메뉴 건너뛰기




Volumn 21, Issue 11, 2014, Pages 753-761

Treatment options beyond IFNα and NUCs for chronic HBV infection: Expectations for tomorrow

Author keywords

anti HBV drugs; antiviral treatment; cccDNA; HBV life cycle; inhibitors

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CIRCULAR DNA; CORE PROTEIN; CYCLOSPORIN A; CYCLOSPORIN B; DNA VACCINE; EZETIMIBE; HEPATITIS B CORE ANTIGEN; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B VACCINE; HEPATITIS B(E) ANTIBODY; HEPATITIS B(E) ANTIGEN; NUCLEOSIDE DERIVATIVE; OXYSTEROL; PEGINTERFERON ALPHA; RIBONUCLEASE H; RNA DIRECTED DNA POLYMERASE; SODIUM BILE ACID COTRANSPORTER; SYNTHETIC DNA; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR AGONIST; VIRUS ANTIGEN; VIRUS MESSENGER RNA; VIRUS PROTEIN; ALPHA INTERFERON; ANTIVIRUS AGENT; NUCLEOTIDE;

EID: 84907980499     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/jvh.12307     Document Type: Review
Times cited : (11)

References (68)
  • 1
    • 0030707941 scopus 로고    scopus 로고
    • Hepatitis B virus infection
    • Lee WM,. Hepatitis B virus infection. N Engl J Med 1997; 337: 1733-1745.
    • (1997) N Engl J Med , vol.337 , pp. 1733-1745
    • Lee, W.M.1
  • 2
    • 84881023753 scopus 로고    scopus 로고
    • Long-term results of treatment with nucleoside and nucleotide analogues (entecavir and tenofovir) for chronic hepatitis B
    • Asselah T, Marcellin P,. Long-term results of treatment with nucleoside and nucleotide analogues (entecavir and tenofovir) for chronic hepatitis B. Clin Liver Dis 2013; 17: 445-450.
    • (2013) Clin Liver Dis , vol.17 , pp. 445-450
    • Asselah, T.1    Marcellin, P.2
  • 3
    • 70349240414 scopus 로고    scopus 로고
    • Chronic hepatitis B: Update 2009
    • Lok ASF, McMahon BJ,. Chronic hepatitis B: update 2009. Hepatology 2009; 50: 1-36.
    • (2009) Hepatology , vol.50 , pp. 1-36
    • Lok, A.S.F.1    McMahon, B.J.2
  • 4
    • 84862664371 scopus 로고    scopus 로고
    • EASL clinical practice guidelines: Management of chronic hepatitis B virus infection
    • Buti M, Cornberg M, Mutimer D, Pol S, Raimondo G,. EASL clinical practice guidelines: management of chronic hepatitis B virus infection. J Hepatol 2012; 57: 167-185.
    • (2012) J Hepatol , vol.57 , pp. 167-185
    • Buti, M.1    Cornberg, M.2    Mutimer, D.3    Pol, S.4    Raimondo, G.5
  • 6
    • 0001435504 scopus 로고    scopus 로고
    • Hepadnaviridae: The viruses and their replication
    • Knipe D.M. Griffin D.E. Lamb R.A. Martin M.A. Roizman B. Straus S.E. eds. 4th edn. Philadelphia: Lippincott Williams & Wilkins
    • Ganem D, Schneider RJ,. Hepadnaviridae: the viruses and their replication. In:, Knipe DM, Griffin DE, Lamb RA, Martin MA, Roizman B, Straus SE, eds. Fields Virology, 4th edn. Philadelphia: Lippincott Williams & Wilkins, 2001: 2923-2969.
    • (2001) Fields Virology , pp. 2923-2969
    • Ganem, D.1    Schneider, R.J.2
  • 7
    • 1542316127 scopus 로고    scopus 로고
    • Hepatitis B virus infection-natural history and clinical consequences
    • Ganem D, Prince AM,. Hepatitis B virus infection-natural history and clinical consequences. N Engl J Med 2004; 350: 1118-1129.
    • (2004) N Engl J Med , vol.350 , pp. 1118-1129
    • Ganem, D.1    Prince, A.M.2
  • 8
    • 84879327902 scopus 로고    scopus 로고
    • Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus
    • Yan H, Zhong G, Xu G, et al,. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. Elife 2012; 1: e00049.
