A new approach for plasma (xeno)metabolomics based on solid-phase extraction and nanoflow liquid chromatography-nanoelectrospray ionisation mass spectrometry

Journal of Chromatography A

Volumn 1365, Issue , 2014, Pages 72-85

  David, Arthur ^a   Abdul Sada, Alaa ^a   Lange, Anke ^b   Tyler, Charles R ^b   Hill, Elizabeth M ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

^b UNIVERSITY OF EXETER   (United Kingdom)

Author keywords

Metabolomics; Nanoflow; Nanospray; Plasma; Solid phase extraction; Xenometabolome

Indexed keywords

BIOCHEMISTRY; BIOMOLECULES; DIRECT INJECTION; FILTRATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; ION EXCHANGE; IONIZATION OF LIQUIDS; LIQUIDS; MASS SPECTROMETRY; METABOLITES; PHASE SEPARATION; PHOSPHOLIPIDS; PLASMAS; POLYMERS; PROTEOMICS;

METABOLOMICS; NANOFLOWS; NANOSPRAY; SOLID-PHASE EXTRACTION; XENOMETABOLOME;

EXTRACTION;

CATION; DRUG METABOLITE; ICOSANOID; LYSOPHOSPHOLIPID; PHOSPHOLIPID; POLYMER; STEROID; XENOBIOTIC AGENT; BILE ACID; WASTE WATER; WATER POLLUTANT;

ARTICLE; BLOOD LEVEL; CATION EXCHANGE; CHEMICAL STRESS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; FILTRATION; LIMIT OF DETECTION; METABOLITE; METABOLOME; METABOLOMICS; NANOELECTROSPRAY IONISATION MASS SPECTROMETRY; NANOFLOW ULTRA HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PLASMA; PRECIPITATION; QUALITATIVE ANALYSIS; REPRODUCIBILITY; SOLID PHASE EXTRACTION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; XENOMETABOLOMICS; ANIMAL; BLOOD; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NANOTECHNOLOGY; PROCEDURES; RAINBOW TROUT; WASTE WATER; WATER POLLUTANT;

ANIMALS; BILE ACIDS AND SALTS; CATIONS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EICOSANOIDS; METABOLOME; NANOTECHNOLOGY; ONCORHYNCHUS MYKISS; PHOSPHOLIPIDS; SOLID PHASE EXTRACTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STEROIDS; WASTE WATER; WATER POLLUTANTS, CHEMICAL; XENOBIOTICS;

EID: 84908068266     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2014.09.001     Document Type: Article

References (52)

