메뉴 건너뛰기




Volumn 32, Issue 11, 2014, Pages 2880-2892

Regulation of mitochondrial function and cellular energy metabolism by protein kinase C-λ/ι: A novel mode of balancing pluripotency

Author keywords

Embryonic stem cells; Energy metabolism; Mitochondria; PGC1 ; Protein kinase C

Indexed keywords

ISOENZYME; PROTEIN KINASE C; PROTEIN KINASE C LAMBDA;

EID: 84907899134     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1817     Document Type: Article
Times cited : (23)

References (53)
  • 1
    • 84874708595 scopus 로고    scopus 로고
    • Energy metabolism and energy-sensing pathways in mammalian embryonic and adult stem cell fate
    • Rafalski VA, Mancini E, Brunet A,. Energy metabolism and energy-sensing pathways in mammalian embryonic and adult stem cell fate. J Cell Sci 2012; 125: 5597-5608.
    • (2012) J Cell Sci , vol.125 , pp. 5597-5608
    • Rafalski, V.A.1    Mancini, E.2    Brunet, A.3
  • 2
    • 84883489939 scopus 로고    scopus 로고
    • Mitochondrial regulation in pluripotent stem cells
    • Xu X, Duan S, Yi F, et al. Mitochondrial regulation in pluripotent stem cells. Cell Metab 2013; 18: 325-332.
    • (2013) Cell Metab , vol.18 , pp. 325-332
    • Xu, X.1    Duan, S.2    Yi, F.3
  • 3
    • 79959221064 scopus 로고    scopus 로고
    • Energy metabolism in human pluripotent stem cells and their differentiated counterparts
    • Varum S, Rodrigues AS, Moura MB, et al. Energy metabolism in human pluripotent stem cells and their differentiated counterparts. PLoS One 2011; 6: e20914.
    • (2011) PLoS One , vol.6 , pp. e20914
    • Varum, S.1    Rodrigues, A.S.2    Moura, M.B.3
  • 4
    • 84868351585 scopus 로고    scopus 로고
    • Metabolic regulation in pluripotent stem cells during reprogramming and self-renewal
    • Zhang J, Nuebel E, Daley GQ, et al. Metabolic regulation in pluripotent stem cells during reprogramming and self-renewal. Cell Stem Cell 2012; 11: 589-595.
    • (2012) Cell Stem Cell , vol.11 , pp. 589-595
    • Zhang, J.1    Nuebel, E.2    Daley, G.Q.3
  • 5
    • 79953000879 scopus 로고    scopus 로고
    • Mitochondrial function controls proliferation and early differentiation potential of embryonic stem cells
    • Mandal S, Lindgren AG, Srivastava AS, et al. Mitochondrial function controls proliferation and early differentiation potential of embryonic stem cells. Stem Cells 2011; 29: 486-495.
    • (2011) Stem Cells , vol.29 , pp. 486-495
    • Mandal, S.1    Lindgren, A.G.2    Srivastava, A.S.3
  • 6
    • 83455235489 scopus 로고    scopus 로고
    • UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells
    • Zhang J, Khvorostov I, Hong JS, et al. UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells. EMBO J 2011; 30: 4860-4873.
    • (2011) EMBO J , vol.30 , pp. 4860-4873
    • Zhang, J.1    Khvorostov, I.2    Hong, J.S.3
  • 7
    • 84860531487 scopus 로고    scopus 로고
    • HIF1alpha induced switch from bivalent to exclusively glycolytic metabolism during ESC-to-EpiSC/hESC transition
    • Zhou W, Choi M, Margineantu D, et al. HIF1alpha induced switch from bivalent to exclusively glycolytic metabolism during ESC-to-EpiSC/hESC transition. EMBO J 2012; 31: 2103-2116.
    • (2012) EMBO J , vol.31 , pp. 2103-2116
    • Zhou, W.1    Choi, M.2    Margineantu, D.3
  • 8
    • 84871344773 scopus 로고    scopus 로고
    • Analysis of mitochondrial function and localisation during human embryonic stem cell differentiation in vitro
    • Prowse AB, Chong F, Elliott DA, et al. Analysis of mitochondrial function and localisation during human embryonic stem cell differentiation in vitro. PLoS One 2012; 7: e52214.
