Indole and synthetic derivative activate chaperone expression to reduce polyQ aggregation in SCA17 neuronal cell and slice culture models

Drug Design, Development and Therapy

Volumn 8, Issue , 2014, Pages 1929-1939

  Kung, Pin Jui ^a   Tao, Yu Chen ^a   Hsu, Ho Chiang ^a   Chen, Wan Ling ^a   Lin, Te Hsien ^a   Janreddy, Donala ^a   Yao, Ching Fa ^a   Chang, Kuo Hsuan ^b   Lin, Jung Yaw ^a   Su, Ming Tsan ^a   Wu, Chung Hsin ^a   Lee Chen, Guey Jen ^a   Hsieh Li, Hsiu Mei ^a  

^a NATIONAL TAIWAN NORMAL UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

Indole and derivative; PolyQ aggregation; Spinocerebellar ataxia type 17; TATA box binding protein; Therapeutics

Indexed keywords

CHAPERONE; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 70 KDA PROTEIN 1A; HEAT SHOCK PROTEIN 70 KDA PROTEIN 8; HEAT SHOCK TRANSCRIPTION FACTOR 1; INDOLE; INDOLE DERIVATIVE; NC 001 8; POLYGLUTAMINE; TEPRENONE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; NEUROPROTECTIVE AGENT; PEPTIDE; PROTEIN BINDING;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL AGGREGATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG STRUCTURE; HUMAN; HUMAN CELL; IC50; MOUSE; NERVE CELL; NERVE FIBER GROWTH; NEUROPROTECTION; NEWBORN; NONHUMAN; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PURKINJE CELL; SCA17 NEURONAL CELL; SLICE CULTURE; UPREGULATION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; IN VITRO STUDY; METABOLISM; ORGAN CULTURE TECHNIQUE; PATHOLOGY; PROTEIN AGGREGATION, PATHOLOGICAL; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL CULTURE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; IN VITRO TECHNIQUES; INDOLES; MICE; MOLECULAR CHAPERONES; NEURONS; NEUROPROTECTIVE AGENTS; ORGAN CULTURE TECHNIQUES; PEPTIDES; PROTEIN AGGREGATION, PATHOLOGICAL; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84908062029     PISSN: None     EISSN: 11778881     Source Type: Journal    
DOI: 10.2147/DDDT.S67376     Document Type: Article

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