-
2
-
-
79953198245
-
A new era of hepatitis C therapy begins
-
D.M. Jensen A new era of hepatitis C therapy begins N Engl J Med 364 2011 1272 1274
-
(2011)
N Engl J Med
, vol.364
, pp. 1272-1274
-
-
Jensen, D.M.1
-
3
-
-
79959381354
-
Telaprevir for retreatment of HCV infection
-
S. Zeuzem, P. Andreone, S. Pol, E. Lawitz, and M. Diago Telaprevir for retreatment of HCV infection N Engl J Med 364 2011 2417 2428
-
(2011)
N Engl J Med
, vol.364
, pp. 2417-2428
-
-
Zeuzem, S.1
Andreone, P.2
Pol, S.3
Lawitz, E.4
Diago, M.5
-
5
-
-
0032876683
-
Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site
-
C.A. Lesburg, M.B. Cable, E. Ferrari, Z. Hong, and A.F. Mannarino Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site Nat Struct Biol 6 1999 937 943
-
(1999)
Nat Struct Biol
, vol.6
, pp. 937-943
-
-
Lesburg, C.A.1
Cable, M.B.2
Ferrari, E.3
Hong, Z.4
Mannarino, A.F.5
-
6
-
-
0033571463
-
Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus
-
H. Ago, T. Adachi, A. Yoshida, M. Yamamoto, and N. Habuka Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus Structure 7 1999 1417 1426
-
(1999)
Structure
, vol.7
, pp. 1417-1426
-
-
Ago, H.1
Adachi, T.2
Yoshida, A.3
Yamamoto, M.4
Habuka, N.5
-
7
-
-
0033539482
-
Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus
-
S. Bressanelli, L. Tomei, A. Roussel, I. Incitti, and R.L. Vitale Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus Proc Natl Acad Sci U S A 96 1999 13034 13039
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 13034-13039
-
-
Bressanelli, S.1
Tomei, L.2
Roussel, A.3
Incitti, I.4
Vitale, R.L.5
-
8
-
-
82555170294
-
An objective assessment of conformational variability in complexes of hepatitis C virus polymerase with non-nucleoside inhibitors
-
C. Caillet-Saguy, P.C. Simister, and S. Bressanelli An objective assessment of conformational variability in complexes of hepatitis C virus polymerase with non-nucleoside inhibitors J Mol Biol 414 2011 370 384
-
(2011)
J Mol Biol
, vol.414
, pp. 370-384
-
-
Caillet-Saguy, C.1
Simister, P.C.2
Bressanelli, S.3
-
9
-
-
50649091630
-
A locking mechanism regulates RNA synthesis and host protein interaction by the hepatitis C virus polymerase
-
S. Chinnaswamy, I. Yarbrough, S. Palaninathan, C.T. Kumar, and V. Vijayaraghavan A locking mechanism regulates RNA synthesis and host protein interaction by the hepatitis C virus polymerase J Biol Chem 283 2008 20535 20546
-
(2008)
J Biol Chem
, vol.283
, pp. 20535-20546
-
-
Chinnaswamy, S.1
Yarbrough, I.2
Palaninathan, S.3
Kumar, C.T.4
Vijayaraghavan, V.5
-
10
-
-
84864135179
-
Two crucial early steps in RNA synthesis by the hepatitis C virus polymerase involve a dual role of residue 405
-
N. Scrima, C. Caillet-Saguy, M. Ventura, D. Harrus, and T. Astier-Gin Two crucial early steps in RNA synthesis by the hepatitis C virus polymerase involve a dual role of residue 405 J Virol 86 2012 7107 7117
-
(2012)
J Virol
, vol.86
, pp. 7107-7117
-
-
Scrima, N.1
Caillet-Saguy, C.2
Ventura, M.3
Harrus, D.4
Astier-Gin, T.5
-
11
-
-
0035919073
-
A novel mechanism to ensure terminal initiation by hepatitis C virus NS5B polymerase
-
Z. Hong, C.E. Cameron, M.P. Walker, C. Castro, and N. Yao A novel mechanism to ensure terminal initiation by hepatitis C virus NS5B polymerase Virology 285 2001 6 11
-
(2001)
Virology
, vol.285
, pp. 6-11
-
-
Hong, Z.1
Cameron, C.E.2
Walker, M.P.3
Castro, C.4
Yao, N.5
