Structure, activity, and inhibition of the carboxyltransferase β-Subunit of acetyl coenzyme a carboxylase (AccD6) from mycobacterium tuberculosis

Antimicrobial Agents and Chemotherapy

Volumn 58, Issue 10, 2014, Pages 6122-6132

  Reddy, Manchi C M ^a   Breda, Ardala ^a   Bruning, John B ^a,b   Sherekar, Mukul ^a   Valluru, Spandana ^a   Thurman, Cory ^a   Ehrenfeld, Hannah ^a   Sacchettini, James C ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; HALOXYFOP; HERBICIDE; LIGASE INHIBITOR; MALONYL COENZYME A; TUBERCULOSTATIC AGENT; BACTERIAL PROTEIN; PROTEIN BINDING; PYRIDINE DERIVATIVE; TRANSFERASE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL CELL; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DISSOCIATION CONSTANT; DRUG BINDING SITE; ENTHALPY; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBUNIT; IC50; IN VITRO STUDY; ISOTHERMAL TITRATION CALORIMETRY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STRUCTURE ACTIVITY RELATION; CHEMISTRY; DRUG EFFECTS; ENZYME ACTIVATION; ENZYMOLOGY; METABOLISM; THEORETICAL MODEL; X RAY CRYSTALLOGRAPHY;

ACETYL-COA CARBOXYLASE; BACTERIAL PROTEINS; CARBOXYL AND CARBAMOYL TRANSFERASES; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; HERBICIDES; MODELS, THEORETICAL; MYCOBACTERIUM TUBERCULOSIS; PROTEIN BINDING; PYRIDINES;

EID: 84907916561     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.02574-13     Document Type: Article

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