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Volumn 24, Issue 7, 2003, Pages 969-976

Immune responses against Aβ1-42 in HLA class II transgenic mice: Implications for Aβ1-42 immune-mediated therapies

Author keywords

Alzheimer's disease; A vaccination; A 1 42; MHC class II; Tg2576 mice

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; AMYLOID BETA PROTEIN[1-42] ANTIBODY; ANTIBODY; HLA ANTIGEN CLASS 2; HLA DQ ANTIGEN; HLA DR3 ANTIGEN; HLA DR4 ANTIGEN; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); PEPTIDE FRAGMENT;

EID: 0041589303     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-4580(03)00036-8     Document Type: Article
Times cited : (29)

References (29)
  • 1
    • 0035863759 scopus 로고    scopus 로고
    • Type 1 diabetes-predisposing MHC alleles influence the selection of glutamic acid decarboxylase (GAD) 65-specific T cells in a transgenic model
    • Abraham R.S., Wen L., Marietta E.V., David C.S. Type 1 diabetes-predisposing MHC alleles influence the selection of glutamic acid decarboxylase (GAD) 65-specific T cells in a transgenic model. J. Immunol. 166(2):2001;1370-1379.
    • (2001) J. Immunol. , vol.166 , Issue.2 , pp. 1370-1379
    • Abraham, R.S.1    Wen, L.2    Marietta, E.V.3    David, C.S.4
  • 2
    • 0035106780 scopus 로고    scopus 로고
    • Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy
    • Bacskai B.J., Kajdasz S.T., Christie R.H., Carter C., Games D., Seubert P.et al. Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy. Nat. Med. 7(3):2001;369-372.
    • (2001) Nat. Med. , vol.7 , Issue.3 , pp. 369-372
    • Bacskai, B.J.1    Kajdasz, S.T.2    Christie, R.H.3    Carter, C.4    Games, D.5    Seubert, P.6
  • 3
    • 0025331496 scopus 로고
    • Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitus
    • Baisch J.M., Weeks T., Giles R., Hoover M., Stastny P., Capra J.D. Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitus. N. Engl. J. Med. 322(26):1990;1836-1841.
    • (1990) N. Engl. J. Med. , vol.322 , Issue.26 , pp. 1836-1841
    • Baisch, J.M.1    Weeks, T.2    Giles, R.3    Hoover, M.4    Stastny, P.5    Capra, J.D.6
  • 4
    • 0033835996 scopus 로고    scopus 로고
    • Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
    • Bard F., Cannon C., Barbour R., Burke R.L., Games D., Grajeda H.et al. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat. Med. 6:2000;916-919.
    • (2000) Nat. Med. , vol.6 , pp. 916-919
    • Bard, F.1    Cannon, C.2    Barbour, R.3    Burke, R.L.4    Games, D.5    Grajeda, H.6
  • 5
    • 0022637559 scopus 로고
    • HLA-DQ beta-chain polymorphism linked to myasthenia gravis
    • Bell J., Rassenti L., Smoot S., Smith K., Newby C., Hohlfeld R.et al. HLA-DQ beta-chain polymorphism linked to myasthenia gravis. Lancet. 1(8489):1986;1058-1060.
    • (1986) Lancet , vol.1 , Issue.8489 , pp. 1058-1060
    • Bell, J.1    Rassenti, L.2    Smoot, S.3    Smith, K.4    Newby, C.5    Hohlfeld, R.6
  • 6
    • 0037080361 scopus 로고    scopus 로고
    • Allergic inflammatory response to short ragweed allergenic extract in HLA-DQ transgenic mice lacking CD4 gene
    • Chapoval S.P., Iijima K., Marietta E.V., Smart M.K., Chapoval A.I., Andrews A.G.et al. Allergic inflammatory response to short ragweed allergenic extract in HLA-DQ transgenic mice lacking CD4 gene. J. Immunol. 168(2):2002;890-899.
    • (2002) J. Immunol. , vol.168 , Issue.2 , pp. 890-899
    • Chapoval, S.P.1    Iijima, K.2    Marietta, E.V.3    Smart, M.K.4    Chapoval, A.I.5    Andrews, A.G.6
  • 7
    • 0032586666 scopus 로고    scopus 로고
    • An HLA-DRB1 × 0402 derived peptide (HV3 65-79) prevents collagen-induced arthritis in HLA-DQ8 transgenic mice
    • Das P., Bradley D.S., Geluk A., Griffiths M.M., Luthra H.S., David C.S. An HLA-DRB1 × 0402 derived peptide (HV3 65-79) prevents collagen-induced arthritis in HLA-DQ8 transgenic mice. Hum. Immunol. 60(7):1999;575-582.
    • (1999) Hum. Immunol. , vol.60 , Issue.7 , pp. 575-582
    • Das, P.1    Bradley, D.S.2    Geluk, A.3    Griffiths, M.M.4    Luthra, H.S.5    David, C.S.6
  • 8
    • 0033994751 scopus 로고    scopus 로고
    • Complementation between specific HLA-DR and HLA-DQ genes in transgenic mice determines susceptibility to experimental autoimmune encephalomyelitis