-
12
-
-
0035824671
-
Hepatitis C virus RNA-dependent RNA polymerase (NS5B) as a mediator of the antiviral activity of ribavirin
-
D. Maag, C. Castro, Z. Hong, and C.E. Cameron Hepatitis C virus RNA-dependent RNA polymerase (NS5B) as a mediator of the antiviral activity of ribavirin J Biol Chem 276 2001 46094 46098
-
(2001)
J Biol Chem
, vol.276
, pp. 46094-46098
-
-
Maag, D.1
Castro, C.2
Hong, Z.3
Cameron, C.E.4
-
13
-
-
0042243502
-
Multiple interactions within the hepatitis C virus RNA polymerase repress primer-dependent RNA synthesis
-
C.T. Ranjith-Kumar, L. Gutshall, R.T. Sarisky, and C.C. Kao Multiple interactions within the hepatitis C virus RNA polymerase repress primer-dependent RNA synthesis J Mol Biol 330 2003 675 685
-
(2003)
J Mol Biol
, vol.330
, pp. 675-685
-
-
Ranjith-Kumar, C.T.1
Gutshall, L.2
Sarisky, R.T.3
Kao, C.C.4
-
14
-
-
84864011029
-
Structure of hepatitis C virus polymerase in complex with primer-template RNA
-
R.T. Mosley, T.E. Edwards, E. Murakami, A.M. Lam, and R.L. Grice Structure of hepatitis C virus polymerase in complex with primer-template RNA J Virol 86 2012 6503 6511
-
(2012)
J Virol
, vol.86
, pp. 6503-6511
-
-
Mosley, R.T.1
Edwards, T.E.2
Murakami, E.3
Lam, A.M.4
Grice, R.L.5
-
15
-
-
43149087336
-
Structural insights into mechanisms of catalysis and inhibition in Norwalk virus polymerase
-
D.F. Zamyatkin, F. Parra, J.M. Alonso, D.A. Harki, and B.R. Peterson Structural insights into mechanisms of catalysis and inhibition in Norwalk virus polymerase J Biol Chem 283 2008 7705 7712
-
(2008)
J Biol Chem
, vol.283
, pp. 7705-7712
-
-
Zamyatkin, D.F.1
Parra, F.2
Alonso, J.M.3
Harki, D.A.4
Peterson, B.R.5
-
16
-
-
84858973676
-
Assembly, purification, and pre-steady-state kinetic analysis of active RNA-dependent RNA polymerase elongation complex
-
Z. Jin, V. Leveque, H. Ma, K.A. Johnson, and K. Klumpp Assembly, purification, and pre-steady-state kinetic analysis of active RNA-dependent RNA polymerase elongation complex J Biol Chem 287 2012 10674 10683
-
(2012)
J Biol Chem
, vol.287
, pp. 10674-10683
-
-
Jin, Z.1
Leveque, V.2
Ma, H.3
Johnson, K.A.4
Klumpp, K.5
-
17
-
-
84855509792
-
Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance
-
M.H. Powdrill, E.P. Tchesnokov, R.A. Kozak, R.S. Russell, and R. Martin Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance Proc Natl Acad Sci U S A 108 2011 20509 20513
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 20509-20513
-
-
Powdrill, M.H.1
Tchesnokov, E.P.2
Kozak, R.A.3
Russell, R.S.4
Martin, R.5
-
18
-
-
0013897421
-
3′-Deoxynucleosides. IV. Pyrimidine 3′-deoxynucleosides
-
E. Walton, F.W. Holly, G.E. Boxer, and R.F. Nutt 3′-Deoxynucleosides. IV. Pyrimidine 3′-deoxynucleosides J Org Chem 31 1966 1163 1169
-
(1966)
J Org Chem
, vol.31
, pp. 1163-1169
-
-
Walton, E.1
Holly, F.W.2
Boxer, G.E.3
Nutt, R.F.4
-
19
-
-
0023506538
-
A new synthesis of 2′-C-methylnucleosides starting from d-ribose
-
L.N. Beigelman, B.S. Ermolinsky, G.V. Gurskaya, E.N. Tsapkina, and M. Karpeisky A new synthesis of 2′-C-methylnucleosides starting from d-ribose Nucleic Acids Symp Ser 1987 41 44
-
(1987)
Nucleic Acids Symp ser
, pp. 41-44
-
-
Beigelman, L.N.1
Ermolinsky, B.S.2
Gurskaya, G.V.3
Tsapkina, E.N.4
Karpeisky, M.5
-
20
-
-
0024404657
-
Substrate properties of C′-methylnucleoside triphosphates in a reaction of RNA synthesis catalyzed by Escherichia coli RNA-polymerase
