메뉴 건너뛰기




Volumn 3, Issue 6, 2014, Pages 487-496

In vitro investigation of the mutagenic potential of Aloe vera extracts

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED CARBON; ALOE VERA EXTRACT; ALOIN; ANTHRAQUINONE DERIVATIVE; CARBON; REACTIVE OXYGEN METABOLITE;

EID: 84907991341     PISSN: 2045452X     EISSN: 20454538     Source Type: Journal    
DOI: 10.1039/c4tx00053f     Document Type: Article
Times cited : (14)

References (46)
  • 2
    • 0022726053 scopus 로고
    • The Aloe vera phenomenon: A review of the properties and modern uses of the leaf parenchyma gel
    • D. Grindlay T. Reynolds The Aloe vera phenomenon: a review of the properties and modern uses of the leaf parenchyma gel J. Ethnopharmacol. 1986 16 117 151
    • (1986) J. Ethnopharmacol. , vol.16 , pp. 117-151
    • Grindlay, D.1    Reynolds, T.2
  • 3
    • 0032111029 scopus 로고    scopus 로고
    • Aloe vera: Magic or medicine?
    • 54
    • P. Atherton Aloe vera: magic or medicine? Nurs. Stand. 1998 12 49 52
    • (1998) Nurs. Stand. , vol.12 , pp. 49-52
    • Atherton, P.1
  • 5
    • 84929264242 scopus 로고    scopus 로고
    • Final report on the safety assessment of Aloe Andongensis Extract, Aloe Andongensis Leaf Juice, aloe Arborescens Leaf Extract, Aloe Arborescens Leaf Juice
    • CIR Aloe Arborescens Leaf Protoplasts, Aloe Barbadensis Flower Extract, Aloe Barbadensis Leaf, Aloe Barbadensis Leaf Extract, Aloe Barbadensis Leaf Juice, aloe Barbadensis Leaf Polysaccharides, Aloe Barbadensis Leaf Water, Aloe Ferox Leaf Extract, Aloe Ferox Leaf Juice, and Aloe Ferox Leaf Juice Extract
    • CIR Final report on the safety assessment of Aloe Andongensis Extract, Aloe Andongensis Leaf Juice, aloe Arborescens Leaf Extract, Aloe Arborescens Leaf Juice, Aloe Arborescens Leaf Protoplasts, Aloe Barbadensis Flower Extract, Aloe Barbadensis Leaf, Aloe Barbadensis Leaf Extract, Aloe Barbadensis Leaf Juice, aloe Barbadensis Leaf Polysaccharides, Aloe Barbadensis Leaf Water, Aloe Ferox Leaf Extract, Aloe Ferox Leaf Juice, and Aloe Ferox Leaf Juice Extract Int. J. Toxicol. 2007 26 Suppl 2 1 50
    • (2007) Int. J. Toxicol. , vol.26 , pp. 1-50
  • 6
    • 84907988166 scopus 로고    scopus 로고
    • Toxicology and carcinogenesis studies of a nondecolorized whole leaf extract of Aloe barbadensis Miller (Aloe vera) in F344/N rats and B6C3F1 mice (drinking water study), Natl. Toxicol. Program Tech. Rep. Ser., 2013
    • NTP, Toxicology and carcinogenesis studies of a nondecolorized whole leaf extract of Aloe barbadensis Miller (Aloe vera) in F344/N rats and B6C3F1 mice (drinking water study), Natl. Toxicol. Program Tech. Rep. Ser., 2013, 577, 1-266
    • Natl. Toxicol. Program Tech. Rep. Ser. , vol.577 , pp. 1-266
  • 8
    • 84876581405 scopus 로고    scopus 로고
    • Toxicologic assessment of a commercial decolorized whole leaf aloe vera juice, lily of the desert filtered whole leaf juice with aloesorb
    • I. Sehgal W. D. Winters M. Scott A. David G. Gillis T. Stoufflet A. Nair K. Kousoulas Toxicologic assessment of a commercial decolorized whole leaf aloe vera juice, lily of the desert filtered whole leaf juice with aloesorb J. Toxicol. 2013 2013 802453
    • (2013) J. Toxicol. , vol.2013 , pp. 802453
    • Sehgal, I.1    Winters, W.D.2    Scott, M.3    David, A.4    Gillis, G.5    Stoufflet, T.6    Nair, A.7    Kousoulas, K.8
  • 10
    • 0037046667 scopus 로고    scopus 로고
    • Status of certain additional over-the-counter drug category II and III active ingredients. Final rule