    • (2012) Elife , vol.1 , pp. e00049
    • Yan, H.1    Zhong, G.2    Xu, G.3
  • 9
    • 0022538381 scopus 로고
    • Identification and chemical synthesis of a host cell receptor binding site on hepatitis B virus
    • Neurath AR, Kent SB, Strick N, Parker K,. Identification and chemical synthesis of a host cell receptor binding site on hepatitis B virus. Cell 1986; 46: 429-436.
    • (1986) Cell , vol.46 , pp. 429-436
    • Neurath, A.R.1    Kent, S.B.2    Strick, N.3    Parker, K.4
  • 10
    • 0024347431 scopus 로고
    • Antibodies to synthetic peptides from the preS1 region of the hepatitis B virus (HBV) envelope (env) protein are virus-neutralizing and protective
    • Neurath AR, Seto B, Strick N,. Antibodies to synthetic peptides from the preS1 region of the hepatitis B virus (HBV) envelope (env) protein are virus-neutralizing and protective. Vaccine 1989; 7: 234-236.
    • (1989) Vaccine , vol.7 , pp. 234-236
    • Neurath, A.R.1    Seto, B.2    Strick, N.3
  • 11
    • 84896394502 scopus 로고    scopus 로고
    • Cyclosporin A inhibits hepatitis B and hepatitis D virus entry by cyclophilin-independent interference with the NTCP receptor
    • Nkongolo S, Ni Y, Lempp FA, et al,. Cyclosporin A inhibits hepatitis B and hepatitis D virus entry by cyclophilin-independent interference with the NTCP receptor. J Hepatol 2014; 60: 723-731.
    • (2014) J Hepatol , vol.60 , pp. 723-731
    • Nkongolo, S.1    Ni, Y.2    Lempp, F.A.3
  • 12
    • 84899486063 scopus 로고    scopus 로고
    • Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter, sodium taurocholate cotransporting polypeptide (NTCP)
    • Watashi K, Sluder A, Daito T, et al,. Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter, sodium taurocholate cotransporting polypeptide (NTCP). Hepatology 2014; 59: 1726-1737.
    • (2014) Hepatology , vol.59 , pp. 1726-1737
    • Watashi, K.1    Sluder, A.2    Daito, T.3
  • 13
    • 84893702742 scopus 로고    scopus 로고
    • Evaluation and identification of hepatitis B virus entry inhibitors using HepG2 cells overexpressing a membrane transporter NTCP
    • Iwamoto M, Watashi K, Tsukuda S, et al,. Evaluation and identification of hepatitis B virus entry inhibitors using HepG2 cells overexpressing a membrane transporter NTCP. Biochem Biophys Res Commun 2014; 443: 808-813.
    • (2014) Biochem Biophys Res Commun , vol.443 , pp. 808-813
    • Iwamoto, M.1    Watashi, K.2    Tsukuda, S.3
  • 14
    • 13744257618 scopus 로고    scopus 로고
    • Efficient inhibition of hepatitis B virus infection by acylated peptides derived from the large viral surface protein
    • Gripon P, Cannie I, Urban S,. Efficient inhibition of hepatitis B virus infection by acylated peptides derived from the large viral surface protein. J Virol 2005; 79: 1613-1622.
    • (2005) J Virol , vol.79 , pp. 1613-1622
    • Gripon, P.1    Cannie, I.2    Urban, S.3
  • 15
    • 84876295707 scopus 로고    scopus 로고
    • The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus
    • Volz T, Allweiss L, Ben MBarek M, et al,. The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus. J Hepatol 2013; 58: 861-867.
    • (2013) J Hepatol , vol.58 , pp. 861-867
    • Volz, T.1    Allweiss, L.2    Ben Mbarek, M.3
  • 16
    • 84878178356 scopus 로고    scopus 로고
    • Regulation of hepatitis B virus infection by Rab5, Rab7, and the endolysosomal compartment
    • Macovei A, Petrareanu C, Lazar C, Florian P, Branza-Nichita N,. Regulation of hepatitis B virus infection by Rab5, Rab7, and the endolysosomal compartment. J Virol 2013; 87 (11): 6415-6427.
    • (2013) J Virol , vol.87 , Issue.11 , pp. 6415-6427
    • Macovei, A.1    Petrareanu, C.2    Lazar, C.3    Florian, P.4    Branza-Nichita, N.5
  • 17
    • 84856732297 scopus 로고    scopus 로고
    • Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor
    • Sainz B, Barretto N, Martin DN, et al,. Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor. Nat Med 2012; 18: 281-285.
