-
1
-
-
0028243033
-
Cellular and molecular biology of Alzheimer's disease and animal models
-
Price DL, Sisodia SS (1994) Cellular and molecular biology of Alzheimer's disease and animal models. Annu Rev Med 45:435-446
-
(1994)
Annu Rev Med
, vol.45
, pp. 435-446
-
-
Price, D.L.1
Sisodia, S.S.2
-
2
-
-
0025753852
-
The molecular pathology of Alzheimer's disease
-
Selkoe DJ (1991) The molecular pathology of Alzheimer's disease. Neuron 6:487-498
-
(1991)
Neuron
, vol.6
, pp. 487-498
-
-
Selkoe, D.J.1
-
3
-
-
0026597063
-
Alzheimer's disease: The amyloid cascade hypothesis
-
Hardy JA, Higgins GA (1992) Alzheimer's disease: the amyloid cascade hypothesis. Science 256:184-185
-
(1992)
Science
, vol.256
, pp. 184-185
-
-
Hardy, J.A.1
Higgins, G.A.2
-
4
-
-
0033536163
-
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
-
Schenk DJ, Barbour R, Dunn W et al (1999) Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400:173-177
-
(1999)
Nature
, vol.400
, pp. 173-177
-
-
Schenk, D.J.1
Barbour, R.2
Dunn, W.3
-
5
-
-
84984755327
-
A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
-
Morgan D, Diamond DM, Gottschall PE et al (2000) A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature 408:982-985
-
(2000)
Nature
, vol.408
, pp. 982-985
-
-
Morgan, D.1
Diamond, D.M.2
Gottschall, P.E.3
-
6
-
-
0033835996
-
Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
-
Bard F, Cannon C, Barbour R (2000) Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med 6:916-919
-
(2000)
Nat Med
, vol.6
, pp. 916-919
-
-
Bard, F.1
Cannon, C.2
Barbour, R.3
-
7
-
-
0035902619
-
Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease
-
DeMattos RB, Bales KR, Cummins DJ (2001) Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 98:8850-8855
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 8850-8855
-
-
Demattos, R.B.1
Bales, K.R.2
Cummins, D.J.3
-
8
-
-
0036240395
-
Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model
-
Dodart JC, Bales KR, Gannon KS et al (2002) Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model. Nat Neurosci 5:452-457
-
(2002)
Nat Neurosci
, vol.5
, pp. 452-457
-
-
Dodart, J.C.1
Bales, K.R.2
Gannon, K.S.3
-
9
-
-
0037393454
-
Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: A case report
-
Nicoll JA, Wilkinson D, Holmes C et al (2003) Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nat Med 9:448-452
-
(2003)
Nat Med
, vol.9
, pp. 448-452
-
-
Nicoll, J.A.1
Wilkinson, D.2
Holmes, C.3
-
10
-
-
1042265187
-
Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease
-
Ferrer I, Rovira MB, Guerra MLS et al (2004) Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease. Brain Pathol 14:11-20
-
(2004)
Brain Pathol
, vol.14
, pp. 11-20
-
-
Ferrer, I.1
Rovira, M.B.2
Guerra, M.3
-
11
-
-
19944429065
-
Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease
-
Masliah E, Hansen L, Adame A et al (2005) Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease. Neurology 64:129-131
-
(2005)
Neurology
, vol.64
, pp. 129-131
-
-
Masliah, E.1
Hansen, L.2
Adame, A.3
-
13
-
-
33748767945
-
Amyloid-beta peptide remnants in AN-1792-immunized Alzheimer's disease patients: A biochemical analysis