    • FDA
    • FDA Status of certain additional over-the-counter drug category II and III active ingredients. Final rule Fed. Regist. 2002 67 31125 31127
    • (2002) Fed. Regist. , vol.67 , pp. 31125-31127
  • 12
    • 79952296197 scopus 로고    scopus 로고
    • Photocarcinogenesis study of aloe vera [CAS NO. 481-72-1(Aloe-emodin)] in SKH-1 mice (simulated solar light and topical application study)
    • NTP
    • NTP Photocarcinogenesis study of aloe vera [CAS NO. 481-72-1(Aloe-emodin)] in SKH-1 mice (simulated solar light and topical application study) Natl. Toxicol. Program Tech. Rep. Ser. 2010 533 7 110
    • (2010) Natl. Toxicol. Program Tech. Rep. Ser. , vol.533 , pp. 7-110
  • 13
    • 84872410230 scopus 로고    scopus 로고
    • Clear evidence of carcinogenic activity by a whole-leaf extract of Aloe barbadensis miller (Aloe vera) in F344/N rats
    • M. D. Boudreau P. W. Mellick G. R. Olson R. P. Felton B. T. Thorn F. A. Beland Clear evidence of carcinogenic activity by a whole-leaf extract of Aloe barbadensis miller (Aloe vera) in F344/N rats Toxicol. Sci. 2013 131 26 39
    • (2013) Toxicol. Sci. , vol.131 , pp. 26-39
    • Boudreau, M.D.1    Mellick, P.W.2    Olson, G.R.3    Felton, R.P.4    Thorn, B.T.5    Beland, F.A.6
  • 14
    • 0036886916 scopus 로고    scopus 로고
    • The influence of long-term Aloe vera ingestion on age-related disease in male Fischer 344 rats
    • Y. Ikeno G. B. Hubbard S. Lee B. P. Yu J. T. Herlihy The influence of long-term Aloe vera ingestion on age-related disease in male Fischer 344 rats Phytother. Res. 2002 16 712 718
    • (2002) Phytother. Res. , vol.16 , pp. 712-718
    • Ikeno, Y.1    Hubbard, G.B.2    Lee, S.3    Yu, B.P.4    Herlihy, J.T.5
  • 15
    • 84876303184 scopus 로고    scopus 로고
    • Safety of purified decolorized (low anthraquinone) whole leaf Aloe vera (L) Burm f juice in a 3-month drinking water toxicity study in F344 rats
    • A. Shao A. Broadmeadow G. Goddard E. Bejar V. Frankos Safety of purified decolorized (low anthraquinone) whole leaf Aloe vera (L) Burm. f. juice in a 3-month drinking water toxicity study in F344 rats Food Chem. Toxicol. 2013 57 21 31
    • (2013) Food Chem. Toxicol. , vol.57 , pp. 21-31
    • Shao, A.1    Broadmeadow, A.2    Goddard, G.3    Bejar, E.4    Frankos, V.5
  • 16
    • 84873743663 scopus 로고    scopus 로고
    • An in vitro and in vivo toxicologic evaluation of a stabilized aloe vera gel supplement drink in mice
    • I. Sehgal W. D. Winters M. Scott K. Kousoulas An in vitro and in vivo toxicologic evaluation of a stabilized aloe vera gel supplement drink in mice Food Chem. Toxicol. 2013 55 363 370
    • (2013) Food Chem. Toxicol. , vol.55 , pp. 363-370
    • Sehgal, I.1    Winters, W.D.2    Scott, M.3    Kousoulas, K.4
  • 17
    • 84891904722 scopus 로고    scopus 로고
    • Methods for using the mouse lymphoma assay to screen for chemical mutagenicity and photo-mutagenicity
    • in, ed. G. W. Caldwell and Z. Yan, Humana Press, New York, 561-592
    • N. Mei, X. Guo and M. M. Moore, Methods for using the mouse lymphoma assay to screen for chemical mutagenicity and photo-mutagenicity, in Optimization in Drug Discovery: In Vitro Methods, ed., G. W. Caldwell, and, Z. Yan, Humana Press, New York, 2014, pp. 561-592
    • (2014) Optimization in Drug Discovery: In Vitro Methods
    • Mei, N.1    Guo, X.2    Moore, M.M.3
  • 19
    • 33845260110 scopus 로고    scopus 로고