-
L.P. Savochkina, T.V. Sviriaeva, L.N. Beigel'man, N. Padiukova, and D.A. Kuznetsov Substrate properties of C′-methylnucleoside triphosphates in a reaction of RNA synthesis catalyzed by Escherichia coli RNA-polymerase Mol Biol (Mosk) 23 1989 1700 1710
-
(1989)
Mol Biol (Mosk)
, vol.23
, pp. 1700-1710
-
-
Savochkina, L.P.1
Sviriaeva, T.V.2
Beigel'Man, L.N.3
Padiukova, N.4
Kuznetsov, D.A.5
-
21
-
-
0141456064
-
Bovine viral diarrhea virus as a surrogate model of hepatitis C virus for the evaluation of antiviral agents
-
V.E. Buckwold, B.E. Beer, and R.O. Donis Bovine viral diarrhea virus as a surrogate model of hepatitis C virus for the evaluation of antiviral agents Antiviral Res 60 2003 1 15
-
(2003)
Antiviral Res
, vol.60
, pp. 1-15
-
-
Buckwold, V.E.1
Beer, B.E.2
Donis, R.O.3
-
22
-
-
33747090879
-
-
Patent number WO/2002/057425
-
Carroll SS, LaFemina R, Hall DL, Himmelberger AL, Kuo LC, et al.: Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase. Patent number WO/2002/057425; 2002.
-
(2002)
Nucleoside Derivatives As Inhibitors of RNA-dependent RNA Viral Polymerase
-
-
Carroll, S.S.1
Lafemina, R.2
Hall, D.L.3
Himmelberger, A.L.4
Kuo, L.C.5
-
25
-
-
7744230038
-
NM 283 has potent antiviral activity against genotype 1 chronic hepatitis C virus (HCV-1) infection in the chimpanzee
-
D.N. Standring, R. Lanford, T. Wright, R.T. Chung, and V. Bichko NM 283 has potent antiviral activity against genotype 1 chronic hepatitis C virus (HCV-1) infection in the chimpanzee J Hepatol 38 2003 3
-
(2003)
J Hepatol
, vol.38
, pp. 3
-
-
Standring, D.N.1
Lanford, R.2
Wright, T.3
Chung, R.T.4
Bichko, V.5
-
26
-
-
56849123853
-
Efficacy and safety of valopicitabine in combination with pegylated interferon-alpha (pegIFN) and ribavirin (RBV) in patients with chronic hepatitis C
-
F. Poordad, E.J. Lawitz, N. Gitlin, M. Rodriguez-Torres, and T. Box Efficacy and safety of valopicitabine in combination with pegylated interferon-alpha (pegIFN) and ribavirin (RBV) in patients with chronic hepatitis C Hepatology 46 2007 866A
-
(2007)
Hepatology
, vol.46
, pp. 866A
-
-
Poordad, F.1
Lawitz, E.J.2
Gitlin, N.3
Rodriguez-Torres, M.4
Box, T.5
-
27
-
-
0037809239
-
Inhibition of hepatitis C virus RNA replication by 2′-modified nucleoside analogs
-
S.S. Carroll, J.E. Tomassini, M. Bosserman, K. Getty, and M.W. Stahlhut Inhibition of hepatitis C virus RNA replication by 2′-modified nucleoside analogs J Biol Chem 278 2003 11979 11984
-
(2003)
J Biol Chem
, vol.278
, pp. 11979-11984
-
-
Carroll, S.S.1
Tomassini, J.E.2
Bosserman, M.3
Getty, K.4
Stahlhut, M.W.5
-
28
-
-
4644257970
-
A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties
-
D.B. Olsen, A.B. Eldrup, L. Bartholomew, B. Bhat, and M.R. Bosserman A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties Antimicrob Agents Chemother 48 2004 3944 3953
-
(2004)
Antimicrob Agents Chemother
, vol.48
, pp. 3944-3953
-
-
Olsen, D.B.1
Eldrup, A.B.2
Bartholomew, L.3
Bhat, B.4
Bosserman, M.R.5
-
29
-
-
62949195680
-
Robust antiviral efficacy upon administration of a nucleoside analog to hepatitis C virus-infected chimpanzees
-
S.S. Carroll, S. Ludmerer, L. Handt, K. Koeplinger, and N.R. Zhang Robust antiviral efficacy upon administration of a nucleoside analog to hepatitis C virus-infected chimpanzees Antimicrob Agents Chemother 53 2009 926 934
-
(2009)
Antimicrob Agents Chemother
, vol.53
