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Volumn 371, Issue 3-4, 1996, Pages 165-173

Genotoxicity of the laxative drug components emodin, aloe-emodin and danthron in mammalian cells: Topoisomerase II mediated?

Author keywords

1,8 Dihydroxyanthraquinone; Aloe emodin; Comet assay; Danthron; Emodin; Micronucleus; Mouse L5178Y cell; Topoisomerase II

Indexed keywords

ALOE EMODIN; AMSACRINE; DANTRON; DNA TOPOISOMERASE (ATP HYDROLYSING); EMODIN; ETOPOSIDE; LAXATIVE; VINBLASTINE;

EID: 0030596126     PISSN: 01651218     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1218(96)90105-6     Document Type: Article
Times cited : (138)

References (42)
  • 2
    • 0029167642 scopus 로고
    • Novel anthraquinones from undifferentiated cell cultures of Galium verum
    • Banthorpe D.V., White J.J. Novel anthraquinones from undifferentiated cell cultures of Galium verum. Phytochemistry. 38:1995;107-111.
    • (1995) Phytochemistry , vol.38 , pp. 107-111
    • Banthorpe, D.V.1    White, J.J.2
  • 4
    • 0027373873 scopus 로고
    • Cleavages of the O-and C-Glucosyl Bonds of Anthrone and 10,10′-Bianthrone Derivatives by Human Intestinal Bacteria
    • Hattori M., Akao T., Kobashi K., Namba T. Cleavages of the O-and C-Glucosyl Bonds of Anthrone and 10,10′-Bianthrone Derivatives by Human Intestinal Bacteria. Pharmacology. 47:(suppl. 1):1993;125-133.
    • (1993) Pharmacology , vol.47 , Issue.SUPPL. 1 , pp. 125-133
    • Hattori, M.1    Akao, T.2    Kobashi, K.3    Namba, T.4
  • 7
    • 0027178983 scopus 로고
    • Anthranoid laxative abuse - A risk for colorectal cancer?
    • Siegers C.P., von Hetzberg-Lottin E., Otte M., Schneider B. Anthranoid laxative abuse - a risk for colorectal cancer? Gut. 34:(8):1993;1099-1101.
    • (1993) Gut , vol.34 , Issue.8 , pp. 1099-1101
    • Siegers, C.P.1    Von Hetzberg-Lottin, E.2    Otte, M.3    Schneider, B.4
  • 8
    • 0027407545 scopus 로고
    • Laxative use not a risk for colorectal cancer: Data from the Melbourne colorectal cancer study
    • Kune G.A. Laxative use not a risk for colorectal cancer: data from the Melbourne colorectal cancer study. Z. Gastroenterol. 1:1993;140-143.
    • (1993) Z. Gastroenterol. , vol.1 , pp. 140-143
    • Kune, G.A.1
  • 9
    • 0020693140 scopus 로고
    • Mutagenicity of anthraquinones in the Salmonella preincuabation test
    • Tikkanen L., Matsushima T., Natori S. Mutagenicity of anthraquinones in the Salmonella preincuabation test. Mutat. Res. 116:1983;297-304.
    • (1983) Mutat. Res. , vol.116 , pp. 297-304
    • Tikkanen, L.1    Matsushima, T.2    Natori, S.3
  • 10
    • 0021736323 scopus 로고
    • Lack of activity of the bacterial mutagen emodin in HGPRT and SCE assay with V79 Chinese hamster cells
    • Bruggemann I.M., van der Hoeven J.C.M. Lack of activity of the bacterial mutagen emodin in HGPRT and SCE assay with V79 Chinese hamster cells. Mutat. Res. 138:1984;219-224.
    • (1984) Mutat. Res. , vol.138 , pp. 219-224
    • Bruggemann, I.M.1    Van Der Hoeven, J.C.M.2
  • 11
    • 0023260454 scopus 로고
    • Investigations on DNA binding in rat liver and in Salmonella and on mutagenicity in the Ames test by emodin, a natural anthraquinone
    • Bösch R., Friederich U., Lutz W.K., Brocker E., Bachmann M., Schlatter C. Investigations on DNA binding in rat liver and in Salmonella and on mutagenicity in the Ames test by emodin, a natural anthraquinone. Mutat. Res. 188:1987;161-168.
    • (1987) Mutat. Res. , vol.188 , pp. 161-168
    • Bösch, R.1    Friederich, U.2    Lutz, W.K.3    Brocker, E.4    Bachmann, M.5    Schlatter, C.6
  • 13
    • 0026576710 scopus 로고
    • Mutagenicity of substituted anthraquinones in the Ames/Salmonella microsome system
    • Krivobok S., Seigle-Murandi F., Steiman R., Marzin D.R., Betina V. Mutagenicity of substituted anthraquinones in the Ames/Salmonella microsome system. Mutat. Res. 279:(1):1992;1-8.