    • (2012) Nat Med , vol.18 , pp. 281-285
    • Sainz, B.1    Barretto, N.2    Martin, D.N.3
  • 18
    • 84872108188 scopus 로고    scopus 로고
    • Ezetimibe blocks hepatitis B virus infection after virus uptake into hepatocytes
    • Lucifora J, Esser K, Protzer U,. Ezetimibe blocks hepatitis B virus infection after virus uptake into hepatocytes. Antiviral Res 2013; 97: 195-197.
    • (2013) Antiviral Res , vol.97 , pp. 195-197
    • Lucifora, J.1    Esser, K.2    Protzer, U.3
  • 19
    • 46049093989 scopus 로고    scopus 로고
    • J hepatitis B virus-cell interactions and pathogenesis
    • Nguyen DH, Ludgate L, Hu J,. J hepatitis B virus-cell interactions and pathogenesis. J Cell Physiol 2008; 216: 289-294.
    • (2008) J Cell Physiol , vol.216 , pp. 289-294
    • Nguyen, D.H.1    Ludgate, L.2    Hu, J.3
  • 20
    • 0023028191 scopus 로고
    • Formation of the pool of covalently closed circular viral DNA in hepadnavirus-infected cells
    • Tuttleman JS, Pourcel C, Summers J,. Formation of the pool of covalently closed circular viral DNA in hepadnavirus-infected cells. Cell 1986; 47: 451-460.
    • (1986) Cell , vol.47 , pp. 451-460
    • Tuttleman, J.S.1    Pourcel, C.2    Summers, J.3
  • 21
    • 84896029673 scopus 로고    scopus 로고
    • Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA
    • Lucifora J, Xia Y, Reisinger F, Zhang K, Stadler D, et al,. Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Science 2014; 343 (6176): 1221-1228.
    • (2014) Science , vol.343 , Issue.6176 , pp. 1221-1228
    • Lucifora, J.1    Xia, Y.2    Reisinger, F.3    Zhang, K.4    Stadler, D.5
  • 22
    • 33644854241 scopus 로고    scopus 로고
    • Hepatitis B virus replication is regulated by the acetylation status of hepatitis B virus cccDNA-bound H3 and H4 histones
    • Pollicino T, Belloni L, Raffa G, et al,. Hepatitis B virus replication is regulated by the acetylation status of hepatitis B virus cccDNA-bound H3 and H4 histones. Gastroenterology 2006; 130: 823-837.
    • (2006) Gastroenterology , vol.130 , pp. 823-837
    • Pollicino, T.1    Belloni, L.2    Raffa, G.3
  • 23
    • 68049123446 scopus 로고    scopus 로고
    • Nuclear HBx binds in vivo on the HBV minichromosome, modifies the epigenetic regulation of ccc-DNA function and potentiates HBV replication
    • Belloni L, Pollicino T, Cimino L, Raffa G, Raimondo G, Levrero M,. Nuclear HBx binds in vivo on the HBV minichromosome, modifies the epigenetic regulation of ccc-DNA function and potentiates HBV replication. J Hepatol 2008; 48: s25.
    • (2008) J Hepatol , vol.48 , pp. s25
    • Belloni, L.1    Pollicino, T.2    Cimino, L.3    Raffa, G.4    Raimondo, G.5    Levrero, M.6
  • 24
    • 84907964474 scopus 로고    scopus 로고
    • Targeting the cccDNA by epigenetic drugs inhibits HBV transcription and replication
    • Palumbo TG, Belloni L, Pediconi N, Levrero M,. Targeting the cccDNA by epigenetic drugs inhibits HBV transcription and replication. Hepatology 2013; 58 (S1): 650A.
    • (2013) Hepatology , vol.58 , Issue.S1 , pp. 650A
    • Palumbo, T.G.1    Belloni, L.2    Pediconi, N.3    Levrero, M.4
  • 25
    • 0031771112 scopus 로고    scopus 로고
    • Structure and function of the encapsidation signal of hepadnaviridae
    • Kramvis A, Kew MC,. Structure and function of the encapsidation signal of hepadnaviridae. J Viral Hepat 1998; 5: 357-367.
    • (1998) J Viral Hepat , vol.5 , pp. 357-367
    • Kramvis, A.1    Kew, M.C.2
  • 26
    • 0019949367 scopus 로고
    • Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate
    • Summers J, Mason WS,. Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate. Cell 1982; 29: 403-415.
    • (1982) Cell , vol.29 , pp. 403-415
    • Summers, J.1    Mason, W.S.2
  • 27
    • 0028019410 scopus 로고
    • Gene inhibition using antisense oligodeoxynucleotides
    • Wagner RW,. Gene inhibition using antisense oligodeoxynucleotides. Nature 1994; 372: 333-335.
