Interleukin-8 promotes cell migration through integrin αvβ6 upregulation in colorectal cancer

Cancer Letters

Volumn 354, Issue 2, 2014, Pages 245-253

  Sun, Qi ^a   Sun, Fengkai ^a   Wang, Ben ^a   Liu, Song ^b   Niu, Weibo ^a   Liu, Enyu ^a   Peng, Cheng ^a   Wang, Jiayong ^a   Gao, Huijie ^a   Liang, Benjia ^a   Niu, Zhengchuan ^a   Zou, Xueqing ^a   Niu, Jun ^a  

^a SHANDONG UNIVERSITY   (China)

^b BINZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Colorectal cancer; Integrin v 6; Interleukin 8; Migration

Indexed keywords

ALPHAVBETA6 INTEGRIN; CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR2; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR ETS 1; ETS1 PROTEIN, HUMAN; INTEGRIN; MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN; TUMOR ANTIGEN;

ARTICLE; CELL MIGRATION; COLORECTAL CANCER; COLORECTAL CANCER CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MAJOR CLINICAL STUDY; METASTASIS POTENTIAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TUMOR INVASION; UPREGULATION; CELL MOTION; COLORECTAL TUMOR; GENE SILENCING; GENETICS; HT 29 CELL LINE; IMMUNOLOGY; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ANTIBODIES, MONOCLONAL; ANTIGENS, NEOPLASM; CELL MOVEMENT; COLORECTAL NEOPLASMS; GENE KNOCKDOWN TECHNIQUES; HT29 CELLS; HUMANS; INTEGRINS; INTERLEUKIN-8; MAP KINASE SIGNALING SYSTEM; PROTO-ONCOGENE PROTEIN C-ETS-1; RECEPTORS, INTERLEUKIN-8A; RECEPTORS, INTERLEUKIN-8B; RECOMBINANT PROTEINS; UP-REGULATION;

EID: 84907992266     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2014.08.021     Document Type: Article

References (56)

