Bromate induces loss of heterozygosity in the Thymidine kinase gene of L5178Y/Tk+/--3.7.2C mouse lymphoma cells

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 537, Issue 1, 2003, Pages 21-28

  Harrington Brock, Karen ^a   Collard, Deborah D ^a   Chen, Tao ^b  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

Bromate; Loss of heterozygosity; Mouse lymphoma assay; Mutation

Indexed keywords

BROMATE; MUTAGENIC AGENT; POTASSIUM BROMATE; SODIUM BROMATE; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ASSAY; CELL STRAIN V 79; CYTOTOXICITY; GENE FREQUENCY; GENE INDUCTION; GENE MUTATION; GENETIC ANALYSIS; GENETIC PARAMETERS; HETEROZYGOSITY LOSS; LYMPHOMA CELL; MOUSE; MOUSE STRAIN; MUTAGEN TESTING; MUTAGENICITY; MUTANT; NONHUMAN; PRIORITY JOURNAL; SURVIVAL;

ANIMALIA; MAMMALIA;

EID: 0038734411     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(03)00044-5     Document Type: Article

References (36)

1. Fiessinger F., Rook J.J., Duguet J.P. Alternative methods for chlorination. Sci. Total Environ. 47:1985;299-315.
2. IARC, Some naturally occurring and synthetic food components, furocoumarines and ultraviolet radiation, in: IARC Monographs on Evaluation of the Carcinogenic Risk of Chemicals to Humans, IARC Scientific Publication, Lyon, France, 1986, pp. 207-220.
3. Kurokawa Y., Aoki S., Matsushima Y., Takamura N., Imazawa T., Hayashi Y. Dose-response studies on the carcinogenicity of potassium bromate in F344 rats after long-term oral administration. J. Natl. Cancer Inst. 77:1986;977-982.
4. Kurokawa Y., Maekawa A., Takahashi M., Hayashi Y. Toxicity and carcinogenicity of potassium bromate - a new renal carcinogen. Environ. Health Perspect. 87:1990;309-335.
5. DeAngelo A.B., George M.H., Kilburn S.R., Moore T.M., Wolf D.C. Carcinogenicity of potassium bromate administered in the drinking water to male B6C3F1 mice and F344/N rats. Toxicol. Pathol. 26:1998;587-594.
6. Ishidate M. Jr., Yoshikawa K. Chromosome aberration tests with Chinese hamster cells in vitro with and without metabolic activation - a comparative study on mutagens and carcinogens. Arch. Toxicol. Suppl. 4:1980;41-44.
7. T. Kawachi, T. Yahagi, T. Kada, Y. Tazima, M. Ishidate, M. Sasaki, T. Sugiyama, Cooperative Programme on Short-Term Assays for Carcinogenicity in Japan, IARC Science Publication, Lyon, France, 1980, pp. 323-330.
8. Ishidate M. Jr., Sofuni T., Yoshikawa K., Hayashi M., Nohmi T., Sawada M., Matsuoka A. Primary mutagenicity screening of food additives currently used in Japan. Food Chem. Toxicol. 22:1984;623-636.
9. Allen J.W., Collins B.W., Lori A., Afshari A.J., George M.H., DeAngelo A.B., Fuscoe J.C. Erythrocyte and spermatid micronucleus analyses in mice chronically exposed to potassium bromate in drinking water. Environ. Mol. Mutagen. 36:2000;250-253.
10. Speit G., Haupter S., Schutz P., Kreis P. Comparative evaluation of the genotoxic properties of potassium bromate and potassium superoxide in V79 Chinese hamster cells. Mutat. Res. 439:1999;213-221.
11. Kasai H., Nishimura S., Kurokawa Y., Hayashi Y. Oral administration of the renal carcinogen, potassium bromate, specifically produces 8-hydroxydeoxyguanosine in rat target organ DNA. Carcinogenesis. 8:1987;1959-1961.
12. Sai K., Uchiyama S., Ohno Y., Hasegawa R., Kurokawa Y. Generation of active oxygen species in vitro by the interaction of potassium bromate with rat kidney cell. Carcinogenesis. 13:1992;333-339.
13. Sai K., Tyson C.A., Thomas D.W., Dabbs J.E., Hasegawa R., Kurokawa Y. Oxidative DNA damage induced by potassium bromate in isolated rat renal proximal tubules and renal nuclei. Cancer Lett. 87:1994;1-7.