    • (1992) Mutat. Res. , vol.279 , Issue.1 , pp. 1-8
    • Krivobok, S.1    Seigle-Murandi, F.2    Steiman, R.3    Marzin, D.R.4    Betina, V.5
  • 14
    • 0028964366 scopus 로고
    • Structure-activity relationships of anthraquinones as inhibitors of 7-ethoxycoumarin O-deethylase and mutagenicity of 2-amino-3-methylimidazo(4,5-f)quinoline
    • Hao N.J., Huang M.P., Lee H. Structure-activity relationships of anthraquinones as inhibitors of 7-ethoxycoumarin O-deethylase and mutagenicity of 2-amino-3-methylimidazo(4,5-f)quinoline. Mutat. Res. 328:1995;183-191.
    • (1995) Mutat. Res. , vol.328 , pp. 183-191
    • Hao, N.J.1    Huang, M.P.2    Lee, H.3
  • 15
    • 0029030412 scopus 로고
    • Emodin inhibits the mutagenicity and DNA adducts induced by 1-nitropyrene
    • Su H.Y., Cheng S.H., Chen C.C., Lee H. Emodin inhibits the mutagenicity and DNA adducts induced by 1-nitropyrene. Mutat. Res. 329:1995;205-212.
    • (1995) Mutat. Res. , vol.329 , pp. 205-212
    • Su, H.Y.1    Cheng, S.H.2    Chen, C.C.3    Lee, H.4
  • 16
    • 0023850985 scopus 로고
    • Cytotoxic and mutagenic effects of emodin on cultured mouse carcinoma FM3A cells
    • Morita H., Umeda H., Masuda T., Ueno Y. Cytotoxic and mutagenic effects of emodin on cultured mouse carcinoma FM3A cells. Mutat. Res. 204:1988;329-332.
    • (1988) Mutat. Res. , vol.204 , pp. 329-332
    • Morita, H.1    Umeda, H.2    Masuda, T.3    Ueno, Y.4
  • 17
    • 0021927266 scopus 로고
    • 2-Hydroxy-emodin, an active metabolite of emodin in the hepatic microsomes of rats
    • Masuda T., Hairakawa K., Morooka N., Nakano S., Ueno Y. 2-Hydroxy-emodin, an active metabolite of emodin in the hepatic microsomes of rats. Mutat. Res. 149:1985;327-332.
    • (1985) Mutat. Res. , vol.149 , pp. 327-332
    • Masuda, T.1    Hairakawa, K.2    Morooka, N.3    Nakano, S.4    Ueno, Y.5
  • 19
    • 0018854928 scopus 로고
    • A review of the genetic effects of the naturally occuring flavonoids, anthraquinones and related compounds
    • Brown J.P. A review of the genetic effects of the naturally occuring flavonoids, anthraquinones and related compounds. Mutat. Res. 75:1980;243-277.
    • (1980) Mutat. Res. , vol.75 , pp. 243-277
    • Brown, J.P.1
  • 20
    • 8944252222 scopus 로고
    • Genotoxicity, cell transformation and growth stimulation (promotion) in vitro induced by hydroxyanthraquinones
    • 7th Edn.
    • Wölfle D., Westendorf J., Schmutte C., Dominiak M., Poginski B., Marquardt H. Genotoxicity, cell transformation and growth stimulation (promotion) in vitro induced by hydroxyanthraquinones. 7th Edn. Proc. Amer. Canc. Res. 30:1989;142.
    • (1989) Proc. Amer. Canc. Res. , vol.30 , pp. 142
    • Wölfle, D.1    Westendorf, J.2    Schmutte, C.3    Dominiak, M.4    Poginski, B.5    Marquardt, H.6
  • 21
    • 0019839096 scopus 로고
    • Accion clastogenica de un compuesto antraguinonico en linfocitos humanos
    • Carballo M.A., D'Aquino M., Aranda E.I. Accion clastogenica de un compuesto antraguinonico en linfocitos humanos. Medicina (Buenos Aires). 41:1981;531-534.
    • (1981) Medicina (Buenos Aires) , vol.41 , pp. 531-534
    • Carballo, M.A.1    D'Aquino, M.2    Aranda, E.I.3
  • 22
    • 0028970785 scopus 로고
    • Clastogenicity of anthraquinones in V79 and in three derived cell lines expressing P450 enzymes
    • Simi S., Morelli S., Gervasi P.G., Rainaldi G. Clastogenicity of anthraquinones in V79 and in three derived cell lines expressing P450 enzymes. Mutat. Res. 347:1995;151-156.
    • (1995) Mutat. Res. , vol.347 , pp. 151-156
    • Simi, S.1    Morelli, S.2    Gervasi, P.G.3    Rainaldi, G.4
  • 23
    • 0013947605 scopus 로고
    • Interaction between deoxyribonucleic acid and some anthracene and anthraquinone derivatives
