PTU-induced hypothyroidism in rats leads to several early neuropathological signs of Alzheimer's disease in the hippocampus and spatial memory impairments

Hippocampus

Volumn 24, Issue 11, 2014, Pages 1381-1393

  Chaalal, Amina ^a,b   Poirier, Roseline ^a,b   Blum, David ^c,d,e   Gillet, Brigitte ^a,b   Le Blanc, Pascale ^a,b   Basquin, Marie ^c,d   Buée, Luc ^c,d,e   Laroche, Serge ^a,b   Enderlin, Valérie ^a,b  

^a CNRS   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

^c UNIV LILLE   (France)

^d JEAN PIERRE AUBERT RESEARCH CENTER   (France)

^e LILLE UNIVERSITY HOSPITAL   (France)

Author keywords

Behavior; Inflammation; Risk factor; Signaling pathways; Tau

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; EARLY GROWTH RESPONSE FACTOR 1; GLYCOGEN SYNTHASE KINASE 3BETA; MITOGEN ACTIVATED PROTEIN KINASE; NEUROGRANIN; PROPYLTHIOURACIL; TAU PROTEIN; CYTOKINE; MAPT PROTEIN, RAT;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; BRAIN SIZE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; EXPLORATORY BEHAVIOR; HIPPOCAMPUS; HISTOPATHOLOGY; HYPOTHYROIDISM; INFLAMMATION; LEARNING; LOCOMOTION; MALE; MEMORY; NERVE CELL PLASTICITY; NEUROPATHOLOGY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SPATIAL MEMORY; ANIMAL; DISEASE COURSE; DISEASE MODEL; IMMUNOMODULATION; MEMORY DISORDER; METABOLISM; MOTOR ACTIVITY; ORGAN SIZE; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; RANDOMIZATION; WISTAR RAT;

ALZHEIMER DISEASE; ANIMALS; ANXIETY; CYTOKINES; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; HIPPOCAMPUS; HYPOTHYROIDISM; MALE; MEMORY DISORDERS; MOTOR ACTIVITY; NEUROIMMUNOMODULATION; ORGAN SIZE; PHOSPHORYLATION; RANDOM ALLOCATION; RATS, WISTAR; SPATIAL MEMORY; TAU PROTEINS;

EID: 84907952097     PISSN: 10509631     EISSN: 10981063     Source Type: Journal    
DOI: 10.1002/hipo.22319     Document Type: Article

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