As an independent unfavorable prognostic factor, IL-8 promotes metastasis of nasopharyngeal carcinoma through induction of epithelial-mesenchymal transition and activation of AKT signaling

Carcinogenesis

Volumn 33, Issue 7, 2012, Pages 1302-1309

  Li, Xin Jian ^a,b,d   Peng, Li Xia ^a   Shao, Jian Yong ^a   Lu, Wen Hua ^a   Zhang, Jia Xing ^a   Chen, Shi ^a   Chen, Zhi Yuan ^a   Xiang, Yan Qun ^a   Bao, Ying Na ^a,c   Zheng, Fang Jing ^a,c   Zeng, Mu Sheng ^a   Kang, Tie Bang ^a   Zeng, Yi Xin ^a   Teh, Bin Tean ^b,c   Qian, Chao Nan ^a,c  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^b DIVISION OF MEDICAL ONCOLOGY   (Singapore)

^c VAN ANDEL RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; INTERLEUKIN 8; PROTEIN KINASE B; SHORT HAIRPIN RNA;

ADULT; AGE; ARTICLE; AUTOCRINE EFFECT; CANCER CELL; CANCER PATIENT; CANCER SURVIVAL; CANCER TISSUE; CELL GROWTH; CELL INVASION; CELL MIGRATION; CELL MOTILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DISEASE SEVERITY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENDER; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; METASTASIS; METASTASIS FREE SURVIVAL; NASOPHARYNX CARCINOMA; OVERALL SURVIVAL; PARACRINE SIGNALING; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

BASE SEQUENCE; DNA PRIMERS; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL-MESENCHYMAL TRANSITION; HUMANS; INTERLEUKIN-8; NASOPHARYNGEAL NEOPLASMS; NEOPLASM METASTASIS; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-AKT; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 84865185941     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgs181     Document Type: Article

References (47)

