De novo design of self-assembled hexapeptides as β-amyloid (Aβ) peptide inhibitors

ACS Chemical Neuroscience

Volumn 5, Issue 10, 2014, Pages 972-981

  Wang, Qiuming ^a   Liang, Guizhao ^b   Zhang, Mingzhen ^a   Zhao, Jun ^a   Patel, Kunal ^a   Yu, Xiang ^a   Zhao, Chao ^a   Ding, Binrong ^c   Zhang, Ge ^a   Zhou, Feimeng ^c   Zheng, Jie ^a  

^a University of Akron   (United States)

^b CHONGQING UNIVERSITY   (China)

^c CALIFORNIA STATE UNIVERSITY   (United States)

Author keywords

Alzheimer's disease; amyloid cytotoxicity; Amyloid inhibitor; protein misfolding; self assembled peptide

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; HEXAPEPTIDE; NEUROPROTECTIVE AGENT; OLIGOPEPTIDE; THIAZOLE DERIVATIVE; THIOFLAVINE;

ARTICLE; BINDING COMPETITION; CONTROLLED STUDY; DRUG DESIGN; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HYBRID; NEUROTOXICITY; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; ATOMIC FORCE MICROSCOPY; CELL SURVIVAL; CHEMISTRY; CIRCULAR DICHROISM; DRUG EFFECTS; FLUORESCENCE; METABOLISM; MOLECULAR DYNAMICS; PROCEDURES; PROTEIN MULTIMERIZATION; SURFACE PLASMON RESONANCE; TUMOR CELL LINE;

AMYLOID BETA-PEPTIDES; CELL LINE, TUMOR; CELL SURVIVAL; CIRCULAR DICHROISM; DRUG DESIGN; FLUORESCENCE; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MICROSCOPY, ATOMIC FORCE; MOLECULAR DYNAMICS SIMULATION; NEUROPROTECTIVE AGENTS; OLIGOPEPTIDES; PROTEIN MULTIMERIZATION; SURFACE PLASMON RESONANCE; THIAZOLES;

EID: 84908018826     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn500165s     Document Type: Article

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