Measurement of pH near dissolving enteric coatings

International Journal of Pharmaceutics

Volumn 247, Issue 1-2, 2002, Pages 139-146

  Harianawala, Abizer I ^a   Bogner, Robin H ^a   Bradley, Michael ^b  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b VALPARAISO UNIVERSITY   (United States)

Author keywords

Enteric coating; Fluorescein; Hydroxypropylmethylcellulose phthalate (HP); Microenvironment; pH

Indexed keywords

BUFFER; FLUORESCEIN; HYDROXYPROPYLMETHYLCELLULOSE PHTHALATE; POLYMER;

ARTICLE; MATHEMATICAL MODEL; PH; PRIORITY JOURNAL; SPECTROPHOTOMETER;

HYDROGEN-ION CONCENTRATION; SOLUBILITY; SPECTROPHOTOMETRY; TABLETS, ENTERIC-COATED;

EID: 0037168256     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(02)00404-0     Document Type: Article

References (12)

1. Bogner R.H., LaPorte S.L., Hartz B.M., Albanese D.L., Bradley M. Experimental evidence for the development of a microvisous layer near the surface of dissolving polyethylene glycol. Int. J. Pharm. 151:1997;155-164.
2. Dangel C., Kolter K., Reich H.-B., Schepky G. Aqueous enteric coatings with methacrylic acid copolymer type C on acidic and basic drugs in tablets and pellets, part II: Dosage forms containing indomethacin and diclofenac sodium. Pharm. Technol. 24:(4):2000;36-42.
3. Davis M., Ichikawa I., Williams E.J., Banker G.S. Comparison and evaluation of enteric polymer properties in aqueous solutions. Int. J. Pharm. 28:1986;157-166.
4. Gupta, M.K., Garad, S. Bogner, R.H., 2000. Mathematical modeling of pH in the microenvironment of dissolving enteric polymer films using finite difference analysis, AAPS Pharm. Sci., 2(4) Supplement, Abstract #2214.
5. Harianawala, A.I., 1998. Investigation of Viscosity, pH and Dielectric Constant of the Microenvironment Surrounding a Dissolving Enteric Polymer Film, University of Connecticut, Ph.D. Thesis.
6. Higuchi W., Parrott E.L., Wurster D.E., Higuchi T. Investigation of drug release from solids. J. Am. Pharm. Assoc. 47:1958;376-383.
7. Horter D., Dressman J.B. Influence of physicochemical properties on dissolution of drugs in the gastrointestinal tract. Adv. Drug Deliv. Rev. 25:1997;3-14.
8. Katori N., Aoyagi N., Terao T. Estimation of agitation intensity in the gi tract in humans and dogs based on in vitro in vivo correlation. Pharm. Res. 12:1995;237-243.
9. McNamara D.P., Amidon G.L. Dissolution of acidic and basic compounds from the rotating disk: Influence of convective diffusion and reaction. J. Pharm. Sci. 75:1986;858-868.
10. Mooney K.G., Mintiun M.A., Himmelstein K.J., Stella V.J. Dissolution kinetics of carboxylic acids II: Effect of buffers. J. Pharm. Sci. 70:1981;22-32.
11. Ozturk S.S., Palsson B.O., Donohoe B., Dressman J.B. Kinetics of release from enteric-coated tablets. Pharm. Res. 5:1988;550-565.
12. Russell T.L., Berardi R.R., Barnett J.L., Dermentzoglou L.C., Jarvenpaa K.M., Schmaltz S.P., Dressman J.B. Upper gastrointestinal pH in seventy-nine, elderly, North American men and women. Pharm. Res. 10:1993;187-196.