Antiproliferative and differentiating activities of a novel series of histone deacetylase inhibitors

ACS Medicinal Chemistry Letters

Volumn 1, Issue 8, 2010, Pages 411-415

  Binaschi, Monica ^a   Boldetti, Andrea ^b   Gianni, Maurizio ^b   Maggi, Carlo Alberto ^a   Gensini, Martina ^a   Bigioni, Mario ^a   Parlani, Massimo ^a   Giolitti, Alessandro ^a   Fratelli, Maddalena ^b   Valli, Claudia ^b   Terao, Mineko ^b   Garattini, Enrico ^b  

^a Menarini Ricerche SpA   (Italy)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

macrolactone; MDR reversing agents; nonnatural natural product; P glycoprotein; Taxanes

Indexed keywords

HISTONE DEACETYLASE INHIBITOR; RETINOIC ACID; TUBULIN;

ACETYLATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL GROWTH; CONTROLLED STUDY; DOSE RESPONSE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MYELOID LEUKEMIA; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TUMOR CELL;

ANIMALIA;

EID: 78649235170     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml1001163     Document Type: Article

References (15)

1. Yoo, C. B.; Jones, P. A. Epigenetic therapy of cancer: Past, present and future Nat. Rev. Drug Discovery 2006, 5, 37-50
2. Minucci, S.; Pelicci, P. G. Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer Nat. Rev. Cancer 2006, 6, 38-51
3. de Ruijter, A. J.; van Gennip, A. H.; Caron, H. N.; Kemp, S.; van Kuilenburg, A. B. Histone deacetylases (HDACs): Characterization of the classical HDAC family Biochem. J. 2003, 370, 737-749
4. Valenzuela-Fernandez, A.; Cabrero, J. R.; Serrador, J. M.; Sanchez-Madrid, F. HDAC6: A key regulator of cytoskeleton, cell migration and cell-cell interactions Trends Cell Biol. 2008, 18, 291-297
5. Zhang, C.; Richon, V.; Ni, X.; Talpur, R.; Duvic, M. Selective induction of apoptosis by histone deacetylase inhibitor SAHA in cutaneous T-cell lymphoma cells: Relevance to mechanism of therapeutic action J. Invest. Dermatol. 2005, 125, 1045-1052
6. Lane, A. A.; Chabner, B. A. Histone deacetylase inhibitors in cancer therapy J. Clin. Oncol. 2009, 27, 5459-5468
7. Ficner, R. Novel structural insights into class I and II histone deacetylases Curr. Top. Med. Chem. 2009, 9, 235-240
8. Marks, P. A.; Breslow, R. Dimethyl sulfoxide to vorinostat: Development of this histone deacetylase inhibitor as an anticancer drug Nat. Biotechnol. 2007, 25, 84-90
9. Richon, V. M.; Emiliani, S.; Verdin, E.; Webb, Y.; Breslow, R.; Rifkind, R. A.; Marks, P. A. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases Proc. Natl. Acad. Sci. U.S.A. 1998, 95, 3003-3007
10. Minucci, S.; Pelicci, P. G. Retinoid receptors in health and disease: Co-regulators and the chromatin connection Semin. Cell Dev. Biol. 1999, 10, 215-225
11. Garattini, E.; Terao, M. Cytodifferentiation: A novel approach to cancer treatment and prevention Curr. Opin. Pharmacol. 2001, 1, 358-363
12. Garattini, E.; Gianni, M.; Terao, M. Retinoids as differentiating agents in oncology: A network of interactions with intracellular pathways as the basis for rational therapeutic combinations Curr. Pharm. Des. 2007, 13, 1375-1400
13. Gianni, M.; Boldetti, A.; Guarnaccia, V.; Rambaldi, A.; Parrella, E.; Raska, I., Jr.; Rochette-Egly, C.; Del Sal, G.; Rustighi, A.; Terao, M.; Garattini, E. Inhibition of the peptidyl-prolyl-isomerase Pin1 enhances the responses of acute myeloid leukemia cells to retinoic acid via stabilization of RARalpha and PML-RARalpha Cancer Res. 2009, 69, 1016-1026
14. Gianni, M.; Kalac, Y.; Ponzanelli, I.; Rambaldi, A.; Terao, M.; Garattini, E. Tyrosine kinase inhibitor STI571 potentiates the pharmacologic activity of retinoic acid in acute promyelocytic leukemia cells: Effects on the degradation of RARalpha and PML-RARalpha Blood 2001, 97, 3234-3243
15. Gianni, M.; Li Calzi, M.; Terao, M.; Guiso, G.; Caccia, S.; Barbui, T.; Rambaldi, A.; Garattini, E. AM580, a stable benzoic derivative of retinoic acid, has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells Blood 1996, 87, 1520-1531