    • Photomutagenicity of anhydroretinol and 5,6-epoxyretinyl palmitate in mouse lymphoma cells
    • N. Mei Q. Xia L. Chen M. M. Moore T. Chen P. P. Fu Photomutagenicity of anhydroretinol and 5,6-epoxyretinyl palmitate in mouse lymphoma cells Chem. Res. Toxicol. 2006 19 1435 1440
    • (2006) Chem. Res. Toxicol. , vol.19 , pp. 1435-1440
    • Mei, N.1    Xia, Q.2    Chen, L.3    Moore, M.M.4    Chen, T.5    Fu, P.P.6
  • 20
    • 76549107081 scopus 로고    scopus 로고
    • Cytotoxicity and mutagenicity of retinol with ultraviolet A irradiation in mouse lymphoma cells
    • N. Mei J. Hu Q. Xia P. P. Fu M. M. Moore T. Chen Cytotoxicity and mutagenicity of retinol with ultraviolet A irradiation in mouse lymphoma cells Toxicol. In Vitro 2010 24 439 444
    • (2010) Toxicol. in Vitro , vol.24 , pp. 439-444
    • Mei, N.1    Hu, J.2    Xia, Q.3    Fu, P.P.4    Moore, M.M.5    Chen, T.6
  • 21
    • 79952307634 scopus 로고    scopus 로고
    • Mutagenicity of 11 cigarette smoke condensates in two versions of the mouse lymphoma assay
    • X. Guo T. L. Verkler Y. Chen P. A. Richter G. M. Polzin M. M. Moore N. Mei Mutagenicity of 11 cigarette smoke condensates in two versions of the mouse lymphoma assay Mutagenesis 2011 26 273 281
    • (2011) Mutagenesis , vol.26 , pp. 273-281
    • Guo, X.1    Verkler, T.L.2    Chen, Y.3    Richter, P.A.4    Polzin, G.M.5    Moore, M.M.6    Mei, N.7
  • 22
    • 18044367138 scopus 로고    scopus 로고
    • Mutagenic effects of 4-hydroxynonenal triacetate, a chemically protected form of the lipid peroxidation product 4-hydroxynonenal, as assayed in L5178Y/Tk+/- mouse lymphoma cells
    • S. P. Singh T. Chen L. Chen N. Mei E. McLain V. Samokyszyn J. J. Thaden M. M. Moore P. Zimniak Mutagenic effects of 4-hydroxynonenal triacetate, a chemically protected form of the lipid peroxidation product 4-hydroxynonenal, as assayed in L5178Y/Tk+/- mouse lymphoma cells J. Pharmacol. Exp. Ther. 2005 313 855 861
    • (2005) J. Pharmacol. Exp. Ther. , vol.313 , pp. 855-861
    • Singh, S.P.1    Chen, T.2    Chen, L.3    Mei, N.4    McLain, E.5    Samokyszyn, V.6    Thaden, J.J.7    Moore, M.M.8    Zimniak, P.9
  • 25
    • 27644571180 scopus 로고    scopus 로고
    • Photomutagenicity of retinyl palmitate by ultraviolet a irradiation in mouse lymphoma cells
    • N. Mei Q. Xia L. Chen M. M. Moore P. P. Fu T. Chen Photomutagenicity of retinyl palmitate by ultraviolet a irradiation in mouse lymphoma cells Toxicol. Sci. 2005 88 142 149
    • (2005) Toxicol. Sci. , vol.88 , pp. 142-149
    • Mei, N.1    Xia, Q.2    Chen, L.3    Moore, M.M.4    Fu, P.P.5    Chen, T.6
  • 27
    • 84907997481 scopus 로고    scopus 로고
    • OECD, Proposal for updating testing guideline 473-In vitro mammalian chromosomal aberration test
    • OECD, Proposal for updating testing guideline 473-In vitro mammalian chromosomal aberration test, http://www.oecd.org/env/ehs/testing/TG473-Dec2013-WNT4thCR.pdf, 2013
    • (2013)
  • 28
    • 34047217354 scopus 로고    scopus 로고
    • 3′-azido-3′-deoxythymidine induces deletions in L5178Y mouse lymphoma cells
    • J. Wang T. Chen M. Honma L. Chen M. M. Moore 3′-azido-3′-deoxythymidine induces deletions in L5178Y mouse lymphoma cells Environ. Mol. Mutagen. 2007 48 248 257
    • (2007) Environ. Mol. Mutagen. , vol.48 , pp. 248-257
    • Wang, J.1    Chen, T.2    Honma, M.3    Chen, L.4    Moore, M.M.5
  • 29
    • 34249106703 scopus 로고    scopus 로고