    • Swanbeck G. Interaction between deoxyribonucleic acid and some anthracene and anthraquinone derivatives. Biochem. Biophys. Acta. 123:1966;630-633.
    • (1966) Biochem. Biophys. Acta , vol.123 , pp. 630-633
    • Swanbeck, G.1
  • 24
    • 0028122271 scopus 로고
    • Mutagenicity and carcinogenicity of topoisomerase-interactive agents
    • Anderson R.D., Berger N.A. Mutagenicity and carcinogenicity of topoisomerase-interactive agents. Mutation Research. 309:1994;109-142.
    • (1994) Mutation Research , vol.309 , pp. 109-142
    • Anderson, R.D.1    Berger, N.A.2
  • 25
    • 0024499711 scopus 로고
    • DNA topoisomerase II must act at mitosis to prevent nondisjunction and chromosomes breakage
    • Holm C., Stearns T., Bostein D. DNA topoisomerase II must act at mitosis to prevent nondisjunction and chromosomes breakage. Mol. Cell. Biol. 9:1989;159-168.
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 159-168
    • Holm, C.1    Stearns, T.2    Bostein, D.3
  • 26
    • 0025938867 scopus 로고
    • Inhibitors of topoisomerase II prevent chromatid separation in mammalian cells but do not prevent exit from mitosis
    • 7th Edn.
    • Downes C.S., Mullinger A.M., Johnson R.T. Inhibitors of topoisomerase II prevent chromatid separation in mammalian cells but do not prevent exit from mitosis. 7th Edn. Proc. Natl. Acad. Sci. USA. 88:1991;8895-8899.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 8895-8899
    • Downes, C.S.1    Mullinger, A.M.2    Johnson, R.T.3
  • 27
    • 0024997668 scopus 로고
    • The role of DNA topoisomerases in recombination and genomic stability: A double-edged sword?
    • Wang J.R., Caron P.R., Kim R.A. The role of DNA topoisomerases in recombination and genomic stability: a double-edged sword? Cell. 62:1990;403-406.
    • (1990) Cell , vol.62 , pp. 403-406
    • Wang, J.R.1    Caron, P.R.2    Kim, R.A.3
  • 28
    • 0023411590 scopus 로고
    • Hypothesis: Some mutagens directly alter specific chromosomal proteins (DNA topoisomerase II and peripheral proteins) to produce chromosome stickiness, which causes chromosome aberrations
    • Gaulden M.E. Hypothesis: some mutagens directly alter specific chromosomal proteins (DNA topoisomerase II and peripheral proteins) to produce chromosome stickiness, which causes chromosome aberrations. Mutagenesis. 2:1987;357-365.
    • (1987) Mutagenesis , vol.2 , pp. 357-365
    • Gaulden, M.E.1
  • 29
    • 0023919963 scopus 로고
    • A simple technique for quantitation of low levels of DNA dammage in individual cells
    • Singh N.P., McCoy M.T., Tice R.R., Schneider E.L. A simple technique for quantitation of low levels of DNA dammage in individual cells. Exp. Cell Res. 175:1988;184-191.
    • (1988) Exp. Cell Res. , vol.175 , pp. 184-191
    • Singh, N.P.1    McCoy, M.T.2    Tice, R.R.3    Schneider, E.L.4
  • 30
    • 0027956970 scopus 로고
    • Is micronucleus induction by aneugens an early event leading to mutagenesis?
    • Stopper H., Eckert I., Schiffmann D., Spencer D.L., Caspary W.J. Is micronucleus induction by aneugens an early event leading to mutagenesis? Mutagenesis. 9:(5):1994;411-416.
    • (1994) Mutagenesis , vol.9 , Issue.5 , pp. 411-416
    • Stopper, H.1    Eckert, I.2    Schiffmann, D.3    Spencer, D.L.4    Caspary, W.J.5
  • 31
    • 0029095542 scopus 로고
    • The use of the L5178Y mouse lymphoma cells to assess mutagenic, clastogenic and aneugenic activity of chemicals
    • Combes R.D., Stopper H., Caspary W.J. The use of the L5178Y mouse lymphoma cells to assess mutagenic, clastogenic and aneugenic activity of chemicals. Mutagenesis. 10:(5):1995;403-408.
    • (1995) Mutagenesis , vol.10 , Issue.5 , pp. 403-408
    • Combes, R.D.1    Stopper, H.2    Caspary, W.J.3
  • 32
    • 0028267015 scopus 로고
    • Megabase pair deletions in mutant mammalian cells following exposure to amsacrine, an inhibitor of DNA topoisomerase II
