Antimycobacterial activity generated by the amide coupling of (-)-fenchone derived aminoalcohol with cinnamic acids and analogues

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 21, 2014, Pages 5030-5033

  Slavchev, Ivaylo ^a   Dobrikov, Georgi M ^a   Valcheva, Violeta ^b   Ugrinova, Iva ^c   Pasheva, Evdokia ^c   Dimitrov, Vladimir ^a  

^a INSTITUTE OF ORGANIC CHEMISTRY   (Bulgaria)

^b INSTITUTE OF MICROBIOLOGY   (Bulgaria)

^c INSTITUTE OF MOLECULAR BIOLOGY   (Bulgaria)

Author keywords

Amides; Cinnamic acids; Fenchone; Tuberculosis

Indexed keywords

AMIDE; AMINOALCOHOL; ANTIMYCOBACTERIAL AGENT; CINNAMIC ACID DERIVATIVE; FENCHONE DERIVATIVE; UNCLASSIFIED DRUG; CINNAMIC ACID; FENCHONE; NORBORNANE DERIVATIVE; TUBERCULOSTATIC AGENT;

ACYLATION; ANTIBACTERIAL ACTIVITY; ANTIMYCOBACTERIAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; EMBRYO; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPOPHILICITY; MYCOBACTERIUM TUBERCULOSIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; HEK293 CELL LINE; MICROBIAL SENSITIVITY TEST; STEREOISOMERISM;

ACYLATION; AMIDES; AMINO ALCOHOLS; ANTITUBERCULAR AGENTS; CELL SURVIVAL; CINNAMATES; HEK293 CELLS; HUMANS; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; NORBORNANES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84907964961     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.09.021     Document Type: Article

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