1. Nicholson J.K. Global systems biology, personalized medicine and molecular epidemiology. Mol. Syst. Biol. 2006, 2:1-6.
2. Holmes E., Loo R.L., Cloarec O., Coen M., Tang H., Maibaum E., Bruce S., Chan Q., Elliott P., Stamler J., Wilson I.D., Lindon J.C., Nicholson J.K. Detection of urinary drug metabolite (xenometabolome) signatures in molecular epidemiology studies via statistical total correlation (NMR) spectroscopy. Anal. Chem. 2007, 79:2629-2640.
3. Bruce S.J., Tavazzi I., Parisod V.r., Rezzi S., Kochhar S., Guy P.A. Investigation of human blood plasma sample preparation for performing metabolomics using ultrahigh performance liquid chromatography/mass spectrometry. Anal. Chem. 2009, 81:3285-3296.
4. Buscher J.M., Czernik D., Ewald J.C., Sauer U., Zamboni N. Cross-platform comparison of methods for quantitative metabolomics of primary metabolism. Anal. Chem. 2009, 81:2135-2143.
5. Jonsson P., Bruce S.J., Moritz T., Trygg J., Sjostrom M., Plumb R., Granger J., Maibaum E., Nicholson J.K., Holmes E., Antti H. Extraction, interpretation and validation of information for comparing samples in metabolic LC/MS data sets. Analyst 2005, 130:701-707.
6. Nordstrom A., Want E., Northen T., Lehtio J., Siuzdak G. Multiple ionization mass spectrometry strategy used to reveal the complexity of metabolomics. Anal. Chem. 2008, 80:421-429.
7. Roux A., Lison D., Junot C., Heilier J.F. Applications of liquid chromatography coupled to mass spectrometry-based metabolomics in clinical chemistry and toxicology: a review. Clin. Biochem. 2011, 44:119-135.
8. Griffin J.L., Shockcor J.P. Metabolic profiles of cancer cells. Nat. Rev. Cancer 2004, 4:551-561.
9. Antignac J.P., Courant F., Pinel G., Bichon E., Monteau F., Elliott C., Le Bizec B. Mass spectrometry-based metabolomics applied to the chemical safety of food. Trac-Trend Anal. Chem. 2011, 30:292-301.
10. Bundy J.G., Davey M.P., Viant M.R. Environmental metabolomics: a critical review and future perspectives. Metabolomics 2009, 5:3-21.
11. Daughton C.G., Ternes T.A. Pharmaceuticals and personal care products in the environment: agents of subtle change?. Environ. Health Perspect. 1999, 107(Suppl. 6):907-938.
12. Fent K., Weston A.A., Caminada D. Ecotoxicology of human pharmaceuticals. Aquat. Toxicol. 2006, 76:122-159.
13. Kuster M., de Alda M.J., Hernando M.D., Petrovic M., Martin-Alonso J., Barcelo D. Analysis and occurrence of pharmaceuticals, estrogens, progestogens and polar pesticides in sewage treatment plant effluents, river water and drinking water in the Llobregat river basin (Barcelona, Spain). J. Hydrol. 2008, 358:112-123.
14. Corcoran J., Winter M.J., Tyler C.R. Pharmaceuticals in the aquatic environment: a critical review of the evidence for health effects in fish. Crit. Rev. Toxicol. 2010, 40:287-304.
15. Gibson R., Tyler C.R., Hill E.M. Analytical methodology for the identification of estrogenic contaminants in fish bile. J. Chromatogr. A 2005, 1066:33-40.
16. Jobling S., Burn R.W., Thorpe K., Williams R., Tyler C. Statistical Modeling Suggests that Antiandrogens in Effluents from Wastewater Treatment Works Contribute to Widespread Sexual Disruption in Fish Living in English Rivers. Environ. Health Perspect. 2009, 117:797-802.
17. Hill E.M., Evans K.L., Horwood J., Rostkowski P., Oladapo F.O., Gibson R., Shears J.A., Tyler C.R. Profiles and some initial identifications of (anti)androgenic compounds in fish exposed to wastewater treatment works effluents. Environ. Sci. Technol. 2010, 44:1137-1143.
18. Flores-Valverde A.M., Horwood J., Hill E.M. Disruption of the steroid metabolome in fish caused by exposure to the environmental estrogen 17 alpha-ethinylestradiol. Environ. Sci. Technol. 2010, 44:3552-3558.