    • Determination of the anthraquinones aloe-emodin and aloin-A by liquid chromatography with mass spectrometric and diode array detection
    • M. A. Elsohly W. Gul B. Avula I. A. Khan Determination of the anthraquinones aloe-emodin and aloin-A by liquid chromatography with mass spectrometric and diode array detection J. AOAC Int. 2007 90 28 42
    • (2007) J. AOAC Int. , vol.90 , pp. 28-42
    • Elsohly, M.A.1    Gul, W.2    Avula, B.3    Khan, I.A.4
  • 30
    • 0030714659 scopus 로고    scopus 로고
    • Cytotoxicity of a low molecular weight fraction from Aloe vera (Aloe barbadensis Miller) gel
    • H. Avila J. Rivero F. Herrera G. Fraile Cytotoxicity of a low molecular weight fraction from Aloe vera (Aloe barbadensis Miller) gel Toxicon 1997 35 1423 1430
    • (1997) Toxicon , vol.35 , pp. 1423-1430
    • Avila, H.1    Rivero, J.2    Herrera, F.3    Fraile, G.4
  • 31
    • 38549145867 scopus 로고    scopus 로고
    • Aloin induces apoptosis in Jurkat cells
    • E. J. Buenz Aloin induces apoptosis in Jurkat cells Toxicol. In Vitro 2008 22 422 429
    • (2008) Toxicol. in Vitro , vol.22 , pp. 422-429
    • Buenz, E.J.1
  • 32
    • 0030596126 scopus 로고    scopus 로고
    • Genotoxicity of the laxative drug components emodin, aloe-emodin and danthron in mammalian cells: Topoisomerase II mediated?
    • S. O. Muller I. Eckert W. K. Lutz H. Stopper Genotoxicity of the laxative drug components emodin, aloe-emodin and danthron in mammalian cells: topoisomerase II mediated? Mutat. Res. 1996 371 165 173
    • (1996) Mutat. Res. , vol.371 , pp. 165-173
    • Muller, S.O.1    Eckert, I.2    Lutz, W.K.3    Stopper, H.4
  • 33
    • 0031793967 scopus 로고    scopus 로고
    • Biotransformation of the anthraquinones emodin and chrysophanol by cytochrome P450 enzymes. Bioactivation to genotoxic metabolites
    • S. O. Mueller H. Stopper W. Dekant Biotransformation of the anthraquinones emodin and chrysophanol by cytochrome P450 enzymes. Bioactivation to genotoxic metabolites Drug Metab. Dispos. 1998 26 540 546
    • (1998) Drug Metab. Dispos. , vol.26 , pp. 540-546
    • Mueller, S.O.1    Stopper, H.2    Dekant, W.3
  • 34
    • 78549231954 scopus 로고    scopus 로고
    • Emodin triggers DNA double-strand breaks by stabilizing topoisomerase II-DNA cleavage complexes and by inhibiting ATP hydrolysis of topoisomerase II
    • Y. Li Y. Luan X. Qi M. Li L. Gong X. Xue X. Wu Y. Wu M. Chen G. Xing J. Yao J. Ren Emodin triggers DNA double-strand breaks by stabilizing topoisomerase II-DNA cleavage complexes and by inhibiting ATP hydrolysis of topoisomerase II Toxicol. Sci. 2010 118 435 443
    • (2010) Toxicol. Sci. , vol.118 , pp. 435-443
    • Li, Y.1    Luan, Y.2    Qi, X.3    Li, M.4    Gong, L.5    Xue, X.6    Wu, X.7    Wu, Y.8    Chen, M.9    Xing, G.10    Yao, J.11    Ren, J.12
  • 35
    • 0025011002 scopus 로고
    • Hydroxyanthraquinones as tumor promoters: Enhancement of malignant transformation of C3H mouse fibroblasts and growth stimulation of primary rat hepatocytes
    • D. Wolfle C. Schmutte J. Westendorf H. Marquardt Hydroxyanthraquinones as tumor promoters: enhancement of malignant transformation of C3H mouse fibroblasts and growth stimulation of primary rat hepatocytes Cancer Res. 1990 50 6540 6544
    • (1990) Cancer Res. , vol.50 , pp. 6540-6544
    • Wolfle, D.1    Schmutte, C.2    Westendorf, J.3    Marquardt, H.4
  • 36
    • 68349133588 scopus 로고    scopus 로고
    • Aloe-emodin-induced DNA fragmentation in the mouse in vivo comet assay