1. Siegel R., Desantis C., Jemal A. Colorectal cancer statistics, 2014. CA Cancer J. Clin 2014, 64:104-117.
2. Raman D., Baugher P.J., Thu Y.M., Richmond A. Role of chemokines in tumor growth. Cancer Lett 2007, 256:137-165.
3. Roebuck K.A. Regulation of interleukin-8 gene expression. J. Interferon Cytokine Res 1999, 19:429-438.
4. Li A., Dubey S., Varney M.L., Dave B.J., Singh R.K. IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis. J. Immunol 2003, 170:3369-3376.
5. Singh R.K., Johansson S.L., Varney M.L. Distinct expression of CXCL8 and its receptors CXCR1 and CXCR2 and their association with vessel density and aggressiveness in malignant melanoma. Am. J. Clin. Pathol 2006, 125:209-216.
6. Cerretti D.P., Kozlosky C.J., Vanden Bos T., Nelson N., Gearing D.P., Beckmann M.P. Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2. Mol. Immunol 1993, 30:359-367.
7. Holmes W.E., Lee J., Kuang W.J., Rice G.C., Wood W.I. Structure and functional expression of a human interleukin-8 receptor. Science 1991, 253:1278-1280.
8. Chuntharapai A., Kim K.J. Regulation of the expression of IL-8 receptor A/B by IL-8: possible functions of each receptor. J. Immunol 1995, 155:2587-2594.
9. Waugh D.J., Wilson C. The interleukin-8 pathway in cancer. Clin. Cancer Res 2008, 14:6735-6741.
10. Li A., Varney M.L., Singh R.K. Expression of interleukin 8 and its receptors in human colon carcinoma cells with different metastatic potentials. Clin. Cancer Res 2001, 7:3298-3304.
11. Kuai W.X., Wang Q., Yang X.Z., Zhao Y., Yu R., Tang X.J. Interleukin-8 associates with adhesion, migration, invasion and chemosensitivity of human gastric cancer cells. World J. Gastroenterol 2012, 18:979-985.
12. Li M., Zhang Y., Feurino L.W., Wang H., Fisher W.E., Brunicardi F.C., et al. Interleukin-8 increases vascular endothelial growth factor and neuropilin expression and stimulates ERK activation in human pancreatic cancer. Cancer Sci 2008, 99:733-737.
13. Yu J., Ren X., Chen Y., Liu P., Wei X., Li H., et al. Dysfunctional activation of neurotensin/IL-8 pathway in hepatocellular carcinoma is associated with increased inflammatory response in microenvironment, more epithelial mesenchymal transition in cancer and worse prognosis in patients. PLoS ONE 2013, 8:e56069.
14. Li X.J., Peng L.X., Shao J.Y., Lu W.H., Zhang J.X., Chen S., et al. As an independent unfavorable prognostic factor, IL-8 promotes metastasis of nasopharyngeal carcinoma through induction of epithelial-mesenchymal transition and activation of AKT signaling. Carcinogenesis 2012, 33:1302-1309.
15. Kido S., Kitadai Y., Hattori N., Haruma K., Kido T., Ohta M., et al. Interleukin 8 and vascular endothelial growth factor - prognostic factors in human gastric carcinomas?. Eur. J. Cancer 2001, 37:1482-1487.
16. Yuan A., Yang P.C., Yu C.J., Chen W.J., Lin F.Y., Kuo S.H., et al. Interleukin-8 messenger ribonucleic acid expression correlates with tumor progression, tumor angiogenesis, patient survival, and timing of relapse in non-small-cell lung cancer. Am. J. Respir. Crit. Care Med 2000, 162:1957-1963.
17. Araki S., Omori Y., Lyn D., Singh R.K., Meinbach D.M., Sandman Y., et al. Interleukin-8 is a molecular determinant of androgen independence and progression in prostate cancer. Cancer Res 2007, 67:6854-6862.
18. Bates R.C., Bellovin D.I., Brown C., Maynard E., Wu B., Kawakatsu H., et al. Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma. J. Clin. Invest 2005, 115:339-347.
19. Desgrosellier J.S., Cheresh D.A. Integrins in cancer: biological implications and therapeutic opportunities. Nat. Rev. Cancer 2010, 10:9-22.
20. Bandyopadhyay A., Raghavan S. Defining the role of integrin alphavbeta6 in cancer. Curr. Drug Targets 2009, 10:645-652.
21. Niu J., Gu X., Turton J., Meldrum C., Howard E.W., Agrez M. Integrin-mediated signalling of gelatinase B secretion in colon cancer cells. Biochem. Biophys. Res. Commun 1998, 249:287-291.
22. Yang G.Y., Xu K.S., Pan Z.Q., Zhang Z.Y., Mi Y.T., Wang J.S., et al. Integrin alpha v beta 6 mediates the potential for colon cancer cells to colonize in and metastasize to the liver. Cancer Sci 2008, 99:879-887.
23. Zhao-Yang Z., Ke-Sen X., Qing-Si H., Wei-Bo N., Jia-Yong W., Yue-Tang M., et al. Signaling and regulatory mechanisms of integrin alphavbeta6 on the apoptosis of colon cancer cells. Cancer Lett 2008, 266:209-215.
24. Liu S., Wang J., Niu W., Liu E., Peng C., Lin P., et al. The beta6-integrin-ERK/MAP kinase pathway contributes to chemo resistance in colon cancer. Cancer Lett 2013, 328:325-334.
25. Wang B., Wang W., Niu W., Liu E., Liu X., Wang J., et al. SDF-1/CXCR4 axis promotes directional migration of colorectal cancer cells through upregulation of integrin alphavbeta6. Carcinogenesis 2014, 35:282-291.
26. Wang J., Wu J., Hong J., Chen R., Xu K., Niu W., et al. PKC promotes the migration of colon cancer cells by regulating the internalization and recycling of integrin alphavbeta6. Cancer Lett 2011, 311:38-47.
27. Ning Y., Manegold P.C., Hong Y.K., Zhang W., Pohl A., Lurje G., et al. Interleukin-8 is associated with proliferation, migration, angiogenesis and chemosensitivity in vitro and in vivo in colon cancer cell line models. Int. J. Cancer 2011, 128:2038-2049.
28. Itoh Y., Joh T., Tanida S., Sasaki M., Kataoka H., Itoh K., et al. IL-8 promotes cell proliferation and migration through metalloproteinase-cleavage proHB-EGF in human colon carcinoma cells. Cytokine 2005, 29:275-282.