, pp. 926-934
-
-
Carroll, S.S.1
Ludmerer, S.2
Handt, L.3
Koeplinger, K.4
Zhang, N.R.5
-
30
-
-
33845247515
-
General catalytic deficiency of hepatitis C virus RNA polymerase with an S282T mutation and mutually exclusive resistance towards 2′-modified nucleotide analogues
-
H. Dutartre, C. Bussetta, J. Boretto, and B. Canard General catalytic deficiency of hepatitis C virus RNA polymerase with an S282T mutation and mutually exclusive resistance towards 2′-modified nucleotide analogues Antimicrob Agents Chemother 50 2006 4161 4169
-
(2006)
Antimicrob Agents Chemother
, vol.50
, pp. 4161-4169
-
-
Dutartre, H.1
Bussetta, C.2
Boretto, J.3
Canard, B.4
-
31
-
-
20944447120
-
Replication fitness and NS5B drug sensitivity of diverse hepatitis C virus isolates characterized by using a transient replication assay
-
S.W. Ludmerer, D.J. Graham, E. Boots, E.M. Murray, and A. Simcoe Replication fitness and NS5B drug sensitivity of diverse hepatitis C virus isolates characterized by using a transient replication assay Antimicrob Agents Chemother 49 2005 2059 2069
-
(2005)
Antimicrob Agents Chemother
, vol.49
, pp. 2059-2069
-
-
Ludmerer, S.W.1
Graham, D.J.2
Boots, E.3
Murray, E.M.4
Simcoe, A.5
-
32
-
-
1542677267
-
Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro
-
G. Migliaccio, J.E. Tomassini, S.S. Carroll, L. Tomei, and S. Altamura Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro J Biol Chem 278 2003 49164 49170
-
(2003)
J Biol Chem
, vol.278
, pp. 49164-49170
-
-
Migliaccio, G.1
Tomassini, J.E.2
Carroll, S.S.3
Tomei, L.4
Altamura, S.5
-
33
-
-
0026740250
-
Synthesis and anti-HIV activity of 4′-azido- and 4′-methoxynucleosides
-
H. Maag, R.M. Rydzewski, M.J. McRoberts, D. Crawford-Ruth, and J.P. Verheyden Synthesis and anti-HIV activity of 4′-azido- and 4′-methoxynucleosides J Med Chem 35 1992 1440 1451
-
(1992)
J Med Chem
, vol.35
, pp. 1440-1451
-
-
Maag, H.1
Rydzewski, R.M.2
McRoberts, M.J.3
Crawford-Ruth, D.4
Verheyden, J.P.5
-
34
-
-
33645232568
-
The novel nucleoside analog R1479 (4′-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture
-
K. Klumpp, V. Leveque, S. Le Pogam, H. Ma, and W.R. Jiang The novel nucleoside analog R1479 (4′-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture J Biol Chem 281 2006 3793 3799
-
(2006)
J Biol Chem
, vol.281
, pp. 3793-3799
-
-
Klumpp, K.1
Leveque, V.2
Le Pogam, S.3
Ma, H.4
Jiang, W.R.5
-
35
-
-
33744910421
-
In vitro selected Con1 subgenomic replicons resistant to 2′-C-methyl-cytidine or to R1479 show lack of cross resistance
-
S. Le Pogam, W.R. Jiang, V. Leveque, S. Rajyaguru, and H. Ma In vitro selected Con1 subgenomic replicons resistant to 2′-C-methyl-cytidine or to R1479 show lack of cross resistance Virology 351 2006 349 359
-
(2006)
Virology
, vol.351
, pp. 349-359
-
-
Le Pogam, S.1
Jiang, W.R.2
Leveque, V.3
Rajyaguru, S.4
Ma, H.5
-
36
-
-
49649094687
-
Robust antiviral activity of R1626, a novel nucleoside analog: A randomized, placebo-controlled study in patients with chronic hepatitis C
-
S.K. Roberts, G. Cooksley, G.J. Dore, R. Robson, and D. Shaw Robust antiviral activity of R1626, a novel nucleoside analog: a randomized, placebo-controlled study in patients with chronic hepatitis C Hepatology 48 2008 398 406
-
(2008)
Hepatology
, vol.48
, pp. 398-406
-
-
Roberts, S.K.1
Cooksley, G.2
Dore, G.J.3
Robson, R.4
Shaw, D.5
-
37
-
-
83055197050
-