    • Shibuya M.L., Ueno A.M., Vannais D.B., Craven P.A., Waldren C.A. Megabase pair deletions in mutant mammalian cells following exposure to amsacrine, an inhibitor of DNA topoisomerase II. Cancer Res. 54:1994;1092-1097.
    • (1994) Cancer Res. , vol.54 , pp. 1092-1097
    • Shibuya, M.L.1    Ueno, A.M.2    Vannais, D.B.3    Craven, P.A.4    Waldren, C.A.5
  • 35
    • 0019321213 scopus 로고
    • Decatenation of kinetoplast DNA by topoisomerase
    • Marini J.C., Miller K.G., Englund P.T. Decatenation of kinetoplast DNA by topoisomerase. J. Biol. Chem. 255:1980;4976-4979.
    • (1980) J. Biol. Chem. , vol.255 , pp. 4976-4979
    • Marini, J.C.1    Miller, K.G.2    Englund, P.T.3
  • 36
    • 0021682073 scopus 로고
    • Enhancement of intercalator-induced deoxyribonucleic acid scission and cytotoxicity in murine leukemia cells treated with 5-azacytidine
    • Zwelling L.A., Minford J., Nichols M., Glazier R.I., Shackney S. Enhancement of intercalator-induced deoxyribonucleic acid scission and cytotoxicity in murine leukemia cells treated with 5-azacytidine. Biochem. Pharmacol. 33:(23):1984;3903-3906.
    • (1984) Biochem. Pharmacol. , vol.33 , Issue.23 , pp. 3903-3906
    • Zwelling, L.A.1    Minford, J.2    Nichols, M.3    Glazier, R.I.4    Shackney, S.5
  • 37
    • 0025817295 scopus 로고
    • Inhibition of replicon initiation in human cells following stabilization of topoisomerase-DNA cleavable complexes
    • Kaufmann W.K., Boyer J.C., Estabrooks L.L., Wilson S.J. Inhibition of replicon initiation in human cells following stabilization of topoisomerase-DNA cleavable complexes. Mol. Cell. Biol. 11:(7):1991;3711-3718.
    • (1991) Mol. Cell. Biol. , vol.11 , Issue.7 , pp. 3711-3718
    • Kaufmann, W.K.1    Boyer, J.C.2    Estabrooks, L.L.3    Wilson, S.J.4
  • 38
    • 0029036445 scopus 로고
    • The role of cell cycle regulation and apoptosis triggering in determining the sensitivity of leukemic cells to topoisomerase I and II inhibitors
    • Topo II
    • Dubrez L., Goldwasser F., Genne P., Pommier Y., Solary E. The role of cell cycle regulation and apoptosis triggering in determining the sensitivity of leukemic cells to topoisomerase I and II inhibitors. Leukemia. 9:(6):1995;1013-1024. Topo II.
    • (1995) Leukemia , vol.9 , Issue.6 , pp. 1013-1024
    • Dubrez, L.1    Goldwasser, F.2    Genne, P.3    Pommier, Y.4    Solary, E.5
  • 39
    • 0025305451 scopus 로고
    • Detection of etoposide resistance by measuring DNA damage in individual Chinese hamster cells
    • Olive P.L., Banath J.P., Durand R.E. Detection of etoposide resistance by measuring DNA damage in individual Chinese hamster cells. J. Natl. Cancer Inst. 82:1990;779-783.
    • (1990) J. Natl. Cancer Inst. , vol.82 , pp. 779-783
    • Olive, P.L.1    Banath, J.P.2    Durand, R.E.3
  • 40
    • 0027429286 scopus 로고
    • Detection of DNA double-strand breaks through the cell cycle after exposure to X-rays, bleomycin, etoposide and 1251dUrd
    • Olive P.L., Banath J.P. Detection of DNA double-strand breaks through the cell cycle after exposure to X-rays, bleomycin, etoposide and 1251dUrd. Int. J. Radiat. Biol. 64:1993;349-358.
    • (1993) Int. J. Radiat. Biol. , vol.64 , pp. 349-358
    • Olive, P.L.1    Banath, J.P.2
  • 41
    • 0011372043 scopus 로고
    • Formation of micronuclei and inhibition of topoisomerase II in the comet-assay in mammalian cells with altered DNA-methylation
    • in press
    • Stopper H., Eckert I., Wagener P., Schulz W. Formation of micronuclei and inhibition of topoisomerase II in the comet-assay in mammalian cells with altered DNA-methylation. Recent Results Cancer Res. 1995;. in press.
    • (1995) Recent Results Cancer Res.
    • Stopper, H.1    Eckert, I.2    Wagener, P.3    Schulz, W.4


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