Comparison of the release profiles of a water soluble drug carried by Eudragit-coated capsules in different in-vitro dissolution liquids

Powder Technology

Volumn 119, Issue 1, 2001, Pages 26-32

  Chan, W A ^a   Boswell, C D ^a   Zhang, Z ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Buffer; Calcium pectinate; Coating; Drug delivery; Eudragit S100; Phosphate

Indexed keywords

DISSOLUTION; DRUG INFUSION; DRUG PRODUCTS; ORGANIC COATINGS;

HUMAN INTESTINES;

COPOLYMERS;

BUFFER; CALCIUM DERIVATIVE; CALCIUM ION; CALCIUM PECTINATE; EUDRAGIT; PECTIN; PHOSPHATE; SODIUM CHLORIDE; THEOPHYLLINE; UNCLASSIFIED DRUG;

COATING; MEDICAL APPLICATION; PH; POWDER;

AQUEOUS SOLUTION; ARTICLE; CONTROLLED DRUG RELEASE; DRUG CAPSULE; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; INTESTINE; PH;

EID: 0035801744     PISSN: 00325910     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0032-5910(01)00401-6     Document Type: Article

References (19)

1. A colon-specific drug delivery system based on drug glycosides and the glycosidase of colonic bacteria
2. The time clock system: A new oral dosage form for fast and complete release of drug after a predetemined lag time
3. Metabolism and urinary excretion of 5-aminosalicylic acid in healthy volunteers when given intravenously of released from absorption at different sites of gastrointestinal tract
4. An evaluation of pectin as a carrier for drug targeting to the colon
5. Modifying the release of properties of Eudragit L30D
6. A pH-dependent colon-targeted oral drug delivery system using methacrylic acid copolymers: II. Manipulation of drug release using Eudragit (R) L100 and Eudragit S 100 combination
7. Gastrointestinal pH profiles in man
8. Measurement of gastrointestinal pH profiles in normal ambulant human subjects
9. Upper gastrointestinal pH in seventy-nine healthy, elderly, north American men and women
10. Design of a new multiparticulate system for potential site-specific and controlled drug delivery to the colonic region
11. Preparation and evaluation of Eudragit acrylic resin for controlled drug release of pseudoephedrine hydrochloride
12. An in vitro investigation into the suitability of pH-dependent polymers for colonic targeting
13. The longevity of chick tissue cultures without renewal of medium
14. Characterization of fluids from the stomach and proximal jejunum in men and women
15. Gastroileal nitrogen and electrolyte movements after bovine milk ingestion in humans
16. A comparison of the bioconversion rates and the Caco-2 cell permeation characteristics of coumarin-based cyclic prodrugs and methylester-based linear prodrugs of RGD peptidomimetics
17. Reductive activation markedly increases the stability of cathepsins B and L to extracellular ionic conditions
18. In-vitro biodegradation of polyhydroxybutyrate-hydroxyvalerate microcapsules exposed to Hank's buffer, newborn calf serum, pancreatin and synthetic gastric juice
19. The use of scintigraphy to provide "Proof of Concept" for novel polysaccharide preparations designed for colonic drug delivery