    • (2012) PLoS One , vol.7 , pp. e52214
    • Prowse, A.B.1    Chong, F.2    Elliott, D.A.3
  • 9
    • 79960945131 scopus 로고    scopus 로고
    • Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming
    • Folmes CD, Nelson TJ, Martinez-Fernandez A, et al. Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming. Cell Metab 2011; 14: 264-271.
    • (2011) Cell Metab , vol.14 , pp. 264-271
    • Folmes, C.D.1    Nelson, T.J.2    Martinez-Fernandez, A.3
  • 10
    • 16344380951 scopus 로고    scopus 로고
    • Low O2 tensions and the prevention of differentiation of hES cells
    • Ezashi T, Das P, Roberts RM,. Low O2 tensions and the prevention of differentiation of hES cells. Proc Natl Acad Sci USA 2005; 102: 4783-4788.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 4783-4788
    • Ezashi, T.1    Das, P.2    Roberts, R.M.3
  • 11
    • 33846420629 scopus 로고    scopus 로고
    • A high glycolytic flux supports the proliferative potential of murine embryonic stem cells
    • Kondoh H, Lleonart ME, Nakashima Y, et al. A high glycolytic flux supports the proliferative potential of murine embryonic stem cells. Antioxid Redox Signal 2007; 9: 293-299.
    • (2007) Antioxid Redox Signal , vol.9 , pp. 293-299
    • Kondoh, H.1    Lleonart, M.E.2    Nakashima, Y.3
  • 12
    • 70349860263 scopus 로고    scopus 로고
    • Enhancement of human embryonic stem cell pluripotency through inhibition of the mitochondrial respiratory chain
    • Varum S, Momcilovic O, Castro C, et al. Enhancement of human embryonic stem cell pluripotency through inhibition of the mitochondrial respiratory chain. Stem Cell Res 2009; 3: 142-156.
    • (2009) Stem Cell Res , vol.3 , pp. 142-156
    • Varum, S.1    Momcilovic, O.2    Castro, C.3
  • 13
    • 80052015415 scopus 로고    scopus 로고
    • Human induced pluripotent stem cells harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining human embryonic stem cell-like metabolic reprogramming
    • Prigione A, Lichtner B, Kuhl H, et al. Human induced pluripotent stem cells harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining human embryonic stem cell-like metabolic reprogramming. Stem Cells 2011; 29: 1338-1348.
    • (2011) Stem Cells , vol.29 , pp. 1338-1348
    • Prigione, A.1    Lichtner, B.2    Kuhl, H.3
  • 14
    • 84855490988 scopus 로고    scopus 로고
    • The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming
    • Panopoulos AD, Yanes O, Ruiz S, et al. The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming. Cell Res 2012; 22: 168-177.
    • (2012) Cell Res , vol.22 , pp. 168-177
    • Panopoulos, A.D.1    Yanes, O.2    Ruiz, S.3
  • 15
    • 79952209101 scopus 로고    scopus 로고
    • Mitochondrial rejuvenation after induced pluripotency
    • Suhr ST, Chang EA, Tjong J, et al. Mitochondrial rejuvenation after induced pluripotency. PLoS One 2010; 5: e14095.
    • (2010) PLoS One , vol.5 , pp. e14095
    • Suhr, S.T.1    Chang, E.A.2    Tjong, J.3
  • 16
    • 84894554252 scopus 로고    scopus 로고
    • HIF1alpha modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2
    • Prigione A, Rohwer N, Hoffmann S, et al. HIF1alpha modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2. Stem Cells 2014; 32: 364-376.
    • (2014) Stem Cells , vol.32 , pp. 364-376
    • Prigione, A.1    Rohwer, N.2    Hoffmann, S.3
  • 17
    • 84891687170 scopus 로고    scopus 로고
    • Cited2, a transcriptional modulator protein, regulates metabolism in murine embryonic stem cells
    • Li Q, Hakimi P, Liu X, et al. Cited2, a transcriptional modulator protein, regulates metabolism in murine embryonic stem cells. J Biol Chem 2014; 289: 251-263.