    • (1994) Nature , vol.372 , pp. 333-335
    • Wagner, R.W.1
  • 28
    • 0027053871 scopus 로고
    • Cleavage of hepatitis B virus RNA by three ribozymes transcribed from a single DNA template
    • von Weizsacker F, Blum HE, Wands JR,. Cleavage of hepatitis B virus RNA by three ribozymes transcribed from a single DNA template. Biochem Biophys Res Commun 1992; 189: 743-748.
    • (1992) Biochem Biophys Res Commun , vol.189 , pp. 743-748
    • Von Weizsacker, F.1    Blum, H.E.2    Wands, J.R.3
  • 29
    • 0029586990 scopus 로고
    • Efficient hammerhead ribozyme-mediated cleavage of the structured hepatitis B virus encapsidation signal in vitro and in cell extracts, but not in intact cells
    • Beck J, Nassal M,. Efficient hammerhead ribozyme-mediated cleavage of the structured hepatitis B virus encapsidation signal in vitro and in cell extracts, but not in intact cells. Nucleic Acids Res 1995; 23: 4954-4962.
    • (1995) Nucleic Acids Res , vol.23 , pp. 4954-4962
    • Beck, J.1    Nassal, M.2
  • 30
    • 84908015811 scopus 로고    scopus 로고
    • (accessed 02 June 2014)
    • http://www.arrowheadresearch.com/programs/ARC-520 (accessed 02 June 2014).
  • 31
    • 84890556390 scopus 로고    scopus 로고
    • Serum hepatitis B surface antigen levels and their utility as a predictor of sustained virological response after antiviral treatment
    • Karayiannis P,. Serum hepatitis B surface antigen levels and their utility as a predictor of sustained virological response after antiviral treatment. Hepat Mon 2012; 12: 420-422.
    • (2012) Hepat Mon , vol.12 , pp. 420-422
    • Karayiannis, P.1
  • 32
    • 52249120971 scopus 로고    scopus 로고
    • Inhibition of hepatitis B virus replication by Bay 41-4109 and its association with nucleocapsid disassembly
    • Wu GY, Zheng XJ, Yin CC, et al,. Inhibition of hepatitis B virus replication by Bay 41-4109 and its association with nucleocapsid disassembly. J Chemother 2008; 20: 458-467.
    • (2008) J Chemother , vol.20 , pp. 458-467
    • Wu, G.Y.1    Zheng, X.J.2    Yin, C.C.3
  • 33
    • 84865773658 scopus 로고    scopus 로고
    • In vitro inhibition of HBV replication by a novel compound, GLS4, and its efficacy against adefovir-dipivoxil-resistant HBV mutations
    • Wang XY, Wei ZM, Wu GY, et al,. In vitro inhibition of HBV replication by a novel compound, GLS4, and its efficacy against adefovir-dipivoxil-resistant HBV mutations. Antivir Ther 2012; 17: 793-803.
    • (2012) Antivir Ther , vol.17 , pp. 793-803
    • Wang, X.Y.1    Wei, Z.M.2    Wu, G.Y.3
  • 34
    • 84907988539 scopus 로고    scopus 로고
    • (accessed 27 June 2014)
    • http://www.drugdevelopment-technology.com/news/newsnovira-initiates-phase-ia-trial-of-nvr-1221-to-treat-chronic-hepatitis-b-infection-258446331.html (accessed 27 June 2014).
  • 35
    • 0036227850 scopus 로고    scopus 로고
    • Inhibition of human hepatitis B virus (HBV) by a novel non-nucleosidic compound in a transgenic mouse model
    • Weber O, Schlemmer KH, Hartmann E, et al,. Inhibition of human hepatitis B virus (HBV) by a novel non-nucleosidic compound in a transgenic mouse model. Antiviral Res 2002; 54: 69-78.
    • (2002) Antiviral Res , vol.54 , pp. 69-78
    • Weber, O.1    Schlemmer, K.H.2    Hartmann, E.3
  • 36
    • 82655183566 scopus 로고    scopus 로고
    • Antiviral activity of Bay 41-4109 on hepatitis B virus in humanized Alb-uPA/SCID mice
    • Brezillon N, Brunelle MN, Massinet H, et al,. Antiviral activity of Bay 41-4109 on hepatitis B virus in humanized Alb-uPA/SCID mice. PLoS One 2011; 6 (12): e25096.