29. Wilson A.J., Byron K., Gibson P.R. Interleukin-8 stimulates the migration of human colonic epithelial cells in vitro. Clin. Sci 1999, 97:385-390.
30. Hoffmann E., Dittrich-Breiholz O., Holtmann H., Kracht M. Multiple control of interleukin-8 gene expression. J. Leukoc. Biol 2002, 72:847-855.
31. Viala E., Pouyssegur J. Regulation of tumor cell motility by ERK mitogen-activated protein kinases. Ann. N. Y. Acad. Sci 2004, 1030:208-218.
32. Varney M.L., Li A., Dave B.J., Bucana C.D., Johansson S.L., Singh R.K. Expression of CXCR1 and CXCR2 receptors in malignant melanoma with different metastatic potential and their role in interleukin-8 (CXCL-8)-mediated modulation of metastatic phenotype. Clin. Exp. Metastasis 2003, 20:723-731.
33. Li A., Varney M.L., Valasek J., Godfrey M., Dave B.J., Singh R.K. Autocrine role of interleukin-8 in induction of endothelial cell proliferation, survival, migration and MMP-2 production and angiogenesis. Angiogenesis 2005, 8:63-71.
34. Rubie C., Frick V.O., Pfeil S., Wagner M., Kollmar O., Kopp B., et al. Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer. World J. Gastroenterol 2007, 13:4996-5002.
35. Kaminska J., Nowacki M.P., Kowalska M., Rysinska A., Chwalinski M., Fuksiewicz M., et al. Clinical significance of serum cytokine measurements in untreated colorectal cancer patients: soluble tumor necrosis factor receptor type I-an independent prognostic factor. Tumour Biol 2005, 26:186-194.
36. Ueda T., Shimada E., Urakawa T. Serum levels of cytokines in patients with colorectal cancer: possible involvement of interleukin-6 and interleukin-8 in hematogenous metastasis. J. Gastroenterol 1994, 29:423-429.
37. Yuan A., Chen J.J., Yao P.L., Yang P.C. The role of interleukin-8 in cancer cells and microenvironment interaction. Front. Biosci 2005, 10:853-865.
38. Varney M.L., Singh S., Li A., Mayer-Ezell R., Bond R., Singh R.K. Small molecule antagonists for CXCR2 and CXCR1 inhibit human colon cancer liver metastases. Cancer Lett 2011, 300:180-188.
39. Zhu Y.M., Woll P.J. Mitogenic effects of interleukin-8/CXCL8 on cancer cells. Future Oncol 2005, 1:699-704.
40. Zhu Y.M., Webster S.J., Flower D., Woll P.J. Interleukin-8/CXCL8 is a growth factor for human lung cancer cells. Br. J. Cancer 2004, 91:1970-1976.
41. Huang J., Yao J.L., Zhang L., Bourne P.A., Quinn A.M., di Sant'Agnese P.A., et al. Differential expression of interleukin-8 and its receptors in the neuroendocrine and non-neuroendocrine compartments of prostate cancer. Am. J. Pathol 2005, 166:1807-1815.
42. Bates R.C., DeLeo M.J., Mercurio A.M. The epithelial-mesenchymal transition of colon carcinoma involves expression of IL-8 and CXCR-1-mediated chemotaxis. Exp. Cell Res 2004, 299:315-324.
43. Addison C.L., Daniel T.O., Burdick M.D., Liu H., Ehlert J.E., Xue Y.Y., et al. The CXC chemokine receptor 2, CXCR2, is the putative receptor for ELR + CXC chemokine-induced angiogenic activity. J. Immunol 2000, 165:5269-5277.
44. Breuss J.M., Gallo J., DeLisser H.M., Klimanskaya I.V., Folkesson H.G., Pittet J.F., et al. Expression of the beta 6 integrin subunit in development, neoplasia and tissue repair suggests a role in epithelial remodeling. J. Cell Sci 1995, 108(Pt 6):2241-2251.
45. Wang Y., Xu R.C., Zhang X.L., Niu X.L., Qu Y., Li L.Z., et al. Interleukin-8 secretion by ovarian cancer cells increases anchorage-independent growth, proliferation, angiogenic potential, adhesion and invasion. Cytokine 2012, 59:145-155.
46. Wang Y., Qu Y., Niu X.L., Sun W.J., Zhang X.L., Li L.Z. Autocrine production of interleukin-8 confers cisplatin and paclitaxel resistance in ovarian cancer cells. Cytokine 2011, 56:365-375.
47. Manna S.K., Ramesh G.T. Interleukin-8 induces nuclear transcription factor-kappaB through a TRAF6-dependent pathway. J. Biol. Chem 2005, 280:7010-7021.
48. Niu J., Dorahy D.J., Gu X., Scott R.J., Draganic B., Ahmed N., et al. Integrin expression in colon cancer cells is regulated by the cytoplasmic domain of the beta6 integrin subunit. Int. J. Cancer 2002, 99:529-537.
49. Milkiewicz M., Uchida C., Gee E., Fudalewski T., Haas T.L. Shear stress-induced Ets-1 modulates protease inhibitor expression in microvascular endothelial cells. J. Cell. Physiol 2008, 217:502-510.
50. Callaway K.A., Rainey M.A., Riggs A.F., Abramczyk O., Dalby K.N. Properties and regulation of a transiently assembled ERK2.Ets-1 signaling complex. Biochemistry 2006, 45:13719-13733.
51. Reiland J., Furcht L.T., McCarthy J.B. CXC-chemokines stimulate invasion and chemotaxis in prostate carcinoma cells through the CXCR2 receptor. Prostate 1999, 41:78-88.
52. Lee C.Y., Huang C.Y., Chen M.Y., Lin C.Y., Hsu H.C., Tang C.H. IL-8 increases integrin expression and cell motility in human chondrosarcoma cells. J. Cell. Biochem 2011, 112:2549-2557.
53. Luca M., Huang S., Gershenwald J.E., Singh R.K., Reich R., Bar-Eli M. Expression of interleukin-8 by human melanoma cells up-regulates MMP-2 activity and increases tumor growth and metastasis. Am. J. Pathol 1997, 151:1105-1113.
54. Palena C., Hamilton D.H., Fernando R.I. Influence of IL-8 on the epithelial-mesenchymal transition and the tumor microenvironment. Future Oncol 2012, 8:713-722.
55. Lee L.F., Louie M.C., Desai S.J., Yang J., Chen H.W., Evans C.P., et al. Interleukin-8 confers androgen-independent growth and migration of LNCaP: differential effects of tyrosine kinases Src and FAK. Oncogene 2004, 23:2197-2205.
56. Daub H., Weiss F.U., Wallasch C., Ullrich A. Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Nature 1996, 379:557-560.