Balapiravir plus peginterferon alfa-2a (40 kD)/ribavirin in a randomized trial of hepatitis C genotype 1 patients
-
D.R. Nelson, S. Zeuzem, P. Andreone, P. Ferenci, and R. Herring Balapiravir plus peginterferon alfa-2a (40 kD)/ribavirin in a randomized trial of hepatitis C genotype 1 patients Ann Hepatol 11 2012 15 31
-
(2012)
Ann Hepatol
, vol.11
, pp. 15-31
-
-
Nelson, D.R.1
Zeuzem, S.2
Andreone, P.3
Ferenci, P.4
Herring, R.5
-
38
-
-
38349194473
-
2′-Deoxy-4′-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2′-alpha-hydroxyl groups
-
K. Klumpp, G. Kalayanov, H. Ma, S. Le Pogam, and V. Leveque 2′-Deoxy-4′-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2′-alpha-hydroxyl groups J Biol Chem 283 2008 2167 2175
-
(2008)
J Biol Chem
, vol.283
, pp. 2167-2175
-
-
Klumpp, K.1
Kalayanov, G.2
Ma, H.3
Le Pogam, S.4
Leveque, V.5
-
39
-
-
67649971795
-
The application of phosphoramidate ProTide technology to the potent anti-HCV compound 4′-azidocytidine (R1479)
-
C. McGuigan, M.R. Kelleher, P. Perrone, S. Mulready, and G. Luoni The application of phosphoramidate ProTide technology to the potent anti-HCV compound 4′-azidocytidine (R1479) Bioorg Med Chem Lett 19 2009 4250 4254
-
(2009)
Bioorg Med Chem Lett
, vol.19
, pp. 4250-4254
-
-
McGuigan, C.1
Kelleher, M.R.2
Perrone, P.3
Mulready, S.4
Luoni, G.5
-
40
-
-
65649096631
-
The design, synthesis, and antiviral activity of monofluoro and difluoro analogues of 4′-azidocytidine against hepatitis C virus replication: The discovery of 4′-azido-2′-deoxy-2′-fluorocytidine and 4′-azido-2′-dideoxy-2′,2′-difluorocytidine
-
D.B. Smith, G. Kalayanov, C. Sund, A. Winqvist, and T. Maltseva The design, synthesis, and antiviral activity of monofluoro and difluoro analogues of 4′-azidocytidine against hepatitis C virus replication: the discovery of 4′-azido-2′-deoxy-2′-fluorocytidine and 4′-azido-2′-dideoxy-2′,2′-difluorocytidine J Med Chem 52 2009 2971 2978
-
(2009)
J Med Chem
, vol.52
, pp. 2971-2978
-
-
Smith, D.B.1
Kalayanov, G.2
Sund, C.3
Winqvist, A.4
Maltseva, T.5
-
41
-
-
34047112960
-
Design, synthesis, and antiviral properties of 4′-substituted ribonucleosides as inhibitors of hepatitis C virus replication: The discovery of R1479
-
D.B. Smith, J.A. Martin, K. Klumpp, S.J. Baker, and P.A. Blomgren Design, synthesis, and antiviral properties of 4′-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479 Bioorg Med Chem Lett 17 2007 2570 2576
-
(2007)
Bioorg Med Chem Lett
, vol.17
, pp. 2570-2576
-
-
Smith, D.B.1
Martin, J.A.2
Klumpp, K.3
Baker, S.J.4
Blomgren, P.A.5
-
42
-
-
84870774679
-
Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides
-
J.J. Arnold, S.D. Sharma, J.Y. Feng, A.S. Ray, and E.D. Smidansky Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides PLoS Pathog 8 2012 e1003030
-
(2012)
PLoS Pathog
, vol.8
, pp. 1003030
-
-
Arnold, J.J.1
Sharma, S.D.2
Feng, J.Y.3
Ray, A.S.4
Smidansky, E.D.5
-
43
-
-
9144238660
-
Inhibition of the subgenomic hepatitis C virus replicon in huh-7 cells by 2′-deoxy-2′-fluorocytidine
-
L.J. Stuyver, T.R. McBrayer, T. Whitaker, P.M. Tharnish, and M. Ramesh Inhibition of the subgenomic hepatitis C virus replicon in huh-7 cells by 2′-deoxy-2′-fluorocytidine Antimicrob Agents Chemother 48 2004 651 654
-
(2004)
Antimicrob Agents Chemother
, vol.48
, pp. 651-654
-
-
Stuyver, L.J.1
McBrayer, T.R.2
Whitaker, T.3
Tharnish, P.M.4
Ramesh, M.5
-
44
-
-
33646457538
