 scopus 로고    scopus 로고
    • Role of endocrine and growth factors on the ovarian surface epithelium
    • DOI 10.1111/j.1447-0756.2007.00478.x
    • Role of endocrine and growth factors on the ovarian surface epithelium. Wong AS, Leung PC, J Obstet Gynaecol Res 2007 33 3 16 10.1111/j.1447-0756.2007. 00478.x 17212660 (Pubitemid 46028466)
    • (2007) Journal of Obstetrics and Gynaecology Research , vol.33 , Issue.1 , pp. 3-16
    • Wong, A.S.T.1    Leung, P.C.K.2
  • 26
    • 80054913739 scopus 로고    scopus 로고
    • The impact of ovulation on fallopian tube epithelial cells: Evaluating three hypotheses connecting ovulation and serous ovarian cancer
    • 10.1530/ERC-11-0107 21813729
    • The impact of ovulation on fallopian tube epithelial cells: evaluating three hypotheses connecting ovulation and serous ovarian cancer. King SM, Hilliard TS, Wu LY, Jaffe RC, Fazleabas AT, Burdette JE, Endocr Relat Cancer 2011 18 627 642 10.1530/ERC-11-0107 21813729
    • (2011) Endocr Relat Cancer , vol.18 , pp. 627-642
    • King, S.M.1    Hilliard, T.S.2    Wu, L.Y.3    Jaffe, R.C.4    Fazleabas, A.T.5    Burdette, J.E.6
  • 27
    • 34547773120 scopus 로고    scopus 로고
    • Physical properties of alginate hydrogels and their effects on in vitro follicle development
    • DOI 10.1016/j.biomaterials.2007.07.001, PII S014296120700525X
    • Physical properties of alginate hydrogels and their effects on in vitro follicle development. West ER, Xu M, Woodruff TK, Shea LD, Biomaterials 2007 28 4439 4448 10.1016/j.biomaterials.2007.07.001 17643486 (Pubitemid 47225113)
    • (2007) Biomaterials , vol.28 , Issue.30 , pp. 4439-4448
    • West, E.R.1    Xu, M.2    Woodruff, T.K.3    Shea, L.D.4
  • 28
    • 3042592008 scopus 로고    scopus 로고
    • A modified medium that significantly improves the growth of human normal ovarian surface epithelial (OSE) cells in vitro
    • DOI 10.1038/labinvest.3700093
    • A modified medium that significantly improves the growth of human normal ovarian surface epithelial (OSE) cells in vitro. Li NF, Wilbanks G, Balkwill F, Jacobs IJ, Dafou D, Gayther SA, Lab Invest 2004 84 923 931 10.1038/labinvest. 3700093 15077121 (Pubitemid 38833252)
    • (2004) Laboratory Investigation , vol.84 , Issue.7 , pp. 923-931
    • Li, N.F.1    Wilbanks, G.2    Balkwill, F.3    Jacobs, I.J.4    Dafou, D.5    Gayther, S.A.6
  • 30
    • 0030909657 scopus 로고    scopus 로고
    • Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins
    • DOI 10.1210/en.138.4.1427
    • Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins. Parrizas M, Gazit A, Levitzki A, Wertheimer E, LeRoith D, Endocrinology 1997 138 1427 1433 10.1210/en.138.4.1427 9075698 (Pubitemid 27137089)
    • (1997) Endocrinology , vol.138 , Issue.4 , pp. 1427-1433
    • Parrizas, M.1    Gazit, A.2    Levitzki, A.3    Wertheimer, E.4    Leroith, D.5
  • 31
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • DOI 10.1038/378785a0
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA, Nature 1995 378 785 789 10.1038/378785a0 8524413 (Pubitemid 26004411)
    • (1995) Nature , vol.378 , Issue.6559 , pp. 785-789
    • Cross, D.A.E.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 32
    • 58149395054 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinases in cell migration
    • 10.1042/BC20080079 19055486
    • Phosphoinositide 3-kinases in cell migration. Cain RJ, Ridley AJ, Biol Cell 2009 101 13 29 10.1042/BC20080079 19055486
    • (2009) Biol Cell , vol.101 , pp. 13-29
    • Cain, R.J.1    Ridley, A.J.2
  • 33
    • 70849106162 scopus 로고    scopus 로고
    • The mammalian ovary from genesis to revelation
    • 10.1210/er.2009-0012 19776209
    • The mammalian ovary from genesis to revelation. Edson MA, Nagaraja AK, Matzuk MM, Endocr Rev 2009 30 624 712 10.1210/er.2009-0012 19776209
    • (2009) Endocr Rev , vol.30 , pp. 624-712
