Caenorhabditis elegans dnj-14, the orthologue of the DNAJC5 gene mutated in adult onset neuronal ceroid lipofuscinosis, provides a new platform for neuroprotective drug screening and identifies a SIR-2.1-independent action of resveratrol

Human Molecular Genetics

Volumn 23, Issue 22, 2014, Pages 5916-5927

  Kashyap, Sudhanva S ^a   Johnson, James R ^a   McCue, Hannah V ^a   Chen, Xi ^a   Edmonds, Matthew J ^a   Ayala, Mimieveshiofuo ^a   Graham, Margaret E ^a   Jenn, Robert C ^a   Barclay, Jeff W ^a   Burgoyne, Robert D ^a   Morgan, Alan ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

RESVERATROL; ROLIPRAM; SIRTUIN 2; SIRTUIN 2.1; UNCLASSIFIED DRUG; CAENORHABDITIS ELEGANS PROTEIN; CYSTEINE STRING PROTEIN; HEAT SHOCK PROTEIN 40; MEMBRANE PROTEIN; SIR-2.1 PROTEIN, C ELEGANS; SIRTUIN; STILBENE DERIVATIVE;

ADULT; ADULT DISEASE; ADULT ONSET NEURONAL CEROID LIPOFUSCINOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAENORHABDITIS ELEGANS; CHEMORECEPTOR; CONTROLLED STUDY; DEGENERATIVE DISEASE; DNAJC5 GENE; DNJ 14 GENE; DRUG IDENTIFICATION; DRUG SCREENING; GENETIC DISORDER; LOCOMOTION; LONGEVITY; MIDDLE AGED; MOTOR DYSFUNCTION; MUTANT; MUTATOR GENE; NERVE DEGENERATION; NEURONAL CEROID LIPOFUSCINOSIS; NEUROPHARMACOLOGY; NEUROPROTECTION; NEUROTRANSMISSION; NONHUMAN; ONSET AGE; ORTHOLOGY; PHENOTYPE; PROTEIN FUNCTION; SENSORY DYSFUNCTION; SENSORY NERVE CELL; YOUNG ADULT; ANIMAL; DISEASE MODEL; DRUG EFFECTS; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; LIFE EXPECTANCY; METABOLISM; NEURONAL CEROID-LIPOFUSCINOSES; PRECLINICAL STUDY;

CAENORHABDITIS ELEGANS;

ADULT; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; HSP40 HEAT-SHOCK PROTEINS; HUMANS; LIFE EXPECTANCY; MEMBRANE PROTEINS; NEURONAL CEROID-LIPOFUSCINOSES; SIRTUINS; STILBENES;

EID: 84907962493     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddu316     Document Type: Article

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