State-dependent properties of a new T-type calcium channel blocker enhance CaV3.2 selectivity and support analgesic effects

Pain

Volumn 154, Issue 2, 2013, Pages 283-293

  Francois, Amaury ^a,b   Kerckhove, Nicolas ^c,d   Meleine, Mathieu ^c,d   Alloui, Abdelkrim ^c,d   Barrere, Christian ^a,b   Gelot, Agathe ^c,d   Uebele, Victor N ^e   Renger, John J ^e   Eschalier, Alain ^c,d,f   Ardid, Denis ^c,d   Bourinet, Emmanuel ^a,b  

^a INSTITUT DE GÉNOMIQUE FONCTIONNELLE   (France)

^b UNIV MONTPELLIER   (France)

^c UNIVERSITÉ CLERMONT AUVERGNE   (France)

^d INSERM   (France)

^e MERCK RESEARCH LABORATORIES   (United States)

^f UNIVERSITY HOSPITAL OF CLERMONT FERRAND   (France)

Author keywords

Analgesia; Colonic hypersensitivity; IBS; Somatic pain; T type calcium channel

Indexed keywords

ANALGESIC AGENT; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL T TYPE; TTA A2; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CHRONIC PAIN; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYPERSENSITIVITY; IRRITABLE COLON; MALE; MOUSE; NERVE CELL EXCITABILITY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; SENSORY NERVE CELL;

EID: 84872680652     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1016/j.pain.2012.10.023     Document Type: Article

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