    • (2011) PLoS One , vol.6 , Issue.12 , pp. e25096
    • Brezillon, N.1    Brunelle, M.N.2    Massinet, H.3
  • 37
    • 84885924778 scopus 로고    scopus 로고
    • Preclinical characterization of GLS4, an inhibitor of hepatitis B virus core particle assembly
    • Wu G, Liu B, Zhang Y, Li J, et al,. Preclinical characterization of GLS4, an inhibitor of hepatitis B virus core particle assembly. Antimicrob Agents Chemother 2013; 57: 5344-5354.
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 5344-5354
    • Wu, G.1    Liu, B.2    Zhang, Y.3    Li, J.4
  • 38
    • 0028091053 scopus 로고
    • Reverse transcription in hepatitis B viruses is primed by a tyrosine residue of the polymerase
    • Zoulim F, Seeger C,. Reverse transcription in hepatitis B viruses is primed by a tyrosine residue of the polymerase. J Virol 1994; 68: 6-13.
    • (1994) J Virol , vol.68 , pp. 6-13
    • Zoulim, F.1    Seeger, C.2
  • 39
    • 0028300388 scopus 로고
    • Hepadnavirus P protein utilizes a tyrosine residue in the TP domain to prime reverse transcription
    • Weber M, Bronsema V, Bartos H, Bosserhoff A, Bartenschlager R, Schaller H,. Hepadnavirus P protein utilizes a tyrosine residue in the TP domain to prime reverse transcription. J Virol 1994; 68: 2994-2999.
    • (1994) J Virol , vol.68 , pp. 2994-2999
    • Weber, M.1    Bronsema, V.2    Bartos, H.3    Bosserhoff, A.4    Bartenschlager, R.5    Schaller, H.6
  • 40
    • 0030225455 scopus 로고    scopus 로고
    • Hepatitis B virus replication-an update
    • Nassal M, Schaller H,. Hepatitis B virus replication-an update. J Viral Hepat 1996; 3: 217-226.
    • (1996) J Viral Hepat , vol.3 , pp. 217-226
    • Nassal, M.1    Schaller, H.2
  • 41
    • 84907975179 scopus 로고    scopus 로고
    • Direct acting antivirals for the treatment of chronic viral hepatitis
    • Karayiannis P,. Direct acting antivirals for the treatment of chronic viral hepatitis. Scientifica (Cairo) 2012; 2012: 478631.
    • (2012) Scientifica (Cairo) , vol.2012 , pp. 478631
    • Karayiannis, P.1
  • 42
    • 84884542210 scopus 로고    scopus 로고
    • β-Thujaplicinol inhibits hepatitis B virus replication by blocking the viral ribonuclease H activity
    • Hu Y, Cheng X, Cao F, Huang A, Tavis JE,. β-Thujaplicinol inhibits hepatitis B virus replication by blocking the viral ribonuclease H activity. Antiviral Res 2013; 99: 221-229.
    • (2013) Antiviral Res , vol.99 , pp. 221-229
    • Hu, Y.1    Cheng, X.2    Cao, F.3    Huang, A.4    Tavis, J.E.5
  • 43
    • 20044387576 scopus 로고    scopus 로고
    • Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones
    • Budihas SR, Gorshkova I, Gaidamakov S, et al,. Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones. Nucleic Acids Res 2005; 33: 1249-1256.
    • (2005) Nucleic Acids Res , vol.33 , pp. 1249-1256
    • Budihas, S.R.1    Gorshkova, I.2    Gaidamakov, S.3
  • 44
    • 64649098298 scopus 로고    scopus 로고
    • HIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: Implications for RNase H inhibition
    • Beilhartz GL, Wendeler M, Baichoo N, Rausch J, Le Grice S, Götte M,. HIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition. J Mol Biol 2009; 388: 462-474.
    • (2009) J Mol Biol , vol.388 , pp. 462-474
    • Beilhartz, G.L.1    Wendeler, M.2    Baichoo, N.3    Rausch, J.4    Le Grice, S.5    Götte, M.6
  • 45
    • 0029950091 scopus 로고    scopus 로고
    • Hepatitis B virus nucleocapsid envelopment does not occur without genomic DNA synthesis
    • Gerelsaikhan T, Tavis JE, Bruss V,. Hepatitis B virus nucleocapsid envelopment does not occur without genomic DNA synthesis. J Virol 1996; 70: 4269-4272.
    • (1996) J Virol , vol.70 , pp. 4269-4272
    • Gerelsaikhan, T.1    Tavis, J.E.2    Bruss, V.3
  • 46
    • 84908015809 scopus 로고    scopus 로고
    • (accessed 02 June 2014)
    • http://www.medhelp.org/posts/Hepatitis-B/New-REP-9AC-Clinical-Trial-/show/2034553 (accessed 02 June 2014).