-
Inhibition of hepatitis C replicon RNA synthesis by beta-d-2′-deoxy-2′-fluoro-2′-C-methylcytidine: A specific inhibitor of hepatitis C virus replication
-
L.J. Stuyver, T.R. McBrayer, P.M. Tharnish, J. Clark, and L. Hollecker Inhibition of hepatitis C replicon RNA synthesis by beta-d-2′-deoxy-2′-fluoro-2′-C-methylcytidine: a specific inhibitor of hepatitis C virus replication Antiviral Chem Chemother 17 2006 79 87
-
(2006)
Antiviral Chem Chemother
, vol.17
, pp. 79-87
-
-
Stuyver, L.J.1
McBrayer, T.R.2
Tharnish, P.M.3
Clark, J.4
Hollecker, L.5
-
45
-
-
35648968189
-
Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-d-2′-deoxy-2′-fluoro-2′-C-methylcytidine (PSI-6130) and identification of a novel active 5′-triphosphate species
-
H. Ma, W.R. Jiang, N. Robledo, V. Leveque, and S. Ali Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-d-2′-deoxy-2′-fluoro-2′-C-methylcytidine (PSI-6130) and identification of a novel active 5′-triphosphate species J Biol Chem 282 2007 29812 29820
-
(2007)
J Biol Chem
, vol.282
, pp. 29812-29820
-
-
Ma, H.1
Jiang, W.R.2
Robledo, N.3
Leveque, V.4
Ali, S.5
-
46
-
-
38649112300
-
The mechanism of action of beta-d-2′-deoxy-2′-fluoro-2′-C-methylcytidine involves a second metabolic pathway leading to beta-d-2′-deoxy-2′-fluoro-2′-C-methyluridine 5′-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase
-
E. Murakami, C. Niu, H. Bao, H.M. Micolochick Steuer, and T Whitaker The mechanism of action of beta-d-2′-deoxy-2′-fluoro-2′-C-methylcytidine involves a second metabolic pathway leading to beta-d-2′-deoxy-2′-fluoro-2′-C-methyluridine 5′-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase Antimicrob Agents Chemother 52 2008 458 464
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 458-464
-
-
Murakami, E.1
Niu, C.2
Bao, H.3
Micolochick Steuer, H.M.4
Whitaker, T.5
-
47
-
-
77953463393
-
Nucleoside analog inhibitors of hepatitis C viral replication: Recent advances, challenges and trends
-
P.A. Furman, A.M. Lam, and E. Murakami Nucleoside analog inhibitors of hepatitis C viral replication: recent advances, challenges and trends Future Med Chem 1 2009 1429 1452
-
(2009)
Future Med Chem
, vol.1
, pp. 1429-1452
-
-
Furman, P.A.1
Lam, A.M.2
Murakami, E.3
-
48
-
-
77957913871
-
Discovery of a beta-d-2′-deoxy-2′-alpha-fluoro-2′-beta-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus
-
M.J. Sofia, D. Bao, W. Chang, J. Du, and D. Nagarathnam Discovery of a beta-d-2′-deoxy-2′-alpha-fluoro-2′-beta-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus J Med Chem 53 2010 7202 7218
-
(2010)
J Med Chem
, vol.53
, pp. 7202-7218
-
-
Sofia, M.J.1
Bao, D.2
Chang, W.3
Du, J.4
Nagarathnam, D.5
-
49
-
-
84903177093
-
Efficiency of incorporation and chain termination determines the inhibition potency of 2′-modified nucleotide analogs against HCV polymerase
-
A. Fung, Z. Jin, N. Dyatkina, G. Wang, and L. Beigelman Efficiency of incorporation and chain termination determines the inhibition potency of 2′-modified nucleotide analogs against HCV polymerase Antimicrob Agents Chemother 58 7 2014 3636 3645 10.1128/AAC.02666-14
-
(2014)
Antimicrob Agents Chemother
, vol.58
, Issue.7
, pp. 3636-3645
-
-
Fung, A.1
Jin, Z.2
Dyatkina, N.3
Wang, G.4
Beigelman, L.5
-
50
-
-
84901627635
-
Current race in the development of DAAs (direct-acting antivirals) against HCV
-
