Actively targeted delivery of anticancer drug to tumor cells by redox-responsive star-shaped micelles

Biomaterials

Volumn 35, Issue 30, 2014, Pages 8711-8722

  Shi, Chunli ^a   Guo, Xing ^a   Qu, Qianqian ^a   Tang, Zhaomin ^a   Wang, Yi ^a   Zhou, Shaobing ^a  

^a SOUTHWEST JIAOTONG UNIVERSITY   (China)

Author keywords

Drug delivery; Nanocarrier; Redox responsive; Star shaped; Tumor targeting

Indexed keywords

CELL CULTURE; DRUG DELIVERY; DRUG PRODUCTS; POLYETHYLENE GLYCOLS; TUMORS;

ANTI-CANCER DRUG DELIVERY; CONFOCAL LASER SCANNING MICROSCOPY; NANOCARRIERS; PHYSIOLOGICAL ENVIRONMENT; REDOX-RESPONSIVE; STAR-SHAPED; SUBCELLULAR LOCALIZATIONS; TUMOR TARGETING;

MICELLES;

COPOLYMER; DOXORUBICIN; GLUTATHIONE; MACROGOL; POLYCAPROLACTONE; ANTINEOPLASTIC AGENT; FOLIC ACID; MICELLE; POLYESTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIODEGRADABILITY; CANCER CELL; CELL SHAPE; CELL SIZE; CELLULAR DISTRIBUTION; CERVICAL CANCER CELL LINE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG RELEASE; ENDOCYTOSIS; EX VIVO STUDY; FEMALE; FLOW CYTOMETRY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; MICELLE; MOLECULAR WEIGHT; MOLECULARLY TARGETED THERAPY; MORPHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RETICULOENDOTHELIAL SYSTEM; SOLID TUMOR; UTERINE CERVIX CANCER; ANIMAL; BAGG ALBINO MOUSE; CELL DEATH; CHEMISTRY; DRUG EFFECTS; NEOPLASMS; NICK END LABELING; NUDE MOUSE; OXIDATION REDUCTION REACTION; PARTICLE SIZE; PATHOLOGY; PROCEDURES; PROTON NUCLEAR MAGNETIC RESONANCE; SYNTHESIS; TISSUE DISTRIBUTION; TUMOR CELL LINE;

MUS;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL DEATH; CELL LINE, TUMOR; DOXORUBICIN; DRUG DELIVERY SYSTEMS; FEMALE; FLOW CYTOMETRY; FOLIC ACID; GLUTATHIONE; HUMANS; IN SITU NICK-END LABELING; MICE, INBRED BALB C; MICE, NUDE; MICELLES; NEOPLASMS; OXIDATION-REDUCTION; PARTICLE SIZE; POLYESTERS; PROTON MAGNETIC RESONANCE SPECTROSCOPY; TISSUE DISTRIBUTION;

EID: 84908015484     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.06.036     Document Type: Article

References (43)