-
Patton RL, Kalback WM, Esh CL (2006) Amyloid-beta peptide remnants in AN-1792-immunized Alzheimer's disease patients: a biochemical analysis. Am J Pathol 169:1048-1063
-
(2006)
Am J Pathol
, vol.169
, pp. 1048-1063
-
-
Patton, R.L.1
Kalback, W.M.2
Esh, C.L.3
-
14
-
-
47149112621
-
Long-term effects of Abeta42 immunization in Alzheimer's disease: Follow-up of a randomised, placebo-controlled phase I trial
-
Holmes C, Boche D, Wilkinson D et al (2008) Long-term effects of Abeta42 immunization in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet 372: 216-223
-
(2008)
Lancet
, vol.372
, pp. 216-223
-
-
Holmes, C.1
Boche, D.2
Wilkinson, D.3
-
15
-
-
20944448555
-
Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial
-
Gilman S, Koller M, Black RS et al (2005) Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial. Neurology 64:1553-1562
-
(2005)
Neurology
, vol.64
, pp. 1553-1562
-
-
Gilman, S.1
Koller, M.2
Black, R.S.3
-
16
-
-
11444267243
-
Evaluation of the safety and immunogenicity of synthetic Abeta42 (AN1792) in patients with AD
-
Bayer AJ, Bullock R, Jones RW et al (2005) Evaluation of the safety and immunogenicity of synthetic Abeta42 (AN1792) in patients with AD. Neurology 64:94-101
-
(2005)
Neurology
, vol.64
, pp. 94-101
-
-
Bayer, A.J.1
Bullock, R.2
Jones, R.W.3
-
17
-
-
0037384333
-
Adjuvant-dependent modulation ofTh1 and Th2 responses to immunization with beta-amyloid
-
Cribbs DH, Ghochikyan A, Tran M et al (2003) Adjuvant-dependent modulation ofTh1 and Th2 responses to immunization with beta-amyloid. Int Immunol 15:505-514
-
(2003)
Int Immunol
, vol.15
, pp. 505-514
-
-
Cribbs, D.H.1
Ghochikyan, A.2
Tran, M.3
-
18
-
-
0037452779
-
Epitope and isotype specificities of antibodies to beta-amyloid peptide for protection against Alzheimer's disease-like neuropathology
-
Bard F, Barbour R, Cannon C et al (2003) Epitope and isotype specificities of antibodies to beta-amyloid peptide for protection against Alzheimer's disease-like neuropathology. Proc Natl Acad Sci U S A 100:2023-2028
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 2023-2028
-
-
Bard, F.1
Barbour, R.2
Cannon, C.3
-
19
-
-
24644458809
-
Abeta42 immunization in Alzheimer's disease generates Abeta N-terminal antibodies
-
Lee M, Bard F, Johnson-Wood K (2005) Abeta42 immunization in Alzheimer's disease generates Abeta N-terminal antibodies. Ann Neurol 58:430-435
-
(2005)
Ann Neurol
, vol.58
, pp. 430-435
-
-
Lee, M.1
Bard, F.2
Johnson-Wood, K.3
-
20
-
-
0036852750
-
Therapeutically effective antibodies against amyloid-beta peptide target amyloidbeta residues 4-10 and inhibit cytotoxicity and fibrillogenesis
-
McLaurin J, Cecal R, Kierstead ME et al (2002) Therapeutically effective antibodies against amyloid-beta peptide target amyloidbeta residues 4-10 and inhibit cytotoxicity and fibrillogenesis. Nat Med 8:1263-1269
-
(2002)
Nat Med
, vol.8
, pp. 1263-1269
-
-
McLaurin, J.1
Cecal, R.2
Kierstead, M.E.3
-
21
-
-
0035854603
-
Characterization of murine immunoglobulin G antibodies against human amyloid-b 1-42
-