    • Edson, M.A.1    Nagaraja, A.K.2    Matzuk, M.M.3
  • 34
    • 0035034886 scopus 로고    scopus 로고
    • Ovarian expression of human insulin-like growth factor-I in transgenic mice results in cyst formation
    • DOI 10.1002/mrd.1020
    • Ovarian expression of human insulin-like growth factor-I in transgenic mice results in cyst formation. Dyck MK, Parlow AF, Senechal JF, Sirard MA, Pothier F, Mol Reprod Dev 2001 59 178 185 10.1002/mrd.1020 11389552 (Pubitemid 32391243)
    • (2001) Molecular Reproduction and Development , vol.59 , Issue.2 , pp. 178-185
    • Dyck, M.K.1    Parlow, A.F.2    Senechal, J.-F.3    Sirard, M.-A.4    Pothier, F.5
  • 35
    • 77950233250 scopus 로고    scopus 로고
    • The effect of insulin signaling on female reproductive function independent of adiposity and hyperglycemia
    • 10.1210/en.2009-0788 20176725
    • The effect of insulin signaling on female reproductive function independent of adiposity and hyperglycemia. Nandi A, Wang X, Accili D, Wolgemuth DJ, Endocrinology 2010 151 1863 1871 10.1210/en.2009-0788 20176725
    • (2010) Endocrinology , vol.151 , pp. 1863-1871
    • Nandi, A.1    Wang, X.2    Accili, D.3    Wolgemuth, D.J.4
  • 36
    • 80051945099 scopus 로고    scopus 로고
    • Animal age, weight and estrus cycle stage impact the quality of in vitro grown follicles
    • 10.1093/humrep/der183 21669966
    • Animal age, weight and estrus cycle stage impact the quality of in vitro grown follicles. Hirshfeld-Cytron JE, Duncan FE, Xu M, Jozefik JK, Shea LD, Woodruff TK, Hum Reprod 2011 26 2473 2485 10.1093/humrep/der183 21669966
    • (2011) Hum Reprod , vol.26 , pp. 2473-2485
    • Hirshfeld-Cytron, J.E.1    Duncan, F.E.2    Xu, M.3    Jozefik, J.K.4    Shea, L.D.5    Woodruff, T.K.6
  • 37
    • 79952279908 scopus 로고    scopus 로고
    • A new hypothesis regarding ovarian follicle development: Ovarian rigidity as a regulator of selection and health
    • 10.1007/s10815-010-9478-4 20872066
    • A new hypothesis regarding ovarian follicle development: ovarian rigidity as a regulator of selection and health. Woodruff TK, Shea LD, J Assist Reprod Genet 2011 28 3 6 10.1007/s10815-010-9478-4 20872066
    • (2011) J Assist Reprod Genet , vol.28 , pp. 3-6
    • Woodruff, T.K.1    Shea, L.D.2
  • 38
    • 33749246034 scopus 로고    scopus 로고
    • Distribution of extracellular matrix proteins type I collagen, type IV collagen, fibronectin, and laminin in mouse folliculogenesis
    • DOI 10.1007/s00418-006-0194-1
    • Distribution of extracellular matrix proteins type I collagen, type IV collagen, fibronectin, and laminin in mouse folliculogenesis. Berkholtz CB, Lai BE, Woodruff TK, Shea LD, Histochem Cell Biol 2006 126 583 592 10.1007/s00418-006-0194-1 16758163 (Pubitemid 44484903)
    • (2006) Histochemistry and Cell Biology , vol.126 , Issue.5 , pp. 583-592
    • Berkholtz, C.B.1    Lai, B.E.2    Woodruff, T.K.3    Shea, L.D.4
  • 39
    • 84869445164 scopus 로고    scopus 로고
    • The Mouse Ovarian Surface Epithelium Contains a Population of LY6A (SCA-1) Expressing Progenitor Cells That Are Regulated by Ovulation-Associated Factors
    • 10.1095/biolreprod.112.100347 22914315
    • The Mouse Ovarian Surface Epithelium Contains a Population of LY6A (SCA-1) Expressing Progenitor Cells That Are Regulated by Ovulation-Associated Factors. Gamwell LF, Collins O, Vanderhyden BC, Biol Reprod 2012 87 80 10.1095/biolreprod.112.100347 22914315
    • (2012) Biol Reprod , vol.87 , pp. 80
    • Gamwell, L.F.1    Collins, O.2    Vanderhyden, B.C.3
  • 40
    • 0029328269 scopus 로고
    • The ovarian insulin and insulin-like growth factor system with an emphasis on domestic animals
    • 10.1016/0739-7240(95)00021-6 7587167
    • The ovarian insulin and insulin-like growth factor system with an emphasis on domestic animals. Spicer LJ, Echternkamp SE, Domest Anim Endocrinol 1995 12 223 245 10.1016/0739-7240(95)00021-6 7587167
