PET imaging demonstrates histone deacetylase target engagement and clarifies brain penetrance of known and novel small molecule inhibitors in rat

ACS Chemical Neuroscience

Volumn 5, Issue 10, 2014, Pages 1055-1062

  Schroeder, F A ^a   Wang, C ^a   Van De Bittner, G C ^a   Neelamegam, R ^a   Takakura, W R ^a   Karunakaran, A ^a   Wey, H Y ^a   Reis, S A ^a   Gale, J ^b   Zhang, Y L ^b   Holson, E B ^b   Haggarty, S J ^a   Hooker, J M ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Neuroimaging epigenetics; preclinical; radiotracer; rodent; translational

Indexed keywords

AMIDOHYDROLASE INHIBITOR; BENZAMIDE; CN 147; GIVINOSTAT; HISTONE DEACETYLASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 2B; HISTONE DEACETYLASE INHIBITOR; HYDROLASE INHIBITOR; HYDROXAMIC ACID; IMIPRAMINE; MARTINOSTAT; MARTINOSTAT C 11; TACEDINALINE; TRACER; UNCLASSIFIED DRUG; VORINOSTAT; ANTIDEPRESSANT AGENT; BENZAMIDE DERIVATIVE; CARBON; RADIOPHARMACEUTICAL AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIDEPRESSANT ACTIVITY; ARTICLE; BRAIN; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG PENETRATION; DRUG TARGETING; FORCED SWIM TEST; IC50; IN VIVO STUDY; MOLECULAR PROBE; NEUROIMAGING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT; ANIMAL; DEPRESSIVE DISORDER; DISEASE MODEL; DRUG EFFECTS; GENETIC EPIGENESIS; METABOLISM; MOTOR ACTIVITY; PATHOPHYSIOLOGY; PROCEDURES; SCINTISCANNING;

RATTUS; RODENTIA;

ANIMALS; ANTIDEPRESSIVE AGENTS; BENZAMIDES; BRAIN; CARBON RADIOISOTOPES; DEPRESSIVE DISORDER; DISEASE MODELS, ANIMAL; EPIGENESIS, GENETIC; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; MOTOR ACTIVITY; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RATS;

EID: 84908021130     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn500162j     Document Type: Article

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