  • 47
    • 0034948510 scopus 로고    scopus 로고
    • Efficacy and limitations of a specific immunotherapy in chronic hepatitis B
    • Pol S, Nalpas B, Driss F, et al,. Efficacy and limitations of a specific immunotherapy in chronic hepatitis B. J Hepatol 2001; 34: 917-921.
    • (2001) J Hepatol , vol.34 , pp. 917-921
    • Pol, S.1    Nalpas, B.2    Driss, F.3
  • 48
    • 0032769963 scopus 로고    scopus 로고
    • A pilot study of the CY-1899 T-cell vaccine in subjects chronically infected with hepatitis B virus. The CY1899 T Cell Vaccine Study Group
    • Heathcote J, McHutchison J, Lee S, et al,. A pilot study of the CY-1899 T-cell vaccine in subjects chronically infected with hepatitis B virus. The CY1899 T Cell Vaccine Study Group. Hepatology 1999; 30: 531-536.
    • (1999) Hepatology , vol.30 , pp. 531-536
    • Heathcote, J.1    McHutchison, J.2    Lee, S.3
  • 49
    • 84882811237 scopus 로고    scopus 로고
    • YIC Efficacy Trial Study Team. Results of a phase III clinical trial with an HBsAg-HBIG immunogenic complex therapeutic vaccine for chronic hepatitis B patients: Experiences and findings
    • Xu DZ, Wang XY, Shen XL, et al,. YIC Efficacy Trial Study Team. Results of a phase III clinical trial with an HBsAg-HBIG immunogenic complex therapeutic vaccine for chronic hepatitis B patients: experiences and findings. J Hepatol 2013; 59: 450-456.
    • (2013) J Hepatol , vol.59 , pp. 450-456
    • Xu, D.Z.1    Wang, X.Y.2    Shen, X.L.3
  • 50
    • 84873088935 scopus 로고    scopus 로고
    • A novel therapeutic hepatitis B vaccine induces cellular and humoral immune responses and breaks tolerance in hepatitis B virus (HBV) transgenic mice
    • Buchmann P, Dembek C, Kuklick L, et al,. A novel therapeutic hepatitis B vaccine induces cellular and humoral immune responses and breaks tolerance in hepatitis B virus (HBV) transgenic mice. Vaccine 2013; 31: 1197-1203.
    • (2013) Vaccine , vol.31 , pp. 1197-1203
    • Buchmann, P.1    Dembek, C.2    Kuklick, L.3
  • 51
    • 84908009563 scopus 로고    scopus 로고
    • Therapeutic vaccination for chronic hepatitis B (CHB) using heterologous protein prime/vector boost vaccination scheme
    • (Abstract 752)
    • Jager C, Ringelhan M, Dembek C, Backes S, et al,. Therapeutic vaccination for chronic hepatitis B (CHB) using heterologous protein prime/vector boost vaccination scheme. J Hepatol 2013; 58 (Suppl. 1): S305 (Abstract 752).
    • (2013) J Hepatol , vol.58 , pp. S305
    • Jager, C.1    Ringelhan, M.2    Dembek, C.3    Backes, S.4
  • 52
    • 84925490214 scopus 로고    scopus 로고
    • A phase III clinical trial with a nasal vaccine containing both HBsAg and HBcAg in patients with chronic hepatitis B
    • (Abstract 760)
    • Mahtab MA, Akbar F, Uddin H, Rahman S, et al,. A phase III clinical trial with a nasal vaccine containing both HBsAg and HBcAg in patients with chronic hepatitis B. J Hepatol 2013; 58 (Suppl. 1): S309 (Abstract 760).
    • (2013) J Hepatol , vol.58 , pp. S309
    • Mahtab, M.A.1    Akbar, F.2    Uddin, H.3    Rahman, S.4
  • 53
    • 84908014925 scopus 로고    scopus 로고
    • Safety, tolerability and immunogenicity of GS-4774, an HBV-specific therapeutic vaccine, in healthy volunteers
    • (Abstract 938)
    • Gaggar A, Coeshott C, Subramanian M, McHutchison JG, Apelian D,. Safety, tolerability and immunogenicity of GS-4774, an HBV-specific therapeutic vaccine, in healthy volunteers. Hepatology 2013; 58 (Suppl. 1): 656A (Abstract 938).