    • (1995) Domest Anim Endocrinol , vol.12 , pp. 223-245
    • Spicer, L.J.1    Echternkamp, S.E.2
  • 41
    • 0027692073 scopus 로고
    • Changes in serum somatotropin, somatotropin mRNA, and serum and follicular insulin-like growth factor-I in response to feed restriction in cows actively immunized against growth hormone-releasing factor
    • 8270525
    • Changes in serum somatotropin, somatotropin mRNA, and serum and follicular insulin-like growth factor-I in response to feed restriction in cows actively immunized against growth hormone-releasing factor. Kirby CJ, Armstrong JD, Huff BG, Stanko RL, Harvey RW, Heimer EP, Campbell RM, J Anim Sci 1993 71 3033 3042 8270525
    • (1993) J Anim Sci , vol.71 , pp. 3033-3042
    • Kirby, C.J.1    Armstrong, J.D.2    Huff, B.G.3    Stanko, R.L.4    Harvey, R.W.5    Heimer, E.P.6    Campbell, R.M.7
  • 42
    • 0035947085 scopus 로고    scopus 로고
    • Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa
    • DOI 10.1016/S1097-2765(01)00247-7
    • Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa. Chung CY, Potikyan G, Firtel RA, Mol Cell 2001 7 937 947 10.1016/S1097-2765(01)00247-7 11389841 (Pubitemid 32525741)
    • (2001) Molecular Cell , vol.7 , Issue.5 , pp. 937-947
    • Chung, C.Y.1    Potikyan, G.2    Firtel, R.A.3
  • 43
    • 84866885402 scopus 로고    scopus 로고
    • The PI3K/Akt/mTOR signaling pathway mediates insulin-like growth factor 1-induced E-cadherin down-regulation and cell proliferation in ovarian cancer cells
    • 10.1016/j.canlet.2012.08.016 22922215
    • The PI3K/Akt/mTOR signaling pathway mediates insulin-like growth factor 1-induced E-cadherin down-regulation and cell proliferation in ovarian cancer cells. Lau MT, Leung PC, Cancer Lett 2012 326 191 198 10.1016/j.canlet.2012.08. 016 22922215
    • (2012) Cancer Lett , vol.326 , pp. 191-198
    • Lau, M.T.1    Leung, P.C.2
  • 44
    • 69249120472 scopus 로고    scopus 로고
    • Loss of ovarian function in the VCD mouse-model of menopause leads to insulin resistance and a rapid progression into the metabolic syndrome
    • 10.1152/ajpregu.90762.2008 19439618
    • Loss of ovarian function in the VCD mouse-model of menopause leads to insulin resistance and a rapid progression into the metabolic syndrome. Romero-Aleshire MJ, Diamond-Stanic MK, Hasty AH, Hoyer PB, Brooks HL, Am J Physiol Regul Integr Comp Physiol 2009 297 587 R592 10.1152/ajpregu.90762.2008 19439618
    • (2009) Am J Physiol Regul Integr Comp Physiol , vol.297
    • Romero-Aleshire, M.J.1    Diamond-Stanic, M.K.2    Hasty, A.H.3    Hoyer, P.B.4    Brooks, H.L.5
  • 45
    • 33646028498 scopus 로고    scopus 로고
    • Clinicopathologic study of the putative precursor lesions of epithelial ovarian cancer in low-risk women
    • 10.1111/j.1525-1438.2006.00574.x 16681718
    • Clinicopathologic study of the putative precursor lesions of epithelial ovarian cancer in low-risk women. Tok EC, Ertunc D, Tataroglu C, Yazici G, Kanat H, Dilek S, Int J Gynecol Cancer 2006 16 501 506 10.1111/j.1525-1438.2006. 00574.x 16681718
    • (2006) Int J Gynecol Cancer , vol.16 , pp. 501-506
    • Tok, E.C.1    Ertunc, D.2    Tataroglu, C.3    Yazici, G.4    Kanat, H.5    Dilek, S.6
  • 46
    • 0025872869 scopus 로고
    • Ovarian surface epithelium: Autonomous production of connective tissue-type extracellular matrix
    • 10.1095/biolreprod44.4.717 1710511
    • Ovarian surface epithelium: autonomous production of connective tissue-type extracellular matrix. Auersperg N, Maclaren IA, Kruk PA, Biol Reprod 1991 44 717 724 10.1095/biolreprod44.4.717 1710511
    • (1991) Biol Reprod , vol.44 , pp. 717-724
    • Auersperg, N.1    Maclaren, I.A.2    Kruk, P.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.