E. De Clercq Current race in the development of DAAs (direct-acting antivirals) against HCV Biochem Pharmacol 89 2014 441 452
-
(2014)
Biochem Pharmacol
, vol.89
, pp. 441-452
-
-
De Clercq, E.1
-
51
-
-
84858722318
-
Nucleoside, nucleotide, and non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA-polymerase
-
M.J. Sofia, W. Chang, P.A. Furman, R.T. Mosley, and B.S. Ross Nucleoside, nucleotide, and non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA-polymerase J Med Chem 55 2012 2481 2531
-
(2012)
J Med Chem
, vol.55
, pp. 2481-2531
-
-
Sofia, M.J.1
Chang, W.2
Furman, P.A.3
Mosley, R.T.4
Ross, B.S.5
-
52
-
-
84900822177
-
Synthesis of 2′-O,4′-C-alkylene-bridged ribonucleosides and their evaluation as inhibitors of HCV NS5B polymerase
-
C. Chapron, R. Glen, M. La Colla, B.A. Mayes, and J.F. McCarville Synthesis of 2′-O,4′-C-alkylene-bridged ribonucleosides and their evaluation as inhibitors of HCV NS5B polymerase Bioorg Med Chem Lett 24 2014 2699 2702
-
(2014)
Bioorg Med Chem Lett
, vol.24
, pp. 2699-2702
-
-
Chapron, C.1
Glen, R.2
La Colla, M.3
Mayes, B.A.4
McCarville, J.F.5
-
53
-
-
84907934395
-
-
Patent number WO/2012/142085
-
Girijavallabhan V, Njoroge FG, Bogen S, Verma V, Bennett F, et al.: 2′-Substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases. Patent number WO/2012/142085; 2012.
-
(2012)
2′-Substituted Nucleoside Derivatives and Methods of Use Thereof for the Treatment of Viral Diseases
-
-
Girijavallabhan, V.1
Njoroge, F.G.2
Bogen, S.3
Verma, V.4
Bennett, F.5
-
54
-
-
0025743809
-
The phylogeny of RNA-dependent RNA polymerases of positive-strand RNA viruses
-
E.V. Koonin The phylogeny of RNA-dependent RNA polymerases of positive-strand RNA viruses J Gen Virol 72 Pt 9 1991 2197 2206
-
(1991)
J Gen Virol
, vol.72
, Issue.9
, pp. 2197-2206
-
-
Koonin, E.V.1
-
55
-
-
84925285590
-
Common and unique features of viral RNA-dependent polymerases
-
[Epub ahead of print]
-
A.J. Te Velthuis Common and unique features of viral RNA-dependent polymerases Cell Mol Life Sci 2014 [Epub ahead of print]
-
(2014)
Cell Mol Life Sci
-
-
Te Velthuis, A.J.1
-
56
-
-
34848918867
-
2′-C-Methyl branched pyrimidine ribonucleoside analogues: Potent inhibitors of RNA virus replication
-
S. Benzaria, D. Bardiot, T. Bouisset, C. Counor, and C. Rabeson 2′-C-Methyl branched pyrimidine ribonucleoside analogues: potent inhibitors of RNA virus replication Antiviral Chem Chemother 18 2007 225 242
-
(2007)
Antiviral Chem Chemother
, vol.18
, pp. 225-242
-
-
Benzaria, S.1
Bardiot, D.2
Bouisset, T.3
Counor, C.4
Rabeson, C.5
-
57
-
-
77952669442
-
Efficacy of 2′-C-methylcytidine against yellow fever virus in cell culture and in a hamster model
-
J.G. Julander, A.K. Jha, J.A. Choi, K.H. Jung, and D.F. Smee Efficacy of 2′-C-methylcytidine against yellow fever virus in cell culture and in a hamster model Antiviral Res 86 2010 261 267
-
(2010)
Antiviral Res
, vol.86
, pp. 261-267
-
-
Julander, J.G.1
Jha, A.K.2
Choi, J.A.3
Jung, K.H.4
Smee, D.F.5
-
58
-
-
84901257134
-
Inhibitors of the tick-borne, hemorrhagic fever-associated flaviviruses
-
M. Flint, L.K. McMullan, K.A. Dodd, B.H. Bird, and M.L. Khristova Inhibitors of the tick-borne, hemorrhagic fever-associated flaviviruses Antimicrob Agents Chemother 58 2014 3206 3216
-
(2014)
Antimicrob Agents Chemother
, vol.58
, pp. 3206-3216
-
-
Flint, M.1
McMullan, L.K.2
Dodd, K.A.3
Bird, B.H.4
Khristova, M.L.5
-
59
-
-
84868214446
-