    • (2014) J Biol Chem , vol.289 , pp. 251-263
    • Li, Q.1    Hakimi, P.2    Liu, X.3
  • 18
    • 79953786094 scopus 로고    scopus 로고
    • Self-renewal versus lineage commitment of embryonic stem cells: Protein kinase C signaling shifts the balance
    • Dutta D, Ray S, Home P, et al. Self-renewal versus lineage commitment of embryonic stem cells: Protein kinase C signaling shifts the balance. Stem Cells 2011; 29: 618-628.
    • (2011) Stem Cells , vol.29 , pp. 618-628
    • Dutta, D.1    Ray, S.2    Home, P.3
  • 19
    • 84883141564 scopus 로고    scopus 로고
    • Inhibition of protein kinase C signaling maintains rat embryonic stem cell pluripotency
    • Rajendran G, Dutta D, Hong J, et al. Inhibition of protein kinase C signaling maintains rat embryonic stem cell pluripotency. J Biol Chem 2013; 288: 24351-24362.
    • (2013) J Biol Chem , vol.288 , pp. 24351-24362
    • Rajendran, G.1    Dutta, D.2    Hong, J.3
  • 20
    • 84872661171 scopus 로고    scopus 로고
    • Protein kinase C regulates human pluripotent stem cell self-renewal
    • Kinehara M, Kawamura S, Tateyama D, et al. Protein kinase C regulates human pluripotent stem cell self-renewal. PLoS One 2013; 8: e54122.
    • (2013) PLoS One , vol.8 , pp. e54122
    • Kinehara, M.1    Kawamura, S.2    Tateyama, D.3
  • 21
    • 4344652068 scopus 로고    scopus 로고
    • Targeted deletion of protein kinase C lambda reveals a distribution of functions between the two atypical protein kinase C isoforms
    • Soloff RS, Katayama C, Lin MY, et al. Targeted deletion of protein kinase C lambda reveals a distribution of functions between the two atypical protein kinase C isoforms. J Immunol 2004; 173: 3250-3260.
    • (2004) J Immunol , vol.173 , pp. 3250-3260
    • Soloff, R.S.1    Katayama, C.2    Lin, M.Y.3
  • 22
    • 84877763568 scopus 로고    scopus 로고
    • Phenotypical analysis of atypical PKCs in vivo function display a compensatory system at mouse embryonic day 7.5
    • Seidl S, Braun U, Roos N, et al. Phenotypical analysis of atypical PKCs in vivo function display a compensatory system at mouse embryonic day 7.5. PLoS One 2013; 8: e62756.
    • (2013) PLoS One , vol.8 , pp. e62756
    • Seidl, S.1    Braun, U.2    Roos, N.3
  • 23
    • 54449087511 scopus 로고    scopus 로고
    • Activation of the VEGFR1 chromatin domain: An angiogenic signal-ETS1/HIF-2alpha regulatory axis
    • Dutta D, Ray S, Vivian JL, et al. Activation of the VEGFR1 chromatin domain: An angiogenic signal-ETS1/HIF-2alpha regulatory axis. J Biol Chem 2008; 283: 25404-25413.
    • (2008) J Biol Chem , vol.283 , pp. 25404-25413
    • Dutta, D.1    Ray, S.2    Vivian, J.L.3
  • 24
    • 70350376779 scopus 로고    scopus 로고
    • GATA3 is selectively expressed in the trophectoderm of peri-implantation embryo and directly regulates Cdx2 gene expression
    • Home P, Ray S, Dutta D, et al. GATA3 is selectively expressed in the trophectoderm of peri-implantation embryo and directly regulates Cdx2 gene expression. J Biol Chem 2009; 284: 28729-28737.
    • (2009) J Biol Chem , vol.284 , pp. 28729-28737
    • Home, P.1    Ray, S.2    Dutta, D.3
  • 25
    • 84860794346 scopus 로고    scopus 로고
    • Altered subcellular localization of transcription factor TEAD4 regulates first mammalian cell lineage commitment
    • Home P, Saha B, Ray S, et al. Altered subcellular localization of transcription factor TEAD4 regulates first mammalian cell lineage commitment. Proc Natl Acad Sci USA 2012; 109: 7362-7367.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 7362-7367
    • Home, P.1    Saha, B.2    Ray, S.3
  • 26
    • 70350376779 scopus 로고    scopus 로고
    • GATA3 is selectively expressed in the trophectoderm of peri-implantation embryo and directly regulates Cdx2 gene expression
    • Home P, Ray S, Dutta D, et al. GATA3 is selectively expressed in the trophectoderm of peri-implantation embryo and directly regulates Cdx2 gene expression. J Biol Chem 2009; 284: 28729-28737.
