Predicting the gastrointestinal behaviour of modified-release products: Utility of a novel dynamic dissolution test apparatus involving the use of bicarbonate buffers

International Journal of Pharmaceutics

Volumn 475, Issue 1, 2014, Pages 585-591

  Merchant, Hamid A ^a,b   Goyanes, Alvaro ^a   Parashar, Narendra ^a   Basit, Abdul W ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF HUDDERSFIELD   (United Kingdom)

Author keywords

Biorelevant dissolution; Enteric polymers; Gastro resistant coatings; Hydrogen carbonate buffer; pH sensitive polymers; Physiological bicarbonate buffer

Indexed keywords

BICARBONATE; BUFFER; CALCIUM; EUDRAGIT; HYDROXYPROPYLMETHYLCELLULOSE PHTHALATE; MAGNESIUM; PHOSPHATE; POLYMER; POTASSIUM; PREDNISOLONE; SODIUM CHLORIDE; CELLACEFATE; CELLULOSE; DELAYED RELEASE FORMULATION; HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE; METHYLCELLULOSE; METHYLMETHACRYLATE-METHACRYLIC ACID COPOLYMER; POLYMETHACRYLIC ACID DERIVATIVE; POLYVINYL DERIVATIVE; POLYVINYLACETATE PHTHALATE POLYMER;

ARTICLE; DISSOLUTION; DRUG COATING; DRUG RELEASE; ENTERIC COATED TABLET; GAMMA SCINTIGRAPHY; GASTROINTESTINAL TRANSIT; GENERAL DEVICE; IN VIVO STUDY; INTESTINE; PH; TABLET DISINTEGRATION TIME; TABLET FORMULATION; ANALOGS AND DERIVATIVES; BIOLOGICAL MODEL; CHEMISTRY; DELAYED RELEASE FORMULATION; MEDICINAL CHEMISTRY; PROCEDURES; SOLUBILITY;

CELLULOSE; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG LIBERATION; HYDROGEN-ION CONCENTRATION; METHYLCELLULOSE; MODELS, BIOLOGICAL; POLYMETHACRYLIC ACIDS; POLYVINYLS; PREDNISOLONE; SOLUBILITY;

EID: 84907931978     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.09.003     Document Type: Article

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