Town T, Tan J, Sansone N et al (2001) Characterization of murine immunoglobulin G antibodies against human amyloid-b 1-42. Neurosci Lett 307:101-104
-
(2001)
Neurosci Lett
, vol.307
, pp. 101-104
-
-
Town, T.1
Tan, J.2
Sansone, N.3
-
22
-
-
0035694891
-
Duration and specificity of humoral immune responses in mice vaccinated with the Alzheimer's disease-associated beta-amyloid 1-42 peptide
-
Dickey CA, Morgan DG, Kudchodkar S et al (2001) Duration and specificity of humoral immune responses in mice vaccinated with the Alzheimer's disease-associated beta-amyloid 1-42 peptide. DNA Cell Biol 20(11):723-729
-
(2001)
DNA Cell Biol
, vol.20
, Issue.11
, pp. 723-729
-
-
Dickey, C.A.1
Morgan, D.G.2
Kudchodkar, S.3
-
23
-
-
0035689690
-
Nasal vaccination with beta-amyloid peptide for the treatment of Alzheimer's disease
-
Lemere CA, Maron R, Selkoe DJ et al (2001) Nasal vaccination with beta-amyloid peptide for the treatment of Alzheimer's disease. DNA Cell Biol 20:705-711
-
(2001)
DNA Cell Biol
, vol.20
, pp. 705-711
-
-
Lemere, C.A.1
Maron, R.2
Selkoe, D.J.3
-
24
-
-
0034530636
-
Nasal Aß treatment induces anti-Aß antibody production and decreases cerebral amyloid burden in PD-APP mice
-
Lemere CA, Maron R, Spooner ET et al (2000) Nasal Aß treatment induces anti-Aß antibody production and decreases cerebral amyloid burden in PD-APP mice. Ann N Y Acad Sci 920:328-331
-
(2000)
Ann N Y Acad Sci
, vol.920
, pp. 328-331
-
-
Lemere, C.A.1
Maron, R.2
Spooner, E.T.3
-
25
-
-
0041886776
-
Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease
-
Monsonego A, Zota V, Karni A (2003) Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease. J Clin Invest 112(3):415-422
-
(2003)
J Clin Invest
, vol.112
, Issue.3
, pp. 415-422
-
-
Monsonego, A.1
Zota, V.2
Karni, A.3
-
26
-
-
3242694207
-
An attenuated immune response is sufficient to enhance cognition in an Alzheimer's disease mouse model immunized with amyloidbeta derivatives
-
Sigurdsson EM, Knudsen E, Asuni A et al (2004) An attenuated immune response is sufficient to enhance cognition in an Alzheimer's disease mouse model immunized with amyloidbeta derivatives. J Neurosci 24:6277-6282
-
(2004)
J Neurosci
, vol.24
, pp. 6277-6282
-
-
Sigurdsson, E.M.1
Knudsen, E.2
Asuni, A.3
-
27
-
-
0036137241
-
ProPred: Prediction of HLA-DR binding sites
-
Singh H, Raghava GP (2001) ProPred: prediction of HLA-DR binding sites. Bioinformatics 17:1236-1237
-
(2001)
Bioinformatics
, vol.17
, pp. 1236-1237
-
-
Singh, H.1
Raghava, G.P.2
-
28
-
-
0037606124
-
ProPred1: Prediction of promiscuous MHC Class-I binding sites
-
Singh H, Raghava GP (2003) ProPred1: prediction of promiscuous MHC Class-I binding sites. Bioinformatics 19:1009-1014
-
(2003)
Bioinformatics
, vol.19
, pp. 1009-1014
-
-
Singh, H.1
Raghava, G.P.2
-
29
-
-
0041589303
-
Immune responses against Abeta1-42 in HLA class II transgenic mice: Implications for Abeta1-42 immune-mediated therapies
-
Das P, Chapoval S, Howard V et al (2003) Immune responses against Abeta1-42 in HLA class II transgenic mice: implications for Abeta1-42 immune-mediated therapies. Neurobiol Aging 24:969-996
-
(2003)
Neurobiol Aging
, vol.24
, pp. 969-996
-
-
Das, P.1