    • (2009) J Biol Chem , vol.284 , pp. 28729-28737
    • Home, P.1    Ray, S.2    Dutta, D.3
  • 27
    • 37249083079 scopus 로고    scopus 로고
    • Mitochondrial DNA replication during differentiation of murine embryonic stem cells
    • Facucho-Oliveira JM, Alderson J, Spikings EC, et al. Mitochondrial DNA replication during differentiation of murine embryonic stem cells. J Cell Sci 2007; 120: 4025-4034.
    • (2007) J Cell Sci , vol.120 , pp. 4025-4034
    • Facucho-Oliveira, J.M.1    Alderson, J.2    Spikings, E.C.3
  • 28
    • 65549136655 scopus 로고    scopus 로고
    • Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein
    • He L, Sabet A, Djedjos S, et al. Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein. Cell 2009; 137: 635-646.
    • (2009) Cell , vol.137 , pp. 635-646
    • He, L.1    Sabet, A.2    Djedjos, S.3
  • 29
    • 0037023544 scopus 로고    scopus 로고
    • HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors
    • Kyba M, Perlingeiro RC, Daley GQ,. HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors. Cell 2002; 109: 29-37.
    • (2002) Cell , vol.109 , pp. 29-37
    • Kyba, M.1    Perlingeiro, R.C.2    Daley, G.Q.3
  • 31
    • 84873744600 scopus 로고    scopus 로고
    • Glycolysis-respiration relationships in a neuroblastoma cell line
    • Swerdlow RH, E L, Aires D, et al. Glycolysis-respiration relationships in a neuroblastoma cell line. Biochim Biophys Acta 2013; 1830: 2891-2898.
    • (2013) Biochim Biophys Acta , vol.1830 , pp. 2891-2898
    • Swerdlow, R.H.1    Aires, D.2
  • 32
    • 84888799219 scopus 로고    scopus 로고
    • Bioenergetic flux, mitochondrial mass and mitochondrial morphology dynamics in AD and MCI cybrid cell lines
    • Silva DF, Selfridge JE, Lu J, et al. Bioenergetic flux, mitochondrial mass and mitochondrial morphology dynamics in AD and MCI cybrid cell lines. Hum Mol Genet 2013; 22: 3931-3946.
    • (2013) Hum Mol Genet , vol.22 , pp. 3931-3946
    • Silva, D.F.1    Selfridge, J.E.2    Lu, J.3
  • 33
    • 84869388804 scopus 로고    scopus 로고
    • Integration of cellular bioenergetics with mitochondrial quality control and autophagy
    • Hill BG, Benavides GA, Lancaster JR, Jr., et al. Integration of cellular bioenergetics with mitochondrial quality control and autophagy. Biol Chem 2012; 393: 1485-1512.
    • (2012) Biol Chem , vol.393 , pp. 1485-1512
    • Hill, B.G.1    Benavides, G.A.2    Lancaster, J.R.3
  • 34
    • 33646560586 scopus 로고
    • Effects of oligomycin on respiration and swelling of isolated liver mitochondria
    • Chappell JB, Greville GD,. Effects of oligomycin on respiration and swelling of isolated liver mitochondria. Nature 1961; 190: 502-504.
    • (1961) Nature , vol.190 , pp. 502-504
    • Chappell, J.B.1    Greville, G.D.2
  • 35
    • 77049108626 scopus 로고    scopus 로고
    • Mitochondrial uncoupler FCCP activates proton conductance but does not block store-operated Ca(2+) current in liver cells
    • To MS, Aromataris EC, Castro J, et al. Mitochondrial uncoupler FCCP activates proton conductance but does not block store-operated Ca(2+) current in liver cells. Arch Biochem Biophys 2010; 495: 152-158.
