A dynamic system for the simulation of fasting luminal pH-gradients using hydrogen carbonate buffers for dissolution testing of ionisable compounds

European Journal of Pharmaceutical Sciences

Volumn 51, Issue 1, 2014, Pages 224-231

  Garbacz, Grzegorz ^a   Kołodziej, Bartosz ^c   Koziolek, Mirko ^b   Weitschies, Werner ^b   Klein, Sandra ^b  

^a Physiolution GmbH   (Germany)

^b UNIVERSITY OF GREIFSWALD   (Germany)

^c INSTITUTE OF LOW TEMPERATURE AND STRUCTURE RESEARCH   (Poland)

Author keywords

Bicarbonate media; Biorelevant dissolution; Hydrogen carbonate buffer; Modified release; pH gradient; Physiological buffers

Indexed keywords

BICARBONATE; BUFFER; CARBON DIOXIDE; ESOMEPRAZOLE;

ACIDIFICATION; ARTICLE; CONDUCTANCE; DRUG RELEASE; DRUG SOLUBILITY; GAS; IONIC STRENGTH; MICROCOMPUTER; MOLECULAR DYNAMICS; PH; PH MEASUREMENT; PRIORITY JOURNAL;

BICARBONATE MEDIA; BIORELEVANT DISSOLUTION; HYDROGEN CARBONATE BUFFER; MODIFIED RELEASE; PH GRADIENT; PHYSIOLOGICAL BUFFERS;

BICARBONATES; BUFFERS; CARBON DIOXIDE; CARBONATES; CHEMISTRY, PHARMACEUTICAL; HYDROGEN-ION CONCENTRATION; IONS; OSMOLAR CONCENTRATION; PROTON-MOTIVE FORCE; SOLUBILITY; SOLUTIONS;

EID: 84887175449     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2013.09.020     Document Type: Article

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