Chapoval, S.2
Howard, V.3
-
30
-
-
36248941497
-
Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/ oligomeric A{beta} species in amyloid precursor protein transgenic mice
-
Petrushina I, Ghochikyan A, Mktrichyan M et al (2007) Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/ oligomeric A{beta} species in amyloid precursor protein transgenic mice. J Neurosci 27:12721-12731
-
(2007)
J Neurosci
, vol.27
, pp. 12721-12731
-
-
Petrushina, I.1
Ghochikyan, A.2
Mktrichyan, M.3
-
31
-
-
47749107621
-
Reducing AD-like pathology in 3xTg-AD mouse model by DNA epitope vaccine-a novel immunotherapeutic strategy
-
Movsesyan N, Ghochikyan A, Mkrtichyan M et al (2008) Reducing AD-like pathology in 3xTg-AD mouse model by DNA epitope vaccine-a novel immunotherapeutic strategy. PLos One 3:e21
-
(2008)
Plos One
, vol.3
-
-
Movsesyan, N.1
Ghochikyan, A.2
Mkrtichyan, M.3
-
32
-
-
84878805578
-
Refinement of a DNA based Alzheimer's disease epitope vaccine in rabbits
-
Ghochikyan A, Davtyan H, Petrushina I et al (2013) Refinement of a DNA based Alzheimer's disease epitope vaccine in rabbits. Hum Vaccin Immunother 9:1002-1010
-
(2013)
Hum Vaccin Immunother
, vol.9
, pp. 1002-1010
-
-
Ghochikyan, A.1
Davtyan, H.2
Petrushina, I.3
-
33
-
-
84874901987
-
Immunogenicity, efficacy, safety, and mechanism of action of epitope vaccine (Lu AF20513) for Alzheimer's disease: Prelude to a clinical trial
-
Davtyan H, Ghochikyan A, Petrushina I et al (2013) Immunogenicity, efficacy, safety, and mechanism of action of epitope vaccine (Lu AF20513) for Alzheimer's disease: prelude to a clinical trial. J Neurosci 33:4923-4934
-
(2013)
J Neurosci
, vol.33
, pp. 4923-4934
-
-
Davtyan, H.1
Ghochikyan, A.2
Petrushina, I.3
-
35
-
-
0034141839
-
Linear PADRE T helper epitope and carbohydrate B cell epitope conjugates induce specific high titer IgG antibody responses
-
Alexander J, del Guercio MF, Maewal A (2000) Linear PADRE T helper epitope and carbohydrate B cell epitope conjugates induce specific high titer IgG antibody responses. J Immunol 164:1625-1633
-
(2000)
J Immunol
, vol.164
, pp. 1625-1633
-
-
Alexander, J.1
Del Guercio, M.F.2
Maewal, A.3
-
36
-
-
67649635732
-
Rationale for peptide and DNA based epitope vaccines for Alzheimer's disease immunotherapy
-
Ghochikyan A (2009) Rationale for peptide and DNA based epitope vaccines for Alzheimer's disease immunotherapy. CNS Neurol Disord Drug Targets 8:128-143
-
(2009)
CNS Neurol Disord Drug Targets
, vol.8
, pp. 128-143
-
-
Ghochikyan, A.1
-
37
-
-
0037472429
-
Induction of immune responses by DNA vaccines in large animals
-
Babiuk LA, Pontarollo R, Babiuk S et al (2003) Induction of immune responses by DNA vaccines in large animals. Vaccine 21:649-658
-
(2003)
Vaccine
, vol.21
, pp. 649-658
-
-
Babiuk, L.A.1
Pontarollo, R.2
Babiuk, S.3
-
39
-
-
33644884230
-
Immunotherapy for Alzheimer's disease: Potential problems and possible solutions
-
Cribbs DH, Agadjanyan MG (2005) Immunotherapy for Alzheimer's disease: potential problems and possible solutions. Curr Immunol Rev 1:139-155
-
(2005)
Curr Immunol Rev
, vol.1
, pp. 139-155
-
-
Cribbs, D.H.1
Agadjanyan, M.G.2
|