1. Cao,S.M., et al. (2011) The prevalence and prevention of nasopharyngeal carcinoma in China. Chin. J. Cancer, 30, 114-119.
2. Wee,J.T., et al. (2010) Is nasopharyngeal cancer really a "Cantonese cancer"? Chin. J. Cancer, 29, 517-526.
3. Ahmad,A., et al. (1986) Distant metastases of nasopharyngeal carcinoma: a study of 256 male patients. J. Surg. Oncol., 33, 194-197.
4. Geara,F.B., et al. (1997) Carcinoma of the nasopharynx treated by radiotherapy alone: determinants of distant metastasis and survival. Radiother Oncol, 43, 53-61.
5. Lee,A.W., et al. (1993) Retrospective analysis of patients with nasopharyngeal carcinoma treated during 1976-1985: survival after local recurrence. Int. J. Radiat. Oncol. Biol. Phys., 26, 773-782.
6. Huang,C.J., et al. (1996) Patterns of distant metastases in nasopharyngeal carcinoma. Kaohsiung J. Med. Sci., 12, 229-234.
7. Wei,W.I., et al. (2007) The management of neck metastases in nasopharyngeal cancer. Curr. Opin. Otolaryngol. Head Neck Surg., 15, 99-102.
8. Li,G.P., et al. (2011) Proteomic profiling between CNE-2 and its strongly metastatic subclone S-18 and functional characterization of HSP27 in metastasis of nasopharyngeal carcinoma. Proteomics, 11, 2911-2920.
9. Li,X.J., et al. (2011) Serglycin is a theranostic target in nasopharyngeal carcinoma that promotes metastasis. Cancer Res., 71, 3162-3172.
10. Qian,C.N., et al. (2006) Preparing the "soil": the primary tumor induces vasculature reorganization in the sentinel lymph node before the arrival of metastatic cancer cells. Cancer Res, 66, 10365-10376.
11. Waugh,D.J., et al. (2008) The interleukin-8 pathway in cancer. Clin. Cancer Res., 14, 6735-6741.
12. Matsushima,K., et al. (1988) Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor. J. Exp. Med., 167, 1883-1893.
13. Matsushima,K., et al. (1992) Interleukin-8 and MCAF: novel leukocyte recruitment and activating cytokines. Chem. Immunol., 51, 236-265.
14. Huang,D., et al. (2010) Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma. Cancer Res., 70, 1063-1071.
15. Huang,S., et al. (2002) Fully humanized neutralizing antibodies to interleukin-8 (ABX-IL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma. Am. J. Pathol., 161, 125-134.
16. Vegran,F., et al. (2011) Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-kappaB/IL-8 pathway that drives tumor angiogenesis. Cancer Res., 71, 2550-2560.
17. Bar-Eli,M. (1999) Role of interleukin-8 in tumor growth and metastasis of human melanoma. Pathobiology, 67, 12-18.
18. Rofstad,E.K., et al. (2000) Vascular endothelial growth factor, interleukin 8, platelet-derived endothelial cell growth factor, and basic fibroblast growth factor promote angiogenesis and metastasis in human melanoma xenografts. Cancer Res., 60, 4932-4938.
19. Singh,R.K., et al. (1995) Ultraviolet B irradiation promotes tumorigenic and metastatic properties in primary cutaneous melanoma via induction of interleukin 8. Cancer Res., 55, 3669-3674.
20. Luca,M., et al. (1997) Expression of interleukin-8 by human melanoma cells up-regulates MMP-2 activity and increases tumor growth and metastasis. Am. J. Pathol., 151, 1105-1113.
21. Inoue,K., et al. (2000) Interleukin 8 expression regulates tumorigenicity and metastasis in human bladder cancer. Cancer Res., 60, 2290-2299.
22. Karashima,T., et al. (2003) Nuclear factor-kappaB mediates angiogenesis and metastasis of human bladder cancer through the regulation of interleukin-8. Clin. Cancer Res., 9, 2786-2797.
23. Shahzad,M.M., et al. (2010) Stress effects on FosB- and interleukin-8 (IL8)-driven ovarian cancer growth and metastasis. J. Biol. Chem., 285, 35462-35470.
24. Pine,S.R., et al. (2011) Increased levels of circulating interleukin 6, interleukin 8, C-reactive protein, and risk of lung cancer. J. Natl. Cancer Inst., 103, 1112-1122.
25. Dong,J.Q., et al. (2012) Establishment and characterization of a novel nasopharyngeal carcinoma cell line (SUNE2) from a Cantonese patient. Chin. J. Cancer, 31, 36-44.
26. Ji,M.F., et al. (2011) Detection of Stage I nasopharyngeal carcinoma by serologic screening and clinical examination. Chin. J. Cancer, 30, 120-123.
27. Liang,F.Y., et al. (2012) Detecting plasma Epstein-Barr virus DNA to diagnose postradiation nasopharyngeal skull base lesions in nasopharyngeal carcinoma patients: a prospective study. Chin. J. Cancer, 31, 142-149.
28. Hsu,M., et al. (2008) Epstein-Barr virus lytic transactivator Zta enhances chemotactic activity through induction of interleukin-8 in nasopharyngeal carcinoma cells. J. Virol., 82, 3679-3688.
29. Yoshizaki,T., et al. (2001) Induction of interleukin-8 by Epstein-Barr virus latent membrane protein-1 and its correlation to angiogenesis in nasopharyngeal carcinoma. Clin. Cancer Res., 7, 1946-1951.
30. Ren,Q., et al. (2004) Epstein-Barr virus (EBV) latent membrane protein 1 induces interleukin-8 through the nuclear factor-kappa B signaling pathway in EBV-infected nasopharyngeal carcinoma cell line. Laryngoscope, 114, 855-859.
31. Liao,B., et al. (2010) Macrophage migration inhibitory factor contributes angiogenesis by up-regulating IL-8 and correlates with poor prognosis of patients with primary nasopharyngeal carcinoma. J. Surg. Oncol., 102, 844-851.
32. Xie,L.Q., et al. (2010) Co-elevated expression of hepatocyte growth factor and Interleukin-8 contributes to poor prognosis of patients with primary nasopharyngeal carcinoma. Oncol. Rep., 23, 141-150.
33. Scheid,M.P., et al. (2001) PKB/AKT: functional insights from genetic models. Nat. Rev. Mol. Cell Biol., 2, 760-768.
34. Liu,Y., et al. (2012) Activation of AKT is associated with metastasis of nasopharyngeal carcinoma. Tumour Biol., 33, 241-245.
35. MacManus,C.F., et al. (2007) Interleukin-8 signaling promotes translational regulation of cyclin D in androgen-independent prostate cancer cells. Mol. Cancer Res., 5, 737-748.
36. Araki,S., et al. (2007) Interleukin-8 is a molecular determinant of androgen independence and progression in prostate cancer. Cancer Res., 67, 6854-6862.
37. Thiery,J.P., et al. (2009) Epithelial-mesenchymal transitions in development and disease. Cell, 139, 871-890.
38. Shen,Y., et al. (2011) Role of CCR2 and IL-8 in acute lung injury: a new mechanism and therapeutic target. Expert Rev. Respir. Med., 5, 107-114.
39. Skov,L., et al. (2008) IL-8 as antibody therapeutic target in inflammatory diseases: reduction of clinical activity in palmoplantar pustulosis. J. Immunol., 181, 669-679.
40. Hatfield,K.J., et al. (2005) Antiangiogenic therapy in acute myelogenous leukemia: targeting of vascular endothelial growth factor and interleukin 8 as possible antileukemic strategies. Curr. Cancer Drug Targets, 5, 229-248.
41. Kido,S., et al. (2001) Interleukin 8 and vascular endothelial growth factor -prognostic factors in human gastric carcinomas? Eur. J. Cancer, 37, 1482-1487.
42. Shahzad,A., et al. (2010) Interleukin 8 (IL-8) -a universal biomarker? Int. Arch. Med., 3, 11.
43. Yuan,A., et al. (2000) Interleukin-8 messenger ribonucleic acid expression correlates with tumor progression, tumor angiogenesis, patient survival, and timing of relapse in non-small-cell lung cancer. Am. J. Respir. Crit. Care Med., 162, 1957-1963.
44. Apostolakis,S., et al. (2009) Interleukin 8 and cardiovascular disease. Cardiovasc. Res., 84, 353-360.
45. Lai,Y., et al. (2011) Interleukin-8 induces the endothelial cell migration through the activation of phosphoinositide 3-kinase-Rac1/RhoA pathway. Int. J. Biol. Sci., 7, 782-791.
46. Schadendorf, et al. (1994) IL-8 produced by human malignant melanoma cells in vitro is an essential autocrine growth factor. J. Immunol., 153, 3360.
47. Fernando,R.I., et al. (2011) IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells. Cancer Res., 71, 5296-5306.