1. Ferrari M. Cancer nanotechnology: opportunities and challenges. Nat Rev Cancer 2005, 5:161-171.
2. Peer D., Karp J.M., Hong S., Farokhzad O.C., Margalit R., Langer R. Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol 2007, 2:751-760.
3. Zhou Z., Ma X., Jin E., Tang J., Sui M., Shen Y., et al. Linear-dendritic drug conjugates forming long-circulating nanorods for cancer-drug delivery. Biomaterials 2013, 34:5722-5735.
4. Allen T.M., Cullis P.R. Drug delivery systems: entering the mainstream. Science 2004, 303:1818-1822.
5. Matsumura Y., Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res 1986, 46:6387-6392.
6. Fang J., Nakamura H., Maeda H. The EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. Adv Drug Deliv Rev 2011, 63:136-151.
7. Ulbrich K., Šubr V. Polymeric anticancer drugs with pH-controlled activation. Adv Drug Deliv Rev 2004, 56:1023-1050.
8. Shuai X., Merdan T., Schaper A.K., Xi F., Kissel T. Core-cross-linked polymeric micelles as paclitaxel carriers. Bioconjug Chem 2004, 15:441-448.
9. Read E.S., Armes S.P. Recent advances in shell cross-linked micelles. Chem Commun 2007, 29:3021-3035.
10. Dai J., Lin S., Cheng D., Zou S., Shuai X. Interlayer-crosslinked micelle with partially hydrated core showing reduction and pH dual sensitivity for pinpointed intracellular drug release. Angew Chem Int Ed 2011, 50:9404-9408.
11. Zhao Y., Pan D., Wang Z. Comparison of four-arm and six-arm star-shaped mPEG-PLA block copolymer micelles for drug delivery. J Control Release 2013, 172:e84.
12. Park W., Kim D., Kang H.C., Bae Y.H., Na K. Multi-arm histidine copolymer for controlled release of insulin from poly(lactide-co-glycolide) microsphere. Biomaterials 2012, 33:8848-8857.
13. Xu W., Siddiqui I.A., Nihal M., Pilla S., Rosenthal K., Mukhtar H., et al. Aptamer-conjugated and doxorubicin-loaded unimolecular micelles for targeted therapy of prostate cancer. Biomaterials 2013, 34:5244-5253.
14. Su H., Liu Y., Wang D., Wu C., Xia C., Gong Q., et al. Amphiphilic starlike dextran wrapped superparamagnetic iron oxide nanoparticle clusters as effective magnetic resonance imaging probes. Biomaterials 2013, 34:1193-1203.
15. Qian X., Long L., Shi Z., Liu C., Qiu M., Sheng J., et al. Star-branched amphiphilic PLA-b-PDMAEMA copolymers for co-delivery of miR-21 inhibitor and doxorubicin to treat glioma. Biomaterials 2014, 35:2322-2335.
16. Wang F., Bronich T.K., Kabanov A.V., Rauh R.D., Roovers J. Synthesis and characterization of star poly(ε-caprolactone)-b-poly(ethylene glycol) and poly(l-lactide)-b-poly(ethylene glycol) copolymers: evaluation as drug delivery carriers. Bioconjug Chem 2008, 19:1423-1429.
17. Le Dévédec F., Strandman S., Baille W.E., Zhu X. Functional star block copolymers with a cholane core: thermo-responsiveness and aggregation behavior. Polymer 2013, 54:3898-3903.
18. Allen T.M. Ligand-targeted therapeutics in anticancer therapy. Nat Rev Cancer 2002, 2:750-763.
19. Torchilin V.P., Lukyanov A.N., Gao Z., Papahadjopoulos-Sternberg B. Immunomicelles: targeted pharmaceutical carriers for poorly soluble drugs. Proc Natl Acad Sci U S A 2003, 100:6039-6044.
20. Weitman S.D., Lark R.H., Coney L.R., Fort D.W., Frasca V., Zurawski V.R., et al. Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues. Cancer Res 1992, 52:3396-3401.
21. Ross J.F., Chaudhuri P.K., Ratnam M. Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. physiologic and clinical implications. Cancer 1994, 73:2432-2443.
22. Guo X., Shi C., Wang J., Di S., Zhou S. pH-triggered intracellular release from actively targeting polymer micelles. Biomaterials 2013, 34:4544-4554.
23. Ashley C.E., Carnes E.C., Phillips G.K., Padilla D., Durfee P.N., Brown P.A., et al. The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers. Nat Mater 2011, 10:389-397.
