Basal p21 controls population heterogeneity in cycling and quiescent cell cycle states

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 41, 2014, Pages E4386-E4393

  Wesley Overton, K ^a   Spencer, Sabrina L ^b   Noderer, William L ^a   Meyer, Tobias ^b   Wang, Clifford L ^a  

^a Stanford University   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

Cell dormancy; Nongenetic cell heterogeneity; Positive feedback loop; Synthetic uORF; Tumor heterogeneity

Indexed keywords

BROXURIDINE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; LYSINE; S PHASE KINASE ASSOCIATED PROTEIN; SIGNAL PEPTIDE;

BIOLOGICAL MODEL; CELL CYCLE; CELL LINE; CELL SURVIVAL; DRUG EFFECTS; FEEDBACK SYSTEM; HUMAN; KINETICS; METABOLISM; MOLECULAR IMAGING; UBIQUITINATION;

BROMODEOXYURIDINE; CELL CYCLE; CELL LINE; CELL SURVIVAL; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FEEDBACK, PHYSIOLOGICAL; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KINETICS; LYSINE; MODELS, BIOLOGICAL; MOLECULAR IMAGING; S-PHASE KINASE-ASSOCIATED PROTEINS; UBIQUITINATION;

EID: 84907893223     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1409797111     Document Type: Article

References (31)

1. Maheshri N, O'Shea EK (2007) Living with noisy genes: How cells function reliably with inherent variability in gene expression. Annu Rev Biophys Biomol Struct 36:413-434.
2. Niepel M, Spencer SL, Sorger PK (2009) Non-genetic cell-to-cell variability and the consequences for pharmacology. Curr Opin Chem Biol 13(5-6):556-561.
3. Aldridge BB, et al. (2012) Asymmetry and aging of mycobacterial cells lead to variable growth and antibiotic susceptibility. Science 335(6064):100-104.
4. Lee TJ, Yao G, Bennett DC, Nevins JR, You L (2010) Stochastic E2F activation and reconciliation of phenomenological cell-cycle models. PLoS Biol 8(9):e1000488.
5. Wilson A, et al. (2008) Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell 135(6):1118-1129.
6. Passos JF, et al. (2007) Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence. PLoS Biol 5(5):e110.
7. Gaudet S, Spencer SL, Chen WW, Sorger PK (2012) Exploring the contextual sensitivity of factors that determine cell-to-cell variability in receptor-mediated apoptosis. PLoS Comput Biol 8(4):e1002482.
8. Spencer SL, Gaudet S, Albeck JG, Burke JM, Sorger PK (2009) Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature 459(7245):428-432.
9. Cohen AA, et al. (2008) Dynamic proteomics of individual cancer cells in response to a drug. Science 322(5907):1511-1516.
10. Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ (1993) The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75(4):805-816.
11. el-Deiry WS, et al. (1993) WAF1, a potential mediator of p53 tumor suppression. Cell 75(4):817-825.
12. Spencer SL, et al. (2013) The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit. Cell 155(2):369-383.
13. Lu Z, Hunter T (2010) Ubiquitylation and proteasomal degradation of the p21(Cip1), p27(Kip1) and p57(Kip2) CDK inhibitors. Cell Cycle 9(12):2342-2352.
14. Elowitz MB, Levine AJ, Siggia ED, Swain PS (2002) Stochastic gene expression in a single cell. Science 297(5584):1183-1186.
15. To TL, Maheshri N (2010) Noise can induce bimodality in positive transcriptional feedback loops without bistability. Science 327(5969):1142-1145.
16. Wong JV, Yao G, Nevins JR, You L (2011) Viral-mediated noisy gene expression reveals biphasic E2f1 response to MYC. Mol Cell 41(3):275-285.
17. Yao G, Lee TJ, Mori S, Nevins JR, You L (2008) A bistable Rb-E2F switch underlies the restriction point. Nat Cell Biol 10(4):476-482.
18. Yao G, Tan C, West M, Nevins JR, You L (2011) Origin of bistability underlying mammalian cell cycle entry. Mol Syst Biol 7:485.
19. Hahn AT, Jones JT, Meyer T (2009) Quantitative analysis of cell cycle phase durations and PC12 differentiation using fluorescent biosensors. Cell Cycle 8(7):1044-1052.
20. Westergaard LG, Andersen CY (1989) Epidermal growth factor (EGF) in human preovulatory follicles. Hum Reprod 4(3):257-260.
21. Ferreira JP, Noderer WL, Diaz de Arce AJ, Wang CL (2014) Engineering ribosomal leaky scanning and upstream open reading frames for precise control of protein translation. Bioengineered 5(3):186-192.
22. Ferreira JP, Overton KW, Wang CL (2013) Tuning gene expression with synthetic upstream open reading frames. Proc Natl Acad Sci USA 110(28):11284-11289.
23. Dulić V, Stein GH, Far DF, Reed SI (1998) Nuclear accumulation of p21Cip1 at the onset of mitosis: A role at the G2/M-phase transition. Mol Cell Biol 18(1):546-557.
24. Tinkum KL, et al. (2011) Bioluminescence imaging captures the expression and dynamics of endogenous p21 promoter activity in living mice and intact cells. Mol Cell Biol 31(18):3759-3772.
25. Yamamoto H, et al. (1999) Comparative effects of overexpression of p27Kip1 and p21Cip1/Waf1 on growth and differentiation in human colon carcinoma cells. Oncogene 18(1):103-115.
26. Wang W, Nacusi L, Sheaff RJ, Liu X (2005) Ubiquitination of p21Cip1/WAF1 by SCFSkp2: Substrate requirement and ubiquitination site selection. Biochemistry 44(44):14553-14564.
27. Sheaff RJ, et al. (2000) Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination. Mol Cell 5(2):403-410.
28. Venta R, Valk E, Kõivomägi M, Loog M (2012) Double-negative feedback between S-phase cyclin-CDK and CKI generates abruptness in the G1/S switch. Front Physiol 3:459.
29. Cheng T, et al. (2000) Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science 287(5459):1804-1808.
30. Kippin TE, Martens DJ, van der Kooy D (2005) p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity. Genes Dev 19(6):756-767.
31. Peacock RW, Wang CL (2011) A genetic reporter system to gauge cell proliferation rate. Biotechnol Bioeng 108(9):2003-2010.