    • F. Nesslany S. Simar-Meintieres H. Ficheux D. Marzin Aloe-emodin-induced DNA fragmentation in the mouse in vivo comet assay Mutat. Res. 2009 678 13 19
    • (2009) Mutat. Res. , vol.678 , pp. 13-19
    • Nesslany, F.1    Simar-Meintieres, S.2    Ficheux, H.3    Marzin, D.4
  • 37
    • 33845986355 scopus 로고    scopus 로고
    • Photo-irradiation of Aloe vera by UVA-formation of free radicals, singlet oxygen, superoxide, and induction of lipid peroxidation
    • Q. Xia J. J. Yin P. P. Fu M. D. Boudreau Photo-irradiation of Aloe vera by UVA-formation of free radicals, singlet oxygen, superoxide, and induction of lipid peroxidation Toxicol. Lett. 2007 168 165 175
    • (2007) Toxicol. Lett. , vol.168 , pp. 165-175
    • Xia, Q.1    Yin, J.J.2    Fu, P.P.3    Boudreau, M.D.4
  • 40
    • 0038734411 scopus 로고    scopus 로고
    • Bromate induces loss of heterozygosity in the thymidine kinase gene of L5178Y/Tk(+/-)-3.7.2C mouse lymphoma cells
    • K. Harrington-Brock D. D. Collard T. Chen Bromate induces loss of heterozygosity in the thymidine kinase gene of L5178Y/Tk(+/-)-3.7.2C mouse lymphoma cells Mutat. Res. 2003 537 21 28
    • (2003) Mutat. Res. , vol.537 , pp. 21-28
    • Harrington-Brock, K.1    Collard, D.D.2    Chen, T.3
  • 41
    • 0032781218 scopus 로고    scopus 로고
    • Characterization of the genotoxicity of anthraquinones in mammalian cells
    • S. O. Mueller H. Stopper Characterization of the genotoxicity of anthraquinones in mammalian cells Biochim. Biophys. Acta 1999 1428 406 414
    • (1999) Biochim. Biophys. Acta , vol.1428 , pp. 406-414
    • Mueller, S.O.1    Stopper, H.2
  • 42
    • 0030005876 scopus 로고    scopus 로고
    • Genotoxicity of aloeemodin in vitro and in vivo
    • A. Heidemann W. Volkner U. Mengs Genotoxicity of aloeemodin in vitro and in vivo Mutat. Res. 1996 367 123 133
    • (1996) Mutat. Res. , vol.367 , pp. 123-133
    • Heidemann, A.1    Volkner, W.2    Mengs, U.3
  • 43
    • 34447551703 scopus 로고    scopus 로고
    • Genetic toxicity assessment: Employing the best science for human safety evaluation part IV: A strategy in genotoxicity testing in drug development: Some examples
    • E. Lorge V. Gervais N. Becourt-Lhote C. Maisonneuve J. L. Delongeas N. Claude Genetic toxicity assessment: employing the best science for human safety evaluation part IV: a strategy in genotoxicity testing in drug development: some examples Toxicol. Sci. 2007 98 39 42
    • (2007) Toxicol. Sci. , vol.98 , pp. 39-42
    • Lorge, E.1    Gervais, V.2    Becourt-Lhote, N.3    Maisonneuve, C.4    Delongeas, J.L.5    Claude, N.6
  • 44
    • 84871931422 scopus 로고    scopus 로고
    • Evaluation of the highest concentrations used in the in vitro chromosome aberrations assay
    • L. Brookmire J. J. Chen D. D. Levy Evaluation of the highest concentrations used in the in vitro chromosome aberrations assay Environ. Mol. Mutagen. 2013 54 36 43
    • (2013) Environ. Mol. Mutagen. , vol.54 , pp. 36-43
    • Brookmire, L.1    Chen, J.J.2    Levy, D.D.3
  • 45
    • 2142845959 scopus 로고    scopus 로고
    • Aloe vera: A valuable ingredient for the food, pharmaceutical and cosmetic industries-a review
    • K. Eshun Q. He Aloe vera: a valuable ingredient for the food, pharmaceutical and cosmetic industries-a review Crit. Rev. Food Sci. Nutr. 2004 44 91 96
    • (2004) Crit. Rev. Food Sci. Nutr. , vol.44 , pp. 91-96
    • Eshun, K.1    He, Q.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.