    • (2013) Hepatology , vol.58 , pp. 656A
    • Gaggar, A.1    Coeshott, C.2    Subramanian, M.3    McHutchison, J.G.4    Apelian, D.5
  • 54
    • 0034991493 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides with hepatitis B surface antigen (HBsAg) for vaccination in HBsAg-transgenic mice
    • Malanchere-Bres E, Payette PJ, Mancini M, Tiollais P, Davis HL, Michel ML,. CpG oligodeoxynucleotides with hepatitis B surface antigen (HBsAg) for vaccination in HBsAg-transgenic mice. J Virol 2001; 75: 6482-6491.
    • (2001) J Virol , vol.75 , pp. 6482-6491
    • Malanchere-Bres, E.1    Payette, P.J.2    Mancini, M.3    Tiollais, P.4    Davis, H.L.5    Michel, M.L.6
  • 55
    • 17944402906 scopus 로고    scopus 로고
    • CpG DNA overcomes hyporesponsiveness to hepatitis B vaccine in orangutans
    • Davis HL, Suparto II, Weeratna RR, et al,. CpG DNA overcomes hyporesponsiveness to hepatitis B vaccine in orangutans. Vaccine 2000; 18: 1920-1924.
    • (2000) Vaccine , vol.18 , pp. 1920-1924
    • Davis, H.L.1    Suparto, I.I.2    Weeratna, R.R.3
  • 56
    • 84874622721 scopus 로고    scopus 로고
    • Changes in innate and permissive immune responses after HBV transgenic mouse vaccination and llong-term-siRNA treatment
    • Ren GL, Huang GY, Zheng H, et al,. Changes in innate and permissive immune responses after HBV transgenic mouse vaccination and llong-term-siRNA treatment. PLoS One 2013; 8: e57525.
    • (2013) PLoS One , vol.8 , pp. e57525
    • Ren, G.L.1    Huang, G.Y.2    Zheng, H.3
  • 57
    • 84865560260 scopus 로고    scopus 로고
    • Immune tolerance against HBV can be overcome in HBV transgenic mice by immunization with dendritic cells pulsed by HBVsvp
    • Farag MM, Tedjokusumo R, Flechtenmacher C, et al,. Immune tolerance against HBV can be overcome in HBV transgenic mice by immunization with dendritic cells pulsed by HBVsvp. Vaccine 2012; 30: 6034-6039.
    • (2012) Vaccine , vol.30 , pp. 6034-6039
    • Farag, M.M.1    Tedjokusumo, R.2    Flechtenmacher, C.3
  • 58
    • 84908005176 scopus 로고    scopus 로고
    • A clinical trial on anti -HBV-DC vaccine combined with lamivudine and thymosin -a1 in the HBeAg positive patients of chronic hepatitis B virus infection
    • (Abstract 781)
    • Wu FB, Yang YJ, Zhang LY, et al,. A clinical trial on anti -HBV-DC vaccine combined with lamivudine and thymosin -a1 in the HBeAg positive patients of chronic hepatitis B virus infection. J Hepatol 2013; 58 (Suppl. 1): S318 (Abstract 781).
    • (2013) J Hepatol , vol.58 , pp. S318
    • Wu, F.B.1    Yang, Y.J.2    Zhang, L.Y.3
  • 59
    • 84868205293 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells induce efficient stimulation of antiviral immunity in the context of chronic hepatitis B virus infection
    • Martinet J, Leroy V, Dufeu-Duchesne T, et al,. Plasmacytoid dendritic cells induce efficient stimulation of antiviral immunity in the context of chronic hepatitis B virus infection. Hepatology 2012; 56: 1706-1718.
    • (2012) Hepatology , vol.56 , pp. 1706-1718
    • Martinet, J.1    Leroy, V.2    Dufeu-Duchesne, T.3
  • 60
    • 84865283534 scopus 로고    scopus 로고
    • Strong and multi-antigen specific immunity by hepatitis B core antigen (HBcAg)-based vaccines in a murine model of chronic hepatitis B: HBcAg is a candidate for a therapeutic vaccine against hepatitis B virus
    • Akbar SM, Chen S, Al-Mahtab M, Abe M, Hiasa Y, Onji M,. Strong and multi-antigen specific immunity by hepatitis B core antigen (HBcAg)-based vaccines in a murine model of chronic hepatitis B: HBcAg is a candidate for a therapeutic vaccine against hepatitis B virus. Antiviral Res 2012; 96: 59-64.
    • (2012) Antiviral Res , vol.96 , pp. 59-64
    • Akbar, S.M.1    Chen, S.2    Al-Mahtab, M.3    Abe, M.4    Hiasa, Y.5    Onji, M.6
  • 61
    • 84906896613 scopus 로고    scopus 로고
    • Advances and challenges in the development of therapeutic DNA vaccines against hepatitis B virus infection
    • Cova L,. Advances and challenges in the development of therapeutic DNA vaccines against hepatitis B virus infection. Curr Gene Ther 2014; 14: 149-60.