Inhibition of norovirus replication by the nucleoside analogue 2′-C-methylcytidine
-
J. Rocha-Pereira, D. Jochmans, K. Dallmeier, P. Leyssen, and R. Cunha Inhibition of norovirus replication by the nucleoside analogue 2′-C-methylcytidine Biochem Biophys Res Commun 427 2012 796 800
-
(2012)
Biochem Biophys Res Commun
, vol.427
, pp. 796-800
-
-
Rocha-Pereira, J.1
Jochmans, D.2
Dallmeier, K.3
Leyssen, P.4
Cunha, R.5
-
60
-
-
84886924040
-
The viral polymerase inhibitor 2′-C-methylcytidine inhibits Norwalk virus replication and protects against norovirus-induced diarrhea and mortality in a mouse model
-
J. Rocha-Pereira, D. Jochmans, Y. Debing, E. Verbeken, and M.S. Nascimento The viral polymerase inhibitor 2′-C-methylcytidine inhibits Norwalk virus replication and protects against norovirus-induced diarrhea and mortality in a mouse model J Virol 87 2013 11798 11805
-
(2013)
J Virol
, vol.87
, pp. 11798-11805
-
-
Rocha-Pereira, J.1
Jochmans, D.2
Debing, Y.3
Verbeken, E.4
Nascimento, M.S.5
-
61
-
-
84911373368
-
Proof of concept for the inhibition of foot-and-mouth disease virus replication by the anti-viral drug 2′-C-methylcytidine in severe combined immunodeficient mice
-
D.J. Lefebvre, A.R. De Vleeschauwer, N. Goris, D. Kollanur, and A. Billiet Proof of concept for the inhibition of foot-and-mouth disease virus replication by the anti-viral drug 2′-C-methylcytidine in severe combined immunodeficient mice Transbound Emerg Dis 2013 10.1111/tbed.12069
-
(2013)
Transbound Emerg Dis
-
-
Lefebvre, D.J.1
De Vleeschauwer, A.R.2
Goris, N.3
Kollanur, D.4
Billiet, A.5
-
62
-
-
77954955357
-
Biochemical characterization of the inhibition of the dengue virus RNA polymerase by beta-d-2′-ethynyl-7-deaza-adenosine triphosphate
-
D.R. Latour, A. Jekle, H. Javanbakht, R. Henningsen, and P. Gee Biochemical characterization of the inhibition of the dengue virus RNA polymerase by beta-d-2′-ethynyl-7-deaza-adenosine triphosphate Antiviral Res 87 2010 213 222
-
(2010)
Antiviral Res
, vol.87
, pp. 213-222
-
-
Latour, D.R.1
Jekle, A.2
Javanbakht, H.3
Henningsen, R.4
Gee, P.5
-
63
-
-
73949141554
-
An adenosine nucleoside inhibitor of dengue virus
-
Z. Yin, Y.L. Chen, W. Schul, Q.Y. Wang, and F. Gu An adenosine nucleoside inhibitor of dengue virus Proc Natl Acad Sci U S A 106 2009 20435 20439
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 20435-20439
-
-
Yin, Z.1
Chen, Y.L.2
Schul, W.3
Wang, Q.Y.4
Gu, F.5
-
64
-
-
84875997317
-
A randomized, double-blind placebo controlled trial of balapiravir, a polymerase inhibitor, in adult dengue patients
-
N.M. Nguyen, C.N. Tran, L.K. Phung, K.T. Duong, and A. Huynh Hle A randomized, double-blind placebo controlled trial of balapiravir, a polymerase inhibitor, in adult dengue patients J Infect Dis 207 2013 1442 1450
-
(2013)
J Infect Dis
, vol.207
, pp. 1442-1450
-
-
Nguyen, N.M.1
Tran, C.N.2
Phung, L.K.3
Duong, K.T.4
Huynh Hle, A.5
-
65
-
-
84055176243
-
Phosphorodiamidates as a promising new phosphate prodrug motif for antiviral drug discovery: Application to anti-HCV agents
-
C. McGuigan, K. Madela, M. Aljarah, C. Bourdin, and M. Arrica Phosphorodiamidates as a promising new phosphate prodrug motif for antiviral drug discovery: application to anti-HCV agents J Med Chem 54 2011 8632 8645
-
(2011)
J Med Chem
, vol.54
, pp. 8632-8645
-
-
McGuigan, C.1
Madela, K.2
Aljarah, M.3
Bourdin, C.4
Arrica, M.5
|