    • (2010) Arch Biochem Biophys , vol.495 , pp. 152-158
    • To, M.S.1    Aromataris, E.C.2    Castro, J.3
  • 36
    • 79956032310 scopus 로고    scopus 로고
    • Mitochondrial complex I: A central regulator of the aging process
    • Stefanatos R, Sanz A,. Mitochondrial complex I: A central regulator of the aging process. Cell Cycle 2011; 10: 1528-1532.
    • (2011) Cell Cycle , vol.10 , pp. 1528-1532
    • Stefanatos, R.1    Sanz, A.2
  • 37
    • 84872225149 scopus 로고    scopus 로고
    • PGC1alpha and mitochondrial metabolism - Emerging concepts and relevance in ageing and neurodegenerative disorders
    • Austin S, St-Pierre J,. PGC1alpha and mitochondrial metabolism-Emerging concepts and relevance in ageing and neurodegenerative disorders. J Cell Sci 2012; 125: 4963-4971.
    • (2012) J Cell Sci , vol.125 , pp. 4963-4971
    • Austin, S.1    St-Pierre, J.2
  • 38
    • 84865842181 scopus 로고    scopus 로고
    • A highly integrated and complex PPARGC1A transcription factor binding network in HepG2 cells
    • Charos AE, Reed BD, Raha D, et al. A highly integrated and complex PPARGC1A transcription factor binding network in HepG2 cells. Genome Res 2012; 22: 1668-1679.
    • (2012) Genome Res , vol.22 , pp. 1668-1679
    • Charos, A.E.1    Reed, B.D.2    Raha, D.3
  • 39
    • 0033538473 scopus 로고    scopus 로고
    • Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
    • Wu Z, Puigserver P, Andersson U, et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 1999; 98: 115-124.
    • (1999) Cell , vol.98 , pp. 115-124
    • Wu, Z.1    Puigserver, P.2    Andersson, U.3
  • 40
    • 79959908506 scopus 로고    scopus 로고
    • HIF induces human embryonic stem cell markers in cancer cells
    • Mathieu J, Zhang Z, Zhou W, et al. HIF induces human embryonic stem cell markers in cancer cells. Cancer Res 2011; 71: 4640-4652.
    • (2011) Cancer Res , vol.71 , pp. 4640-4652
    • Mathieu, J.1    Zhang, Z.2    Zhou, W.3
  • 41
    • 84891590984 scopus 로고    scopus 로고
    • Inhibition of mitochondrial complex III blocks neuronal differentiation and maintains embryonic stem cell pluripotency
    • Pereira SL, Graos M, Rodrigues AS, et al. Inhibition of mitochondrial complex III blocks neuronal differentiation and maintains embryonic stem cell pluripotency. PLoS One 2013; 8: e82095.
    • (2013) PLoS One , vol.8 , pp. e82095
    • Pereira, S.L.1    Graos, M.2    Rodrigues, A.S.3
  • 42
    • 84896032568 scopus 로고    scopus 로고
    • HIF-1alpha and HIF-2alpha are critically involved in hypoxia-induced lipid accumulation in hepatocytes through reducing PGC-1alpha-mediated fatty acid beta-oxidation
    • Liu Y, Ma Z, Zhao C, et al. HIF-1alpha and HIF-2alpha are critically involved in hypoxia-induced lipid accumulation in hepatocytes through reducing PGC-1alpha-mediated fatty acid beta-oxidation. Toxicol Lett 2014; 226: 117-123.
    • (2014) Toxicol Lett , vol.226 , pp. 117-123
    • Liu, Y.1    Ma, Z.2    Zhao, C.3
  • 43
    • 84880311058 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 is a determinant of lobular structure and oxygen consumption in the liver
    • Tsukada K, Tajima T, Hori S, et al. Hypoxia-inducible factor-1 is a determinant of lobular structure and oxygen consumption in the liver. Microcirculation 2013; 20: 385-393.
    • (2013) Microcirculation , vol.20 , pp. 385-393
    • Tsukada, K.1    Tajima, T.2    Hori, S.3
  • 44
    • 54449087511 scopus 로고    scopus 로고
    • Activation of the VEGFR1 chromatin domain: An angiogenic signal-ETS1/HIF-2alpha regulatory axis
    • Dutta D, Ray S, Vivian JL, et al. Activation of the VEGFR1 chromatin domain: An angiogenic signal-ETS1/HIF-2alpha regulatory axis. J Biol Chem 2008; 283: 25404-25413.