    • Das P., Drescher K.M., Geluk A., Bradley D.S., Rodriguez M., David C.S. Complementation between specific HLA-DR and HLA-DQ genes in transgenic mice determines susceptibility to experimental autoimmune encephalomyelitis. Hum. Immunol. 61(3):2000;279-289.
    • (2000) Hum. Immunol. , vol.61 , Issue.3 , pp. 279-289
    • Das, P.1    Drescher, K.M.2    Geluk, A.3    Bradley, D.S.4    Rodriguez, M.5    David, C.S.6
  • 9
    • 0034746897 scopus 로고    scopus 로고
    • Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition
    • Das P., Murphy M.P., Younkin L.H., Younkin S.G., Golde T.E. Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition. Neurobiol. Aging. 122(5):2001;721-727.
    • (2001) Neurobiol. Aging , vol.122 , Issue.5 , pp. 721-727
    • Das, P.1    Murphy, M.P.2    Younkin, L.H.3    Younkin, S.G.4    Golde, T.E.5
  • 10
    • 0035902619 scopus 로고    scopus 로고
    • Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease
    • DeMattos R.B., Bales K.R., Cummins D.J., Dodart J.C., Paul S.M., Holtzman D.M. Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 98(15):2001;8850-8855.
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , Issue.15 , pp. 8850-8855
    • DeMattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Dodart, J.C.4    Paul, S.M.5    Holtzman, D.M.6
  • 11
    • 0036240395 scopus 로고    scopus 로고
    • Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model
    • Dodart J.C., Bales K.R., Gannon K.S., Greene S.J., DeMattos R.B., Mathis C.et al. Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model. Nat. Neurosci. 5(5):2002;452-457.
    • (2002) Nat. Neurosci. , vol.5 , Issue.5 , pp. 452-457
    • Dodart, J.C.1    Bales, K.R.2    Gannon, K.S.3    Greene, S.J.4    DeMattos, R.B.5    Mathis, C.6
  • 12
    • 0028985574 scopus 로고
    • Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
    • Games D., Adams D., Alessandrini R., Barbour R., Berthelette P., Blackwell C.et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature. 373:1995;523-527.
    • (1995) Nature , vol.373 , pp. 523-527
    • Games, D.1    Adams, D.2    Alessandrini, R.3    Barbour, R.4    Berthelette, P.5    Blackwell, C.6
  • 13
    • 0038255971 scopus 로고    scopus 로고
    • Population studies
    • Terasaki PI, Gjertson DW, editors. Los Angeles, California: UCLA Tissue Typing Laboratory.
    • Gjertson DW, Geer L, Lee S-H, Kawata J, Sutrisno R. Population studies. In: Terasaki PI, Gjertson DW, editors. HLA 1997. Los Angeles, California: UCLA Tissue Typing Laboratory.
    • HLA 1997
    • Gjertson, D.W.1    Geer, L.2    Lee, S.-H.3    Kawata, J.4    Sutrisno, R.5
  • 14
    • 0034718027 scopus 로고    scopus 로고
    • Biochemical detection of Abeta isoforms: Implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease
    • Golde T.E., Eckman C.B., Younkin S.G. Biochemical detection of Abeta isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease. Biochem. Biophys. Acta. 1502:2000;172-187.
    • (2000) Biochem. Biophys. Acta , vol.1502 , pp. 172-187
    • Golde, T.E.1    Eckman, C.B.2    Younkin, S.G.3
  • 16
    • 0036853548 scopus 로고    scopus 로고
    • Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease
    • Hock C., Konietzko U., Papassotiropoulos A., Wollmer A., Streffer J., Von Rotz R.C.et al. Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease. Nat. Med. 8(11):2002;1270-1275.
    • (2002) Nat. Med. , vol.8 , Issue.11 , pp. 1270-1275
    • Hock, C.1    Konietzko, U.2    Papassotiropoulos, A.3    Wollmer, A.4    Streffer, J.5    Von Rotz, R.C.6
  • 17
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
    • Hsiao K., Chapman P., Nilsen S., Eckman C., Harigaya Y., Younkin S.et al. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science. 274:1996;99-102.
    • (1996) Science , vol.274 , pp. 99-102
    • Hsiao, K.1    Chapman, P.2    Nilsen, S.3    Eckman, C.4    Harigaya, Y.5    Younkin, S.6
  • 18
    • 0034700471 scopus 로고    scopus 로고
    • Abeta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
    • Janus C., Pearson J., McLaurin J., Mathews P.M., Jiang Y., Schmidt S.D.et al. Abeta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature. 408:2000;979-982.
    • (2000) Nature , vol.408 , pp. 979-982
    • Janus, C.1    Pearson, J.2    McLaurin, J.3    Mathews, P.M.4    Jiang, Y.5    Schmidt, S.D.6
