PGC-1β promotes enterocyte lifespan and tumorigenesis in the intestine

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 42, 2014, Pages E4523-E4531

  Bellafante, Elena ^a,d   Morgano, Annalisa ^a   Salvatore, Lorena ^a   Murzilli, Stefania ^a   Di Tullio, Giuseppe ^a   D'Orazio, Andria ^a   Latorre, Dominga ^b   Villani, Gaetano ^b   Moschetta, Antonio ^b,c  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b UNIVERSITY OF BARI   (Italy)

^c NATIONAL CANCER INSTITUTE GIOVANNI PAOLO II   (Italy)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Colon cancer; Gene expression; Molecular pathology; Nuclear receptors

Indexed keywords

ANTIOXIDANT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1BETA; REACTIVE OXYGEN METABOLITE; OXYGEN; PPARGC1A PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOGENESIS; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; ELECTRON TRANSPORT; HOMEOSTASIS; INTESTINE; INTESTINE CELL; INTESTINE EPITHELIUM; MACROMOLECULE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; ANIMAL; C57BL MOUSE; COLON TUMOR; CYTOLOGY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; IMMUNOHISTOCHEMISTRY; INTESTINE MUCOSA; KNOCKOUT MOUSE; MALE; METABOLISM; MITOCHONDRION; PATHOLOGY; SMALL INTESTINE;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; CARCINOGENESIS; COLONIC NEOPLASMS; ELECTRON TRANSPORT; ENTEROCYTES; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HOMEOSTASIS; IMMUNOHISTOCHEMISTRY; INTESTINAL MUCOSA; INTESTINE, SMALL; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; OXYGEN; REACTIVE OXYGEN SPECIES; TRANSCRIPTION FACTORS;

EID: 84908077919     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1415279111     Document Type: Article

References (20)

1. Ames BN, Shigenaga MK, Gold LS (1993) DNA lesions, inducible DNA repair, and cell division: Three key factors in mutagenesis and carcinogenesis. Environ Health Perspect 101(Suppl 5):35-44.
2. D'Errico I, et al. (2011) Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC1alpha) is a metabolic regulator of intestinal epithelial cell fate. Proc Natl Acad Sci USA 108(16):6603-6608.
3. St-Pierre J, et al. (2006) Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell 127(2):397-408.
4. Wu Z, et al. (1999) Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98(1):115-124.
5. Puigserver P, et al. (1998) A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92(6):829-839.
6. Lin J, et al. (2002) Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature 418(6899):797-801.
7. Lin J, et al. (2003) PGC-1beta in the regulation of hepatic glucose and energy metabolism. J Biol Chem 278(33):30843-30848.
8. Lin J, Handschin C, Spiegelman BM (2005) Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab 1(6):361-370.
9. Valle I, Alvarez-Barrientos A, Arza E, Lamas S, Monsalve M (2005) PGC-1alpha regulates the mitochondrial antioxidant defense system in vascular endothelial cells. Cardiovasc Res 66(3):562-573.
10. Rera M, et al. (2011) Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog. Cell Metab 14(5):623-634.
11. Lin J, Puigserver P, Donovan J, Tarr P, Spiegelman BM (2002) Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor. J Biol Chem 277(3):1645-1648.
12. Jeynes BJ, Altmann GG (1975) A region of mitochondrial division in the epithelium of the small intestine of the rat. Anat Rec 182(3):289-296.
13. Tao R, et al. (2010) Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress. Mol Cell 40(6):893-904.
14. DeNicola GM, et al. (2011) Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature 475(7354):106-109.
15. Papanikolaou A, et al. (1998) Initial levels of azoxymethane-induced DNA methyl adducts are not predictive of tumor susceptibility in inbred mice. Toxicol Appl Pharmacol 150(1):196-203.
16. Popivanova BK, et al. (2008) Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis. J Clin Invest 118(2):560-570.
17. Su LK, et al. (1992) Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science 256(5057):668-670.
18. Kim JW, Tchernyshyov I, Semenza GL, Dang CV (2006) HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia. Cell Metab 3(3):177-185.
19. Kim JW, Gao P, Liu YC, Semenza GL, Dang CV (2007) Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1. Mol Cell Biol 27(21):7381-7393.
20. Hu J, et al. (2012) Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer. Cell 148(4):651-663.