CREB-regulated transcription coactivator 1-dependent transcription in Alzheimer's disease mice

Neurodegenerative Diseases

Volumn 10, Issue 1-4, 2012, Pages 250-252

  Saura, Carlos A ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Alzheimer's disease; Amyloid; cAMP response element binding protein; Gene expression; Memory; Signaling

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CALCINEURIN; CALCIUM; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN REGULATED TRANSCRIPTION COACTIVATOR 1; NUCLEAR RECEPTOR RELATED FACTOR 1; PROTEIN C FOS; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; DEREGULATION; DOWN REGULATION; ENZYME ACTIVITY; HIPPOCAMPUS; MEMORY DISORDER; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

AGE FACTORS; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CALCINEURIN; CALCIUM; CELLS, CULTURED; CEREBRAL CORTEX; CYCLIC AMP; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HUMANS; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; MUTATION; NEURONS; PEPTIDE FRAGMENTS; TETRODOTOXIN; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 84860217099     PISSN: 16602854     EISSN: 16602862     Source Type: Journal    
DOI: 10.1159/000333341     Document Type: Article

References (10)

1. Xu X, Zhan M, Duan W, Prabhu V, Brenneman R, Wood W, Firman J, Li H, Zhang P, Ibe C, Zonderman AB, Longo DL, Poosala S, Becker KG, Mattson MP: Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender. Genome Biol 2007; 8:R234.
2. Berchtold NC, Cribbs DH, Coleman PD, Rogers J, Head E, Kim R, Beach T, Miller C, Troncoso J, Trojanowski JQ, Zielke HR, Cotman CW: Gene expression changes in the course of normal brain aging are sexually dimorphic. Proc Natl Acad Sci USA 2008; 105: 15605-15610.
3. Lee YS, Silva AJ: The molecular and cellular biology of enhanced cognition. Nat Rev Neurosci 2009; 10: 126-140.
4. Altarejos JY, Montminy M: CREB and the CRTC co-activators: sensors for hormonal and metabolic signals. Nat Rev Mol Cell Biol 2011; 12: 141-151.
5. Saura CA, Valero J: The role of CREB signaling in Alzheimer's disease and other cognitive disorders. Rev Neurosci 2011; 22: 153-169.
6. Vitolo OV, Sant'Angelo A, Costanzo V, Battaglia F, Arancio O, Shelanski M: Amyloidβ - peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling. Proc Natl Acad Sci USA 2002; 99: 13217-13221.
7. Mucke L, Masliah E, Yu GQ, Mallory M, Rockenstein E, Tatsuno G, Hu K, Kholodenko D, Johnson-Wood K, McConlogue L: Highlevel neuronal expression of A3β 1 -42 in wildtype human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J Neurosci 2000; 20: 4050-4058.
8. España J, Gimenez-Llort L, Valero J, Miñano A, Rabano A, Rodriguez-Alvarez J, LaFerla FM, Saura CA: Intraneuronal3β 42-amyloid accumulation in the amygdala enhances fear and anxiety in Alzheimer's disease transgenic mice. Biol Psychiatry 2010; 67: 513-521.
9. España J, Valero J, Miñano-Molina AJ, Masgrau R, Martin E, Guardia-Laguarta C, Lleo A, Gimenez-Llort L, Rodriguez-Alvarez J, Saura CA:3β 42-amyloid disrupts activity-dependent gene transcription required for memory through the CREB coactivator CRTC1. J Neurosci 2010; 30: 9402-9410.
10. Lian Q, Ladner CJ, Magnuson D, Lee JM: Selective changes of calcineurin (protein phosphatase 2b) activity in Alzheimer's disease cerebral cortex. Exp Neurol 2001; 167: 158-165.