  • 20
    • 0034530636 scopus 로고    scopus 로고
    • Nasal A beta treatment induces anti-A beta antibody production and decreases cerebral amyloid burden in PDAPP mice
    • Lemere C.A., Maron R., Spooner E.T., Grenfell T.J., Mori C., Desai R.et al. Nasal A beta treatment induces anti-A beta antibody production and decreases cerebral amyloid burden in PDAPP mice. Ann. NY Acad. Sci. 920:2000;328-331.
    • (2000) Ann. NY Acad. Sci. , vol.920 , pp. 328-331
    • Lemere, C.A.1    Maron, R.2    Spooner, E.T.3    Grenfell, T.J.4    Mori, C.5    Desai, R.6
  • 21
    • 0035964312 scopus 로고    scopus 로고
    • Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: Implications for the pathogenesis and treatment of Alzheimer's disease
    • Monsonego A., Maron R., Zota V., Selkoe D.J., Weiner H.L. Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: implications for the pathogenesis and treatment of Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 98(18):2001;10273-10278.
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , Issue.18 , pp. 10273-10278
    • Monsonego, A.1    Maron, R.2    Zota, V.3    Selkoe, D.J.4    Weiner, H.L.5
  • 22
    • 84984755327 scopus 로고    scopus 로고
    • A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
    • Morgan D., Diamond D.M., Gottschall P.E., Ugen K.E., Dickey C., Hardy J.et al. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature. 408:2000;982-985.
    • (2000) Nature , vol.408 , pp. 982-985
    • Morgan, D.1    Diamond, D.M.2    Gottschall, P.E.3    Ugen, K.E.4    Dickey, C.5    Hardy, J.6
  • 23
    • 0030058644 scopus 로고    scopus 로고
    • HLA-DQ8 transgenic mice are highly susceptible to collagen-induced arthritis: A novel model for human polyarthritis
    • Nabozny G.H., Baisch J.M., Cheng S., Cosgrove D., Griffiths M.M., Luthra H.S.et al. HLA-DQ8 transgenic mice are highly susceptible to collagen-induced arthritis: a novel model for human polyarthritis. J. Exp. Med. 183(1):1996;27-37.
    • (1996) J. Exp. Med. , vol.183 , Issue.1 , pp. 27-37
    • Nabozny, G.H.1    Baisch, J.M.2    Cheng, S.3    Cosgrove, D.4    Griffiths, M.M.5    Luthra, H.S.6
  • 24
    • 0025817428 scopus 로고
    • MHC class-II molecules and autoimmunity
    • Nepom G.T., Erlich H. MHC class-II molecules and autoimmunity. Annu. Rev. Immunol. 9:1991;493-525.
    • (1991) Annu. Rev. Immunol. , vol.9 , pp. 493-525
    • Nepom, G.T.1    Erlich, H.2
  • 25
    • 0036604136 scopus 로고    scopus 로고
    • HLA class II influences the immune response and antibody diversification to Ro60/Sjögren's syndrome-A: Heightened antibody responses and epitope spreading in mice expressing HLA-DR molecules
    • Paisansinsup T., Deshmukh U.S., Chowdhary V.R., Luthra H.S., Fu S.M., David C.S. HLA class II influences the immune response and antibody diversification to Ro60/Sjögren's syndrome-A: heightened antibody responses and epitope spreading in mice expressing HLA-DR molecules. J. Immunol. 168(11):2002;5876-5884.
    • (2002) J. Immunol. , vol.168 , Issue.11 , pp. 5876-5884
    • Paisansinsup, T.1    Deshmukh, U.S.2    Chowdhary, V.R.3    Luthra, H.S.4    Fu, S.M.5    David, C.S.6
  • 26
    • 0033536163 scopus 로고    scopus 로고
    • Immunization with amyloid-beta attenuates Alzheimer disease-like pathology in the PDAPP mouse
    • Schenk D., Barbour R., Dunn W., Gordon G., Grajeda H., Guido T.et al. Immunization with amyloid-beta attenuates Alzheimer disease-like pathology in the PDAPP mouse. Nature. 400:1999;173-177.
    • (1999) Nature , vol.400 , pp. 173-177
    • Schenk, D.1    Barbour, R.2    Dunn, W.3    Gordon, G.4    Grajeda, H.5    Guido, T.6
  • 28
    • 0026591609 scopus 로고
    • Cellular studies on antigen presentation by class II MHC molecules
    • Unanue E.R. Cellular studies on antigen presentation by class II MHC molecules. Curr. Opin. Immunol. 4(1):1992;63-69.
    • (1992) Curr. Opin. Immunol. , vol.4 , Issue.1 , pp. 63-69
    • Unanue, E.R.1
  • 29
    • 0029896354 scopus 로고    scopus 로고
    • Mechanisms of neuronal degeneration in Alzheimer's disease
    • Yankner B.A. Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron. 16:1996;921-932.
    • (1996) Neuron , vol.16 , pp. 921-932
    • Yankner, B.A.1


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