    • (2014) Curr Gene Ther , vol.14 , pp. 149-160
    • Cova, L.1
  • 62
    • 84893805242 scopus 로고    scopus 로고
    • Enhancing virus-specific immunity in vivo by combining therapeutic vaccination and PD-L1 blockade in chronic hepadnaviral infection
    • Liu J, Zhang E, Ma Z, et al,. Enhancing virus-specific immunity in vivo by combining therapeutic vaccination and PD-L1 blockade in chronic hepadnaviral infection. PLoS Pathog 2014; 10: e1003856.
    • (2014) PLoS Pathog , vol.10 , pp. e1003856
    • Liu, J.1    Zhang, E.2    Ma, Z.3
  • 63
    • 84863726990 scopus 로고    scopus 로고
    • A pilot randomized controlled trial of dual-plasmid HBV DNA vaccine mediated by in vivo electroporation in chronic hepatitis B patients under lamivudine chemotherapy
    • Yang FQ, Yu YY, Wang GQ, et al,. A pilot randomized controlled trial of dual-plasmid HBV DNA vaccine mediated by in vivo electroporation in chronic hepatitis B patients under lamivudine chemotherapy. J Viral Hepat 2012; 19: 581-593.
    • (2012) J Viral Hepat , vol.19 , pp. 581-593
    • Yang, F.Q.1    Yu, Y.Y.2    Wang, G.Q.3
  • 64
    • 84895493744 scopus 로고    scopus 로고
    • Immunological and antiviral responses after therapeutic DNA immunization in chronic hepatitis B patients efficiently treated by analogues
    • Godon O, Fontaine H, Kahi S, et al,. Immunological and antiviral responses after therapeutic DNA immunization in chronic hepatitis B patients efficiently treated by analogues. Mol Ther 2014; 22: 675-684.
    • (2014) Mol Ther , vol.22 , pp. 675-684
    • Godon, O.1    Fontaine, H.2    Kahi, S.3
  • 65
    • 84922699091 scopus 로고    scopus 로고
    • Safety and immunogenicity of therapeutic DNA vaccine with antiviral drug in chronic HBV patients and its immunogenicity in mice
    • Mar 13. [Epub ahead of print]
    • Yoon SK, Seo YB, Im SJ, et al,. Safety and immunogenicity of therapeutic DNA vaccine with antiviral drug in chronic HBV patients and its immunogenicity in mice. Liver Int 2014; Mar 13. doi: 10.1111/liv.12530. [Epub ahead of print].
    • (2014) Liver Int
    • Yoon, S.K.1    Seo, Y.B.2    Im, S.J.3
  • 66
    • 84879549459 scopus 로고    scopus 로고
    • Combination of DNA prime-adenovirus boost immunization with entecavir elicits sustained control of chronic hepatitis B in the woodchuck model
    • Kosinska AD, Zhang E, Johrden L, et al,. Combination of DNA prime-adenovirus boost immunization with entecavir elicits sustained control of chronic hepatitis B in the woodchuck model. PLoS Pathog 2013; 9: e1003391.
    • (2013) PLoS Pathog , vol.9 , pp. e1003391
    • Kosinska, A.D.1    Zhang, E.2    Johrden, L.3
  • 67
    • 79951866610 scopus 로고    scopus 로고
    • Partially randomized, non-blinded trial of DNA and MVA therapeutic vaccines based on hepatitis B virus surface protein for chronic HBV infection
    • Cavenaugh JS, Awi D, Mendy M, Hill AV, Whittle H, McConkey SJ,. Partially randomized, non-blinded trial of DNA and MVA therapeutic vaccines based on hepatitis B virus surface protein for chronic HBV infection. PLoS One 2011; 6: e14626.
    • (2011) PLoS One , vol.6 , pp. e14626
    • Cavenaugh, J.S.1    Awi, D.2    Mendy, M.3    Hill, A.V.4    Whittle, H.5    McConkey, S.J.6
  • 68
    • 84878276077 scopus 로고    scopus 로고
    • GS-9620, an oral agonist of Toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees
    • Lanford RE, Guerra B, Chavez D, et al,. GS-9620, an oral agonist of Toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees. Gastroenterology 2013; 144: 1508-1517.
    • (2013) Gastroenterology , vol.144 , pp. 1508-1517
    • Lanford, R.E.1    Guerra, B.2    Chavez, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.