14. 3. Cancer Lett. 74:1993;141-145.
15. Ballmaier D., Epe B. Oxidative DNA damage induced by potassium bromate under cell-free conditions and in mammalian cells. Carcinogenesis. 16:1995;335-342.
16. 3), a renal oxidative carcinogen. Mutat. Res. 364:1996;227-233.
17. Sai K., Umemura T., Takagi A., Hasegawa R., Kurokawa Y. The protective role of glutathione, cysteine and Vitamin C against oxidative DNA damage induced in rat kidney by potassium bromate. Jpn. J. Cancer Res. 83:1992;45-51.
18. 3. Free Radic. Biol. Med. 26:1999;1531-1537.
19. Kamiya H., Miura K., Ishikawa H., Inoue H., Nishimura S., Ohtsuka E. c-Ha-ras containing 8-hydroxyguanine at codon 12 induces point mutations at the modified and adjacent positions. Cancer Res. 52:1992;3483-3485.
20. Knudson A.G. Antioncogenes and human cancer. Proc. Natl. Acad. Sci. U.S.A. 90:1993;10914-10921.
21. -/- mutants early in their clonal history. Mutat. Res. 147:1985;237-242.
22. +/- mouse lymphoma cells. Mutat. Res. 151:1985;147-159.
23. +/- mouse lymphoma cells. Mutat. Res. 151:1985;161-174.
24. Blazak W.F., Stewart B.E., Galperin I., Allen K.L., Rudd C.J., Mitchell A.D., Caspary W.J. Chromosome analysis of trifluorothymidine-resistant L5178Y mouse lymphoma cell colonies. Environ. Mutagen. 8:1986;229-240.
25. Applegate M.L., Moore M.M., Broder C.B., Burrell A., Juhn G., Kasweck K.L., Lin P.F., Wadhams A., Hozier J.C. Molecular dissection of mutations at the heterozygous Thymidine kinase locus in mouse lymphoma cells. Proc. Natl. Acad. Sci. U.S.A. 87:1990;51-55.
26. +/--3.7.2C mouse lymphoma cells. Mutagenesis. 17:2002;105-109.
27. -/- mouse lymphoma assay, in: B. Kilbey, M. Legator, C. Ramel (Eds.), Handbook of Mutagenicity Test Procedures, Elsevier, Amsterdam, 1984, pp. 239-268.
28. Clive D., Spector J.F. Laboratory procedure for assessing specific locus mutations at the TK locus in cultured L5178Y mouse lymphoma cells. Mutat. Res. 31:1975;17-29.
29. Chen T., Harrington-Brock K., Moore M.M. Mutant frequency and mutational spectra in the Tk and Hprt genes of N-ethyl-N-nitrosourea-treated mouse lymphoma cells. Environ. Mol. Mutagen. 39:2002;296-305.
30. Rothfuss A., Merk O., Radermacher P., Speit G. Evaluation of mutagenic effects of hyperbaric oxygen (HBO) in vitro. II. Induction of oxidative DNA damage and mutations in the mouse lymphoma assay. Mutat. Res. 471:2000;87-94.
31. Takeuchi T., Matsugo S., Morimoto K. Mutagenicity of oxidative DNA damage in Chinese hamster V79 cells. Carcinogenesis. 18:1997;2051-2055.
32. Nakajima M., Takeuchi T., Ogino K., Morimoto K. Lack of direct involvement of 8-hydroxy-2′-deoxyguanosine in hypoxanthine-guanine phosphoribosyltransferase mutagenesis in V79 cells treated with N,N′-bis(2-hydroxyperoxy-2-methoxyethyl)-1,4,5,8- naphthalenetetracarboxyli c-diimide (NP-III) or riboflavin. Jpn. J. Cancer Res. 93:2002;247-252.
33. Parsons J.L., Chipman J.K. The role of glutathione in DNA damage by potassium bromate in vitro. Mutagenesis. 15:2000;311-316.
34. Weaver D.T. What to do at an end: DNA double-strand-break repair. Trends Genet. 11:1995;388-392.
35. Wijnhoven S.W., Kool H.J., van Teijlingen C.M., van Zeeland A.A., Vrieling H. Loss of heterozygosity in somatic cells of the mouse. An important step in cancer initiation? Mutat. Res. 473:2001;23-36.
36. Honma M., Little J.B. Recombinagenic activity of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate in human lymphoblastoid cells. Carcinogenesis. 16:1995;1717-1722.