24. Wang W., Cheng D., Gong F., Miao X., Shuai X. Design of multifunctional micelle for tumor-targeted intracellular drug release and fluorescent imaging. Adv Mater 2012, 24:115-120.
25. Rapoport N. Physical stimuli-responsive polymeric micelles for anti-cancer drug delivery. Prog Polym Sci 2007, 32:962-990.
26. Cheng R., Feng F., Meng F., Deng C., Feijen J., Zhong Z. Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery. J Control Release 2011, 152:2-12.
27. Wei H., Zhuo R.-X., Zhang X.-Z. Design and development of polymeric micelles with cleavable links for intracellular drug delivery. Prog Polym Sci 2013, 38:503-535.
28. Shim M.S., Kwon Y.J. Stimuli-responsive polymers and nanomaterials for gene delivery and imaging applications. Adv Drug Deliv Rev 2012, 64:1046-1059.
29. Wang J., Yang G., Guo X., Tang Z., Zhong Z., Zhou S. Redox-responsive polyanhydride micelles for cancer therapy. Biomaterials 2014, 35:3080-3090.
30. Bae Y., Fukushima S., Harada A., Kataoka K. Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: polymeric micelles that are responsive to intracellular pH change. Angew Chem Int Ed 2003, 42:4640-4643.
31. Zhou K., Liu H., Zhang S., Huang X., Wang Y., Huang G., et al. Multicolored pH-tunable and activatable fluorescence nanoplatform responsive to physiologic pH stimuli. J Am Chem Soc 2012, 134:7803-7811.
32. Katayama Y., Sonoda T., Maeda M. A polymer micelle responding to the protein kinase a signal. Macromolecules 2001, 34:8569-8573.
33. Cole A.J., David A.E., Wang J., Galbán C.J., Yang V.C. Magnetic brain tumor targeting and biodistribution of long-circulating PEG-modified, cross-linked starch-coated iron oxide nanoparticles. Biomaterials 2011, 32:6291-6301.
34. Zhou S., Deng X., Yang H. Biodegradable poly(ε-caprolactone)-poly(ethylene glycol) block copolymers: characterization and their use as drug carriers for a controlled delivery system. Biomaterials 2003, 24:3563-3570.
35. Zhu J., Zhou Z., Yang C., Kong D., Wan Y., Wang Z. Folate-conjugated amphiphilic star-shaped block copolymers as targeted nanocarriers. J Biomed Mater Res A 2011, 97:498-508.
36. Conner S.D., Schmid S.L. Regulated portals of entry into the cell. Nature 2003, 422:37-44.
37. Cao W., Zhou J., Mann A., Wang Y., Zhu L. Folate-functionalized unimolecular micelles based on a degradable amphiphilic dendrimer-like star polymer for cancer cell-targeted drug delivery. Biomacromolecules 2011, 12:2697-2707.
38. Bosman A.W., Janssen H.M., Meijer E.W. About dendrimers: structure, physical properties, and applications. Chem Rev 1999, 99:1665-1688.
39. Stiriba S.E., Frey H., Haag R. Dendritic polymers in biomedical applications: from potential to clinical use in diagnostics and therapy. Angew Chem Int Ed 2002, 41:1329-1334.
40. Pang X.C., Zhao L., Akinc M., Kim J.K., Lin Z.Q. Novel amphiphilic multi-arm, star-like block copolymers as unimolecular micelles. Macromolecules 2011, 44:3746-3752.
41. Prabaharan M., Grailer J.J., Pilla S., Steeber D.A., Gong S. Folate-conjugated amphiphilic hyperbranched block copolymers based on Boltorn H40, poly(L-lactide) and poly(ethylene glycol) for tumor-targeted drug delivery. Biomaterials 2009, 30:3009-3019.
42. Jabbari E., Yang X., Moeinzadeh S., He X. Drug release kinetics, cell uptake, and tumor toxicity of hybrid VVVVVVKK peptide-assembled polylactide nanoparticles. Eur J Pharm Biopharm 2013, 84:49-62.
43. Fan H., Hu Q.-D., Xu F.-J., Liang W.-Q., Tang G.-P., Yang W.-T. In vivo treatment of tumors using host-guest conjugated nanoparticles functionalized with doxorubicin and therapeutic gene pTRAIL. Biomaterials 2012, 33:1428-1436.