19. Southam A.D., Lange A., Hines A., Hill E.M., Katsu Y., Iguchi T., Tyler C.R., Viant M.R. Metabolomics reveals target and off-target toxicities of a model organophosphate pesticide to roach (Rutilus rutilus): implications for biomonitoring. Environ. Sci. Technol. 2011, 45:3759-3767.
20. Mehinto A.C., Hill E.M., Tyler C.R. Uptake and biological effects of environmentally relevant concentrations of the nonsteroidal anti-inflammatory pharmaceutical diclofenac in rainbow trout (Oncorhynchus mykiss). Environ. Sci. Technol. 2010, 44:2176-2182.
21. Al-Salhi R., Abdul-Sada A., Lange A., Tyler C.R., Hill E.M. The xenometabolome and novel contaminant markers in fish exposed to a wastewater treatment works effluent. Environ. Sci. Technol. 2012, 46:9080-9088.
22. King R., Bonfiglio R., Fernandez-Metzler C., Miller-Stein C., Olah T. Mechanistic investigation of ionization suppression in electrospray ionization. J. Am. Soc. Mass Spectrom. 2000, 11:942-950.
23. Dunn W.B., Ellis D.I. Metabolomics: current analytical platforms and methodologies. Trac-Trend Anal. Chem. 2005, 24:285-294.
24. Wilm M., Mann M. Analytical properties of the nanoelectrospray ion source. Anal. Chem. 1996, 68:1-8.
25. Chetwynd A., David A., Hill E.M., Abdul-Sada A. Evaluation of the sensitivity and reliability of direct nanoflowUPLC-nanoESI-high resolution mass spectrometry for metabolomics profiling. J. Mass Spectrom. 2014, in press. 10.1002/jms.3426.
26. Emmett M.R., Caprioli R.M. Micro-electrospray mass-spectrometry-ultra-high-sensitivity analysis of peptides and proteins. J. Am. Soc. Mass Spectrom. 1994, 5:605-613.
27. Ishihama Y. Proteomic LC-MS systems using nanoscale liquid chromatography with tandem mass spectrometry. J. Chromatogr. A 2005, 1067:73-83.
28. Gama M.R., Collins C.H., Bottoli C.B. Nano-liquid chromatography in pharmaceutical and biomedical research. J. Chromatogr. Sci. 2013, 51:694-703.
29. Theodoridis G.A., Gika H.G., Want E.J., Wilson I.D. Liquid chromatography-mass spectrometry based global metabolite profiling: a review. Anal. Chim. Acta 2012, 711:7-16.
30. Lee J.Y., Min H.K., Moon M.H. Simultaneous profiling of lysophospholipids and phospholipids from human plasma by nanoflow liquid chromatography-tandem mass spectrometry. Anal. Bioanal. Chem. 2011, 400:2953-2961.
31. Uehara T., Yokoi A., Aoshima K., Tanaka S., Kadowaki T., Tanaka M., Oda Y. Quantitative phosphorus metabolomics using nanoflow liquid chromatography-tandem mass spectrometry and culture-derived comprehensive global internal standards. Anal. Chem. 2009, 81:3836-3842.
32. Shi X., Wahlang B., Wei X., Yin X., Falkner K.C., Prough R.A., Kim S.H., Mueller E.G., McClain C.J., Cave M., Zhang X. Metabolomic analysis of the effects of polychlorinated biphenyls in nonalcoholic fatty liver disease. J. Proteome Res. 2012, 11:3805-3815.
33. Boernsen K.O., Gatzek S., Imbert G. Controlled protein precipitation in combination with chip-based nanospray infusion mass spectrometry. An approach for metabolomics profiling of plasma. Anal. Chem. 2005, 77:7255-7264.
34. Medina S., Ferreres F., Garcia-Viguera C., Horcajada M.N., Orduna J., Saviron M., Zurek G., Martinez-Sanz J.M., Gil J.I., Gil-Izquierdo A. Non-targeted metabolomic approach reveals urinary metabolites linked to steroid biosynthesis pathway after ingestion of citrus juice. Food Chem. 2013, 136:938-946.
35. Fischer R., Trudgian D.C., Wright C., Thomas G., Bradbury L.A., Brown M.A., Bowness P., Kessler B.M. Discovery of candidate serum proteomic and metabolomic biomarkers in ankylosing spondylitis. Mol. Cell. Proteomics 2012, 11. M111 013904.
36. Jones D.R., Wu Z., Chauhan D., Anderson K.C., Peng J. A nano ultra-performance liquid chromatography-high resolution mass spectrometry approach for global metabolomic profiling and case study on drug-resistant multiple myeloma. Anal. Chem. 2014, 86:3667-3675.
