The Deubiquitinating Enzyme USP5 Modulates Neuropathic and Inflammatory Pain by Enhancing Cav3.2 Channel Activity

Neuron

Volumn 83, Issue 5, 2014, Pages 1144-1158

  García Caballero, Agustin ^a   Gadotti, Vinicius M ^a   Stemkowski, Patrick ^a   Weiss, Norbert ^a   Souza, Ivana A ^a   Hodgkinson, Victoria ^a   Bladen, Chris ^a   Chen, Lina ^a   Hamid, Jawed ^a   Pizzoccaro, Anne ^b   Deage, Mickael ^b   François, Amaury ^b   Bourinet, Emmanuel ^b   Zamponi, Gerald W ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b INSTITUT DE GÉNOMIQUE FONCTIONNELLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; CALCIUM CHANNEL T TYPE; CALCUIM CHANNEL CAV3.2; DEUBIQUITINASE; POLYPEPTIDE; PROTEIN USP5; PROTEIN WWP1; SHORT HAIRPIN RNA; TYROSYLGLYCYLARGINYLLYSYLLYSYLARGINYLARGINYLGLUTAMINYLARGINYLARGINYLGLUTAMYLALANYLARGINYLARGINYLARGINYLGLUTAMYLGLUTAMYLLYSYLARGINYLLEUCYLARGINYLARGINYLLEUCYLGLUTAMYLARGINYLARGINYLARGINYLARGINYLLYSYLALANYLGLUTAMINE; TYROSYLGLYCYLARGINYLLYSYLLYSYLARGINYLARGINYLMETHIONYLLYSYLHISTIDYLLEUCYLGLUTAMYLGLUTAMYLSERYLASPARAGINYLLYSYLGLUTAMYLALANYLARGINYLGLUTAMYLASPARTYLALANYLGLUTAMYLLEUCYLASPARTLYALANYLGLUTAMYLISOLEUCYLGLUTAMYLLEUCYLGLUTAMYLMETHIONE; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; CA(V)3.2 PROTEIN, MOUSE; FREUND ADJUVANT; NERVE PROTEIN; PEPTIDE; PROTEINASE; UBIQUITIN ISOPEPTIDASE;

AMINO ACID SEQUENCE; ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; ENZYME REGULATION; GENE SILENCING; HYPERSENSITIVITY; IN VIVO STUDY; INFLAMMATORY PAIN; MOUSE; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; PERIPHERAL NERVE INJURY; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEOMICS; SPINAL CORD NERVE CELL; SPINAL GANGLION; UBIQUITINATION; USP5 GENE; ANIMAL; C57BL MOUSE; CELL CULTURE; CHEMICALLY INDUCED DISORDER; CYTOLOGY; DISEASE MODEL; DRUG EFFECT; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; HUMAN; HYPERALGESIA; IN VITRO STUDY; INFLAMMATION; MALE; MEMBRANE POTENTIAL; METABOLISM; NEURALGIA; PAIN THRESHOLD; PATHOPHYSIOLOGY; PHYSIOLOGY; SENSORY RECEPTOR; SPINAL CORD; TRANSGENIC MOUSE;

ANIMALS; CALCIUM CHANNELS, T-TYPE; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENDOPEPTIDASES; FREUND'S ADJUVANT; HUMANS; HYPERALGESIA; INFLAMMATION; MALE; MEMBRANE POTENTIALS; MICE, INBRED C57BL; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; NEURALGIA; PAIN THRESHOLD; PEPTIDES; SENSORY RECEPTOR CELLS; SPINAL CORD; TRANSFECTION; UBIQUITINATION;

EID: 84907982806     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2014.07.036     Document Type: Article

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