Mechanism for the inhibition of the carboxyl- transferase domain of acetyl-coenzyme A carboxylase by pinoxaden

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 51, 2010, Pages 22072-22077

  Yu, Linda P C ^a   Kim, Yi Seul ^a   Tong, Liang ^a  

^a Howard Hughes Medical Institute   (United States)

Author keywords

Fatty acid metabolism; Metabolic syndrome; Structure based drug design

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; HERBICIDE; PINOXADEN; TEPRALOXYDIM; UNCLASSIFIED DRUG; ENZYME INHIBITOR; FUSED HETEROCYCLIC RINGS; SACCHAROMYCES CEREVISIAE PROTEIN; TRANSFERASE;

ARTICLE; CONFORMATIONAL TRANSITION; CROSS RESISTANCE; CRYSTAL STRUCTURE; ENZYME BINDING; ENZYME INHIBITION; ENZYME STRUCTURE; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SACCHAROMYCES CEREVISIAE; CHEMISTRY; DRUG ANTAGONISM; ENZYME ACTIVE SITE; ENZYMOLOGY; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ACETYL-COA CARBOXYLASE; CARBOXYL AND CARBAMOYL TRANSFERASES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HERBICIDES; HETEROCYCLIC COMPOUNDS, 2-RING; PROTEIN BINDING; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78650638635     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1012039107     Document Type: Article

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