    • (2008) J Biol Chem , vol.283 , pp. 25404-25413
    • Dutta, D.1    Ray, S.2    Vivian, J.L.3
  • 45
    • 84868007565 scopus 로고    scopus 로고
    • Physiological roles of mitochondrial reactive oxygen species
    • Sena LA, Chandel NS,. Physiological roles of mitochondrial reactive oxygen species. Mol Cell 2012; 48: 158-167.
    • (2012) Mol Cell , vol.48 , pp. 158-167
    • Sena, L.A.1    Chandel, N.S.2
  • 46
    • 80053537984 scopus 로고    scopus 로고
    • RACK1, a multifaceted scaffolding protein: Structure and function
    • Adams DR, Ron D, Kiely PA,. RACK1, a multifaceted scaffolding protein: Structure and function. Cell Commun Signal 2011; 9: 22.
    • (2011) Cell Commun Signal , vol.9 , pp. 22
    • Adams, D.R.1    Ron, D.2    Kiely, P.A.3
  • 47
    • 34047215555 scopus 로고    scopus 로고
    • RACK1 vs. HSP90: Competition for HIF-1 alpha degradation vs. Stabilization
    • Liu YV, Semenza GL,. RACK1 vs. HSP90: Competition for HIF-1 alpha degradation vs. stabilization. Cell Cycle 2007; 6: 656-659.
    • (2007) Cell Cycle , vol.6 , pp. 656-659
    • Liu, Y.V.1    Semenza, G.L.2
  • 48
    • 37549028456 scopus 로고    scopus 로고
    • Calcineurin promotes hypoxia-inducible factor 1alpha expression by dephosphorylating RACK1 and blocking RACK1 dimerization
    • Liu YV, Hubbi ME, Pan F, et al. Calcineurin promotes hypoxia-inducible factor 1alpha expression by dephosphorylating RACK1 and blocking RACK1 dimerization. J Biol Chem 2007; 282: 37064-37073.
    • (2007) J Biol Chem , vol.282 , pp. 37064-37073
    • Liu, Y.V.1    Hubbi, M.E.2    Pan, F.3
  • 49
    • 84856739946 scopus 로고    scopus 로고
    • Hypoxia-inducible factors in physiology and medicine
    • Semenza GL,. Hypoxia-inducible factors in physiology and medicine. Cell 2012; 148: 399-408.
    • (2012) Cell , vol.148 , pp. 399-408
    • Semenza, G.L.1
  • 50
    • 77950900273 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible genes by PGC-1 alpha
    • Shoag J, Arany Z,. Regulation of hypoxia-inducible genes by PGC-1 alpha. Arterioscler Thromb Vasc Biol 2010; 30: 662-666.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 662-666
    • Shoag, J.1    Arany, Z.2
  • 51
    • 76049100577 scopus 로고    scopus 로고
    • HIF-1: Upstream and downstream of cancer metabolism
    • Semenza GL,. HIF-1: Upstream and downstream of cancer metabolism. Curr Opin Genet Dev 2010; 20: 51-56.
    • (2010) Curr Opin Genet Dev , vol.20 , pp. 51-56
    • Semenza, G.L.1
  • 52
    • 80053926733 scopus 로고    scopus 로고
    • Cripto regulates hematopoietic stem cells as a hypoxic-niche-related factor through cell surface receptor GRP78
    • Miharada K, Karlsson G, Rehn M, et al. Cripto regulates hematopoietic stem cells as a hypoxic-niche-related factor through cell surface receptor GRP78. Cell Stem Cell 2011; 9: 330-344.
    • (2011) Cell Stem Cell , vol.9 , pp. 330-344
    • Miharada, K.1    Karlsson, G.2    Rehn, M.3
  • 53
    • 77956205122 scopus 로고    scopus 로고
    • The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche
    • Simsek T, Kocabas F, Zheng J, et al. The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche. Cell Stem Cell 2010; 7: 380-390.
    • (2010) Cell Stem Cell , vol.7 , pp. 380-390
    • Simsek, T.1    Kocabas, F.2    Zheng, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.