37. Zelena E., Dunn W.B., Broadhurst D., Francis-McIntyre S., Carroll K.M., Begley P., O'Hagan S., Knowles J.D., Halsall A., Wilson I.D., Kell D.B. Development of a robust and repeatable UPLC-MS method for the long-term metabolomic study of human serum. Anal. Chem. 2009, 81:1357-1364.
38. Michopoulos F., Lai L., Gika H., Theodoridis G., Wilson I. UPLC-MS-based analysis of human plasma for metabonomics using solvent precipitation or solid phase extraction. J. Proteome Res. 2009, 8:2114-2121.
39. Vuckovic D. Current trends and challenges in sample preparation for global metabolomics using liquid chromatography-mass spectrometry. Anal. Bioanal. Chem. 2012, 403:1523-1548.
40. Tulipani S., Llorach R., Urpi-Sarda M., Andres-Lacueva C. Comparative analysis of sample preparation methods to handle the complexity of the blood fluid metabolome: when less is more. Anal. Chem. 2013, 85:341-348.
41. Yang Y., Cruickshank C., Armstrong M., Mahaffey S., Reisdorph R., Reisdorph N. New sample preparation approach for mass spectrometry-based profiling of plasma results in improved coverage of metabolome. J. Chromatogr. A 2013, 1300:217-226.
42. Mitra S. Sample preparation techniques in analytical chemistry 2003, Wiley, Hoboken, New Jersey.
43. Want E.J., Wilson I.D., Gika H., Theodoridis G., Plumb R.S., Shockcor J., Holmes E., Nicholson J.K. Global metabolic profiling procedures for urine using UPLC-MS. Nat. Protoc. 2010, 5:1005-1018.
44. Cai H., Chen H., Yi T., Daimon C.M., Boyle J.P., Peers C., Maudsley S., Martin B. VennPlex-a novel Venn diagram program for comparing and visualizing datasets with differentially regulated datapoints. PLoS One 2013, 8:1-6.
45. Wiklund S., Johansson E., Sjostrom L., Mellerowicz E.J., Edlund U., Shockcor J.P., Gottfries J., Moritz T., Trygg J. Visualization of GC/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models. Anal. Chem. 2008, 80:115-122.
46. Sandra K., Pereira Ados S., Vanhoenacker G., David F., Sandra P. Comprehensive blood plasma lipidomics by liquid chromatography/quadrupole time-of-flight mass spectrometry. J. Chromatogr. A 2010, 1217:4087-4099.
47. Xia Y.Q., Jemal M. Phospholipids in liquid chromatography/mass spectrometry bioanalysis: comparison of three tandem mass spectrometric techniques for monitoring plasma phospholipids, the effect of mobile phase composition on phospholipids elution and the association of phospholipids with matrix effects. Rapid Commun. Mass Spectrosc. 2009, 23:2125-2138.
48. Hojjati M.R., Jiang X.C. Rapid, specific, and sensitive measurements of plasma sphingomyelin and phosphatidylcholine. J. Lipid Res. 2006, 47:673-676.
49. Vuckovic D., Pawliszyn J. Systematic evaluation of solid-phase microextraction coatings for untargeted metabolomic profiling of biological fluids by liquid chromatography-mass spectrometry. Anal. Chem. 2011, 83:1944-1954.
50. Wishart D.S., Jewison T., Guo A.C., Wilson M., Knox C., Liu Y., Djoumbou Y., Mandal R., Aziat F., Dong E., Bouatra S., Sinelnikov I., Arndt D., Xia J., Liu P., Yallou F., Bjorndahl T., Perez-Pineiro R., Eisner R., Allen F., Neveu V., Greiner R., Scalbert A. HMDB 3.0-The Human Metabolome Database in 2013. Nucleic Acids Res. 2013, 41:D801-D807.
51. Brown J.N., Paxeus N., Forlin L., Larsson D.G.L. Variations in bioconcentration of human pharmaceuticals from sewage effluents into fish blood plasma. Environ. Toxicol. Pharmacol. 2007, 24:267-274.
52. Want E.J., O'Maille G., Smith C.A., Brandon T.R., Uritboonthai W., Qin C., Trauger S.A., Siuzdak G. Solvent-dependent metabolite distribution, clustering, and protein extraction for serum profiling with mass spectrometry. Anal. Chem. 2006, 78:743-752.