Mechanistic evaluation of ginkgo biloba leaf extract-induced genotoxicity in L5178Y cells

Toxicological Sciences

Volumn 139, Issue 2, 2014, Pages 338-349

  Lin, Haixia ^a   Guo, Xiaoqing ^a   Zhang, Suhui ^a,b   Dial, Stacey L ^a   Guo, Lei ^a   Manjanatha, Mugimane G ^a   Moore, Martha M ^a,c   Mei, Nan ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b SHANGHAI INSTITUTE FOR FOOD AND DRUG CONTROL   (China)

^c ENVIRON INTERNATIONAL CORPORATION   (United States)

Author keywords

DNA damage; Genotoxicity; Ginkgo biloba leaf extract; Kaempferol; Oxidative stress; Qquercetin 3 d glucoside; Quercetin

Indexed keywords

ANTILEUKEMIC AGENT; BILOBALIDE; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; DOUBLE STRANDED DNA; GINKGO BILOBA EXTRACT; GINKGOLIDE A; GINKGOLIDE B; GINKGOLIDE C; GLUTATHIONE; HISTONE H2AX; ISORHAMNETIN; KAEMPFEROL; QUERCETIN; QUERCETIN 3 BETA DEXTRO GLUCOSIDE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; GINKGO BILOBA EXTRACT 50; KAEMPFEROL DERIVATIVE; MUTAGENIC AGENT; PLANT EXTRACT;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CARCINOGENICITY; CELL VIABILITY; CHROMOSOME 11; CHROMOSOME DAMAGE; COMET ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DIET SUPPLEMENTATION; DNA DAMAGE; DOUBLE STRANDED DNA BREAK; GENE LOCUS; GENOTOXICITY; GINKGO BILOBA; HETEROZYGOSITY LOSS; IN VITRO STUDY; L5178Y CELL LINE; METABOLIC ACTIVATION; MOUSE; MUTAGENICITY; MUTATION RATE; NONHUMAN; OXIDATIVE STRESS; PLANT LEAF; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; CELL LINE; CELL SURVIVAL; CHEMISTRY; CULTURE TECHNIQUE; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; TOXICITY;

ANIMALS; CELL CULTURE TECHNIQUES; CELL LINE; CELL SURVIVAL; COMET ASSAY; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; GINKGO BILOBA; GLUTATHIONE; KAEMPFEROLS; MICE; MUTAGENS; PLANT EXTRACTS; PLANT LEAVES; QUERCETIN; REACTIVE OXYGEN SPECIES;

EID: 84899947283     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu037     Document Type: Article

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