Antimycobacterial activity of chiral aminoalcohols with camphane scaffold

European Journal of Medicinal Chemistry

Volumn 81, Issue , 2014, Pages 150-157

  Petkova, Zhanina ^a   Valcheva, Violeta ^b   Momekov, Georgi ^c   Petrov, Petar ^d   Dimitrov, Vladimir ^a   Doytchinova, Irini ^c   Stavrakov, Georgi ^c   Stoyanova, Malinka ^a  

^a INSTITUTE OF ORGANIC CHEMISTRY   (Bulgaria)

^b INSTITUTE OF MICROBIOLOGY   (Bulgaria)

^c MEDICAL UNIVERSITY OF SOFIA   (Bulgaria)

^d UNIVERSITY OF SOFIA   (Bulgaria)

Author keywords

Camphor; Cytotoxicity; MDR TB; Mycobacterium tuberculosis; QSAR

Indexed keywords

1 (1 HYDROXY 2 MORPHOLINOETHYL) 7,7 DIMETHYLBICYCLO[2.2.1]HEPTAN 2 ONE; 1 (1 HYDROXY 2 THIOMORPHOLINOETHYL) 7,7 DIMETHYLBICYCLO[2.2.1]HEPTAN 2 ONE; 1 [1 HYDROXY 2 (4 METHYLPIPERAZIN 1 YL)ETHYL] 7,7 DIMETHYLBICYCLO[2.2.1]HEPTAN 2 ONE; 1 [1 HYDROXY 2 (4 PHENYLPIPERAZIN 1 YL)ETHYL] 7,7 DIMETHYLBICYCLO[2.2.1]HEPTAN 2 ONE; 1 [2 [4 (2 FLUOROPHENYL)PIPERAZIN 1 YL]1 HYDROXYETHYL] 7,7 DIMETHYLBICYCLO[2.2.1]HEPTAN 2 ONE; 1 [2 [4 (4 CHLOROPHENYL)PIPERAZIN 1 YL] 1 HYDROXYETHYL] 7,7 DIMETHYLBICYCLO[2.2.1]HEPTAN 2 ONE; 1 [2 [4 (4 FLUOROPHENYL)PIPERAZIN 1 YL] 1 HYDROXYETHYL] 7,7 DIMETHYLBICYCLO[2.2.1]HEPTAN 2 ONE; AMINOALCOHOL; ANTIMYCOBACTERIAL AGENT; CAMPHOR DERIVATIVE; ETHAMBUTOL; ETHYLENE OXIDE DERIVATIVE; MOLECULAR SCAFFOLD; UNCLASSIFIED DRUG; BORNANE DERIVATIVE; CAMPHANE; TUBERCULOSTATIC AGENT;

AMINOLYSIS; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CELL MEMBRANE PERMEABILITY; CELL VIABILITY; CHIRALITY; CONTROLLED STUDY; DIASTEREOISOMER; DRUG CYTOTOXICITY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; EPOXIDATION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHARMACOPHORE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY; CELL SURVIVAL; CHEMISTRY; CONFORMATION; DOSE RESPONSE; DRUG EFFECTS; HEK293 CELL LINE; MICROBIAL SENSITIVITY TEST; SYNTHESIS;

AMINO ALCOHOLS; ANTITUBERCULAR AGENTS; BORNANES; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HEK293 CELLS; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR CONFORMATION; MYCOBACTERIUM TUBERCULOSIS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84900845090     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.05.007     Document Type: Article

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